STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation.


:Fcgamma receptors (FcgammaRs) on mononuclear phagocytes trigger autoantibody and immune complex-induced diseases through coupling the self-reactive immunoglobulin G (IgG) response to innate effector pathways, such as phagocytosis, and the recruitment of inflammatory cells. FcRgamma-based activation is critical in the pathogenesis of these diseases, although the contribution of FcgammaR-mediated calcium signaling in autoimmune injury is unclear. Here we show that macrophages lacking the endoplasmic reticulum-resident calcium sensor, STIM1, cannot activate FcgammaR-induced Ca(2+) entry and phagocytosis. As a direct consequence, STIM1 deficiency results in resistance to experimental immune thrombocytopenia and anaphylaxis, autoimmune hemolytic anemia, and acute pneumonitis. These results establish STIM1 as a novel and essential component of FcgammaR activation and also indicate that inhibition of STIM1-dependent signaling might become a new strategy to prevent or treat IgG-dependent immunologic diseases.






Braun A,Gessner JE,Varga-Szabo D,Syed SN,Konrad S,Stegner D,Vögtle T,Schmidt RE,Nieswandt B




Has Abstract


2009-01-29 00:00:00
















  • The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells.

    abstract::The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We...


    pub_type: 杂志文章


    authors: Mamani-Matsuda M,Cosma A,Weller S,Faili A,Staib C,Garçon L,Hermine O,Beyne-Rauzy O,Fieschi C,Pers JO,Arakelyan N,Varet B,Sauvanet A,Berger A,Paye F,Andrieu JM,Michel M,Godeau B,Buffet P,Reynaud CA,Weill JC

    更新日期:2008-05-01 00:00:00

  • Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection.

    abstract::Rituximab, a monoclonal antibody that targets CD20 on B cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this success, a substantial proportion of B-cell lymphomas are unresponsive or develop resistance, hence more potent anti-CD20 monoclonal antibodies (mAbs) are cont...


    pub_type: 杂志文章


    authors: Beers SA,French RR,Chan HT,Lim SH,Jarrett TC,Vidal RM,Wijayaweera SS,Dixon SV,Kim H,Cox KL,Kerr JP,Johnston DA,Johnson PW,Verbeek JS,Glennie MJ,Cragg MS

    更新日期:2010-06-24 00:00:00

  • Defective adhesion of blood platelets to vascular microfibrils in the Bernard-Soulier syndrome.

    abstract::Bernard-Soulier syndrome (BSS) platelets, which lack the membrane glycoprotein complex Ib-IX, do not adhere to subendothelium. The adhesion of platelets from two patients with BSS to subendothelial microfibrils (MFs) and type I collagen was compared in an in vitro assay adapted to patients with low platelet count. Wit...


    pub_type: 杂志文章


    authors: Fauvel-Lafève F,Tabaka V,Caen JP,Legrand YJ

    更新日期:1993-10-01 00:00:00

  • Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study.

    abstract::The conjunctival microcirculation of 18 homozygous sickle cell disease (SCD) patients during steady-state, painful crisis, and postcrisis conditions was recorded on high-resolution videotapes using intravital microscopy. Selected videotape sequences were subsequently coded, frame-captured, studied, and blindly analyze...


    pub_type: 杂志文章


    authors: Cheung AT,Chen PC,Larkin EC,Duong PL,Ramanujam S,Tablin F,Wun T

    更新日期:2002-06-01 00:00:00

  • Identification of normal human peripheral blood monocytes and liver as sites of synthesis of coagulation factor XIII a-chain.

    abstract::Factor XIII is the fibrin-stabilizing factor that covalently cross-links fibrin monomers to form a highly organized, stable fibrin clot. The plasma form of factor XIII is a heterodimer, a2b2, consisting of two a-chains and two b-chains; the intracellular form, such as in platelets and placenta, is a dimer, a2, consist...


    pub_type: 杂志文章


    authors: Weisberg LJ,Shiu DT,Conkling PR,Shuman MA

    更新日期:1987-08-01 00:00:00

  • High numbers of CD4+ T cells showing abnormal recognition of DR antigens in lymphoid organs involved by Hodgkin's disease.

    abstract::Purified T lymphocytes (E rosetting cells) isolated from the involved lymphoid organs (lymph nodes and spleen) of five patients with Hodgkin's disease (HD) were cloned under culture conditions (phytohemagglutinin plus interleukin-2) that allow clonal expansion of most T lymphocytes. A total number of 104 CD4+ T cell c...


    pub_type: 杂志文章


    authors: Maggi E,Parronchi P,Macchia D,Bellesi G,Romagnani S

    更新日期:1988-05-01 00:00:00

  • Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss.

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    pub_type: 杂志文章


    authors: Kaufman Y,Ifergan I,Rothem L,Jansen G,Assaraf YG

    更新日期:2006-04-15 00:00:00

  • Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation.

    abstract::The CCAAT/enhancer binding protein-alpha (C/EBPalpha) is a transcription factor required for differentiation of myeloid progenitors. In addition to specific DNA binding, C/EBPalpha is also involved in protein-protein interactions, some of which (p21, Cdk2/Cdk4, E2F) appear to be required for inhibition of proliferatio...


    pub_type: 杂志文章


    authors: Keeshan K,Santilli G,Corradini F,Perrotti D,Calabretta B

    更新日期:2003-08-15 00:00:00

  • Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa.

    abstract::Because free factor VIIa is inactivated only very slowly by a plasma concentration of antithrombin III (AT III) even in the presence of heparin, it has been assumed that AT III plays no significant role in regulating the initiation of tissue factor-dependent blood coagulation. However, in the present study, we present...


    pub_type: 杂志文章


    authors: Rao LV,Rapaport SI,Hoang AD

    更新日期:1993-05-15 00:00:00

  • Rituximab for the treatment of refractory autoimmune hemolytic anemia in children.

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    pub_type: 临床试验,杂志文章


    authors: Zecca M,Nobili B,Ramenghi U,Perrotta S,Amendola G,Rosito P,Jankovic M,Pierani P,De Stefano P,Bonora MR,Locatelli F

    更新日期:2003-05-15 00:00:00

  • Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy.

    abstract::Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring re...


    pub_type: 杂志文章


    authors: Gardner R,Wu D,Cherian S,Fang M,Hanafi LA,Finney O,Smithers H,Jensen MC,Riddell SR,Maloney DG,Turtle CJ

    更新日期:2016-05-19 00:00:00

  • Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders.

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    pub_type: 杂志文章


    authors: Ishii T,Wang J,Zhang W,Mascarenhas J,Hoffman R,Dai Y,Wisch N,Xu M

    更新日期:2009-06-04 00:00:00

  • Transfusion-associated AIDS: donor-recipient human immunodeficiency virus exhibits genetic heterogeneity.

    abstract::The genetic diversity of the human immunodeficiency virus (HIV) isolated from transfusion-associated AIDS patients has been examined. Restriction enzyme mapping studies of integrated proviral DNA of donor and recipient origin demonstrated genomic variation between isolates. Analysis of the molecularly cloned viral gen...


    pub_type: 杂志文章


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    更新日期:1987-06-01 00:00:00

  • T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation.

    abstract::T-cell depletion (TCD) of the donor marrow graft has been shown to reduce the severity of graft-versus-host disease (GVHD) in patients with chronic-phase (CP) chronic myelogenous leukemia (CML) undergoing HLA-identical sibling allogeneic marrow transplantation. However, there has been a corresponding reduction in the ...


    pub_type: 杂志文章


    authors: Drobyski WR,Hessner MJ,Klein JP,Kabler-Babbitt C,Vesole DH,Margolis DA,Keever-Taylor CA

    更新日期:1999-07-15 00:00:00

  • Genetic heterogeneity in heterocellular hereditary persistence of fetal hemoglobin.

    abstract::A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...


    pub_type: 杂志文章


    authors: Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

    更新日期:1997-07-01 00:00:00

  • Bedside filtration of blood products in the prevention of HLA alloimmunization--a prospective randomized study. Alloimmunisation Study Group.

    abstract::To test the efficacy of poststorage bedside leucodepletion of blood products in the prevention of primary HLA alloimmunization and its clinical sequelae, 172 patients with hematologic malignancy requiring intensive red blood cell and platelet support were randomized to receive either standard or filtered red blood cel...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Williamson LM,Wimperis JZ,Williamson P,Copplestone JA,Gooi HC,Morgenstern GR,Norfolk DR

    更新日期:1994-05-15 00:00:00

  • TMA: beware of complements.

    abstract::In this issue of Blood, Jodele and colleagues report that defective complement regulation contributes to the development of thrombotic microangiopathy (TMA) after hematopoietic stem cell transplantation (HSCT) with important implications for diagnosis and management of this severe clinical complication. ...


    pub_type: 评论,杂志文章


    authors: Ricklin D,Cines DB

    更新日期:2013-09-19 00:00:00

  • Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group.

    abstract::In a randomized multicenter study the influence of hydroxyurea versus busulfan on the duration of the chronic phase and on survival of chronic myelogenous leukemia (CML) was determined. In addition cross resistance and adverse reactions of the drugs were analyzed. From July 1983 to January 1991, 441 CML patients were ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hehlmann R,Heimpel H,Hasford J,Kolb HJ,Pralle H,Hossfeld DK,Queisser W,Löffler H,Heinze B,Georgii A

    更新日期:1993-07-15 00:00:00

  • In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia.

    abstract::Severe congenital neutropenia (CN) is a rare bone marrow failure syndrome with a high incidence of acute leukemia. In previous studies, we could show that point mutations in the gene for the granulocyte colony-stimulating factor (G-CSF) receptor CSF3R are a highly predictive marker for leukemic development in CN patie...


    pub_type: 杂志文章


    authors: Germeshausen M,Welte K,Ballmaier M

    更新日期:2009-01-15 00:00:00

  • Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells.

    abstract::Endothelial cells (ECs) express 2 members of the cadherin family, VE and N-cadherin. Although VE-cadherin induces EC homotypic adhesion, N-cadherin function in ECs remains largely unknown. EC-specific inactivation of either VE or N-cadherin leads to early fetal lethality suggesting that these cadherins play a nonredun...


    pub_type: 杂志文章


    authors: Giampietro C,Taddei A,Corada M,Sarra-Ferraris GM,Alcalay M,Cavallaro U,Orsenigo F,Lampugnani MG,Dejana E

    更新日期:2012-03-01 00:00:00

  • ADAMTS13 turns 3.

    abstract::It has now been 3 years since the von Willebrand factor (VWF)-cleaving protease implicated in thrombocytopenic purpura (TTP) pathogenesis was identified as ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13). More than 50 ADAMTS13 mutations resulting in familial TTP have been reported...


    pub_type: 杂志文章,评审


    authors: Levy GG,Motto DG,Ginsburg D

    更新日期:2005-07-01 00:00:00

  • Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation.

    abstract::Erythropoiesis is regulated at multiple levels to ensure the proper generation of mature red cells under multiple physiological conditions. To probe the contribution of long noncoding RNAs (lncRNAs) to this process, we examined >1 billion RNA-seq reads of polyadenylated and nonpolyadenylated RNA from differentiating m...


    pub_type: 杂志文章


    authors: Alvarez-Dominguez JR,Hu W,Yuan B,Shi J,Park SS,Gromatzky AA,van Oudenaarden A,Lodish HF

    更新日期:2014-01-23 00:00:00

  • TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation.

    abstract::Recent studies have identified several populations of progenitor cells in the human thymus. The hematopoietic precursor activity of these populations has been determined. The most primitive human thymocytes express high levels of CD34 and lack CD1a. These cells acquire CD1a and differentiate into CD4(+)CD8(+) through ...


    pub_type: 杂志文章


    authors: Blom B,Verschuren MC,Heemskerk MH,Bakker AQ,van Gastel-Mol EJ,Wolvers-Tettero IL,van Dongen JJ,Spits H

    更新日期:1999-05-01 00:00:00

  • CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.

    abstract::CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable proportion of human neutrophils that mediates surface expression of the antineutrophil cytoplasmic antibody antigen proteinase 3. CD177 associates with β2 integrins and recognizes platelet endothelial cell adhesion molecule 1 (PECAM...


    pub_type: 杂志文章


    authors: Bai M,Grieshaber-Bouyer R,Wang J,Schmider AB,Wilson ZS,Zeng L,Halyabar O,Godin MD,Nguyen HN,Levescot A,Cunin P,Lefort CT,Soberman RJ,Nigrovic PA

    更新日期:2017-11-09 00:00:00

  • Visualization of nitric oxide production by individual platelets during adhesion in flowing blood.

    abstract::Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversial. By using a sens...


    pub_type: 杂志文章


    authors: Cozzi MR,Guglielmini G,Battiston M,Momi S,Lombardi E,Miller EC,De Zanet D,Mazzucato M,Gresele P,De Marco L

    更新日期:2015-01-22 00:00:00

  • Comparison of intravenous bolus injection or continuous infusion of recombinant single chain urokinase-type plasminogen activator (saruplase) for thrombolysis. A canine model of combined coronary arterial and femoral venous thrombosis.

    abstract::The thrombolytic efficacy of recombinant unglycosylated full length single chain urokinase-type plasminogen activator (rscu-PA, saruplase), applied either as single intravenous bolus or as a continuous infusion over 60 minutes, was studied in 5 randomized blinded groups of 5 dogs with combined copper coil induced coro...


    pub_type: 杂志文章


    authors: Rapold HJ,Wu ZM,Stassen T,Van de Werf F,Collen D

    更新日期:1990-10-15 00:00:00

  • Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.

    abstract::The retinoblastoma (Rb) tumor suppressor plays important roles in regulating hematopoiesis, particularly erythropoiesis. In an effort to understand whether Rb function can be mediated by E2F transcription factors in a BM-derived hematopoietic system in mice, we uncovered a functional synergy between Rb and E2F8 to pro...


    pub_type: 杂志文章


    authors: Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L

    更新日期:2012-05-10 00:00:00

  • Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma.

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    pub_type: 杂志文章


    authors: Asaoku H,Kawano M,Iwato K,Tanabe O,Tanaka H,Hirano T,Kishimoto T,Kuramoto A

    更新日期:1988-08-01 00:00:00

  • Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells.

    abstract::Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, w...


    pub_type: 杂志文章


    authors: Becknell B,Hughes TL,Freud AG,Blaser BW,Yu J,Trotta R,Mao HC,Caligiuri de Jesús ML,Alghothani M,Benson DM Jr,Lehman A,Jarjoura D,Perrotti D,Bates MD,Caligiuri MA

    更新日期:2007-03-15 00:00:00

  • Interrelationships of polymorphonuclear neutrophil membrane-bound calcium, membrane potential, and chemiluminescence: studies in single living cells.

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    pub_type: 杂志文章


    authors: Sullivan GW,Donowitz GR,Sullivan JA,Mandell GL

    更新日期:1984-12-01 00:00:00