Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia.

abstract：:Professional antigen-presenting cells (APCs) are sentinel cells of the immune system that present antigen to T lymphocytes and mediate an appropriate immune response. It is therefore surprising that knowledge of the professional APCs in human lymph nodes is limited. Using 3-color immunohistochemistry, we have identifi...

journal_title：Blood

authors： Angel CE,Chen CJ,Horlacher OC,Winkler S,John T,Browning J,MacGregor D,Cebon J,Dunbar PR

更新日期：2009-02-05 00:00:00

abstract：:Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischemic stroke (IS), or non-MI ischemic heart disease (non-MI-IHD). The design was 3 case-control studies ...

journal_title：Blood

authors： Juul K,Tybjaerg-Hansen A,Steffensen R,Kofoed S,Jensen G,Nordestgaard BG

更新日期：2002-07-01 00:00:00

abstract：:We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet generation were recor...

journal_title：Blood

authors： Di Buduo CA,Wray LS,Tozzi L,Malara A,Chen Y,Ghezzi CE,Smoot D,Sfara C,Antonelli A,Spedden E,Bruni G,Staii C,De Marco L,Magnani M,Kaplan DL,Balduini A

更新日期：2015-04-02 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation (BMT) at 235 centers worldwide to examine the incidence of and risk factors for posttransplant lymphoproliferative disorders (PTLD). PTLD developed in 78 recipients, with 64 cases occurring less than 1 year after transplantation. The cum...

journal_title：Blood

authors： Curtis RE,Travis LB,Rowlings PA,Socié G,Kingma DW,Banks PM,Jaffe ES,Sale GE,Horowitz MM,Witherspoon RP,Shriner DA,Weisdorf DJ,Kolb HJ,Sullivan KM,Sobocinski KA,Gale RP,Hoover RN,Fraumeni JF Jr,Deeg HJ

更新日期：1999-10-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is associated with KS, primary effusion lymphoma (PEL), and multicentric Castleman disease. Reactivation of KSHV in latently infected cells and subsequent plasma viremia occur before the development of KS. Intracellular signaling pathways involved in KSHV reactivation were ...

journal_title：Blood

authors： Zoeteweij JP,Moses AV,Rinderknecht AS,Davis DA,Overwijk WW,Yarchoan R,Orenstein JM,Blauvelt A

更新日期：2001-04-15 00:00:00

abstract：:Polymorphonuclear neutrophils (PMN) contain multiple distinct secretory compartments that are sequentially mobilized during cell activation. Complement receptor type 1 (CR1) is a marker for a readily mobilizable secretory vesicle compartment, which can undergo exocytic fusion with the plasma membrane independently of ...

journal_title：Blood

authors： Jost C,Klickstein L,Wetzler E,Kumar A,Berger M

更新日期：1998-07-01 00:00:00

abstract：:Studies were performed on 15 untreated and 14 treated patients with multiple myeloma. The monocyte content was normal in blood but elevated in mononuclear leukocytes (MNL) from treated but not untreated patients (p less than 0.001). This correlated with the severity of lymphopenia in blood (p less than 0.01). Three pa...

journal_title：Blood

authors： Twomey JJ,Laughter AH,Rice L,Ford RJ

更新日期：1982-08-01 00:00:00

abstract：:Circulating endothelial progenitor cells (EPCs) are thought to contribute to angiogenesis following vascular injury, stimulating interest in their ability to mediate therapeutic angiogenesis. However, the number of EPCs in the blood is low, limiting endogenous repair, and a method to rapidly mobilize EPCs has not been...

journal_title：Blood

authors： Shepherd RM,Capoccia BJ,Devine SM,Dipersio J,Trinkaus KM,Ingram D,Link DC

更新日期：2006-12-01 00:00:00

abstract：:The regulator of G-protein signaling (RGS) negatively regulates the alpha subunit of G proteins by accelerating their intrinsic guanosine triphosphatase (GTPase) activity. Here are reported the isolation and characterization of a novel mouse RGS, termed RGS18, which is a new member of RGS subfamily B. Northern blot an...

journal_title：Blood

authors： Nagata Y,Oda M,Nakata H,Shozaki Y,Kozasa T,Todokoro K

更新日期：2001-05-15 00:00:00

abstract：:We investigated the effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy on the natural killer (NK) cell lineage in patients with aplastic anemia and myelodysplastic syndrome. Selected bone marrow (BM) cel...

journal_title：Blood

authors： Shibuya A,Taguchi K,Kojima H,Abe T

更新日期：1991-12-15 00:00:00

abstract：:Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6% of surviving patients tested t...

journal_title：Blood

authors： Strickland DK,Riely CA,Patrick CC,Jones-Wallace D,Boyett JM,Waters B,Fleckenstein JF,Dean PJ,Davila R,Caver TE,Hudson MM

更新日期：2000-05-15 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy derived from precursors of plasmacytoid dendritic cells. We analyzed 21 cases with array-based comparative genomic hybridization (aCGH). Complete or partial chromosomal losses largely outnumbered the gains, with common deleted reg...

journal_title：Blood

authors： Lucioni M,Novara F,Fiandrino G,Riboni R,Fanoni D,Arra M,Venegoni L,Nicola M,Dallera E,Arcaini L,Onida F,Vezzoli P,Travaglino E,Boveri E,Zuffardi O,Paulli M,Berti E

更新日期：2011-10-27 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion and has been ranked as one of the leading causes of transfusion-related fatalities. Nonetheless, many details of the immunopathogenesis of TRALI, particularly with respect to recipient factors are unknown. We used a murine model of ...

journal_title：Blood

authors： Fung YL,Kim M,Tabuchi A,Aslam R,Speck ER,Chow L,Kuebler WM,Freedman J,Semple JW

更新日期：2010-10-21 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with remarkable preclinical and clinical antitumor activity in multiple myeloma (MM) patients. The initial rationale for its use in MM was inhibition of nuclear factor (NF)-kappaB activity by blocking proteasomal degradation of inhibitor of kappaBalpha (IkappaBalpha). Bortezomib in...

journal_title：Blood

authors： Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC

更新日期：2009-07-30 00:00:00

abstract：:Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...

journal_title：Blood

authors： Dhédin N,Huynh A,Maury S,Tabrizi R,Beldjord K,Asnafi V,Thomas X,Chevallier P,Nguyen S,Coiteux V,Bourhis JH,Hichri Y,Escoffre-Barbe M,Reman O,Graux C,Chalandon Y,Blaise D,Schanz U,Lhéritier V,Cahn JY,Dombret H,If

更新日期：2015-04-16 00:00:00

abstract：:Oncogenic RAS alleles encode proteins that accumulate in the guanosine triphosphate (GTP)-bound state. Because post-translational processing of Ras by farnesyltransferase is essential for biologic function, inhibitors of this enzyme have been developed as rational cancer therapeutics. We have investigated farnesyltran...

journal_title：Blood

authors： Mahgoub N,Taylor BR,Gratiot M,Kohl NE,Gibbs JB,Jacks T,Shannon KM

更新日期：1999-10-01 00:00:00

abstract：:The Scianna blood group encompasses the high-frequency antigens Sc1 and Sc3 and the low-frequency antigen Sc2. Another low-frequency antigen Rd (Radin) was suggested to belong to the Scianna blood group. The molecular basis of the Scianna blood group was unknown. The erythrocyte membrane-associated protein (ERMAP) sha...

journal_title：Blood

authors： Wagner FF,Poole J,Flegel WA

更新日期：2003-01-15 00:00:00

abstract：:Using flow cytometric techniques, we determined the pretreatment distribution of DNA content in propidium iodide-stained leukemic blasts from 205 children with "standard-risk" acute lymphoblastic leukemia (ALL). Risk assignment was based on an initial WBC count less than 100 X 10(9)/L, no thymic mass, no meningeal leu...

journal_title：Blood

authors： Look AT,Roberson PK,Williams DL,Rivera G,Bowman WP,Pui CH,Ochs J,Abromowitch M,Kalwinsky D,Dahl GV

更新日期：1985-05-01 00:00:00

abstract：:At inflammatory sites, proteoglycans are both secreted by activated mononuclear leukocytes and released as a consequence of extracellular matrix degradation. Chondroitin 4-sulfate proteoglycans constitute the predominant ones produced by activated human monocytes/macrophages. In this study, we show that two chondroiti...

journal_title：Blood

authors： Rachmilewitz J,Tykocinski ML

更新日期：1998-07-01 00:00:00

abstract：:Fcgamma receptors (FcgammaRs) on mononuclear phagocytes trigger autoantibody and immune complex-induced diseases through coupling the self-reactive immunoglobulin G (IgG) response to innate effector pathways, such as phagocytosis, and the recruitment of inflammatory cells. FcRgamma-based activation is critical in the ...

journal_title：Blood

authors： Braun A,Gessner JE,Varga-Szabo D,Syed SN,Konrad S,Stegner D,Vögtle T,Schmidt RE,Nieswandt B

更新日期：2009-01-29 00:00:00

abstract：:The Wrb antigen is a high-frequency human erythrocyte antigen invariably absent from En (a-) erythrocytes, which lack glycophorin A. However, glycophorin A from En (a+) Wr (a+b-) red cells has an amino acid sequence identical to that of glycophorin A from Wr (b+) erythrocytes. Evidence has suggested that the Wrb antig...

journal_title：Blood

authors： Telen MJ,Chasis JA

更新日期：1990-08-15 00:00:00

abstract：:We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)-induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous administration of APC markedly reduced I/R-induced renal dysfunction and histological changes, whereas intravenous administration of dansyl glutamylglycy...

journal_title：Blood

authors： Mizutani A,Okajima K,Uchiba M,Noguchi T

更新日期：2000-06-15 00:00:00

abstract：:We developed a risk score to predict event-free survival (EFS) after allogeneic hematopoietic cell transplantation for sickle cell disease. The study population (n = 1425) was randomly split into training (n = 1070) and validation (n = 355) cohorts. Risk factors were identified and validated via Cox regression models....

journal_title：Blood

authors： Brazauskas R,Scigliuolo GM,Wang HL,Cappelli B,Ruggeri A,Fitzhugh CD,Hankins JS,Kanter J,Meerpohl JJ,Panepinto JA,Rondelli D,Shenoy S,Walters MC,Wagner JE,Tisdale JF,Gluckman E,Eapen M

更新日期：2020-07-30 00:00:00

abstract：:We developed 2bF9 transgenic mice in a hemophilia B mouse model with the expression of human factor IX (FIX) under control of the platelet-specific integrin alphaIIb promoter, to determine whether ectopically expressing FIX in megakaryocytes can enable the storage of FIX in platelet alpha-granules and corrects the mur...

journal_title：Blood

authors： Zhang G,Shi Q,Fahs SA,Kuether EL,Walsh CE,Montgomery RR

更新日期：2010-08-26 00:00:00

abstract：:Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote the expansion of chronic lymphocytic leukemia (CLL) B cells. The spleen tyrosine kinase (Syk), a key component of BCR signaling, can be blocked by R406, a small-molecule Syk inhibitor, that displayed activity in CLL patients in a ...

journal_title：Blood

authors： Quiroga MP,Balakrishnan K,Kurtova AV,Sivina M,Keating MJ,Wierda WG,Gandhi V,Burger JA

更新日期：2009-07-30 00:00:00

abstract：:PAX5-JAK2 has recently been identified as a novel recurrent fusion gene in B-cell precursor acute lymphoblastic leukemia, but the function of the encoded chimeric protein has not yet been characterized in detail. Herein we show that the PAX5-JAK2 chimera, which consists of the DNA-binding paired domain of PAX5 and the...

journal_title：Blood

authors： Schinnerl D,Fortschegger K,Kauer M,Marchante JR,Kofler R,Den Boer ML,Strehl S

更新日期：2015-02-19 00:00:00

abstract：:The initial B-cell repertoire is generated by combinatorial immunoglobulin V(D)J gene segment rearrangements that occur in a preferential sequence. Because cellular proliferation occurs during the course of these rearrangement events, it has been proposed that intraclonal diversification occurs during this phase of B-...

journal_title：Blood

authors： Wang YH,Zhang Z,Burrows PD,Kubagawa H,Bridges SL Jr,Findley HW,Cooper MD

更新日期：2003-02-01 00:00:00

abstract：:Commercial porcine factor VIII concentrate (Hyate:C) is effective in treatment of patients with hemophilia A who have circulating antibodies to factor VIII. The molecular forms of factor VIII in the concentrate were identified and evaluated in light of the known properties of porcine and human factor VIII. The factor ...

journal_title：Blood

authors： Lollar P,Parker CG,Tracy RP

更新日期：1988-01-01 00:00:00

abstract：:Glycoprotein VI (GPVI) is an essential platelet receptor for collagens that is exclusively expressed in the megakaryocytic lineage. Transcription of the human gene GP6 is driven largely by GATA-binding protein 1 (GATA-1), specificity protein 1 (Sp1), and Friend leukemia integration 1 (Fli-1). In this report, we show t...

journal_title：Blood

authors： Kanaji S,Kanaji T,Jacquelin B,Chang M,Nugent DJ,Komatsu N,Moroi M,Izuhara K,Kunicki TJ

更新日期：2005-05-15 00:00:00