Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum.

abstract：:Mutations in PIEZO1 are the primary cause of hereditary xerocytosis, a clinically heterogeneous, dominantly inherited disorder of erythrocyte dehydration. We used next-generation sequencing-based techniques to identify PIEZO1 mutations in individuals from 9 kindreds referred with suspected hereditary xerocytosis (HX) ...

journal_title：Blood

authors： Glogowska E,Schneider ER,Maksimova Y,Schulz VP,Lezon-Geyda K,Wu J,Radhakrishnan K,Keel SB,Mahoney D,Freidmann AM,Altura RA,Gracheva EO,Bagriantsev SN,Kalfa TA,Gallagher PG

更新日期：2017-10-19 00:00:00

abstract：:The putative chemokine receptor BLR1 has been identified as the first G-protein-coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation...

journal_title：Blood

authors： Förster R,Schweigard G,Johann S,Emrich T,Kremmer E,Nerl C,Lipp M

更新日期：1997-07-15 00:00:00

abstract：:In this study, we examined in detail the interaction of platelet factor-4 (PF-4) with fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) and the effect of PF-4-derived synthetic peptides. We show that a peptide between amino acids 47 and 70 that contains the heparin-binding lysine-rich si...

journal_title：Blood

authors： Jouan V,Canron X,Alemany M,Caen JP,Quentin G,Plouet J,Bikfalvi A

更新日期：1999-08-01 00:00:00

abstract：:To obtain insight into the mechanism(s) of posttransplantation humoral immunodeficiency, we evaluated factors affecting serum antibody levels against polio, tetanus, Haemophilus influenzae, and Streptococcus pneumoniae in 87 patients. Patients with hematologic malignancies were randomized to receive marrow versus bloo...

journal_title：Blood

authors： Storek J,Viganego F,Dawson MA,Herremans MM,Boeckh M,Flowers ME,Storer B,Bensinger WI,Witherspoon RP,Maloney DG

更新日期：2003-04-15 00:00:00

abstract：:The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is considered to be frequently offset by graft-versus-host disease (GVHD). Thus, impr...

journal_title：Blood

authors： Kawase T,Matsuo K,Kashiwase K,Inoko H,Saji H,Ogawa S,Kato S,Sasazuki T,Kodera Y,Morishima Y,Japan Marrow Donor Program.

更新日期：2009-03-19 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) regulates hematopoietic stem/progenitor cell (HSPC) activity. However, the receptor(s) responsible for PGE(2) signaling remains unclear. Here, we identified EP4 as a receptor activated by PGE(2) to regulate HSPCs. Knockdown of Ep4 in HSPCs reduced long-term reconstitution capacity, whereas ...

journal_title：Blood

authors： Ikushima YM,Arai F,Hosokawa K,Toyama H,Takubo K,Furuyashiki T,Narumiya S,Suda T

更新日期：2013-03-14 00:00:00

abstract：:The regulatory Tat protein of human immunodeficiency virus type-1 (HIV-1) exerts a pleyotropic activity on the survival and proliferation of different cell types in culture. In this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T...

journal_title：Blood

authors： Zauli G,Gibellini D,Caputo A,Bassini A,Negrini M,Monne M,Mazzoni M,Capitani S

更新日期：1995-11-15 00:00:00

abstract：:Autologous membrane-bound IgG was isolated from a subpopulation of human red blood cells (RBC) with specific density greater than 1.110, by affinity chromatography of purified RBC membrane glycoprotein preparations using immobilized wheat germ agglutinin and immobilized anti-human immunoglobulin (Ig) as immunoabsorben...

journal_title：Blood

authors： Alderman EM,Fudenberg HH,Lovins RE

更新日期：1981-08-01 00:00:00

abstract：:Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

journal_title：Blood

authors： Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

更新日期：2020-12-24 00:00:00

abstract：:Hematologic engraftment and immune reconstitution were examined in patients who received cyclophosphamide and total body irradiation therapy followed by infusion of autologous bone marrow purged with anti-B1 monoclonal antibody (MoAb) and complement as therapy for non-Hodgkin's lymphoma. Hematologic engraftment was pr...

journal_title：Blood

authors： Anderson KC,Ritz J,Takvorian T,Coral F,Daley H,Gorgone BC,Freedman AS,Canellos GP,Schlossman SF,Nadler LM

更新日期：1987-02-01 00:00:00

abstract：:Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA). For both fluoride ...

journal_title：Blood

authors： English D,Roloff JS,Lukens JN

更新日期：1981-07-01 00:00:00

abstract：:The bone marrow (BM) microenvironment consists of extracellular-matrix and the cellular compartment including immune cells. Multiple myeloma (MM) cell and BM accessory cell interaction promotes MM survival via both cell-cell contact and cytokines. Immunomodulatory agents (IMiDs) target not only MM cells, but also MM c...

journal_title：Blood

authors： Görgün G,Calabrese E,Soydan E,Hideshima T,Perrone G,Bandi M,Cirstea D,Santo L,Hu Y,Tai YT,Nahar S,Mimura N,Fabre C,Raje N,Munshi N,Richardson P,Anderson KC

更新日期：2010-10-28 00:00:00

abstract：:Approximately 20% of children with acute lymphoblastic leukemia (ALL) relapse because of failure to eradicate the disease. Current drug efficacy studies focus on reducing leukemia cell burden. However, if drugs have limited effects on leukemia-initiating cells (LICs), then these cells may expand and eventually cause r...

journal_title：Blood

authors： Diamanti P,Cox CV,Moppett JP,Blair A

更新日期：2013-02-21 00:00:00

abstract：:Studies with the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin-3 (IL-3) fusion protein, PIXY321, demonstrated enhanced biological activity of this molecule in comparison with GM-CSF or IL-3 alone or in combination. Experiments were performed to study the mechanisms resulting in PIXY321-induced ...

journal_title：Blood

authors： Mignacca RC,Lee HJ,Kwon EM,Sakamoto KM

更新日期：1996-08-01 00:00:00

abstract：:CD44, a cell surface glycoprotein, is involved in lymphocyte trafficking from the blood to lymphatic tissues, and is of importance in dissemination of lymphoma. A variant form of CD44 that has additional amino acids in the common protein backbone (CD44v6) also seems to play a role in the metastatic dissemination of ma...

journal_title：Blood

authors： Ristamäki R,Joensuu H,Salmi M,Jalkanen S

更新日期：1994-07-01 00:00:00

abstract：:Twenty four samples of DNA from 23 unrelated individuals were analyzed for the presence of a novel restriction fragment length polymorphism (RFLP) involving the proto-oncogene ETS-1 at an Xba I site. Four samples from unrelated individuals lacked an Xba I site, giving rise to a longer restriction fragment detectable b...

journal_title：Blood

authors： Savage PD,Hanson CA,Kersey JH

更新日期：1987-07-01 00:00:00

abstract：:The recombinant thrombopoietins have been shown to be effective stimulators of platelet production in cancer patients. It was therefore of interest to determine if one of these, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), could be used to increase platelet counts and conseque...

journal_title：Blood

authors： Kuter DJ,Goodnough LT,Romo J,DiPersio J,Peterson R,Tomita D,Sheridan W,McCullough J

更新日期：2001-09-01 00:00:00

abstract：:The tyrosine kinase receptor fetal liver kinase 1 (Flk-1) plays a crucial role in vasculogenesis and angiogenesis, but its target genes remain elusive. Comparing Flk-1(+/+) with Flk-1(-/-) embryonic stem (ES) cells, we identified transcripts regulated by the vascular endothelial growth factor A (VEGF-A)/Flk-1 pathway ...

journal_title：Blood

authors： Zippo A,De Robertis A,Bardelli M,Galvagni F,Oliviero S

更新日期：2004-06-15 00:00:00

abstract：:The extended use of brentuximab-vedotin was reported for CD30(+) nonanaplastic peripheral T-cell lymphomas (PTCLs) with promising efficacy. CD30 status assessment is thus a critical factor for therapeutic decision, but the reliability of immunohistochemistry (IHC) in evaluating its expression remains to be defined. Th...

journal_title：Blood

authors： Bossard C,Dobay MP,Parrens M,Lamant L,Missiaglia E,Haioun C,Martin A,Fabiani B,Delarue R,Tournilhac O,Delorenzi M,Gaulard P,de Leval L

更新日期：2014-11-06 00:00:00

abstract：:We prospectively studied 98 chronic myeloid leukemia (CML) patients after bone marrow transplantation by competitive polymerase chain reaction to detect and quantify leukemia-specific BCR-ABL mRNA. Of 69 patients who had persistently undetectable, decreasing, or low BCR-ABL levels ( < 50 transcripts/microgram RNA) on ...

journal_title：Blood

authors： Lin F,van Rhee F,Goldman JM,Cross NC

更新日期：1996-05-15 00:00:00

abstract：:Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA). Different GA isoforms are encoded by the genes GLS1 and GLS2 in humans. Herein, we show that glutamine levels control mitochondri...

journal_title：Blood

authors： Jacque N,Ronchetti AM,Larrue C,Meunier G,Birsen R,Willems L,Saland E,Decroocq J,Maciel TT,Lambert M,Poulain L,Hospital MA,Sujobert P,Joseph L,Chapuis N,Lacombe C,Moura IC,Demo S,Sarry JE,Recher C,Mayeux P,Tambur

更新日期：2015-09-10 00:00:00

abstract：:Glycoprotein (GP) Ibalpha, a member of the leucine-rich repeat (LRR) protein family, mediates platelet adhesion to immobilized von Willebrand factor (VWF). We investigated the role in VWF binding of charged residues in the LRR region of GP Ibalpha that are conserved in human, canine, and murine proteins. Substitution ...

journal_title：Blood

authors： Peng Y,Shrimpton CN,Dong JF,López JA

更新日期：2005-09-15 00:00:00

abstract：:An imbalance between cellular apoptosis and survival may be critical for the pathogenesis of lymphoma. Therefore, the gene expression pattern in lymph node preparations from patients with mantle cell lymphoma (MCL) was compared to the pattern in nonmalignant hyperplastic lymph nodes (HLs). Oligonucleotide microarray a...

journal_title：Blood

authors： Hofmann WK,de Vos S,Tsukasaki K,Wachsman W,Pinkus GS,Said JW,Koeffler HP

更新日期：2001-08-01 00:00:00

abstract：:A global phase 3 study evaluated the pharmacokinetics, efficacy, and safety of recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in 63 previously treated male patients (12-61 years) with severe hemophilia B (factor IX [FIX] activity ≤2%). The study included 2 groups: group 1 patients recei...

journal_title：Blood

authors： Santagostino E,Martinowitz U,Lissitchkov T,Pan-Petesch B,Hanabusa H,Oldenburg J,Boggio L,Negrier C,Pabinger I,von Depka Prondzinski M,Altisent C,Castaman G,Yamamoto K,Álvarez-Roman MT,Voigt C,Blackman N,Jacobs I,PROLONG

更新日期：2016-04-07 00:00:00

abstract：:Joint bleeding after (sports) trauma, after major joint surgery, or as seen in hemophilia in general leads to arthropathy. Joint degeneration is considered to result from the direct effects of blood components on cartilage and indirectly from synovial inflammation. Blood-provided proinflammatory cytokines trigger chon...

journal_title：Blood

authors： van Vulpen LF,Schutgens RE,Coeleveld K,Alsema EC,Roosendaal G,Mastbergen SC,Lafeber FP

更新日期：2015-11-05 00:00:00

abstract：:The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects wit...

journal_title：Blood

authors： Layrisse M,Martínez-Torres C,Renzy M,Leets I

更新日期：1975-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry. It was recently demonstrated that HIV-1 glycoprotein 120 (gp120) elevated calcium and activated several ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo...

journal_title：Blood

authors： Del Corno M,Liu QH,Schols D,de Clercq E,Gessani S,Freedman BD,Collman RG

更新日期：2001-11-15 00:00:00

abstract：:We compared 48-hour urinary iron excretion after a twice-daily subcutaneous bolus injection of deferoxamine and after 12 hours of subcutaneous continuous infusion of the drug in 27 patients with iron overload (mean age, 55.7 years). In most patients, the iron overload was due to multiple transfusions administered duri...

journal_title：Blood

authors： Franchini M,Gandini G,de Gironcoli M,Vassanelli A,Borgna-Pignatti C,Aprili G

更新日期：2000-05-01 00:00:00

abstract：:Severe deficiency of ADAMTS13, a plasma metalloprotease, leads to thrombotic thrombocytopenic purpura. ADAMTS13 contains 10 putative N-glycosylation sites in or near its metalloprotease sequence, spacer region, thrombospondin type 1 repeat no. 4 (TSR no. 4), and CUB domains. Tunicamycin treatment markedly decreased th...

journal_title：Blood

authors： Zhou W,Tsai HM

更新日期：2009-01-22 00:00:00

abstract：:The pathologic hallmarks of thrombotic thrombocytopenic purpura (TTP) include endothelial cell proliferation and subendothelial hyalin deposits in the microvasculature leading to symptomatic thrombotic occlusions. Plasma or sera from three consecutive patients with TTP were subjected to multiple analyses to determine ...

journal_title：Blood

authors： Burns ER,Zucker-Franklin D

更新日期：1982-10-01 00:00:00