Natural killer T-cell autoreactivity leads to a specialized activation state.

abstract：:We prepared a heterohybrid cell line that secretes a human IgM monoclonal autoantibody that recognizes an antigen found on thrombin-activated or stored platelets. The surface expression of the epitope recognized by this autoantibody, 5E5, increases with time as platelets age in vitro, suggesting that it may represent ...

journal_title：Blood

authors： Nugent DJ,Kunicki TJ,Berglund C,Bernstein ID

更新日期：1987-07-01 00:00:00

abstract：:Follicular lymphoma (FL) is characterized by a relatively indolent clinical course, but the disease often transforms into a more aggressive large cell lymphoma with a rapidly progressive clinical course. In the present study, we analyzed 41 cases of FL known to have subsequently transformed to aggressive lymphoma and ...

journal_title：Blood

authors： Akasaka T,Lossos IS,Levy R

更新日期：2003-08-15 00:00:00

abstract：:Interleukin-3 (IL-3) is a hematopoietic growth factor that regulates the differentiation of multilineage and committed progenitor cells and the functions of some mature blood cells. The expression of human IL-3 appears to be restricted to stimulated T lymphocytes. We have investigated the kinetics and mechanisms invol...

journal_title：Blood

authors： Ryan GR,Milton SE,Lopez AF,Bardy PG,Vadas MA,Shannon MF

更新日期：1991-03-15 00:00:00

abstract：:Distinct human dendritic cell (DC) subsets differentially control immunity. Thus, insights into their in vivo functions are important to understand the launching and modulation of immune responses. We show that nonobese diabetic/LtSz-scid/scid (NOD/SCID) mice engrafted with human CD34+ hematopoietic progenitors develo...

journal_title：Blood

authors： Palucka AK,Gatlin J,Blanck JP,Melkus MW,Clayton S,Ueno H,Kraus ET,Cravens P,Bennett L,Padgett-Thomas A,Marches F,Islas-Ohlmayer M,Garcia JV,Banchereau J

更新日期：2003-11-01 00:00:00

abstract：:Viral infections have been associated with reduced platelet counts, the biological significance of which has remained elusive. Here, we show that infection with encephalomyocarditis virus (EMCV) rapidly reduces platelet count, and this response is attributed to platelet Toll-like receptor 7 (TLR7). Platelet-TLR7 stimu...

journal_title：Blood

authors： Koupenova M,Vitseva O,MacKay CR,Beaulieu LM,Benjamin EJ,Mick E,Kurt-Jones EA,Ravid K,Freedman JE

更新日期：2014-07-31 00:00:00

abstract：:Until recently, IgE-activated mast cells have been regarded merely as effector cells of adaptive immune responses, involved in allergic reactions and mucosal immunity to parasites. Herein, we report that murine dermal mast cells, activated by local administration of a cream containing the synthetic TLR7 ligand imiquim...

journal_title：Blood

authors： Heib V,Becker M,Warger T,Rechtsteiner G,Tertilt C,Klein M,Bopp T,Taube C,Schild H,Schmitt E,Stassen M

更新日期：2007-08-01 00:00:00

abstract：:Perioperative management of antithrombotic therapy is a situation that occurs frequently and requires consideration of the patient, the procedure, and an expanding array of anticoagulant and antiplatelet agents. Preoperative assessment must address each patient's risk for thromboembolic events balanced against the ris...

journal_title：Blood

authors： Ortel TL

更新日期：2012-12-06 00:00:00

abstract：:We used the polymerase chain reaction (PCR) to detect ALL1-AF4 rearrangements, the molecular hallmark of t(4;11) in a series of 46 pre-pre-B (CD19+, CD24+, CD10/CD20/cylgM/sIgM-) acute lymphoblastic leukemias (ALL). Eighteen patients (39%) exhibited fusion transcripts including 4 of 12 children and 14 of 34 adults. Th...

journal_title：Blood

authors： Janssen JW,Ludwig WD,Borkhardt A,Spadinger U,Rieder H,Fonatsch C,Hossfeld DK,Harbott J,Schulz AS,Repp R

更新日期：1994-12-01 00:00:00

abstract：:Hydroxyurea (HU), a drug effective in the treatment of sickle cell disease, is thought to indirectly promote fetal hemoglobin (Hb F) production by perturbing the maturation of erythroid precursors. The molecular mechanisms involved in HU-mediated regulation of gamma-globin expression are currently unclear. We identifi...

journal_title：Blood

authors： Tang DC,Zhu J,Liu W,Chin K,Sun J,Chen L,Hanover JA,Rodgers GP

更新日期：2005-11-01 00:00:00

abstract：:In subjects mismatched in the HLA alleles C*03:03/C*03:04 no allogeneic cytotoxic T-lymphocyte responses are detected in vitro. Hematopoietic stem cell transplantation (HSCT) with unrelated donors (UDs) showed no association between the HLA-C allele mismatches (CAMMs) and adverse outcomes; antigen mismatches at this a...

journal_title：Blood

authors： Fernandez-Viña MA,Wang T,Lee SJ,Haagenson M,Aljurf M,Askar M,Battiwalla M,Baxter-Lowe LA,Gajewski J,Jakubowski AA,Marino S,Oudshoorn M,Marsh SG,Petersdorf EW,Schultz K,Turner EV,Waller EK,Woolfrey A,Umejiego J,Spell

更新日期：2014-02-20 00:00:00

abstract：:Th17 cells play an essential role in the pathogenesis of autoimmune and inflammatory diseases. Most of our current understanding on Th17 cell differentiation relies on studies carried out in mice, whereas the molecular mechanisms controlling human Th17 cell differentiation are less well defined. In this study, we iden...

journal_title：Blood

authors： Tuomela S,Salo V,Tripathi SK,Chen Z,Laurila K,Gupta B,Äijö T,Oikari L,Stockinger B,Lähdesmäki H,Lahesmaa R

更新日期：2012-06-07 00:00:00

abstract：:To develop safer and more effective vectors for gene therapy of X-linked severe combined immunodeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV virus. The CL20i4-hgamma(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by t...

journal_title：Blood

authors： Zhou S,Mody D,DeRavin SS,Hauer J,Lu T,Ma Z,Hacein-Bey Abina S,Gray JT,Greene MR,Cavazzana-Calvo M,Malech HL,Sorrentino BP

更新日期：2010-08-12 00:00:00

abstract：:Hematopoietic stem cells purified from mouse bone marrow are quiescent with less than 2% of Lin- Hoechst(low)/Rhodamine(low) (Lin- Ho(low)/Rho(low)) and 10% to 15% of Lin-/Sca+ cells in S phase. These cells enter proliferative cycle and progress through G1 and into S phase in the presence of cytokines and 5% heat-inac...

journal_title：Blood

authors： Reddy GP,Tiarks CY,Pang L,Wuu J,Hsieh CC,Quesenberry PJ

更新日期：1997-09-15 00:00:00

abstract：:Antisense oligodeoxynucleotide (ODN) drugs might be more effective if their delivery was optimized and they were targeted to short-lived proteins encoded by messenger RNA (mRNA) species with equally short half-lives. To test this hypothesis, an ODN targeted to the c-myb proto-oncogene was developed and used to purge m...

journal_title：Blood

authors： Luger SM,O'Brien SG,Ratajczak J,Ratajczak MZ,Mick R,Stadtmauer EA,Nowell PC,Goldman JM,Gewirtz AM

更新日期：2002-02-15 00:00:00

abstract：:Although plasmacytoid dendritic cells (pDCs) are involved in HIV-1 pathogenesis, the precise mechanism of interaction between pDCs and HIV-1 in vivo is not clear. The conflicting reports in HIV-1-infected patients highlight the importance of studying the interaction between HIV-1 and pDCs in relevant in vivo models. T...

journal_title：Blood

authors： Zhang L,Jiang Q,Li G,Jeffrey J,Kovalev GI,Su L

更新日期：2011-06-09 00:00:00

abstract：:In previous experimental animal studies it has been demonstrated that antibody depletion is not followed by increased antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 patients treated with...

journal_title：Blood

authors： Goldammer A,Derfler K,Herkner K,Bradwell AR,Hörl WH,Haas M

更新日期：2002-07-01 00:00:00

abstract：:Tn polyagglutinability syndrome is an acquired condition where erythrocytes express Tn neo-antigen and become susceptible to hemagglutination by the naturally occurring anti-Tn present in normal sera. Early studies had indicated that O-linked N-acetyl galactosamine was the sole serologic Tn determinant, but more recen...

journal_title：Blood

authors： Blumenfeld OO,Lalezari P,Khorshidi M,Puglia K,Fukuda M

更新日期：1992-11-01 00:00:00

abstract：:Although much of the function of von Willebrand factor (VWF) has been revealed, detailed insight into the molecular structure that enables VWF to orchestrate hemostatic processes, in particular factor VIII (FVIII) binding and stabilization in plasma, is lacking. Here, we present the high-resolution solution structure ...

journal_title：Blood

authors： Shiltagh N,Kirkpatrick J,Cabrita LD,McKinnon TA,Thalassinos K,Tuddenham EG,Hansen DF

更新日期：2014-06-26 00:00:00

abstract：:Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a posttranscriptional mechanism. In this study, we explored the underlying means by ...

journal_title：Blood

authors： Hahn CK,Lowrey CH

更新日期：2014-10-23 00:00:00

abstract：:The replating capability of human multipotential (colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte [CFU-GEMM]) and erythroid (burst-forming unit-erythroid [BFU-E]) progenitors was assessed in vitro as a potential measure of self-renewal using purified, recombinant (r) human (hu) or murine (mu) mast...

journal_title：Blood

authors： Carow CE,Hangoc G,Cooper SH,Williams DE,Broxmeyer HE

更新日期：1991-11-01 00:00:00

abstract：:We have investigated the interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis. Acidic FGF (aFGF) stimulated the proliferation of murine megakaryocytes and human erythroleukemia (HEL) cells in a concentration-dependent manner. The concentrations of aFGF required to elicit half-maximum and maximum eff...

journal_title：Blood

authors： Bikfalvi A,Han ZC,Fuhrmann G

更新日期：1992-10-15 00:00:00

abstract：:T-cell progenitors in the embryonic bone marrow express the tyrosine kinase receptor c-kit. RR5, an anti-MHC class II beta chain monoclonal antibody, subdivides this c-kit positive population. Intrathymic transfer experiments showed that most of the T-cell progenitors belong to the MHC class II(+)/c-kit(+) bone marrow...

journal_title：Blood

authors： Ody C,Corbel C,Dunon D,Vainio O,Imhof BA

更新日期：2000-12-01 00:00:00

abstract：:Some multilineage hemopoietic colonies contain, in addition to myeloid cells, T lymphocytes. These proliferate extensively in liquid suspension culture under the influence of a T cell growth factor provided by phytohemagglutinin-T cell-conditioned medium (PHA-TCM). The clonal origin of these myeloid and lymphoid compo...

journal_title：Blood

authors： Lim B,Jamal N,Tritchler D,Messner HA

更新日期：1984-06-01 00:00:00

abstract：:Mutations that produce glucose-6-phosphate dehydrogenase (G6PD) deficiency have been identified in samples from patients with hemolytic disease in the United States, and in G6PD-deficient samples from Greece, the Canary Islands, the Czech and Slovak Republics, South China, and in samples from the Coriell Cell Reposito...

journal_title：Blood

authors： Xu W,Westwood B,Bartsocas CS,Malcorra-Azpiazu JJ,Indrák K,Beutler E

更新日期：1995-01-01 00:00:00

abstract：:Depletion of guanine nucleotide pools after inhibition of inosine monophosphate dehydrogenase (IMPDH) potently inhibits DNA synthesis by arresting cells in G1 and has been shown to induce the differentiation of cultured myeloid and erythroid cell lines, as well as chronic granulocytic leukemic cells after blast transf...

journal_title：Blood

authors： Laliberté J,Yee A,Xiong Y,Mitchell BS

更新日期：1998-04-15 00:00:00

abstract：:Mast cells play a critical role in innate immunity, allergy, and autoimmune diseases. The receptor/ligand interactions that mediate mast cell activation are poorly defined. The alpha2beta1 integrin, a receptor for collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1 (MMP-1), endorepellin, and several v...

journal_title：Blood

authors： Edelson BT,Stricker TP,Li Z,Dickeson SK,Shepherd VL,Santoro SA,Zutter MM

更新日期：2006-01-01 00:00:00

abstract：:ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative stat...

journal_title：Blood

authors： Neubauer A,Shannon K,Liu E

更新日期：1991-02-01 00:00:00

abstract：:Previous studies have shown that cytokine-dependent eosinophils undergo apoptosis, yet the mechanisms governing this phenomenon remain obscure. Fas antigen is a transmembrane glycoprotein belonging to the tumor necrosis factor receptor family. Cross-linking of Fas antigen in numerous cell types leads to apoptosis. In ...

journal_title：Blood

authors： Druilhe A,Cai Z,Hailé S,Chouaib S,Pretolani M

更新日期：1996-04-01 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) family of cytokines regulates vascular development and inflammatory responses. We have recently shown that exposure of human umbilical vein endothelial cells (HUVECs) to hypoxia (1% O(2)) increases gene expression and bioactivation of TGF-beta2 and induces its downstream ...

journal_title：Blood

authors： Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA

更新日期：2003-03-15 00:00:00

abstract：:Several features of chronic lymphocytic leukemia (CLL) suggest that immune-based strategies may have therapeutic potential. A promising approach is provided by the transduction of CLL cells with CD40 ligand (CD40L) by viral vectors to enhance their immunogenicity. We compared the antigen-presenting capacity of CD40L-t...

journal_title：Blood

authors： Mayr C,Kofler DM,Büning H,Bund D,Hallek M,Wendtner CM

更新日期：2005-11-01 00:00:00