Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol.

abstract：:This phase 1/2 study assessed parsaclisib (INCB050465), a next-generation, potent, and highly selective phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor, in patients with relapsed or refractory B-cell malignancies, alone or in combination with a Janus kinase 1 inhibitor (itacitinib) or chemotherapy (rituximab, ifosfa...

journal_title：Blood

authors： Forero-Torres A,Ramchandren R,Yacoub A,Wertheim MS,Edenfield WJ,Caimi P,Gutierrez M,Akard L,Escobar C,Call J,Persky D,Iyer S,DeMarini DJ,Zhou L,Chen X,Dawkins F,Phillips TJ

更新日期：2019-04-18 00:00:00

abstract：:"Fetal" erythrocytes are present in older children and certain adults with hematologic disorders. To determine if regenerating bone marrow produces such cells, we examined the blood of seven allogeneic bone marrow transplant recipients. Six patients were engrafted with donor cells, while on e patients recovered autolo...

journal_title：Blood

authors： Alter BP,Rappeport JM,Huisman TH,Schroeder WA,Nathan DG

更新日期：1976-12-01 00:00:00

abstract：:In contrast to other diverse therapies for the X-linked bleeding disorder hemophilia that are currently in clinical development, gene therapy holds the promise of a lasting cure with a single drug administration. Near-to-complete correction of hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficienc...

journal_title：Blood

authors： Perrin GQ,Herzog RW,Markusic DM

更新日期：2019-01-31 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) are crucial effectors in innate immunity. In this study, we show that imatinib, a potent inhibitor of BCR/ABL tyrosine kinase activity, in the presence of Flt3-Ligand, could induce CD34+ progenitors from chronic myeloid leukemia (CML) to give rise in vitro to typical BDCA-2+ type I ...

journal_title：Blood

authors： Mohty M,Jourdan E,Mami NB,Vey N,Damaj G,Blaise D,Isnardon D,Olive D,Gaugler B

更新日期：2004-06-15 00:00:00

abstract：:The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We...

journal_title：Blood

authors： Mamani-Matsuda M,Cosma A,Weller S,Faili A,Staib C,Garçon L,Hermine O,Beyne-Rauzy O,Fieschi C,Pers JO,Arakelyan N,Varet B,Sauvanet A,Berger A,Paye F,Andrieu JM,Michel M,Godeau B,Buffet P,Reynaud CA,Weill JC

更新日期：2008-05-01 00:00:00

abstract：:Induction of transplantation tolerance by means of bone marrow (BM) transplantation could become a reality if it was possible to achieve engraftment of hematopoietic stem cells under nonlethal preparatory cytoreduction of the recipient. To that end, BM facilitating cells, veto cells, or other tolerance-inducing cells,...

journal_title：Blood

authors： Bachar-Lustig E,Li HW,Gur H,Krauthgamer R,Marcus H,Reisner Y

更新日期：1999-11-01 00:00:00

abstract：:Severe congenital neutropenia (CN) (Kostmann syndrome) is a hematologic disorder characterized by a maturation arrest of myelopoiesis at the promyelocyte/myelocyte stage of development. This arrest results in severe neutropenia leading to absolute neutrophil counts (ANC) below 0.2 x 10(9)/L associated with severe bact...

journal_title：Blood

authors： Zeidler C,Welte K,Barak Y,Barriga F,Bolyard AA,Boxer L,Cornu G,Cowan MJ,Dale DC,Flood T,Freedman M,Gadner H,Mandel H,O'Reilly RJ,Ramenghi U,Reiter A,Skinner R,Vermylen C,Levine JE

更新日期：2000-02-15 00:00:00

abstract：:Fibrin is essential for hemostasis; however, abnormal fibrin formation is hypothesized to increase thrombotic risk. We previously showed that in situ thrombin generation on a cell's surface modulates the 3-dimensional structure and stability of the fibrin network. Currently, we compared the abilities of extravascular ...

journal_title：Blood

authors： Campbell RA,Overmyer KA,Selzman CH,Sheridan BC,Wolberg AS

更新日期：2009-11-26 00:00:00

abstract：:P-selectin (CD62P) is a member of the selectin family of adhesion molecules involved in the regulation of leukocyte traffic. P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-like molecule that is thought to be a primary ligand for P-selectin. The interaction of P-selectin with PSGL-1 results in leukocyte rolling a...

journal_title：Blood

authors： Snapp KR,Wagers AJ,Craig R,Stoolman LM,Kansas GS

更新日期：1997-02-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell characterized by abnormal circulation and proliferation of malignant progenitors. In contrast to their normal counterparts, CML progenitors adhere poorly to bone marrow stroma or fibronectin (FN). Aside from anchoring progenitors ...

journal_title：Blood

authors： Lundell BI,McCarthy JB,Kovach NL,Verfaillie CM

更新日期：1996-03-15 00:00:00

abstract：:Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cel...

journal_title：Blood

authors： Nilsson L,Edén P,Olsson E,Månsson R,Astrand-Grundström I,Strömbeck B,Theilgaard-Mönch K,Anderson K,Hast R,Hellström-Lindberg E,Samuelsson J,Bergh G,Nerlov C,Johansson B,Sigvardsson M,Borg A,Jacobsen SE

更新日期：2007-10-15 00:00:00

abstract：:Anti-CD22 moxetumomab pasudotox achieved 46% complete remissions (CRs) in previously reported phase 1 testing in relapsed/refractory hairy cell leukemia (HCL; n = 28). The importance of minimal residual disease (MRD) after CR in HCL is unknown. A 21-patient extension cohort received 50 µg/kg every other day for 3 dose...

journal_title：Blood

authors： Kreitman RJ,Tallman MS,Robak T,Coutre S,Wilson WH,Stetler-Stevenson M,FitzGerald DJ,Santiago L,Gao G,Lanasa MC,Pastan I

更新日期：2018-05-24 00:00:00

abstract：:Immunological control may contribute to achievement of deep molecular response in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor (TKI) therapy and may promote treatment-free remission (TFR). We investigated effector and suppressor immune responses in CML patients at diagnosis (n = 21), on TKI (im...

journal_title：Blood

authors： Hughes A,Clarson J,Tang C,Vidovic L,White DL,Hughes TP,Yong AS

更新日期：2017-03-02 00:00:00

abstract：:The rapid transformation of human blood platelets from inert discoid cells to spheroechinocytes that is induced by adenosine diphosphate (ADP) has been followed by right-angle light scattering intensity measurements using a laser light source and a sensitive photomultiplier. Two steps have been observed, and their rat...

journal_title：Blood

authors： Hantgan RR

更新日期：1984-10-01 00:00:00

abstract：:Allogeneic stem cell transplantation with umbilical cord blood (UCB) cells is limited by the cell dose a single unit provides recipients. Ex vivo expansion is one strategy to increase the number of cells available for transplantation. Aastrom Biosciences developed an automated continuous perfusion culture device for e...

journal_title：Blood

authors： Jaroscak J,Goltry K,Smith A,Waters-Pick B,Martin PL,Driscoll TA,Howrey R,Chao N,Douville J,Burhop S,Fu P,Kurtzberg J

更新日期：2003-06-15 00:00:00

abstract：:In systemic light-chain amyloidosis, λ light chains produced by clonal plasma cells cause organ damage and early death. In pursuit of novel therapy, we developed 1 pool of short interfering RNA (siRNA) targeting the constant region of λ light chains that substantially and promptly reduces λ-light-chain production and ...

journal_title：Blood

authors： Zhou P,Ma X,Iyer L,Chaulagain C,Comenzo RL

更新日期：2014-05-29 00:00:00

abstract：:Natural killer (NK) cells participate in host defense by surveying for and ultimately killing virally infected or malignant target cells. NK cell cytotoxicity is a tightly regulated process that proceeds stepwise from adhesion and activation to the secretion of preformed lytic granule contents onto a diseased or stres...

journal_title：Blood

authors： James AM,Hsu HT,Dongre P,Uzel G,Mace EM,Banerjee PP,Orange JS

更新日期：2013-04-04 00:00:00

abstract：:The molecular basis for the hereditary persistence of fetal hemoglobin (HPFH) phenotype was studied in a Chinese individual who was heterozygous for a nondeletion form of A gamma-HPFH. Both allelic A gamma-globin genes were isolated by molecular cloning and subjected to nucleotide sequence analysis. One A gamma gene p...

journal_title：Blood

authors： Gelinas R,Bender M,Lotshaw C,Waber P,Kazazian H Jr,Stamatoyannopoulos G

更新日期：1986-06-01 00:00:00

abstract：:Host defenses in the human neonate are limited by immaturity in phagocytic immunity. Such limitations seem to predispose infected newborns to neutropenia from an exhaustion of the neutrophil reserve. Among the critical defects thus far identified in neonatal phagocytic immunity is a specific reduction in the capacity ...

journal_title：Blood

authors： Gillan ER,Christensen RD,Suen Y,Ellis R,van de Ven C,Cairo MS

更新日期：1994-09-01 00:00:00

abstract：:Aneuploidy and lg light chain restriction were used as separate, independent tumor specific markers to study 26 patients with multiple myeloma to determine whether bone marrow B cells, as defined by CD19 expression, are clonally related to myeloma plasma cells. Specimens were characterized using multidimensional flow ...

journal_title：Blood

authors： McSweeney PA,Wells DA,Shults KE,Nash RA,Bensinger WI,Buckner CD,Loken MR

更新日期：1996-07-15 00:00:00

abstract：:Measurement of plasma levels of two secreted platelet proteins (beta-thromboglobulin and platelet factor 4) has been suggested as a means for detecting increased platelet activation in vivo. A crucial question in the measurement is the distinction between in vivo and in vitro secretion of the proteins. One approach to...

journal_title：Blood

authors： Kaplan KL,Owen J

更新日期：1981-02-01 00:00:00

abstract：:Pyrimidine 5' nucleotidase (P5'N-1) deficiency is an autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associa...

journal_title：Blood

authors： Marinaki AM,Escuredo E,Duley JA,Simmonds HA,Amici A,Naponelli V,Magni G,Seip M,Ben-Bassat I,Harley EH,Thein SL,Rees DC

更新日期：2001-06-01 00:00:00

abstract：:For this study, 118 children with standard-risk acute lymphoblastic leukemia (ALL) were given randomized assignments to receive native or pegylated Escherichia coli asparaginase as part of induction and 2 delayed intensification phases. Patients treated with pegaspargase had more rapid clearance of lymphoblasts from d...

journal_title：Blood

authors： Avramis VI,Sencer S,Periclou AP,Sather H,Bostrom BC,Cohen LJ,Ettinger AG,Ettinger LJ,Franklin J,Gaynon PS,Hilden JM,Lange B,Majlessipour F,Mathew P,Needle M,Neglia J,Reaman G,Holcenberg JS,Stork L

更新日期：2002-03-15 00:00:00

abstract：:Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas (cBCLs). We performed a survey of 84 canine NHL tumor...

journal_title：Blood

authors： Bushell KR,Kim Y,Chan FC,Ben-Neriah S,Jenks A,Alcaide M,Fornika D,Grande BM,Arthur S,Gascoyne RD,Steidl C,Morin RD

更新日期：2015-02-05 00:00:00

abstract：:Adult T-cell leukemia (ATL) is neoplasm of the mature helper T lymphocytes and human T-cell lymphotropic virus type-I (HTLV-I) has been shown to be causative virus of ATL. Because HTLV-I integrates its provirus randomly into host chromosomal DNA, monoclonal integration of HTLV-I provirus indicates the clonal prolifera...

journal_title：Blood

authors： Takemoto S,Matsuoka M,Yamaguchi K,Takatsuki K

更新日期：1994-11-01 00:00:00

abstract：:ETS2 and ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated in human cancer. People with Down syndrome (DS), who are trisomic for Hsa21, are predisposed to acute megakaryoblastic leukemia (AMKL). DS-AMKL blasts harbor a mutation in GATA1, which leads to loss of full-length...

journal_title：Blood

authors： Stankiewicz MJ,Crispino JD

更新日期：2009-04-02 00:00:00

abstract：:The bone and immune systems are closely related through cellular and molecular interactions. Because bone-resorbing osteoclasts (OCs) are derived from the monocyte/macrophage lineage, similar to dendritic cells (DCs), we hypothesized that OCs could serve as antigen-presenting cells (APCs) to activate T cells. In this ...

journal_title：Blood

authors： Li H,Hong S,Qian J,Zheng Y,Yang J,Yi Q

更新日期：2010-07-15 00:00:00

abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...

journal_title：Blood

authors： Nichols WL,Gastineau DA,Solberg LA Jr,Mann KG

更新日期：1985-06-01 00:00:00

abstract：:There is evidence from bone marrow transplantation that T cells may be involved in the immunologic control of leukemia. But many patients relapse despite a potent graft-versus-leukemia effect mediated by allogeneic T cells. The expression of the FasL protein has been suggested as a mechanism of tumor immune escape. We...

journal_title：Blood

authors： Buzyn A,Petit F,Ostankovitch M,Figueiredo S,Varet B,Guillet JG,Ameisen JC,Estaquier J

更新日期：1999-11-01 00:00:00

abstract：:CCAAT/enhancer binding proteins (C/EBPs) are a family of factors that regulate cell growth and differentiation. These factors, particularly C/EBPalpha and C/EBPepsilon, have important roles in normal myelopoiesis. In addition, loss of C/EBP activity appears to have a role in the pathogenesis of myeloid disorders inclu...

journal_title：Blood

authors： Truong BT,Lee YJ,Lodie TA,Park DJ,Perrotti D,Watanabe N,Koeffler HP,Nakajima H,Tenen DG,Kogan SC

更新日期：2003-02-01 00:00:00