Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease.

abstract：:The effects of alpha 2-antiplasmin and fibrin on the activation of plasminogen by recombinant staphylokinase (STAR) were studied in an effort to elucidate further the molecular basis of the fibrin-specificity of this fibrinolytic agent. In purified systems consisting of 1.5 mumol/L intact or low-M(r) plasminogen and 3...

journal_title：Blood

authors： Silence K,Collen D,Lijnen HR

更新日期：1993-08-15 00:00:00

abstract：:Cytarabine (Ara-C) is currently used in the treatment of adult acute myeloid leukemia (AML). To predict the results of induction chemotherapy, it could be useful to detect leukemic cells that are resistant to Ara-C in patients with AML. Using a bromodeoxyuridine/DNA (BrdUrd/DNA) staining method in flow cytometry (FCM)...

journal_title：Blood

authors： Lacombe F,Belloc F,Dumain P,Puntous M,Makhoul PC,Saux MC,Bernard P,Boisseau MR,Reiffers J

更新日期：1994-08-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease defined by transcriptional classifications, specific signaling and survival pathways, and multiple low-frequency genetic alterations. Preclinical model systems that capture the genetic and functional heterogeneity of DLBCL are urgently needed. Here, we g...

journal_title：Blood

authors： Chapuy B,Cheng H,Watahiki A,Ducar MD,Tan Y,Chen L,Roemer MG,Ouyang J,Christie AL,Zhang L,Gusenleitner D,Abo RP,Farinha P,von Bonin F,Thorner AR,Sun HH,Gascoyne RD,Pinkus GS,van Hummelen P,Wulf GG,Aster JC,Weinst

更新日期：2016-05-05 00:00:00

abstract：:A gamma-chain variant with a lower molecular weight than the normal gamma chain was detected in a new congenital abnormal fibrinogen with impaired polymerization of the fibrin monomer and with normal release of fibrinopeptides A and B in a 45-year-old male. Purified fibrinogen analyzed on SDS-polyacrylamide gel electr...

journal_title：Blood

authors： Yoshida N,Okuma M,Moroi M,Matsuda M

更新日期：1986-09-01 00:00:00

abstract：:We hypothesized that a granulocyte macrophage colony-stimulating factor (GMCSF) and interleukin 15 (IL-15) fusokine (GIFT15) would possess greater immune-stimulatory properties than their combined use. Unexpectedly, tumor cells engineered to secrete GIFT15 protein led to suppression of natural killer (NK) and NKT-cell...

journal_title：Blood

authors： Rafei M,Wu JH,Annabi B,Lejeune L,François M,Galipeau J

更新日期：2007-03-01 00:00:00

abstract：:Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signaling is involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the most common subtypes of cutaneous T-cell lymphoma. By immunohistochemistry of 4...

journal_title：Blood

authors： Kamstrup MR,Gjerdrum LM,Biskup E,Lauenborg BT,Ralfkiaer E,Woetmann A,Ødum N,Gniadecki R

更新日期：2010-10-07 00:00:00

abstract：:Cultured mononuclear phagocytes produce soluble factors that stimulate endothelial cells to release GM-colony-stimulating activity (GM-CSA). One such factor was recently identified as interleukin 1 (IL 1). Studies were designed to determine which types of granulopoietic factors are released by IL 1-stimulated endothel...

journal_title：Blood

authors： Zsebo KM,Yuschenkoff VN,Schiffer S,Chang D,McCall E,Dinarello CA,Brown MA,Altrock B,Bagby GC Jr

更新日期：1988-01-01 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorgan system cGVHD and associated bronchiolitis obliterans syndrome (BOS...

journal_title：Blood

authors： Flynn R,Du J,Veenstra RG,Reichenbach DK,Panoskaltsis-Mortari A,Taylor PA,Freeman GJ,Serody JS,Murphy WJ,Munn DH,Sarantopoulos S,Luznik L,Maillard I,Koreth J,Cutler C,Soiffer RJ,Antin JH,Ritz J,Dubovsky JA,Byrd JC,

更新日期：2014-06-19 00:00:00

abstract：:Epstein-Barr virus (EBV)-specific cellular memory is not transferred from mother to child. Therefore, EBV-induced B-cell proliferation in in vitro-infected cord blood mononuclear cell cultures is not inhibited. However, by addition of immunomodulators, polysaccharide K (PSK) or truncated thioredoxin (Trx80) that activ...

journal_title：Blood

authors： Liu A,Claesson HE,Mahshid Y,Klein G,Klein E

更新日期：2008-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a major gram-negative bacterial component that stimulates innate immune response and also induces B-lymphocyte activation. Recent studies have revealed that common molecular patterns of microorganisms such as LPS are recognized by toll-like receptors (TLRs). B cells have 2 known TLRs that m...

journal_title：Blood

authors： Yazawa N,Fujimoto M,Sato S,Miyake K,Asano N,Nagai Y,Takeuchi O,Takeda K,Okochi H,Akira S,Tedder TF,Tamaki K

更新日期：2003-08-15 00:00:00

abstract：:The receptor for hyaluronic acid-mediated motility (RHAMM) is an antigen eliciting both humoral and cellular immune responses in patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and multiple myeloma (MM). We initiated a phase 1 clinical trial vaccinating 10 patients with R3 (ILSLELMKL), a hi...

journal_title：Blood

authors： Schmitt M,Schmitt A,Rojewski MT,Chen J,Giannopoulos K,Fei F,Yu Y,Götz M,Heyduk M,Ritter G,Speiser DE,Gnjatic S,Guillaume P,Ringhoffer M,Schlenk RF,Liebisch P,Bunjes D,Shiku H,Dohner H,Greiner J

更新日期：2008-02-01 00:00:00

abstract：:The glutathione S-transferase (GST) genes are involved in the metabolism of environmental carcinogens and of some classes of chemotherapy drugs. GSTM1 and GSTT1 genotypes are polymorphic in humans, and the phenotypic absence of enzyme activity is caused by a homozygous inherited deletion of the gene. Previous, smaller...

journal_title：Blood

authors： Davies SM,Bhatia S,Ross JA,Kiffmeyer WR,Gaynon PS,Radloff GA,Robison LL,Perentesis JP

更新日期：2002-07-01 00:00:00

abstract：:Familial hemophagocytic lymphohistiocytosis (FHL) is a rare genetic disorder associated with the onset early in life of overwhelming activation of T lymphocytes and macrophages invariably leading to death. Allogeneic bone marrow transplantation (BMT) from an HLA-identical related donor is the treatment of choice in pa...

journal_title：Blood

authors： Jabado N,de Graeff-Meeder ER,Cavazzana-Calvo M,Haddad E,Le Deist F,Benkerrou M,Dufourcq R,Caillat S,Blanche S,Fischer A

更新日期：1997-12-15 00:00:00

abstract：:Stat5 proteins are critical signaling molecules activated by many cytokines. Within the immune system, Stat5 plays important roles related to the development of thymocytes and proliferation of T cells. Stat5 has been implicated in malignant transformation, and moreover, the activated tyrosine phosphorylated form of St...

journal_title：Blood

authors： Bessette K,Lang ML,Fava RA,Grundy M,Heinen J,Horne L,Spolski R,Al-Shami A,Morse HC 3rd,Leonard WJ,Kelly JA

更新日期：2008-01-01 00:00:00

abstract：:Some patients lose chimerism following nonmyeloablative hematopoietic cell transplantation (HCT), yet, surprisingly, enjoy sustained tumor remissions. We hypothesized that host-versus-graft (HVG) alloresponses might induce antitumor effects against recipient tumors. We explored this question in mice by administering r...

journal_title：Blood

authors： Rubio MT,Kim YM,Sachs T,Mapara M,Zhao G,Sykes M

更新日期：2003-09-15 00:00:00

abstract：:Recently, a novel gene of the major histocompatibility complex (MHC) class I family, HFE (HLA-H), has been found to be mutated in a large proportion of hereditary hemochromatosis (HH) patients. Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (bet...

journal_title：Blood

authors： Santos M,Clevers H,de Sousa M,Marx JJ

更新日期：1998-04-15 00:00:00

abstract：:Reticular dysgenesis is a rare inherited immunodeficiency characterized by the lack of blood monocytes and neutrophils and low lymphocyte counts, contrasting with normal red blood cell counts and normal or decreased platelet counts. Whether dendritic cells or macrophages, both of which derive primarily from blood mono...

journal_title：Blood

authors： Emile JF,Geissmann F,Martin OC,Radford-Weiss I,Lepelletier Y,Heymer B,Espanol T,de Santes KB,Bertrand Y,Brousse N,Casanova JL,Fischer A

更新日期：2000-07-01 00:00:00

abstract：:In search of a possible involvement of the human herpesvirus type 6 (HHV-6) in human Hodgkin's and non-Hodgkin's lymphomas, we studied the levels of anti-HHV-6 antibodies in the sera of 94 cases by an immunofluorescence assay, as well as the presence of HHV-6 sequences in the affected tissues of 66 cases by polymerase...

journal_title：Blood

authors： Torelli G,Marasca R,Luppi M,Selleri L,Ferrari S,Narni F,Mariano MT,Federico M,Ceccherini-Nelli L,Bendinelli M

更新日期：1991-05-15 00:00:00

abstract：:Telomere erosion may be counteracted by telomerase. Here we explored telomere length (TL) and telomerase activity (TA) in primary cutaneous T-cell lymphoma (CTCL) by using quantitative polymerase chain reaction and interphase quantitative fluorescence in situ hybridization assays. Samples from patients with Sézary syn...

journal_title：Blood

authors： Chevret E,Andrique L,Prochazkova-Carlotti M,Ferrer J,Cappellen D,Laharanne E,Idrissi Y,Boettiger A,Sahraoui W,Ruiz F,Pham-Ledard A,Vergier B,Belloc F,Dubus P,Beylot-Barry M,Merlio JP

更新日期：2014-03-20 00:00:00

abstract：:Omenn syndrome (OS) is a severe immunodeficiency associated with erythroderma, lymphoproliferation, elevated IgE, and hyperactive oligoclonal T cells. A restricted T-cell repertoire caused by defective thymic T-cell development and selection, lymphopenia with homeostatic proliferation, and lack of regulatory T cells a...

journal_title：Blood

authors： Fuchs S,Rensing-Ehl A,Pannicke U,Lorenz MR,Fisch P,Jeelall Y,Rohr J,Speckmann C,Vraetz T,Farmand S,Schmitt-Graeff A,Krüger M,Strahm B,Henneke P,Enders A,Horikawa K,Goodnow C,Schwarz K,Ehl S

更新日期：2015-10-01 00:00:00

abstract：:Previous studies have shown that cytokine-dependent eosinophils undergo apoptosis, yet the mechanisms governing this phenomenon remain obscure. Fas antigen is a transmembrane glycoprotein belonging to the tumor necrosis factor receptor family. Cross-linking of Fas antigen in numerous cell types leads to apoptosis. In ...

journal_title：Blood

authors： Druilhe A,Cai Z,Hailé S,Chouaib S,Pretolani M

更新日期：1996-04-01 00:00:00

abstract：:In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is mainly found in CD8(+) T cells and not in CD4(+) T cells. Telomerase, a ribonucleoprotein enzyme that can synthesize telomeric sequence onto chromosomal ends, can compensate for telomere loss. Here, we investigated if telomerase activity...

journal_title：Blood

authors： Wolthers KC,Otto SA,Wisman GB,Fleury S,Reiss P,ten Kate RW,van der Zee AG,Miedema F

更新日期：1999-02-01 00:00:00

abstract：:Deregulation of signal transduction pathways (STPs) may promote leukemogenesis by conferring cell proliferation and survival advantages in acute myelogenous leukemia (AML). Several agents targeting STPs are under development; however, redundancy and cross-talk between STPs could activate multiple downstream effectors ...

journal_title：Blood

authors： Kornblau SM,Womble M,Qiu YH,Jackson CE,Chen W,Konopleva M,Estey EH,Andreeff M

更新日期：2006-10-01 00:00:00

abstract：:Myeloma bone disease is due to interactions of myeloma cells with the bone marrow microenvironment, and is associated with pathologic fractures, neurologic symptoms and hypercalcemia. Adjacent to myeloma cells, the formation and activation of osteoclasts is increased, which results in enhanced bone resorption. The rec...

journal_title：Blood

authors： Sezer O,Heider U,Zavrski I,Kühne CA,Hofbauer LC

更新日期：2003-03-15 00:00:00

abstract：:Serum cobalamin (vitamin B12) and unsaturated B12 binding capacity (UBBC) have been measured in 24 cases of hypereosinophilia: 16 were cases of hypereosinophilic syndrome (HES) and 8 of secondary eosinophilia. The two groups were similar with respect to absolute eosinophil counts. Serum cobalamin and UBBC were found t...

journal_title：Blood

authors： Zittoun J,Farcet JP,Marquet J,Sultan C,Zittoun R

更新日期：1984-04-01 00:00:00

abstract：:Alkylureas are capable of inhibiting sickling in vitro and the gelation of solutions of hemoglobin S at concentrations between 0.05 and 0.1 M with increasing effectiveness that is directly proportional to the length of the alkyl chain (butyl greater than propyl greater than ethyl greater than methyl). 6The inhibitory ...

journal_title：Blood

authors： Elbaum D,Roth EF Jr,Neumann G,Jaffé ER,Bookchin RM,Nagel RL

更新日期：1976-08-01 00:00:00

abstract：:Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular target...

journal_title：Blood

authors： Valent P,Akin C,Metcalfe DD

更新日期：2017-03-16 00:00:00

abstract：:HIV/AIDS has long been at the forefront of the development of gene- and cell-based therapies. Although conventional gene therapy approaches typically involve the addition of anti-HIV genes to cells using semirandomly integrating viral vectors, newer genome editing technologies based on engineered nucleases are now all...

journal_title：Blood

authors： Wang CX,Cannon PM

更新日期：2016-05-26 00:00:00

abstract：:Human hematopoietic progenitor cells express L-selectin and also express PSGL-1, a ligand for all selectins. Using a shear-based adhesion assay, a hematopoietic cell L-selectin ligand (HCLL) that is expressed on the hematopoietic cell line KG1a and on normal human hematopoietic progenitors was previously identified. T...

journal_title：Blood

authors： Sackstein R,Dimitroff CJ

更新日期：2000-10-15 00:00:00

abstract：:Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KG1a, KG1, and HL60. Both KG1a and KG1 cells express the CD34 antigen...

journal_title：Blood

authors： Morimoto K,Robin E,Le Bousse-Kerdiles MC,Li Y,Clay D,Jasmin C,Smadja-Joffe F

更新日期：1994-02-01 00:00:00