Quantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency.

abstract：:People with hemophilia were formerly at very high risk of infection with hepatitis C virus (HCV). Approximately 20% of HCV-infected patients spontaneously clear the virus. To identify correlates of spontaneous clearance of HCV, we studied a cohort of HCV-infected hemophilic subjects without human immunodeficiency viru...

journal_title：Blood

authors： Zhang M,Rosenberg PS,Brown DL,Preiss L,Konkle BA,Eyster ME,Goedert JJ,Second Multicenter Hemophilia Cohort Study.

更新日期：2006-02-01 00:00:00

abstract：:Before the contemporary development of rationally designed antineoplastic therapies, cladribine was identified as a lymphocyte-specific agent. Its profound impact on the natural history of hairy cell leukemia, with responses approaching 100% and a median duration of response of nearly a decade after only a single 7-da...

journal_title：Blood

authors： Sigal DS,Miller HJ,Schram ED,Saven A

更新日期：2010-10-21 00:00:00

abstract：:Evidence is presented showing that a protein tyrosine phosphatase different from CD45 is present on the membrane of human hematopoietic cells. The molecule recognized by the monoclonal antibody 143-41, which has been classified as CD148 in the VI International Workshop on Leukocyte Differentiation Antigens, was immuno...

journal_title：Blood

authors： de la Fuente-García MA,Nicolás JM,Freed JH,Palou E,Thomas AP,Vilella R,Vives J,Gayá A

更新日期：1998-04-15 00:00:00

abstract：:Lipoxygenases (LXs) catalyze formation of leukotrienes and hydroxy-eicosatetraenoic acids (HETEs), proinflammatory, and spasmogenic autacoids that are critical for host defense systems. We studied the expression and regulation of LX genes (12-LX, 5-LX, and 15-LX) and the 5-lipoxygenase activating protein (FLAP) in hum...

journal_title：Blood

authors： Kaminski WE,Jendraschak E,Baumann K,Kiefl R,Fischer S,Marcus AJ,Broekman MJ,von Schacky C

更新日期：1996-01-01 00:00:00

abstract：:The glycoprotein CD47 (integrin-associated protein, IAP) is present on the surface of virtually all cells, including red blood cells (RBCs). CD47 acts like a marker of self by ligating the macrophage inhibitory receptor signal regulatory protein alpha (SIRPalpha). In this manner mild reactivity of wild-type RBCs with ...

journal_title：Blood

authors： Oldenborg PA,Gresham HD,Chen Y,Izui S,Lindberg FP

更新日期：2002-05-15 00:00:00

abstract：:Red cell concentrates (RCC) are stored for 35 to 42 days in plastic containers manufactured with the liquid plasticizer di(2-ethylhexyl)phthalate (DEHP). DEHP leaches from the polyvinylchloride (PVC) plastic bag, then binds to and stabilizes the RC membrane. This study was undertaken to determine the deformability of ...

journal_title：Blood

authors： Labow RS,Card RT,Rock G

更新日期：1987-07-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secret...

journal_title：Blood

authors： Yee C,Biondi A,Wang XH,Iscove NN,de Sousa J,Aarden LA,Wong GG,Clark SC,Messner HA,Minden MD

更新日期：1989-08-01 00:00:00

abstract：:Circulating monocytes can differentiate into dendritic cells (moDCs), which are potent inducers of adaptive immune responses. Previous reports show that granulocyte macrophage-colony-stimulating factor (GM-CSF) and interleukin-4 induce monocyte differentiation into moDCs in vitro, but little is known about the physiol...

journal_title：Blood

authors： Zhang AL,Colmenero P,Purath U,Teixeira de Matos C,Hueber W,Klareskog L,Tarner IH,Engleman EG,Söderström K

更新日期：2007-10-01 00:00:00

abstract：:Toll-like receptors orchestrate rapid local protective innate-immune responses to invading pathogens and optimize leukocyte priming of subsequent adaptive responses. Paradoxically, systemic excess of the TLR2 ligand, bacterial lipoprotein (BLP), suppresses peripheral inflammatory responses. Here, we demonstrate that t...

journal_title：Blood

authors： McKimmie CS,Moore M,Fraser AR,Jamieson T,Xu D,Burt C,Pitman NI,Nibbs RJ,McInnes IB,Liew FY,Graham GJ

更新日期：2009-04-30 00:00:00

abstract：:Cyclopentenone prostaglandins are potent inhibitors of nuclear factor-kappa B (NF-kappa B), a transcription factor with a critical role in promoting inflammation and connected with multiple aspects of oncogenesis and cancer cell survival. In the present report, we investigated the role of NF-kappa B in the antineoplas...

journal_title：Blood

authors： Piva R,Gianferretti P,Ciucci A,Taulli R,Belardo G,Santoro MG

更新日期：2005-02-15 00:00:00

abstract：:Interleukin-6 (IL-6) administered as a single intravenous (IV) injection caused the following changes in the peripheral circulation of rats: (a) a biphasic neutrophilia with an initial peak at 1.5 hours and a second sustained wave of neutrophilia between four and 12 hours, (b) a mild lymphocytosis at 0.5 hours and a m...

journal_title：Blood

authors： Ulich TR,del Castillo J,Guo KZ

更新日期：1989-01-01 00:00:00

abstract：:Neutrophils from healthy elderly donors generate significantly less diacylglycerol (DAG) and inositol triphosphate (IP3) than neutrophils from young donors, following stimulation by the chemotactic peptide, formyl-methionyl-leucylphenylalanine (FMLP). The defect in signal transduction occurred at a point proximal to t...

journal_title：Blood

authors： Lipschitz DA,Udupa KB,Indelicato SR,Das M

更新日期：1991-09-01 00:00:00

abstract：:The frequent occurrence of TF gene involvement in translocations associated with leukemia is remarkable, although not yet explained. The wide variety of TFs involved in these translocations and the different stages of cellular maturation argue against a unifying mechanism. Recombinases, active during B-cell and T-cell...

journal_title：Blood

authors： Nichols J,Nimer SD

更新日期：1992-12-15 00:00:00

abstract：:CD99 is a crucial regulator of the transmigration (diapedesis) of leukocytes through the blood vessel wall. Here, we report that CD99 acts at 2 different steps in the extravasation process. In agreement with previous antibody-blocking experiments, we found that CD99 gene inactivation caused neutrophil accumulation bet...

journal_title：Blood

authors： Goswami D,März S,Li YT,Artz A,Schäfer K,Seelige R,Pacheco-Blanco M,Jing D,Bixel MG,Araki M,Araki K,Yamamura KI,Vestweber D

更新日期：2017-03-30 00:00:00

abstract：:The congenital sideroblastic anemias (CSAs) are relatively uncommon diseases characterized by defects in mitochondrial heme synthesis, iron-sulfur (Fe-S) cluster biogenesis, or protein synthesis. Here we demonstrate that mutations in HSPA9, a mitochondrial HSP70 homolog located in the chromosome 5q deletion syndrome 5...

journal_title：Blood

authors： Schmitz-Abe K,Ciesielski SJ,Schmidt PJ,Campagna DR,Rahimov F,Schilke BA,Cuijpers M,Rieneck K,Lausen B,Linenberger ML,Sendamarai AK,Guo C,Hofmann I,Newburger PE,Matthews D,Shimamura A,Snijders PJ,Towne MC,Niemeyer CM,

更新日期：2015-12-17 00:00:00

abstract：:Studies have demonstrated that common polymorphisms in Th1 and Th2 cytokine genes can alter gene expression, modulate the balance between Th1/Th2 responsiveness, and influence susceptibility for autoimmune disorders, infectious diseases, and cancer. We analyzed one or more single nucleotide polymorphisms (SNPs) in 20 ...

journal_title：Blood

authors： Lan Q,Zheng T,Rothman N,Zhang Y,Wang SS,Shen M,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Boyle P,Zhang B,Zou K,Zhu Y,Chanock S

更新日期：2006-05-15 00:00:00

abstract：:The mouse Pim-1 gene encodes two cytoplasmic serine-threonine-specific protein kinases. The gene has been found to be activated (overexpressed) by retroviral insertion in hematopoietic tumors in mice. Transgenic mice that overexpress Pim-1 (E mu-Pim-1) have a low incidence of spontaneous T-cell lymphomas and an increa...

journal_title：Blood

authors： Domen J,van der Lugt NM,Laird PW,Saris CJ,Clarke AR,Hooper ML,Berns A

更新日期：1993-09-01 00:00:00

abstract：:The laboratory of Judah Folkman identified the potent endogenous antiangiogenic protein angiostatin in 1994.(1) In this issue of Blood, Lee and colleagues propose 2 new mechanisms of action for angiostatin that may represent promising targets for new cancer therapeutics.(2). ...

journal_title：Blood

authors： Mowery YM,Pizzo SV

更新日期：2009-08-27 00:00:00

abstract：:We have previously shown that the plant-derived compound parthenolide (PTL) can impair the survival and leukemogenic activity of primary human acute myeloid leukemia (AML) stem cells. However, despite the activity of this agent, PTL also induces cellular protective responses that likely function to reduce its overall ...

journal_title：Blood

authors： Hassane DC,Sen S,Minhajuddin M,Rossi RM,Corbett CA,Balys M,Wei L,Crooks PA,Guzman ML,Jordan CT

更新日期：2010-12-23 00:00:00

abstract：:Conventional chemotherapy has failed to substantially prolong survival for patients with advanced follicular lymphoma. To improve outcomes, the German Low-Grade Lymphoma Study Group (GLSG) initiated a randomized trial to compare the effect of potentially curative myeloablative radiochemotherapy followed by autologous ...

journal_title：Blood

authors： Lenz G,Dreyling M,Schiegnitz E,Forstpointner R,Wandt H,Freund M,Hess G,Truemper L,Diehl V,Kropff M,Kneba M,Schmitz N,Metzner B,Pfirrmann M,Unterhalt M,Hiddemann W,German Low-Grade Lymphoma Study Group.

更新日期：2004-11-01 00:00:00

abstract：:We evaluated the efficacy of umbilical cord blood (UCB) in the setting of a nonmyeloablative regimen consisting of fludarabine (200 mg/m2), cyclophosphamide (50 mg/kg), and a single fraction of total body irradiation (200 cGy) with cyclosporine and mycophenolate mofetil for posttransplantation immunoprophylaxis. The t...

journal_title：Blood

authors： Brunstein CG,Barker JN,Weisdorf DJ,DeFor TE,Miller JS,Blazar BR,McGlave PB,Wagner JE

更新日期：2007-10-15 00:00:00

abstract：:The intracellular Ca(2+) concentration of many nonexcitable cells is regulated by calcium store release and store-operated calcium entry (SOCE). In platelets, STIM1 was recently identified as the main calcium sensor expressed in the endoplasmic reticulum. To evaluate the role of the SOC channel moiety, Orai1, in plate...

journal_title：Blood

authors： Bergmeier W,Oh-Hora M,McCarl CA,Roden RC,Bray PF,Feske S

更新日期：2009-01-15 00:00:00

abstract：:Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)-skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and m...

journal_title：Blood

authors： Dummer R,Hassel JC,Fellenberg F,Eichmüller S,Maier T,Slos P,Acres B,Bleuzen P,Bataille V,Squiban P,Burg G,Urosevic M

更新日期：2004-09-15 00:00:00

abstract：:Personalized immunotherapy of lymphoma based on tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellular immune responses in 50%-75% of follicular lymphoma patients, indicating that this therapy can be clinically successful. We have developed a novel vaccine against lymphoma consist...

journal_title：Blood

authors： Carlring J,Szabo MJ,Dickinson R,De Leenheer E,Heath AW

更新日期：2012-03-01 00:00:00

abstract：:Despite many studies on the pathophysiology of antiphospholipid antibodies (aPL), the mechanism by which aPL causes thrombosis has not been established. We have tried to elucidate the paradox between the prolongation of the clotting time of phospholipid-dependent coagulation tests in vitro and the occurrence of thromb...

journal_title：Blood

authors： Oosting JD,Derksen RH,Bobbink IW,Hackeng TM,Bouma BN,de Groot PG

更新日期：1993-05-15 00:00:00

abstract：:Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of gran...

journal_title：Blood

authors： Wong WY,Powars DR,Operskalski EA,Hassett J,Parker JW,Sarnaik S,Pegelow CH,Hilgartner MW,Johnson CS,Zhou Y

更新日期：1995-04-15 00:00:00

abstract：:By using an enzyme-linked immunosorbent assay, the presence of the soluble form of the interleukin-2 receptor (sIL-2R) was evaluated in the peripheral blood of 54 patients with B cell chronic lymphocytic leukemia (B-CLL). Serum levels of sIL-2R were correlated with clinical features, relevant hematologic and immunolog...

journal_title：Blood

authors： Semenzato G,Foa R,Agostini C,Zambello R,Trentin L,Vinante F,Benedetti F,Chilosi M,Pizzolo G

更新日期：1987-08-01 00:00:00

abstract：:We prospectively studied 98 chronic myeloid leukemia (CML) patients after bone marrow transplantation by competitive polymerase chain reaction to detect and quantify leukemia-specific BCR-ABL mRNA. Of 69 patients who had persistently undetectable, decreasing, or low BCR-ABL levels ( < 50 transcripts/microgram RNA) on ...

journal_title：Blood

authors： Lin F,van Rhee F,Goldman JM,Cross NC

更新日期：1996-05-15 00:00:00

abstract：:NOTCH1 is mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in approximately one-half of CLL cases even in the absence of NOTCH1 mutations. Hence, there appear to be additional factors responsible for the impairment of NOTCH1 deg...

journal_title：Blood

authors： Close V,Close W,Kugler SJ,Reichenzeller M,Yosifov DY,Bloehdorn J,Pan L,Tausch E,Westhoff MA,Döhner H,Stilgenbauer S,Oswald F,Mertens D

更新日期：2019-02-21 00:00:00

abstract：:We describe in vitro studies and a therapeutic trial of retinoic acid (RA) in a patient with acute promyelocytic leukemia (APL) refractory to chemotherapy. Bone marrow promyelocytes from the patient, prior to RA, matured morphologically in liquid culture with RA (97% maturing myeloid cells compared with 26% in control...

journal_title：Blood

authors： Flynn PJ,Miller WJ,Weisdorf DJ,Arthur DC,Brunning R,Branda RF

更新日期：1983-12-01 00:00:00