Cellular response to hypoxia involves signaling via Smad proteins.

abstract：:Monoclonal antibodies were raised after injecting mice with isolated human dense granules. Several of these monoclonals were found to recognize a 40-Kd dense granule membrane protein. Western blot and immunofluorescent analysis confirmed the dense-granule specificity. After thrombin activation, the protein was found i...

journal_title：Blood

authors： Gerrard JM,Lint D,Sims PJ,Wiedmer T,Fugate RD,McMillan E,Robertson C,Israels SJ

更新日期：1991-01-01 00:00:00

abstract：:The myelodysplastic syndromes (MDSs) are hematologically diverse hematopoietic stem cell malignancies primarily affecting older individuals. The incidence of MDS in the United States is estimated at 3.3 per 100 000; however, evidence suggests underreporting of MDS to centralized cancer registries. Contrary to clinical...

journal_title：Blood

authors： Cogle CR,Craig BM,Rollison DE,List AF

更新日期：2011-06-30 00:00:00

abstract：:Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in ...

journal_title：Blood

authors： Lindemann A,Ludwig WD,Oster W,Mertelsmann R,Herrmann F

更新日期：1989-03-01 00:00:00

abstract：:Active immunization with the idiotype of follicular lymphoma induces tumor-specific immunity. T cells induced in vivo by idiotype vaccination recognize human leukocyte antigen (HLA)--restricted hypervariable but not conserved idiotype peptides. We hypothesized that idiotype-directed T-cell immunity occurs naturally an...

journal_title：Blood

authors： Strothmeyer AM,Papaioannou D,Dühren-von Minden M,Navarrete M,Zirlik K,Heining-Mikesch K,Veelken H

更新日期：2010-09-09 00:00:00

abstract：:Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages. Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic disorder. Hepcidin is produced mainly b...

journal_title：Blood

authors： Zumerle S,Mathieu JR,Delga S,Heinis M,Viatte L,Vaulont S,Peyssonnaux C

更新日期：2014-06-05 00:00:00

abstract：:Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8(+) and CD4(+) T cells, respectively. Here, we show that targeting Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) to one of them, the human multilectin DEC-205 receptor,...

journal_title：Blood

authors： Gurer C,Strowig T,Brilot F,Pack M,Trumpfheller C,Arrey F,Park CG,Steinman RM,Münz C

更新日期：2008-08-15 00:00:00

abstract：:Leukemia inhibitory factor (LIF)/differentiation-inhibiting activity (DIA)/human interleukin for DA cells (HILDA) is a cytokine with biologic activities involving a variety of different types of target cells. Here we have tested LIF/DIA for possible effects on the growth and differentiation of normal human hematopoiet...

journal_title：Blood

authors： Leary AG,Wong GG,Clark SC,Smith AG,Ogawa M

更新日期：1990-05-15 00:00:00

abstract：:We have applied a proteomics approach to analyze signaling cascades in human platelets stimulated by thrombin receptor activating peptide (TRAP). By analyzing basal and TRAP-activated platelets using 2-dimensional gel electrophoresis (2-DE), we detected 62 differentially regulated protein features. From these, 41 coul...

journal_title：Blood

authors： García A,Prabhakar S,Hughan S,Anderson TW,Brock CJ,Pearce AC,Dwek RA,Watson SP,Hebestreit HF,Zitzmann N

更新日期：2004-03-15 00:00:00

abstract：:We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8- [double-negative, DN], T-cell receptor [TCR] alpha beta+). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no differ...

journal_title：Blood

authors： Suzushima H,Asou N,Nishimura S,Nishikawa K,Wang JX,Okubo T,Naito M,Hattori T,Takatsuki K

更新日期：1993-02-15 00:00:00

abstract：:One of the mechanisms by which normal hematopoietic progenitor cells remain localized within the bone marrow microenvironment is likely to involve adhesion of these cells to extracellular matrix (ECM) proteins. For example, there is evidence that uncommitted, HLA-DR-negative progenitor cells and committed erythroid pr...

journal_title：Blood

authors： Koenigsmann M,Griffin JD,DiCarlo J,Cannistra SA

更新日期：1992-02-01 00:00:00

abstract：:We report on a second generation of transgenic mice produced by crossing a transgenic mouse line expressing high levels of human alpha and beta S chains (alpha H beta S [beta MDD]) with a line expressing human alpha and beta S-Antilles (beta SAnt). We hypothesized that mice expressing both hemoglobins (Hbs) would have...

journal_title：Blood

authors： Fabry ME,Sengupta A,Suzuka SM,Costantini F,Rubin EM,Hofrichter J,Christoph G,Manci E,Culberson D,Factor SM,Nagel RL

更新日期：1995-09-15 00:00:00

abstract：:Bleeding problems are associated with defects in platelet alpha-granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized ...

journal_title：Blood

authors： Lo B,Li L,Gissen P,Christensen H,McKiernan PJ,Ye C,Abdelhaleem M,Hayes JA,Williams MD,Chitayat D,Kahr WH

更新日期：2005-12-15 00:00:00

abstract：:Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the huma...

journal_title：Blood

authors： Berger LC,Hawley RG

更新日期：1997-01-01 00:00:00

abstract：:The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but not T cells. Here w...

journal_title：Blood

authors： Deane JA,Kharas MG,Oak JS,Stiles LN,Luo J,Moore TI,Ji H,Rommel C,Cantley LC,Lane TE,Fruman DA

更新日期：2007-04-01 00:00:00

abstract：:The spatial distribution of subpopulations of hemopoietic progenitor cells following syngeneic transplantation was investigated at the single-cell level. The location of infused hemopoietic progenitor cells within the femoral bone marrow of nonablated recipients was determined by 5-(and-6)-carboxyfluorescein diacetate...

journal_title：Blood

authors： Nilsson SK,Johnston HM,Coverdale JA

更新日期：2001-04-15 00:00:00

abstract：:p15(INK4b) gene is an inhibitor of cyclin-dependent kinase (CDK) 4 and CDK6 whose expression is induced by transforming growth factor (TGF)beta. Recent reports suggest frequent methylation of the p15(INK4b) gene promoter in leukemias, and it has been proposed that this methylation could be necessary for leukemic cells...

journal_title：Blood

authors： Quesnel B,Guillerm G,Vereecque R,Wattel E,Preudhomme C,Bauters F,Vanrumbeke M,Fenaux P

更新日期：1998-04-15 00:00:00

abstract：:Regulatory CD25(+)CD4+ T cells (Treg cells) are a central element of peripheral tolerance. Little is known, however, about phenotypic and functional characteristics of these cells with regard to memory. In this study we show that the chemokine receptor CCR6 is expressed on a distinct subset of mouse Treg cells. Simila...

journal_title：Blood

authors： Kleinewietfeld M,Puentes F,Borsellino G,Battistini L,Rötzschke O,Falk K

更新日期：2005-04-01 00:00:00

abstract：:Over the past 2 decades considerable evidence has accumulated on the association between hepatitis C virus (HCV) and hepatitis B virus (HBV) and several hematologic malignancies, most notably B-cell non-Hodgkin lymphoma (NHL). In this review we summarize this evidence, address possible mechanisms whereby hepatitis vir...

journal_title：Blood

authors： Marcucci F,Mele A

更新日期：2011-02-10 00:00:00

abstract：:MRP14 (S100A9) is the major calcium-binding protein of neutrophils and monocytes. Targeted gene disruption reveals an essential role of this S100 protein for transendothelial migration of phagocytes. The underlying molecular mechanism comprises major alterations of cytoskeletal metabolism. MRP14, in complex with its b...

journal_title：Blood

authors： Vogl T,Ludwig S,Goebeler M,Strey A,Thorey IS,Reichelt R,Foell D,Gerke V,Manitz MP,Nacken W,Werner S,Sorg C,Roth J

更新日期：2004-12-15 00:00:00

abstract：:Using a cohort of C57BL/6 (B6) x (NZB x B6)F1 backcross male mice bearing the Yaa (Y-linked autoimmune acceleration) mutation, we mapped and characterized the NZB-derived susceptibility loci predisposing to the development of autoimmune hemolytic anemia (AHA). Our analysis identified 2 major loci on NZB chromosome 7 a...

journal_title：Blood

authors： Kikuchi S,Amano H,Amano E,Fossati-Jimack L,Santiago-Raber ML,Moll T,Ida A,Kotzin BL,Izui S

更新日期：2005-08-15 00:00:00

abstract：:HTLV-II has been found in some cases of the rare T-cell form of hairy-cell leukemia (HCL) and in a leukopenic chronic T-cell leukemia mimicking HCL. We asked whether the virus is implicated in the more frequent B-cell form of HCL. DNA extracted from the mononuclear cells derived from spleen (eight cases) or peripheral...

journal_title：Blood

authors： Lion T,Razvi N,Golomb HM,Brownstein RH

更新日期：1988-10-01 00:00:00

abstract：:Steroid-resistant or steroid-refractory acute graft-versus-host disease (SR-aGVHD) poses one of the most vexing challenges faced by providers who care for patients after allogeneic hematopoietic cell transplantation. For the past 4 decades, research in the field has been driven by the premise that persistent graft-ver...

journal_title：Blood

authors： Martin PJ

更新日期：2020-05-07 00:00:00

abstract：:"Fetal" erythrocytes are present in older children and certain adults with hematologic disorders. To determine if regenerating bone marrow produces such cells, we examined the blood of seven allogeneic bone marrow transplant recipients. Six patients were engrafted with donor cells, while on e patients recovered autolo...

journal_title：Blood

authors： Alter BP,Rappeport JM,Huisman TH,Schroeder WA,Nathan DG

更新日期：1976-12-01 00:00:00

abstract：:Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in ∼12% of patients with acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2-hydroxyglutarate resulting in DNA and histone hypermethylation, which leads to blocked cellular differentiation. Enasidenib (AG-221/CC-90007) is a firs...

journal_title：Blood

authors： Stein EM,DiNardo CD,Pollyea DA,Fathi AT,Roboz GJ,Altman JK,Stone RM,DeAngelo DJ,Levine RL,Flinn IW,Kantarjian HM,Collins R,Patel MR,Frankel AE,Stein A,Sekeres MA,Swords RT,Medeiros BC,Willekens C,Vyas P,Tosolini A

更新日期：2017-08-10 00:00:00

abstract：:Acute promyelocytic leukemias (APLs) are characterized by a translocation that involves chromosomes 15 and 17. The translocation breakpoints have recently been identified and shown to involve the RAR-alpha gene on 17 and myl on 15. Here we report Southern blotting analysis of 26 APLs, including cases with normal karyo...

journal_title：Blood

authors： Biondi A,Rambaldi A,Alcalay M,Pandolfi PP,Lo Coco F,Diverio D,Rossi V,Mencarelli A,Longo L,Zangrilli D

更新日期：1991-04-01 00:00:00

abstract：:Current immunotherapeutic trials for patients with multiple myeloma (MM) focus on the idiotype (Id) as a tumor-specific antigen for active immunization. To bypass the need for the identification of shared MM-associated antigens and the characterization of possible immunogenic T-cell epitopes in a human leukocyte antig...

journal_title：Blood

authors： Milazzo C,Reichardt VL,Müller MR,Grünebach F,Brossart P

更新日期：2003-02-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia in which venous thrombosis is the most common cause of death. Here we address the risk factors for thrombosis and the role of warfarin prophylaxis in PNH. The median follow-up of 163 PNH patients was 6 years (range, 0.2-38 years). Of the patient...

journal_title：Blood

authors： Hall C,Richards S,Hillmen P

更新日期：2003-11-15 00:00:00

abstract：:The acute myeloid leukemia (AML) treatment landscape has changed substantially since 2017. New targeted drugs have emerged, including venetoclax to target B-cell lymphoma 2, midostaurin and gilteritinib to target FLT3, and ivosidenib and enasidenib to target mutant isocitrate dehydrogenase 1 and 2, respectively. Other...

journal_title：Blood

authors： DiNardo CD,Wei AH

更新日期：2020-01-09 00:00:00

abstract：:Using a polyclonal antiserum against canine CD34, we previously found that CD34 is expressed on canine bone marrow progenitor cells in a manner analogous to that found in humans. To further characterize CD34+ cells and to facilitate preclinical canine stem cell transplant studies, monoclonal antibodies (MoAbs) were ra...

journal_title：Blood

authors： McSweeney PA,Rouleau KA,Wallace PM,Bruno B,Andrews RG,Krizanac-Bengez L,Sandmaier BM,Storb R,Wayner E,Nash RA

更新日期：1998-03-15 00:00:00

abstract：:On the basis of the finding of alternatively spliced mRNAs, the alpha-subunit of the receptor for GM-CSF is thought to exist in both a membrane spanning (tmGMRalpha) and a soluble form (solGMRalpha). However, only limited data has been available to support that the solGMRalpha protein product exists in vivo. We hypoth...

journal_title：Blood

authors： Sayani F,Montero-Julian FA,Ranchin V,Prevost JM,Flavetta S,Zhu W,Woodman RC,Brailly H,Brown CB

更新日期：2000-01-15 00:00:00