Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts.

abstract：:The shape and parameters of platelet size distributions were studied in 50 normal persons and 97 patients in order to test the proposed thesis that platelet size heterogeneity results mainly from aging in the circulation. This thesis was contradicted (1) by size distributions of age-homogeneous, newly-born cell popula...

journal_title：Blood

authors： Paulus JM

更新日期：1975-09-01 00:00:00

abstract：:Salivary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neoplasms that are often associated with Sjogren's syndrome. To better define the cell of origin and evaluate whether antigen receptor stimulation may be playing a role in tumor growth, the Ig heavy and light chain var...

journal_title：Blood

authors： Bahler DW,Miklos JA,Swerdlow SH

更新日期：1997-05-01 00:00:00

abstract：:We evaluated the efficacy of umbilical cord blood (UCB) in the setting of a nonmyeloablative regimen consisting of fludarabine (200 mg/m2), cyclophosphamide (50 mg/kg), and a single fraction of total body irradiation (200 cGy) with cyclosporine and mycophenolate mofetil for posttransplantation immunoprophylaxis. The t...

journal_title：Blood

authors： Brunstein CG,Barker JN,Weisdorf DJ,DeFor TE,Miller JS,Blazar BR,McGlave PB,Wagner JE

更新日期：2007-10-15 00:00:00

abstract：:Elevated levels of interleukin 7 (IL-7) have been correlated with various T-cell depletion conditions, including HIV infection, and suggested as an indicator of HIV disease progression (AIDS and death). Here, the assessment of pathogenic simian immunodeficiency virus (SIVmac239) infection in rhesus macaques demonstrat...

journal_title：Blood

authors： Muthukumar A,Wozniakowski A,Gauduin MC,Paiardini M,McClure HM,Johnson RP,Silvestri G,Sodora DL

更新日期：2004-02-01 00:00:00

abstract：:The effects of alpha 2-antiplasmin and fibrin on the activation of plasminogen by recombinant staphylokinase (STAR) were studied in an effort to elucidate further the molecular basis of the fibrin-specificity of this fibrinolytic agent. In purified systems consisting of 1.5 mumol/L intact or low-M(r) plasminogen and 3...

journal_title：Blood

authors： Silence K,Collen D,Lijnen HR

更新日期：1993-08-15 00:00:00

abstract：:Low-density lipoprotein (LDL) receptor (LDLR) and LDLR-related protein (LRP) are members of the LDLR family of endocytic receptors. LRP recognizes a wide spectrum of structurally and functionally unrelated ligands, including coagulation factor VIII (FVIII). In contrast, the ligand specificity of LDLR is restricted to ...

journal_title：Blood

authors： Bovenschen N,Mertens K,Hu L,Havekes LM,van Vlijmen BJ

更新日期：2005-08-01 00:00:00

abstract：:We explored adeno-associated viral vector (AAV)-mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage. In young adult mice with plasma FVII < 1% of normal, a single tail vein administratio...

journal_title：Blood

authors： Binny C,McIntosh J,Della Peruta M,Kymalainen H,Tuddenham EG,Buckley SM,Waddington SN,McVey JH,Spence Y,Morton CL,Thrasher AJ,Gray JT,Castellino FJ,Tarantal AF,Davidoff AM,Nathwani AC

更新日期：2012-01-26 00:00:00

abstract：:It has been suggested that neutrophil tissue repopulation following bone marrow transplantation (BMT) serves as an earlier and more relevant marker of susceptibility to infection than circulating neutrophil counts. In a previous study using an oral rinse protocol, we found that oral neutrophil recovery always preceded...

journal_title：Blood

authors： Cheretakis C,Leung R,Sun CX,Dror Y,Glogauer M

更新日期：2006-10-15 00:00:00

abstract：:Recent analyses of circulating blood B cells in myeloma have generated controversy concerning the exact levels of these cells and whether they may represent circulating clonal tumor B cells. Previous reports suggested that CD19+ B cells are markedly increased in myeloma patients and that this population shares clonoty...

journal_title：Blood

authors： Kay NE,Leong T,Kyle RA,Greipp P,Billadeau D,Van Ness B,Bone N,Oken MM

更新日期：1997-07-01 00:00:00

abstract：:The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) is the most problematic and costly complication of FVIII replacement therapy that affects up to 30% of previously untreated patients with severe hemophilia A. The development of inhibitors is a multifactorial complication i...

journal_title：Blood

authors： Gorski MM,Blighe K,Lotta LA,Pappalardo E,Garagiola I,Mancini I,Mancuso ME,Fasulo MR,Santagostino E,Peyvandi F

更新日期：2016-06-09 00:00:00

abstract：:The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and multicentric Castleman's disease (MCD). Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in lymph nodes of about 40% of human immunodef...

journal_title：Blood

authors： Bélec L,Mohamed AS,Authier FJ,Hallouin MC,Soe AM,Cotigny S,Gaulard P,Gherardi RK

更新日期：1999-06-01 00:00:00

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia (ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed childhood B-precursor ALL, we used human 500K single-nucleotide polymorphism arrays to identify somatic copy number alterations (CNAs) in 20 diag...

journal_title：Blood

authors： Yang JJ,Bhojwani D,Yang W,Cai X,Stocco G,Crews K,Wang J,Morrison D,Devidas M,Hunger SP,Willman CL,Raetz EA,Pui CH,Evans WE,Relling MV,Carroll WL

更新日期：2008-11-15 00:00:00

abstract：:Gene therapy for hemophilia B aims to ameliorate bleeding risk and provide endogenous factor IX (FIX) activity/synthesis through a single treatment, eliminating the requirement for FIX concentrate. AMT-060 combines an adeno-associated virus-5 (AAV5) vector with a liver-specific promoter driving expression of a codon-o...

journal_title：Blood

authors： Miesbach W,Meijer K,Coppens M,Kampmann P,Klamroth R,Schutgens R,Tangelder M,Castaman G,Schwäble J,Bonig H,Seifried E,Cattaneo F,Meyer C,Leebeek FWG

更新日期：2018-03-01 00:00:00

abstract：:The dendritic cell (DC)-specific molecule DC-SIGN is a receptor for the HIV-1 envelope glycoprotein gp120 and is essential for the dissemination of HIV-1. DC-SIGN is expressed by DCs, both monocyte-derived DCs and DCs in several tissues, including mucosa and lymph nodes. To identify a DC-SIGN(+) DC in blood that may b...

journal_title：Blood

authors： Engering A,Van Vliet SJ,Geijtenbeek TB,Van Kooyk Y

更新日期：2002-09-01 00:00:00

abstract：:Aggregation of high-affinity receptors for immunoglobulin E (Fc epsilon RI) on the surface of mast cells results in degranulation, a response that is potentiated by binding of stem cell factor (SCF) to its receptor Kit. We observed that one of the major initial signaling events associated with Fc epsilon RI-mediated a...

journal_title：Blood

authors： Tkaczyk C,Horejsi V,Iwaki S,Draber P,Samelson LE,Satterthwaite AB,Nahm DH,Metcalfe DD,Gilfillan AM

更新日期：2004-07-01 00:00:00

abstract：:Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages. The expression of short isoforms lacking DNA-binding motifs alters the differentiation capacities of hematopoietic progenitors, arresting lineage commitment. We sought to determine whether molecular abnormaliti...

journal_title：Blood

authors： Iacobucci I,Lonetti A,Messa F,Cilloni D,Arruga F,Ottaviani E,Paolini S,Papayannidis C,Piccaluga PP,Giannoulia P,Soverini S,Amabile M,Poerio A,Saglio G,Pane F,Berton G,Baruzzi A,Vitale A,Chiaretti S,Perini G,Foà R

更新日期：2008-11-01 00:00:00

abstract：:Human erythroid alpha-spectrin alleles responsible for hereditary elliptocytosis (alphaHE alleles) undergo increased incorporation into red blood cell membranes when the polymorphism alphaLELY (LELY: Low Expression LYon) occurs in trans. The alphaLELY polymorphism is characterized by a mutation in exon 40 at codon 185...

journal_title：Blood

authors： Wilmotte R,Harper SL,Ursitti JA,Maréchal J,Delaunay J,Speicher DW

更新日期：1997-11-15 00:00:00

abstract：:Natural killer T (NKT) cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self-antigens. The nature of NKT-cell autoreactive activation remains poorly understood. We show here that the mitogen-activated protein kinase (MAPK) pathway is operative during human NKT...

journal_title：Blood

authors： Wang X,Chen X,Rodenkirch L,Simonson W,Wernimont S,Ndonye RM,Veerapen N,Gibson D,Howell AR,Besra GS,Painter GF,Huttenlocher A,Gumperz JE

更新日期：2008-11-15 00:00:00

abstract：:Acute myeloid leukemia (AML) is an aggressive malignancy with a relapse rate approaching 50%, despite aggressive chemotherapy. New therapies for AML are targeted at signal transduction pathways known to support blast survival, such as the Stat3 pathway. Aberrant activation of Stat3 has been demonstrated in many differ...

journal_title：Blood

authors： Redell MS,Ruiz MJ,Alonzo TA,Gerbing RB,Tweardy DJ

更新日期：2011-05-26 00:00:00

abstract：:The cell-surface expression of the MIC2 antigen defined by the monoclonal antibody 12E7 was investigated on human leukocytes in bone marrow (BM), thymus, and peripheral blood (PB) using multiparameter flow cytometry and cell sorting. In contrast to preceding reports, we found that the MIC2 antigen is not restricted to...

journal_title：Blood

authors： Dworzak MN,Fritsch G,Buchinger P,Fleischer C,Printz D,Zellner A,Schöllhammer A,Steiner G,Ambros PF,Gadner H

更新日期：1994-01-15 00:00:00

abstract：:MCL-1 is a Bcl-2 family member that has been described as antiapoptotic in various myeloid neoplasms. Therefore, MCL-1 has been suggested as a potential new therapeutic target. Systemic mastocytosis (SM) is a myeloid neoplasm involving mast cells (MCs) and their progenitors. In the present study, we examined the expre...

journal_title：Blood

authors： Aichberger KJ,Mayerhofer M,Gleixner KV,Krauth MT,Gruze A,Pickl WF,Wacheck V,Selzer E,Müllauer L,Agis H,Sillaber C,Valent P

更新日期：2007-04-01 00:00:00

abstract：:Although proinflammatory cytokines are key mediators of tissue damage during graft-versus-host disease (GVHD), IFNgamma has previously been attributed with both protective and pathogenic effects. We have resolved this paradox by using wild-type (wt), IFNgamma(-/-), and IFNgammaR(-/-) mice as donors or recipients in we...

journal_title：Blood

authors： Burman AC,Banovic T,Kuns RD,Clouston AD,Stanley AC,Morris ES,Rowe V,Bofinger H,Skoczylas R,Raffelt N,Fahy O,McColl SR,Engwerda CR,McDonald KP,Hill GR

更新日期：2007-08-01 00:00:00

abstract：:At present, one of the most sensitive assays for human erythropoietin (Ep) is a bioassay that measures the Ep-dependent proliferation of spleen cells from phenylhydrazine-treated mice after 24 hours in culture. We describe how this assay can be used as the basis of a very sensitive method for detecting mouse antibodie...

journal_title：Blood

authors： Wognum AW,Lansdorp PM,Eaves CJ,Krystal G

更新日期：1988-06-01 00:00:00

abstract：:The receptors for interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are heterodimers comprised of ligand specific alpha chains and a common beta chain. The genes encoding the IL-5 receptor alpha chain and the common beta chain reside on chromosome 3 and 22 respectively, while th...

journal_title：Blood

authors： Kremer E,Baker E,D'Andrea RJ,Slim R,Phillips H,Moretti PA,Lopez AF,Petit C,Vadas MA,Sutherland GR

更新日期：1993-07-01 00:00:00

abstract：:Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only co...

journal_title：Blood

authors： Zhang DL,Ghosh MC,Ollivierre H,Li Y,Rouault TA

更新日期：2018-11-08 00:00:00

abstract：:Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of platelet shedding. Despite this, loss of Bcl-x(L) does not prevent the growth and maturation of megakaryocytes, suggesting redundancy with other prosurvival proteins....

journal_title：Blood

authors： Debrincat MA,Josefsson EC,James C,Henley KJ,Ellis S,Lebois M,Betterman KL,Lane RM,Rogers KL,White MJ,Roberts AW,Harvey NL,Metcalf D,Kile BT

更新日期：2012-06-14 00:00:00

abstract：:Erythropoietin (Ep), insulin, and prostaglandins E1 and A1 (PGE1, PGA1) enhanced heme synthesis by mitochondria isolated from embryonic and adult mouse liver cells. The combination of Ep with PGE1 had an antagonistic effect, while that of Ep with PGA1 gave an additive result. The capability of isolated human platelet ...

journal_title：Blood

authors： Agam G,Djaldetti M

更新日期：1978-06-01 00:00:00

abstract：:A key event in the successful induction of adaptive immune responses is the antigen-specific activation of T cells by dendritic cells (DCs). Although LFA-1 (lymphocyte function-associated antigen 1) on T cells is considered to be important for antigen-specific T-cell activation, the role for LFA-1 on DCs remains elusi...

journal_title：Blood

authors： Balkow S,Heinz S,Schmidbauer P,Kolanus W,Holzmann B,Grabbe S,Laschinger M

更新日期：2010-09-16 00:00:00

abstract：:The selectins are lectin-like cell surface glycoproteins that have been implicated in playing a crucial role in the initiation of leukocyte adhesion to endothelial cells (ECs) during inflammation. Binding of selectins under conditions of flow mediates leukocyte rolling, which in vivo is almost exclusively observed in ...

journal_title：Blood

authors： Olofsson AM,Arfors KE,Ramezani L,Wolitzky BA,Butcher EC,von Andrian UH

更新日期：1994-10-15 00:00:00