Abnormal expression of the B-cell homing chemokine receptor BLR1 during the progression of acquired immunodeficiency syndrome.

abstract：:We performed a pilot study to test the effectiveness of allogeneic bone marrow transplantation in the treatment of chronic myelogenous leukemia. Five patients in the advanced stages of chronic myelogenous leukemia (four in blast crisis, one in accelerated phase) with abnormal chromosomes underwent matched-sibling allo...

journal_title：Blood

authors： McGlave PB,Miller WJ,Hurd DD,Arthur DC,Kim T

更新日期：1981-11-01 00:00:00

abstract：:The transcription factor encoded by the mi locus (MITF) is a transcription factor of the basic-helix-loop-helix zipper protein family. Mice of mi/mi genotype express a normal amount of abnormal MITF, whereas mice of tg/tg genotype do not express any MITFs due to the transgene insertional mutation. The effect of normal...

journal_title：Blood

authors： Ogihara H,Morii E,Kim DK,Oboki K,Kitamura Y

更新日期：2001-02-01 00:00:00

abstract：:Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is the de novo generation of autoreactive T cells. Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral self-antigens (TRA), ...

journal_title：Blood

authors： Dertschnig S,Nusspaumer G,Ivanek R,Hauri-Hohl MM,Holländer GA,Krenger W

更新日期：2013-08-01 00:00:00

abstract：:The use of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) following autologous marrow transplantation for lymphoid malignancies was explored in a phase I/II dose escalation study. rhGM-CSF given as a 2-hour infusion daily for 14 days was well tolerated at doses up to 240 micrograms/m2/da...

journal_title：Blood

authors： Nemunaitis J,Singer JW,Buckner CD,Hill R,Storb R,Thomas ED,Appelbaum FR

更新日期：1988-08-01 00:00:00

abstract：:Brentuximab vedotin induces an overall response rate of 75% in patients with relapsed/refractory Hodgkin lymphoma, but its impact on future allogeneic transplantation (allo-HCT) is not known. We retrospectively examined the records of 18 patients with relapsed/refractory Hodgkin lymphoma who were treated on brentuxima...

journal_title：Blood

authors： Chen R,Palmer JM,Thomas SH,Tsai NC,Farol L,Nademanee A,Forman SJ,Gopal AK

更新日期：2012-06-28 00:00:00

abstract：:In 33 patients with thalassemia and idiopathic hemochromatosis, plasma ferritin protein levels ranged from 36 to 5,850 micrograms/L. The iron content of this ferritin as determined by immunoprecipitation ranged from undetectable amounts to 507 micrograms/L. The mean iron content of ferritin protein in those and other ...

journal_title：Blood

authors： Pootrakul P,Josephson B,Huebers HA,Finch CA

更新日期：1988-04-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...

journal_title：Blood

authors： Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

更新日期：2008-11-01 00:00:00

abstract：:The serpin antithrombin III (AT III) is reported to have hemostasis-regulating and anti-inflammatory properties. To determine its ability to influence thrombin-independent leukocyte responses, the direct effects of the AT III concentrate Kybernin P and a monoclonal antibody-purified AT III on neutrophil migration were...

journal_title：Blood

authors： Dunzendorfer S,Kaneider N,Rabensteiner A,Meierhofer C,Reinisch C,Römisch J,Wiedermann CJ

更新日期：2001-02-15 00:00:00

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:It is thought that an increase in the adhesion of circulating reticulocytes to the vascular endothelium may initiate the vascular occlusion underlying the painful crises and organ failures typical of sickle cell disease (SCD). At least 2 receptors, usually present on reticulocytes, seem to be involved in this adhesion...

journal_title：Blood

authors： Lee K,Gane P,Roudot-Thoraval F,Godeau B,Bachir D,Bernaudin F,Cartron JP,Galactéros F,Bierling P

更新日期：2001-08-15 00:00:00

abstract：:Targeted irradiation of the bone marrow with radiolabeled monoclonal antibodies (radioimmunotherapy) represents a novel therapeutic approach with both myeloablative and antileukemic potential. In an open-label, single-center pilot study, 30 pediatric and adolescent patients undergoing hematopoietic cell transplantatio...

journal_title：Blood

authors： Schulz AS,Glatting G,Hoenig M,Schuetz C,Gatz SA,Grewendorf S,Sparber-Sauer M,Muche R,Blumstein N,Kropshofer G,Suttorp M,Bunjes D,Debatin KM,Reske SN,Friedrich W

更新日期：2011-04-28 00:00:00

abstract：:The causes of anemia and immunosuppression, major outcomes of malaria, are not well established. This study was undertaken to investigate whether erythropoietin (EP) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of infection. Groups of female Balb/c mice infected...

journal_title：Blood

authors： Silverman PH,Schooley JC,Mahlmann LJ

更新日期：1987-02-01 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is now a commonplace procedure. Clinicians who care for patients with hematologic malignancies and aplastic anemia are almost certain to follow up patients after SCT. This review is intended to help clinicians observe patients for probably the most important late complication...

journal_title：Blood

authors： Vogelsang GB

更新日期：2001-03-01 00:00:00

abstract：:This study includes 47 normal subjects and 25 hemophilia B patients without inhibitor(s), showing different factor IX coagulant activity and antigen levels. Genomic DNA, digested with various restriction endonucleases, was hybridized with two different factor IX probes, ie, the cDNA and the subgenomic probe for the in...

journal_title：Blood

authors： Hassan HJ,Orlando M,Leonardi A,Chelucci C,Guerriero R,Mannucci PM,Mariani G,Peschle C

更新日期：1985-02-01 00:00:00

abstract：:The authors have identified a 12-residue carboxyl-terminal extension of Lys-Ser-Pro-Met-Arg-Arg-Phe-Leu-Leu-Phe-Cys-Met in a dysfibrinogen derived from a woman heterozygotic for this abnormality and associated with severe bleeding. This extension is due to a T-to-A mutation that creates AAG encoding Lys at the stop (T...

journal_title：Blood

authors： Sugo T,Nakamikawa C,Yoshida N,Niwa K,Sameshima M,Mimuro J,Weisel JW,Nagita A,Matsuda M

更新日期：2000-12-01 00:00:00

abstract：:An association between platelets, angiogenesis, and cancer has long been recognized, but the mechanisms linking them remains unclear. Platelets regulate new blood vessel growth through numerous stimulators and inhibitors of angiogenesis by several pathways, including differential exocytosis of angiogenesis regulators....

journal_title：Blood

authors： Battinelli EM,Markens BA,Italiano JE Jr

更新日期：2011-08-04 00:00:00

abstract：:Recent reports have shown that leukocyte-leukocyte adhesion is dependent on L-selectin and that leukocyte recognition of L-selectin may be mediated by P-selectin glycoprotein ligand-1 (PSGL-1). We show that the specific attachment and rolling of human neutrophils and the leukemia cell lines HL-60 and U937 on immobiliz...

journal_title：Blood

authors： Ramos CL,Smith MJ,Snapp KR,Kansas GS,Stickney GW,Ley K,Lawrence MB

更新日期：1998-02-01 00:00:00

abstract：:The effects of transforming growth factor-beta 1 (TGF-beta 1) on proliferation and hemoglobinization in K-562 cells, a human multipotential hematopoietic cell line, were studied. We found that TGF-beta 1 could induce hemoglobin accumulation in K-562 cells. Various clones were selected on the basis of the inducibility ...

journal_title：Blood

authors： Chen LL,Dean A,Jenkinson T,Mendelsohn J

更新日期：1989-11-15 00:00:00

abstract：:Venous thromboembolism (VTE) is a frequent complication in cancer patients and represents an important cause of morbidity and mortality. Especially in patients who have a poor life expectancy, preventing death from pulmonary embolism is the mainstay of treatment. Critically ill patients should promptly be administered...

journal_title：Blood

authors： Prandoni P

更新日期：2005-12-15 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV), a DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia. MCPyV sequences have also been detected in various normal tissues in tumor-affected patients. Immunologic studies have detected MCPyV antibodies in as many as 80% of healthy...

journal_title：Blood

authors： Pancaldi C,Corazzari V,Maniero S,Mazzoni E,Comar M,Martini F,Tognon M

更新日期：2011-06-30 00:00:00

abstract：:The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in v...

journal_title：Blood

authors： van de Kar NC,Monnens LA,Karmali MA,van Hinsbergh VW

更新日期：1992-12-01 00:00:00

abstract：:Attempts to maintain or expand primitive hematopoietic stem cells in vitro without the concomitant loss of their differentiative and proliferative potential in vivo have largely been unsuccessful. To investigate this problem, we compared the ability of three cloned bone marrow (BM) stromal cell lines to support the gr...

journal_title：Blood

authors： Szilvassy SJ,Weller KP,Lin W,Sharma AK,Ho AS,Tsukamoto A,Hoffman R,Leiby KR,Gearing DP

更新日期：1996-06-01 00:00:00

abstract：:Mature megakaryocytes form structures called proplatelets that serve as conduits for platelet packaging and release at vascular sinusoids. Since the megakaryocyte expresses abundant levels of integrin alpha IIb beta3, we have examined a role for fibrinogen in proplatelet development and platelet release alongside that...

journal_title：Blood

authors： Larson MK,Watson SP

更新日期：2006-09-01 00:00:00

abstract：:Fibronectin is a major component of the extracellular matrix of adherent layers of human long-term marrow cultures where it may stabilize the extracellular matrix network and provide adhesion sites for primitive hemopoietic cells. This study was devised to analyze the role of adherent cell populations in fibronectin s...

journal_title：Blood

authors： Lerat H,Lissitzky JC,Singer JW,Keating A,Herve P,Charbord P

更新日期：1993-09-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. Recently, oncogenic mutations in NRAS/KRAS, upstream regulators of the RAF/MEK/ERK pathway, have been reported in pulm...

journal_title：Blood

authors： Kamata T,Giblett S,Pritchard C

更新日期：2017-07-27 00:00:00

abstract：:Human T cells were studied with regard to the regulation of interleukin-4 (IL-4) and IL-3 gene expression. IL-4 and IL-3 mRNA were undetectable in unstimulated T cells. On activation with the lectin concanavalin A (Con A), both IL-4 and IL-3 mRNA were expressed. Accumulation of IL-4 mRNA peaked after 6 to 12 hours, wh...

journal_title：Blood

authors： Dokter WH,Esselink MT,Sierdsema SJ,Halie MR,Vellenga E

更新日期：1993-01-01 00:00:00

abstract：:Hypercoagulability and thrombotic tendency are frequently induced by a variety of stressors. Clinically, aged subjects and obese patients are more susceptible to thrombotic diseases associated with stress, but the underlying mechanisms are unknown. We investigated the expression of a procoagulant gene, tissue factor (...

journal_title：Blood

authors： Yamamoto K,Shimokawa T,Yi H,Isobe K,Kojima T,Loskutoff DJ,Saito H

更新日期：2002-12-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is classically described to result from a dysregulation of the complement alternative pathway, leading to glomerular endothelial cell (EC) damage and thrombosis. However, recent findings in families with aHUS of mutations in the DGKE gene, which is not an integral component of...

journal_title：Blood

authors： Bruneau S,Néel M,Roumenina LT,Frimat M,Laurent L,Frémeaux-Bacchi V,Fakhouri F

更新日期：2015-02-05 00:00:00

abstract：:To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and follow the path of least resistance. It is known that this amoeboid migration of DCs requires Cdc42, yet the upstream regulators critical for localization and activ...

journal_title：Blood

authors： Harada Y,Tanaka Y,Terasawa M,Pieczyk M,Habiro K,Katakai T,Hanawa-Suetsugu K,Kukimoto-Niino M,Nishizaki T,Shirouzu M,Duan X,Uruno T,Nishikimi A,Sanematsu F,Yokoyama S,Stein JV,Kinashi T,Fukui Y

更新日期：2012-05-10 00:00:00

abstract：:The combination of high levels of beta2-microglobulin (beta2-m) and chromosome 13 deletion allows identification of a high-risk subgroup of patients with de novo multiple myeloma (MM). In this population of patients, we have evaluated the impact of a murine anti-interleukin 6 (anti-IL-6) monoclonal antibody (BE-8) as ...

journal_title：Blood

authors： Moreau P,Hullin C,Garban F,Yakoub-Agha I,Benboubker L,Attal M,Marit G,Fuzibet JG,Doyen C,Voillat L,Berthou C,Ketterer N,Casassus P,Monconduit M,Michallet M,Najman A,Sotto JJ,Bataille R,Harousseau JL,Intergroupe Fran

更新日期：2006-01-01 00:00:00