Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma.

abstract：:Wiskott-Aldrich syndrome (WAS) pediatric patients exhibit a deficiency in humoral immune memory. However, the mechanism by which Wiskott-Aldrich syndrome protein (WASP) regulates the differentiation and activation of memory B cells remains elusive. Here we examine the early activation events of memory B cells from the...

journal_title：Blood

authors： Bai X,Zhang Y,Huang L,Wang J,Li W,Niu L,Jiang H,Dai R,Zhou L,Zhang Z,Miller H,Song W,Zhao X,Liu C

更新日期：2016-09-29 00:00:00

abstract：:The hereditary stomatocytoses are a series of dominantly inherited hemolytic anemias in which the permeability of the erythrocyte membrane to monovalent cations is pathologically increased. The causative mutations for some forms of hereditary stomatocytosis have been found in the transporter protein genes, RHAG and SL...

journal_title：Blood

authors： Flatt JF,Guizouarn H,Burton NM,Borgese F,Tomlinson RJ,Forsyth RJ,Baldwin SA,Levinson BE,Quittet P,Aguilar-Martinez P,Delaunay J,Stewart GW,Bruce LJ

更新日期：2011-11-10 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) is the most important cytokine involved in the promotion of myelofibrosis. Mechanisms leading to its local activation in the bone marrow environment remain unclear. As a recent study has highlighted the role of thrombospondin-1 (TSP-1) in platelet-derived TGF-β1 activation, we in...

journal_title：Blood

authors： Evrard S,Bluteau O,Tulliez M,Rameau P,Gonin P,Zetterberg E,Palmblad J,Bonnefoy A,Villeval JL,Vainchenker W,Giraudier S,Wagner-Ballon O

更新日期：2011-01-06 00:00:00

abstract：:Three families with polycythemia inherited through apparently different modes are described. Secondary causes of polycythemia were ruled out. Erythropoietin (EPO) levels were normal or low, even after phlebotomy. In vitro erythroid colony growth in standard assay cultures containing EPO was normal; however, in the abs...

journal_title：Blood

authors： Emanuel PD,Eaves CJ,Broudy VC,Papayannopoulou T,Moore MR,D'Andrea AD,Prchal JF,Eaves AC,Prchal JT

更新日期：1992-06-01 00:00:00

abstract：:Endovascular infection is a highly critical complication of invasive Staphylococcus aureus disease. For colonization, staphylococci must first adhere to adhesive endovascular foci. Von Willebrand factor (vWF) is a large, multimeric glycoprotein mediating platelet adhesion at sites of endothelial damage. Earlier it was...

journal_title：Blood

authors： Hartleib J,Köhler N,Dickinson RB,Chhatwal GS,Sixma JJ,Hartford OM,Foster TJ,Peters G,Kehrel BE,Herrmann M

更新日期：2000-09-15 00:00:00

abstract：:Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contac...

journal_title：Blood

authors： Lawrence DN,Jason JM,Bouhasin JD,McDougal JS,Knutsen AP,Evatt BL,Joist JH

更新日期：1985-09-01 00:00:00

abstract：:In a prospective trial in 284 children with B-lineage acute lymphoblastic leukemia (ALL), we assessed the clinical utility of real-time quantitative polymerase chain reaction analysis of antigen receptor gene rearrangements for detection of minimal residual disease (MRD) to identify children at high risk of relapse. A...

journal_title：Blood

authors： Zhou J,Goldwasser MA,Li A,Dahlberg SE,Neuberg D,Wang H,Dalton V,McBride KD,Sallan SE,Silverman LB,Gribben JG,Dana-Farber Cancer Institute ALL Consortium.

更新日期：2007-09-01 00:00:00

abstract：:High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders. To determine the safety and efficacy of high-dose cyclophosphamide among patients with severe refractory autoimmune hemolytic anemia, we treated 9 patients with cyclophosphamide (50...

journal_title：Blood

authors： Moyo VM,Smith D,Brodsky I,Crilley P,Jones RJ,Brodsky RA

更新日期：2002-07-15 00:00:00

abstract：:Serum response factor (SRF) is a ubiquitously expressed transcription factor and master regulator of the actin cytoskeleton. We have previously shown that SRF is essential for megakaryocyte maturation and platelet formation and function. Here we elucidate the role of SRF in neutrophils, the primary defense against inf...

journal_title：Blood

authors： Taylor A,Tang W,Bruscia EM,Zhang PX,Lin A,Gaines P,Wu D,Halene S

更新日期：2014-05-08 00:00:00

abstract：:Infection with human T-cell leukemia virus type II (HTLV-II) has been associated with rare chronic T-cell malignancies and has recently been demonstrated in a significant proportion of American intravenous drug abusers (IVDA). Identification of an HTLV-II-infected cohort of IVDA has allowed analysis of the HTLV-II car...

journal_title：Blood

authors： Rosenblatt JD,Plaeger-Marshall S,Giorgi JV,Swanson P,Chen IS,Chin E,Wang HJ,Canavaggio M,Hausner MA,Black AC

更新日期：1990-07-15 00:00:00

abstract：:Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging diagnosis after hematopoietic stem cell transplantation. Although endothelial injury represents the final common pathway of disease, the exact pathophysiology of TA-TMA remains unclear. Potential causes include infections, chemotherapy, ra...

journal_title：Blood

authors： Laskin BL,Goebel J,Davies SM,Jodele S

更新日期：2011-08-11 00:00:00

abstract：:Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indee...

journal_title：Blood

authors： Burger H,van Tol H,Boersma AW,Brok M,Wiemer EA,Stoter G,Nooter K

更新日期：2004-11-01 00:00:00

abstract：:Both SDF-1 and CXCR4 disruption are lethal to mice at the embryonic stage and cause abnormalities in B lymphopoiesis, myelopoiesis, cardiogenesis, vasculogenesis, and cerebellar development. To investigate the role of SDF-1 and CXCR4 in hematopoiesis during the adult stage, mice reconstituted with bone marrow-derived ...

journal_title：Blood

authors： Onai N,Zhang Yy,Yoneyama H,Kitamura T,Ishikawa S,Matsushima K

更新日期：2000-09-15 00:00:00

abstract：:This study examined the prognostic value of circulating peripheral blood plasma cells (PBPCs) in patients with primary systemic amyloidosis (AL). A sensitive slide-based immunofluorescence technique was used to assess 147 patients for circulating PBPCs. Circulating monoclonal plasma cells were quantified as a percenta...

journal_title：Blood

authors： Pardanani A,Witzig TE,Schroeder G,McElroy EA,Fonseca R,Dispenzieri A,Lacy MQ,Lust JA,Kyle RA,Greipp PR,Gertz MA,Rajkumar SV

更新日期：2003-02-01 00:00:00

abstract：:Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages. Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic disorder. Hepcidin is produced mainly b...

journal_title：Blood

authors： Zumerle S,Mathieu JR,Delga S,Heinis M,Viatte L,Vaulont S,Peyssonnaux C

更新日期：2014-06-05 00:00:00

abstract：:Graft failure was analyzed in 625 patients receiving allogeneic bone marrow transplants from HLA-identical sibling donors as treatment for severe aplastic anemia. Sixty-eight (11%) had no or only transient engraftment. Second bone marrow transplants were successful in achieving extended survival in 16 of 27 patients w...

journal_title：Blood

authors： Champlin RE,Horowitz MM,van Bekkum DW,Camitta BM,Elfenbein GE,Gale RP,Gluckman E,Good RA,Rimm AA,Rozman C

更新日期：1989-02-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major regulator of granulopoiesis and acts through binding to its specific receptor (G-CSF-R) on neutrophilic granulocytes. Previous studies of signaling from the 4 G-CSF-R cytoplasmic tyrosine residues used model cell lines that may have idiosyncratic, nonphysiolog...

journal_title：Blood

authors： Akbarzadeh S,Ward AC,McPhee DO,Alexander WS,Lieschke GJ,Layton JE

更新日期：2002-02-01 00:00:00

abstract：:Stem cell factor (SCF) and interleukin-3 (IL-3) both act on several target hematopoietic populations, including mast cells. We have isolated a unique murine mast cell line, B6M, that is phenotypically similar to immature mast cells. For B6M cells, IL-3 is a survival factor and alone does not stimulate proliferation. S...

journal_title：Blood

authors： O'Farrell AM,Ichihara M,Mui AL,Miyajima A

更新日期：1996-05-01 00:00:00

abstract：:Sixteen patients treated by allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr/abl-specific RNA transcripts at various time points after BMT. In reconstitution experiments, one CML cell per million normal mononuclear cells c...

journal_title：Blood

authors： Roth MS,Antin JH,Bingham EL,Ginsburg D

更新日期：1989-08-01 00:00:00

abstract：:A gamma-chain variant with a lower molecular weight than the normal gamma chain was detected in a new congenital abnormal fibrinogen with impaired polymerization of the fibrin monomer and with normal release of fibrinopeptides A and B in a 45-year-old male. Purified fibrinogen analyzed on SDS-polyacrylamide gel electr...

journal_title：Blood

authors： Yoshida N,Okuma M,Moroi M,Matsuda M

更新日期：1986-09-01 00:00:00

abstract：:In this study, we examined in detail the interaction of platelet factor-4 (PF-4) with fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) and the effect of PF-4-derived synthetic peptides. We show that a peptide between amino acids 47 and 70 that contains the heparin-binding lysine-rich si...

journal_title：Blood

authors： Jouan V,Canron X,Alemany M,Caen JP,Quentin G,Plouet J,Bikfalvi A

更新日期：1999-08-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome characterized by progressive bone marrow failure and cancer predisposition. Eight FA complementation groups have been identified. The FANCA, FANCC, FANCE, FANCF, and FANCG proteins form a nuclear complex required for the monoubiquination of the FANCD2 protein. To ...

journal_title：Blood

authors： Gordon SM,Buchwald M

更新日期：2003-07-01 00:00:00

abstract：:The primary objective was to describe the prevalence and characteristics of microbiologically defined infections and infection-related mortality (IRM) in 492 children with acute myeloid leukemia enrolled on CCG 2961. Secondary objectives were to determine the relationship between demographic, disease-related, and ther...

journal_title：Blood

authors： Sung L,Lange BJ,Gerbing RB,Alonzo TA,Feusner J

更新日期：2007-11-15 00:00:00

abstract：:Primary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma characterized by short survival with current therapies, emphasizing the urgent need to develop new therapeutic approaches. Brentuximab vedotin (SGN-35) is an anti-CD30 monoclonal antibody (cAC10) conjugated by a protease-cleavable linker ...

journal_title：Blood

authors： Bhatt S,Ashlock BM,Natkunam Y,Sujoy V,Chapman JR,Ramos JC,Mesri EA,Lossos IS

更新日期：2013-08-15 00:00:00

abstract：:The interleukin (IL)-22R1 chain of the heterodimeric IL-22 receptor is not expressed on normal leukocytes, but this receptor is expressed on T cells from anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL) patients. To investigate the consequences of aberrant expression of this receptor ...

journal_title：Blood

authors： Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA

更新日期：2011-01-13 00:00:00

abstract：:Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the huma...

journal_title：Blood

authors： Berger LC,Hawley RG

更新日期：1997-01-01 00:00:00

abstract：:Hemoglobin Ohio [beta 142 (H20) Ala replaced by Asp] was found in three members of a white family, all of whom showed erythrocytosis. The variant hemoglobin has a high oxygen affinity, a reduced Bohr effect, and diminished cooperativity. The functional abnormalities of Hb Ohio are explained by the proximity of the sub...

journal_title：Blood

authors： Moo-Penn WF,Schneider RG,Shih T,Jones RT,Govindarajan S,Govindarajan PG,Patchen LC

更新日期：1980-08-01 00:00:00

abstract：:Acquired factor XIII (FXIII) deficiency due to autoantibody against FXIII is a very rare severe hemorrhagic diathesis. Antibodies directed against the A subunit of FXIII, which interfere with different functions of FXIII, have been described. Here, for the first time, we report an autoantibody against the B subunit of...

journal_title：Blood

authors： Ajzner E,Schlammadinger A,Kerényi A,Bereczky Z,Katona E,Haramura G,Boda Z,Muszbek L

更新日期：2009-01-15 00:00:00

abstract：:The human erythrocyte actively phosphorylates and dephosphorylates phosphatidylinositol present in the membrane in an apparent "futile cycle." Recent reports have proposed that this phosphorylation/dephosphorylation cycle is a significant consumer of adenosine-5'-triphosphate (ATP) in the erythrocyte. This study detai...

journal_title：Blood

authors： Dale GL

更新日期：1985-11-01 00:00:00

abstract：:Perforin (Prf1) and granzyme B (GzmB) are essential effector molecules for natural killer (NK)-cell cytotoxicity, but how Prf1 and GzmB expression is regulated during arming of NK cells is poorly defined. We show that human microRNA (miR)-27a* is a negative regulator of NK-cell cytotoxicity by silencing Prf1 and GzmB ...

journal_title：Blood

authors： Kim TD,Lee SU,Yun S,Sun HN,Lee SH,Kim JW,Kim HM,Park SK,Lee CW,Yoon SR,Greenberg PD,Choi I

更新日期：2011-11-17 00:00:00