Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction.


:In search of a possible involvement of the human herpesvirus type 6 (HHV-6) in human Hodgkin's and non-Hodgkin's lymphomas, we studied the levels of anti-HHV-6 antibodies in the sera of 94 cases by an immunofluorescence assay, as well as the presence of HHV-6 sequences in the affected tissues of 66 cases by polymerase chain reaction, using one set of primer oligonucleotides. Our results showed higher anti-HHV-6 antibody titers in human lymphomas than in normal blood donors, but the difference is statistically significant only when normal donors are compared with Hodgkin's lymphoma cases. HHV-6 sequences were detected in 3 of 25 Hodgkin's lymphomas and 0 of the 41 cases of non-Hodgkin's lymphomas studied. The three cases positive for HHV-6 sequences belong to the nodular sclerosis-lymphocyte depletion histologic subtype and share remarkable similarities in their clinical features. Furthermore, Southern blot analysis of total genomic DNA obtained from the neoplastic tissues of two of the three patients showed the same restriction fragment length polymorphism. Our results suggest that: (1) the high level of anti-HHV-6 antibodies in Hodgkin's disease is due to an activation of the immune system not related to the presence of HHV-6 sequences in affected lymph nodes; (2) the presence of HHV-6 sequences in human lymphoid tissues is not a frequent event, rather it is in fact a very rare event in non-Hodgkin's lymphomas, while in Hodgkin's cases it is more frequent than previously reported on the basis of Southern blot analysis; and (3) the presence of HHV-6 sequences in Hodgkin's lymphomas may have a relation with the clinical presentation of the disease.






Torelli G,Marasca R,Luppi M,Selleri L,Ferrari S,Narni F,Mariano MT,Federico M,Ceccherini-Nelli L,Bendinelli M


Has Abstract,Author List Incomplete


1991-05-15 00:00:00














  • Use of alpha-2a-interferon to treat cytogenetic relapse of chronic myeloid leukemia after marrow transplantation.

    abstract::Fourteen patients with cytogenetic relapse of chronic myeloid leukemia (CML) after transplantation with unmanipulated bone marrow were treated with alpha-2a-interferon. There were eight men and six women, median age, 33 years. Twelve patients received marrow from a related allogeneic donor and two received marrow from...


    pub_type: 临床试验,杂志文章


    authors: Higano CS,Chielens D,Raskind W,Bryant E,Flowers ME,Radich J,Clift R,Appelbaum F

    更新日期:1997-10-01 00:00:00

  • Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells.

    abstract::Sphingosine 1-phosphate (S1P), a bioactive lipid, is produced and stored in platelets and is released from activated platelets during blood coagulation activation. Thrombin, which is also generated during blood coagulation, has been shown to induce tissue factor (TF), the initiator of blood coagulation, in endothelial...


    pub_type: 杂志文章


    authors: Takeya H,Gabazza EC,Aoki S,Ueno H,Suzuki K

    更新日期:2003-09-01 00:00:00

  • Following aggressive B-cell lymphoma.

    abstract::In this issue of Blood, Kurtz et al report the potential clinical utility of immunoglobulin high-throughput sequencing as a tool for disease monitoring and surveillance in aggressive B-cell lymphoma. ...


    pub_type: 评论,杂志文章


    authors: Sweetenham JW

    更新日期:2015-06-11 00:00:00

  • The treatment of Burkitt lymphoma in adults.

    abstract::Burkitt lymphoma (BL) is a highly aggressive, B-cell, non-Hodgkin lymphoma (NHL) categorized into endemic, sporadic and immunodeficiency-associated subtypes. BL has distinct pathologic and clinical features, characterized by rapidly progressive tumors with high rates of extranodal involvement. Next generation sequenci...


    pub_type: 杂志文章


    authors: Crombie JL,LaCasce AS

    更新日期:2020-11-10 00:00:00

  • Munc18b/STXBP2 is required for platelet secretion.

    abstract::Platelets are vital for hemostasis because they release their granule contents in response to vascular damage. Platelet exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), whose interactions are governed by regulators, eg, Sec/Munc18 proteins. These proteins chape...


    pub_type: 杂志文章


    authors: Al Hawas R,Ren Q,Ye S,Karim ZA,Filipovich AH,Whiteheart SW

    更新日期:2012-09-20 00:00:00

  • Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin.

    abstract::P-selectin glycoprotein ligand-1 (PSGL-1) serves as the leukocyte ligand for P-selectin, and many of the structural features of its ectodomain required for interactions with P-selectin have been uncovered. In contrast, the function of the highly conserved PSGL-1 cytoplasmic domain has not been explored. Stable transfe...


    pub_type: 杂志文章


    authors: Snapp KR,Heitzig CE,Kansas GS

    更新日期:2002-06-15 00:00:00

  • Ex vivo incubation with growth factors enhances the engraftment of fetal hematopoietic cells transplanted in sheep fetuses.

    abstract::Hematopoietic stem cells (HSC) transplanted in utero are in competition with endogenous HSC; thus, ultimately the graft constitutes a relatively small fraction of total HSC pool. To enhance the engraftment of donor cells in sheep fetuses, we preincubated these cells, ex vivo, for 16 hours at 37 degrees C with the cond...


    pub_type: 杂志文章


    authors: Zanjani ED,Ascensao JL,Harrison MR,Tavassoli M

    更新日期:1992-06-01 00:00:00

  • Gamma heavy chain disease: clinical aspects and characterization of a deleted, noncovalently linked gamma1 heavy chain dimer (BAZ).

    abstract::This report describes the clinical and immunoglobulin features of a patient with gamma heavy chain disease (HCD), who presented with a clinical picture suggestive of an underlying malignancy rather than the usual picture of lymphoma or granulomatous disease. A unique clinical feature was the nearly total replacement o...


    pub_type: 杂志文章


    authors: Faguet GB,Barton BP,Smith LL,Garver FA

    更新日期:1977-04-01 00:00:00

  • Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome.

    abstract::The association of thrombosis and gestational morbidity with antiphospholipid antibodies is termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antip...


    pub_type: 杂志文章


    authors: Cesarman-Maus G,Ríos-Luna NP,Deora AB,Huang B,Villa R,Cravioto Mdel C,Alarcón-Segovia D,Sánchez-Guerrero J,Hajjar KA

    更新日期:2006-06-01 00:00:00

  • Gene profiling of Graffi murine leukemia virus-induced lymphoid leukemias: identification of leukemia markers and Fmn2 as a potential oncogene.

    abstract::The Graffi murine leukemia virus induces a large spectrum of leukemias in mice and thus provides a good model to compare the transcriptome of all types of leukemias. We analyzed the gene expression profiles of both T and B leukemias induced by the virus with DNA microarrays. Given that we considered that a 4-fold chan...


    pub_type: 杂志文章


    authors: Charfi C,Voisin V,Levros LC Jr,Edouard E,Rassart E

    更新日期:2011-02-10 00:00:00

  • Role for CCG-trinucleotide repeats in the pathogenesis of chronic lymphocytic leukemia.

    abstract::Chromosome 11q deletions are frequently observed in chronic lymphocytic leukemia (CLL) in association with progressive disease and a poor prognosis. A minimal region of deletion has been assigned to 11q22-q23. Trinucleotide repeats have been associated with anticipation in disease, and evidence of anticipation has bee...


    pub_type: 杂志文章


    authors: Auer RL,Jones C,Mullenbach RA,Syndercombe-Court D,Milligan DW,Fegan CD,Cotter FE

    更新日期:2001-01-15 00:00:00

  • Activation of the contact system in insect-sting anaphylaxis: association with the development of angioedema and shock.

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    pub_type: 杂志文章


    authors: van der Linden PW,Hack CE,Eerenberg AJ,Struyvenberg A,van der Zwan JK

    更新日期:1993-09-15 00:00:00

  • Notes from the Director, National Heart, Lung, and Blood Institute: transitions.

    abstract::During this time of transition in the federal government and the National Institutes of Health, I write to assure the Blood community of the National Heart, Lung, and Blood Institute's (NHLBI) commitment to new and established investigators as outlined in the NHLBI Strategic Plan. This perspective discusses the NHLBI ...


    pub_type: 杂志文章


    authors: Nabel EG

    更新日期:2009-03-26 00:00:00

  • RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements.

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    pub_type: 杂志文章


    authors: Puig-Kröger A,Sanchez-Elsner T,Ruiz N,Andreu EJ,Prosper F,Jensen UB,Gil J,Erickson P,Drabkin H,Groner Y,Corbi AL

    更新日期:2003-11-01 00:00:00

  • Immunocytochemical discovery of the 22- to 23-Kd subunit of cytochrome b558 at the surface of human peripheral phagocytes.

    abstract::A monoclonal antibody raised against cytochrome b558 reacted specifically with the 22- to 23-Kd protein, the small subunit of this cytochrome. Cytochemical studies showed that the epitope was located on the surfaces of human neutrophils and monocytes. The small subunit of cytochrome b558, therefore, was expressed at l...


    pub_type: 杂志文章


    authors: Nakamura M,Sendo S,van Zwieten R,Koga T,Roos D,Kanegasaki S

    更新日期:1988-11-01 00:00:00

  • Mechanistic basis and efficacy of targeting the β-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors.

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    pub_type: 杂志文章


    authors: Saenz DT,Fiskus W,Mill CP,Perera D,Manshouri T,Lara BH,Karkhanis V,Sharma S,Horrigan SK,Bose P,Kadia TM,Masarova L,DiNardo CD,Borthakur G,Khoury JD,Takahashi K,Bhaskara S,Lin CY,Green MR,Coarfa C,Crews CM,Versto

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    pub_type: 杂志文章


    authors: Fujioka S,Yamada T

    更新日期:1992-04-01 00:00:00

  • Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes.

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    pub_type: 杂志文章


    authors: Laliberté J,Yee A,Xiong Y,Mitchell BS

    更新日期:1998-04-15 00:00:00

  • Stimulation of neutrophil oxidative metabolism by the alternate pathway of complement activation: a mechanism for the spontaneous NBT test.

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    pub_type: 杂志文章


    authors: Strauss RG,Mauer AM,Asbrock T,Spitzer RE,Stitzel AE

    更新日期:1975-06-01 00:00:00

  • CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.

    abstract::A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive im...


    pub_type: 杂志文章


    authors: Shimazu T,Iida R,Zhang Q,Welner RS,Medina KL,Alberola-Lla J,Kincade PW

    更新日期:2012-05-24 00:00:00

  • Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax.

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    pub_type: 杂志文章


    authors: Szocinski JL,Khaled AR,Hixon J,Halverson D,Funakoshi S,Fanslow WC,Boyd A,Taub DD,Durum SK,Siegall CB,Longo DL,Murphy WJ

    更新日期:2002-07-01 00:00:00

  • Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease.

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    pub_type: 杂志文章


    authors: Bean CJ,Boulet SL,Ellingsen D,Pyle ME,Barron-Casella EA,Casella JF,Payne AB,Driggers J,Trau HA,Yang G,Jones K,Ofori-Acquah SF,Hooper WC,DeBaun MR

    更新日期:2012-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Leong SR,Sukumaran S,Hristopoulos M,Totpal K,Stainton S,Lu E,Wong A,Tam L,Newman R,Vuillemenot BR,Ellerman D,Gu C,Mathieu M,Dennis MS,Nguyen A,Zheng B,Zhang C,Lee G,Chu YW,Prell RA,Lin K,Laing ST,Polson AG

    更新日期:2017-02-02 00:00:00

  • Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells.

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    pub_type: 杂志文章


    authors: Chirivi RG,Taraboletti G,Bani MR,Barra L,Piccinini G,Giacca M,Bussolino F,Giavazzi R

    更新日期:1999-09-01 00:00:00

  • Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms.

    abstract::As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. In the present study, we report that NSC606985, a rarely studied camptothecin analog, induces apoptosis in acute myeloid leukemia (AML) cells NB4 and U937 and inhib...


    pub_type: 杂志文章


    authors: Song MG,Gao SM,Du KM,Xu M,Yu Y,Zhou YH,Wang Q,Chen Z,Zhu YS,Chen GQ

    更新日期:2005-05-01 00:00:00

  • Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells.

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    pub_type: 杂志文章


    authors: Fischer K,Voelkl S,Heymann J,Przybylski GK,Mondal K,Laumer M,Kunz-Schughart L,Schmidt CA,Andreesen R,Mackensen A

    更新日期:2005-04-01 00:00:00

  • LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo.

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    pub_type: 杂志文章


    authors: Bovenschen N,Mertens K,Hu L,Havekes LM,van Vlijmen BJ

    更新日期:2005-08-01 00:00:00

  • Reversing anti-factor Xa agents and the unmet needs in trauma patients.

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    pub_type: 杂志文章,评审


    authors: Hunt BJ,Neal MD,Stensballe J

    更新日期:2018-12-06 00:00:00

  • Not fibrin(ogen), but fibrinogen or fibrin.

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    pub_type: 评论,杂志文章


    authors: Litvinov RI,Weisel JW

    更新日期:2015-10-22 00:00:00

  • Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.

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    pub_type: 杂志文章


    authors: Urtishak KA,Edwards AY,Wang LS,Hudome A,Robinson BW,Barrett JS,Cao K,Cory L,Moore JS,Bantly AD,Yu QC,Chen IM,Atlas SR,Willman CL,Kundu M,Carroll AJ,Heerema NA,Devidas M,Hilden JM,Dreyer ZE,Hunger SP,Reaman GH,

    更新日期:2013-04-04 00:00:00