Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice.

Abstract:

:Recently, a novel gene of the major histocompatibility complex (MHC) class I family, HFE (HLA-H), has been found to be mutated in a large proportion of hereditary hemochromatosis (HH) patients. Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (beta2m-/-) mice, that fail to express MHC class I products, develop iron overload. We have now used this animal model of HH to examine the capacity to adapt iron absorption in response to altered iron metabolism in the absence of beta2m-dependent molecule(s). Mucosal uptake, mucosal transfer and retention of iron were measured in control and beta2m-/- mice with altered iron metabolism. Mucosal uptake of Fe(III), but not of Fe(II), by the mutant mice was significantly higher when compared with B6 control mice. Mucosal transfer in the beta2m-/- mice was higher, independent of the iron form tested. No significant differences were found in iron absorption between control and beta2m-/- mice when anemia was induced either by repetitive bleeding or by hemolysis through phenylhydrazine treatment. However, iron absorption in mice made anemic by dietary deprivation of iron was significantly higher in the mutant mice. Furthermore, the beta2m-/- mice manifested an impaired capacity to downmodulate iron absorption when dietary or parenterally iron-loaded. The expression of the defect in iron absorption in the beta2m-/- mice is quantitative, with iron absorption being excessively high for the size of body iron stores. The higher iron absorption capacity in the beta2m-/- mice may involve the initial step of ferric mucosal uptake and the subsequent step of mucosal transfer of iron to the plasma.

journal_name

Blood

journal_title

Blood

authors

Santos M,Clevers H,de Sousa M,Marx JJ

subject

Has Abstract

pub_date

1998-04-15 00:00:00

pages

3059-65

issue

8

eissn

0006-4971

issn

1528-0020

journal_volume

91

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Cross talk between neutrophils and the microbiota.

    abstract::The microbiota has emerged as an important regulator of the host immunity by the induction, functional modulation, or suppression of local and systemic immune responses. In return, the host immune system restricts translocation and fine tunes the composition and distribution of the microbiota to maintain a beneficial ...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2018-11-844555

    authors: Zhang D,Frenette PS

    更新日期:2019-05-16 00:00:00

  • A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation.

    abstract::Donor lymphocyte infusions (DLIs) induce potent graft versus tumor (GVT) effects for relapsed chronic myelogenous leukemia (CML) after allogeneic stem cell transplantation (SCT) but are disappointing for other diseases. Disease resistance can occur if donor T cells are not appropriately activated in vivo. Ex vivo T-ce...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-08-3373

    authors: Porter DL,Levine BL,Bunin N,Stadtmauer EA,Luger SM,Goldstein S,Loren A,Phillips J,Nasta S,Perl A,Schuster S,Tsai D,Sohal A,Veloso E,Emerson S,June CH

    更新日期:2006-02-15 00:00:00

  • Molecular mechanism of transforming growth factor beta-mediated cell-cycle modulation in primary human CD34(+) progenitors.

    abstract::The mechanisms by which transforming growth factor beta (TGF-beta) exerts a negative effect on cell-cycle entry in primary human hematopoietic stem/progenitor cells were examined at the molecular and cellular levels. After treatment of primary human CD34+ progenitors with TGF-beta there was a decrease in the levels of...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v99.2.499

    authors: Dao MA,Hwa J,Nolta JA

    更新日期:2002-01-15 00:00:00

  • Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction.

    abstract::BCL3 encodes a protein with close homology to IkappaB proteins and interacts with p50 NF-kappaB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cell...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Richard M,Louahed J,Demoulin JB,Renauld JC

    更新日期:1999-06-15 00:00:00

  • Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells.

    abstract::Endothelial cells (ECs) express 2 members of the cadherin family, VE and N-cadherin. Although VE-cadherin induces EC homotypic adhesion, N-cadherin function in ECs remains largely unknown. EC-specific inactivation of either VE or N-cadherin leads to early fetal lethality suggesting that these cadherins play a nonredun...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-09-381012

    authors: Giampietro C,Taddei A,Corada M,Sarra-Ferraris GM,Alcalay M,Cavallaro U,Orsenigo F,Lampugnani MG,Dejana E

    更新日期:2012-03-01 00:00:00

  • Interstitial insertion of retinoic acid receptor-alpha gene in acute promyelocytic leukemia with normal chromosomes 15 and 17.

    abstract::The translocation t(15;17)(q22;q21) is seen exclusively in patients with acute promyelocytic leukemia (APL) and in the promyelocytic blast crisis of chronic myeloid leukemia (CML). This translocation juxta-poses the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor-alpha (RARA) gene on ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hiorns LR,Min T,Swansbury GJ,Zelent A,Dyer MJ,Catovsky D

    更新日期:1994-05-15 00:00:00

  • VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy.

    abstract::Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like CD25, and poor response to standard treatments like cladribine. Occasionally, patients with classic HCL respond poorly. Clinical and molecular features of HCL and HCLv has not been compared. Rearrangements expressing im...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-01-201731

    authors: Arons E,Suntum T,Stetler-Stevenson M,Kreitman RJ

    更新日期:2009-11-19 00:00:00

  • Critical role of class IA PI3K for c-Rel expression in B lymphocytes.

    abstract::The fact that the Xid mutation of Btk impairs the ability of pleckstrin homology domain of Btk to bind phosphatidylinositol-(3,4,5)-trisphosphate, a product of class IA phosphoinositide-3 kinases (PI3Ks), has been considered strong evidence for the hypothesis that Btk functions downstream of PI3Ks. We demonstrate here...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-06-163725

    authors: Matsuda S,Mikami Y,Ohtani M,Fujiwara M,Hirata Y,Minowa A,Terauchi Y,Kadowaki T,Koyasu S

    更新日期:2009-01-29 00:00:00

  • Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops.

    abstract::The biologic effects of endothelin-1 (ET-1) are not limited to its potent vasoconstricting activity. The endothelin receptors, ETA and ETB, have differential tissue and functional distributions. Here we showed that dendritic cells (DCs), the major antigen-presenting cells in the adaptive limb of the immune system, pro...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-10-3559

    authors: Guruli G,Pflug BR,Pecher S,Makarenkova V,Shurin MR,Nelson JB

    更新日期:2004-10-01 00:00:00

  • HIV gene therapy research advances.

    abstract::In this issue of Blood, Tebas et al report antiviral effects in a clinical trial of multiple infusions of lentiviral vector–modified autologous CD4T lymphocytes in 17 HIV-infected patients aviremic on antiretroviral therapy (ART). ...

    journal_title:Blood

    pub_type: 评论,杂志文章

    doi:10.1182/blood-2013-01-475921

    authors: Jacobson JM

    更新日期:2013-02-28 00:00:00

  • Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.

    abstract::Contraction of blood clots is necessary for hemostasis and wound healing and to restore flow past obstructive thrombi, but little is known about the structure of contracted clots or the role of erythrocytes in contraction. We found that contracted blood clots develop a remarkable structure, with a meshwork of fibrin a...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-08-523860

    authors: Cines DB,Lebedeva T,Nagaswami C,Hayes V,Massefski W,Litvinov RI,Rauova L,Lowery TJ,Weisel JW

    更新日期:2014-03-06 00:00:00

  • Hodgkin disease: pharmacologic intervention of the CD40-NF kappa B pathway by a protease inhibitor.

    abstract::The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism. A likely candid...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Annunziata CM,Safiran YJ,Irving SG,Kasid UN,Cossman J

    更新日期:2000-10-15 00:00:00

  • Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.

    abstract::Chimeric antigen receptor (CAR) T cells have emerged as a novel form of treatment of patients with B-cell malignancies. In particular, anti-CD19 CAR T-cell therapy has effected impressive clinical responses in B-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma. However, not all patients respond, and...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2018-04-842708

    authors: Scarfò I,Ormhøj M,Frigault MJ,Castano AP,Lorrey S,Bouffard AA,van Scoyk A,Rodig SJ,Shay AJ,Aster JC,Preffer FI,Weinstock DM,Maus MV

    更新日期:2018-10-04 00:00:00

  • Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: an international study of 891 patients.

    abstract::In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable an...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究

    doi:10.1182/blood-2011-02-339002

    authors: Carobbio A,Thiele J,Passamonti F,Rumi E,Ruggeri M,Rodeghiero F,Randi ML,Bertozzi I,Vannucchi AM,Antonioli E,Gisslinger H,Buxhofer-Ausch V,Finazzi G,Gangat N,Tefferi A,Barbui T

    更新日期:2011-06-02 00:00:00

  • Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit.

    abstract::We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-07-228999

    authors: Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

    更新日期:2010-01-28 00:00:00

  • Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia.

    abstract::Juvenile myelomonocytic leukemia (JMML) is a typically aggressive myeloid neoplasm of childhood that is clinically characterized by overproduction of monocytic cells that can infiltrate organs, including the spleen, liver, gastrointestinal tract, and lung. JMML is categorized as an overlap myelodysplastic syndrome/mye...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2014-03-300319

    authors: Chang TY,Dvorak CC,Loh ML

    更新日期:2014-10-16 00:00:00

  • Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy.

    abstract::Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging diagnosis after hematopoietic stem cell transplantation. Although endothelial injury represents the final common pathway of disease, the exact pathophysiology of TA-TMA remains unclear. Potential causes include infections, chemotherapy, ra...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2011-02-321315

    authors: Laskin BL,Goebel J,Davies SM,Jodele S

    更新日期:2011-08-11 00:00:00

  • G protein subunit G alpha 16 expression is restricted to progenitor B cells during human B-cell differentiation.

    abstract::Recently G alpha 16, a new guanosine triphosphate (GTP) binding protein alpha subunit has been described to be specifically expressed in human hematopoietic cells. Expression of G alpha 16 was observed in human cell lines of myelomonocytic and T-lymphocytic origin, but not in human B-cell lines Raji and IM9. We studie...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Mapara MY,Bommert K,Bargou RC,Leng C,Beck C,Ludwig WD,Gierschik P,Dörken B

    更新日期:1995-04-01 00:00:00

  • A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: the results of P9425.

    abstract::Current treatment strategies for Hodgkin lymphoma result in excellent survival but often confer significant long-term toxicity. We designed ABVE-PC (doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide) to (1) enhance treatment efficacy by dose-dense drug delivery and (2) reduce risk of long-te...

    journal_title:Blood

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1182/blood-2008-10-184143

    authors: Schwartz CL,Constine LS,Villaluna D,London WB,Hutchison RE,Sposto R,Lipshultz SE,Turner CS,deAlarcon PA,Chauvenet A

    更新日期:2009-09-03 00:00:00

  • In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells.

    abstract::We have examined the effects of administration of stem cell-factor (SCF) on the number and distribution of pluripotent hematopoietic stem cells (PHSC) in normal mice. Using the competitive repopulation assay we found that in vivo administration of SCF increases the absolute number of PHSC per mouse threefold. The incr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Bodine DM,Seidel NE,Zsebo KM,Orlic D

    更新日期:1993-07-15 00:00:00

  • Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.

    abstract::Fanconi anemia (FA) is a genetic disease characterized by congenital abnormalities, bone marrow failure, and susceptibility to leukemia and other cancers. FANCJ, one of 13 genes linked to FA, encodes a DNA helicase proposed to operate in homologous recombination repair and replicational stress response. The pathogenic...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-11-256016

    authors: Wu Y,Sommers JA,Suhasini AN,Leonard T,Deakyne JS,Mazin AV,Shin-Ya K,Kitao H,Brosh RM Jr

    更新日期:2010-11-11 00:00:00

  • Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.

    abstract::Interleukin-3 (IL-3) is exclusively expressed by activated T and natural killer cells, a function that is tightly controlled both in a lineage-specific and in a stimulation-dependent manner. We have investigated the protein binding characteristics and functional importance of the ACT-1-activating region of the IL-3 pr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Davies K,TePas EC,Nathan DG,Mathey-Prevot B

    更新日期:1993-02-15 00:00:00

  • Phenotype analysis of hematopoietic CD34+ cell populations derived from human umbilical cord blood using flow cytometry and cDNA-polymerase chain reaction.

    abstract::A strategy to phenotype rare populations of hematopoietic cells expressing the cell-surface marker CD34 was studied. The antigenic phenotype of umbilical core blood (CB) CD34+ cells was investigated using flow cytometry and compared with the mRNA-phenotype determined by cDNA-polymerase chain reaction (cDNA-PCR) analys...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Thoma SJ,Lamping CP,Ziegler BL

    更新日期:1994-04-15 00:00:00

  • Accumulation of HIF-1alpha under the influence of nitric oxide.

    abstract::The key player for adaptation to reduced oxygen availability is the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of the redox-sensitive HIF-1alpha and the constitutively expressed HIF-1beta subunits. Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxa...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v97.4.1009

    authors: Sandau KB,Fandrey J,Brüne B

    更新日期:2001-02-15 00:00:00

  • Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia.

    abstract::HS1 (hematopoietic cell-specific Lyn substrate-1) is a cytoskeletal interactor in the B-cell receptor (BCR) signaling pathway whose phosphorylation correlates with prognosis in Chronic Lymphocytic Leukemia (CLL). The differentially phosphorylated sites and the kinases that regulate HS1 activity in CLL remain poorly un...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-09-457119

    authors: ten Hacken E,Scielzo C,Bertilaccio MT,Scarfò L,Apollonio B,Barbaglio F,Stamatopoulos K,Ponzoni M,Ghia P,Caligaris-Cappio F

    更新日期:2013-03-21 00:00:00

  • Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells.

    abstract::The ex vivo expansion of hematopoietic progenitors is a promising approach for accelerating the engraftment of recipients, particularly when cord blood (CB) is used as a source of hematopoietic graft. With the aim of defining the in vivo repopulating properties of ex vivo-expanded CB cells, purified CD34(+) cells were...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Guenechea G,Segovia JC,Albella B,Lamana M,Ramírez M,Regidor C,Fernández MN,Bueren JA

    更新日期:1999-02-01 00:00:00

  • Mechanical properties of sickle cell membranes.

    abstract::The mechanical properties of sickle erythrocyte membranes were evaluated in the ektacytometer. When ghosts from the total red blood cell population were examined, the rigidity of the resealed ghosts and their rate of fragmentation by shear stress (t1/2) were normal. However, fractionation on Stractan density gradients...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Messmann R,Gannon S,Sarnaik S,Johnson RM

    更新日期:1990-04-15 00:00:00

  • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump.

    abstract::Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indee...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-04-1398

    authors: Burger H,van Tol H,Boersma AW,Brok M,Wiemer EA,Stoter G,Nooter K

    更新日期:2004-11-01 00:00:00

  • Myeloma bone marrow plasma cells: evidence for their capacity as antigen-presenting cells.

    abstract::Myeloma plasma cells constitute 10% to 90% of the total bone marrow cell count in patients with multiple myeloma (MM). These cells express a variety of cell surface markers, such as HLA-ABC and HLA-DR, and surface antigens that are necessary for professional antigen-presenting cells, including adhesion and costimulato...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Yi Q,Dabadghao S,Osterborg A,Bergenbrant S,Holm G

    更新日期:1997-09-01 00:00:00

  • Analysis of TNF-receptor and ligand superfamily molecules in patients with lymphoproliferative disease of granular lymphocytes.

    abstract::In 21 patients with lymphoproliferative disease of granular lymphocytes (LDGL), we investigated the expression and the function of molecules belonging to TNF-receptor and TNF-ligand superfamilies (CD30/CD30L; CD40/CD40L; CD27/CD70; Fas [CD95]/FasL[CD95L]). Fourteen patients were characterized by a proliferation of gra...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Zambello R,Trentin L,Facco M,Siviero M,Galvan S,Piazza F,Perin A,Agostini C,Semenzato G

    更新日期:2000-07-15 00:00:00