High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia.

abstract：:Three cases of T-lymphoblastic lymphomas (T-LL) expressing the T cell antigen receptor gamma delta (TCR gamma delta) are reported. All of them were CD3+/beta F1-/TCR delta 1+. Moreover, neoplastic cells reacted with the delta TCS1 monoclonal antibody (MoAb) which binds to the non-disulfide-linked form of the TCR gamma...

journal_title：Blood

authors： Falini B,Flenghi L,Fagioli M,Martelli MF,Pileri S,Grignani F,Beltrami A,Novero D,Pelicci PG

更新日期：1989-11-15 00:00:00

abstract：:Regulatory dendritic cells (DCs) play an important role in maintaining peripheral tolerance or immune homeostasis. Our previous study demonstrated that mature DCs could be driven by splenic stroma to proliferate and differentiate into a novel subset of regulatory DCs (diffDCs) displaying a Th2-biased cytokine profile....

journal_title：Blood

authors： Qian C,Jiang X,An H,Yu Y,Guo Z,Liu S,Xu H,Cao X

更新日期：2006-10-01 00:00:00

abstract：:In a patient with plasma cell leukemia and a kappa type Bence Jones protein in serum and urine, the immunofluorescence study of blood plasma cells showed intracellular gamma and kappa chain determinants. Biosynthesis experiments showed the production of abnormally short heavy chains (45,000 daltons) that assembled wit...

journal_title：Blood

authors： Preud'homme JL,Labaume S,Praloran V

更新日期：1980-12-01 00:00:00

abstract：:Because there is no known genetic abnormality common to all patients with myeloma, it is important to understand how genetic heterogeneity may lead to differences in signal transduction, cell cycle, and response to therapy. Model cell lines have been used to study the effect that mutations in p53 and ras can have on g...

journal_title：Blood

authors： Rowley M,Liu P,Van Ness B

更新日期：2000-11-01 00:00:00

abstract：:The treatment of multiple myeloma has evolved significantly over the last decades from primarily alkylator-based chemotherapeutic agents with minimal efficacy to the introduction of more effective agents including immune modulators and proteasome inhibitors, which have changed the landscape of therapy for this disease...

journal_title：Blood

authors： Hoyos V,Borrello I

更新日期：2016-09-29 00:00:00

abstract：:The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent dihydrofolate reductase inhibitor (Ki = 0.35 pM) and an excellent transport substrate of the RFC (Kt = 0.7 microM). Here, we describe the multiple mechanisms of RFC inactivation in human leukemia PT52...

journal_title：Blood

authors： Kaufman Y,Ifergan I,Rothem L,Jansen G,Assaraf YG

更新日期：2006-04-15 00:00:00

abstract：:Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative disorders characterized by an increased incidence of thrombo-hemorrhagic complications. The acquired somatic Janus kinase 2 (JAK2) V617F mutation is present in the majority of PV and ET patients. Because aberrant protein Tyr-phosp...

journal_title：Blood

authors： Randi ML,Brunati AM,Scapin M,Frasson M,Deana R,Magrin E,Fabris F,Donella-Deana A

更新日期：2010-01-21 00:00:00

abstract：:Chromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These chromosomal anomalies represent one of the most common cytogenetic abnormalities associated with these diseases and usually herald a poor prognosis. In this study t...

journal_title：Blood

authors： Johnson EJ,Scherer SW,Osborne L,Tsui LC,Oscier D,Mould S,Cotter FE

更新日期：1996-05-01 00:00:00

abstract：:Melanotransferrin (MTf) or tumor antigen p97 is a transferrin homolog that binds one iron (Fe) atom and has been suggested to play roles in a variety of processes, including Fe metabolism, eosinophil differentiation, and plasminogen activation. Considering the vital role of Fe in many metabolic pathways, such as DNA a...

journal_title：Blood

authors： Sekyere EO,Dunn LL,Suryo Rahmanto Y,Richardson DR

更新日期：2006-04-01 00:00:00

abstract：:Autosomal recessive STAT1 deficiency is associated with impaired cellular responses to interferons and susceptibility to intracellular bacterial and viral infections. We report here a new form of partial STAT1 deficiency in 2 siblings presenting mycobacterial and viral diseases. Both carried a homozygous missense muta...

journal_title：Blood

authors： Kong XF,Ciancanelli M,Al-Hajjar S,Alsina L,Zumwalt T,Bustamante J,Feinberg J,Audry M,Prando C,Bryant V,Kreins A,Bogunovic D,Halwani R,Zhang XX,Abel L,Chaussabel D,Al-Muhsen S,Casanova JL,Boisson-Dupuis S

更新日期：2010-12-23 00:00:00

abstract：:Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...

journal_title：Blood

authors： Dhédin N,Huynh A,Maury S,Tabrizi R,Beldjord K,Asnafi V,Thomas X,Chevallier P,Nguyen S,Coiteux V,Bourhis JH,Hichri Y,Escoffre-Barbe M,Reman O,Graux C,Chalandon Y,Blaise D,Schanz U,Lhéritier V,Cahn JY,Dombret H,If

更新日期：2015-04-16 00:00:00

abstract：:The CD11b/CD18 leukocyte integrin molecule mediates diverse neutrophil adherence-related functions, including cell:cell and cell:extracellular matrix attachments. To study the individual role of this leukocyte integrin in cell adherence in hematopoietic cells, we expressed the CD11b/CD18 complex on the surface of K562...

journal_title：Blood

authors： Hickstein DD,Grunvald E,Shumaker G,Baker DM,Back AL,Embree LJ,Yee E,Gollahon KA

更新日期：1993-10-15 00:00:00

abstract：:Chemotherapy depletes T cells in AIDS patients on HAART, but preexisting lymphopenia limits the scale compared with non-AIDS patients. Thus T-cell recovery time to baseline may be rapid, but the risk of additional AIDS-related complications persists. ...

journal_title：Blood

authors： Little RF

更新日期：2008-04-15 00:00:00

abstract：:Hypersensitivity to cross-linking agents and predisposition to malignancy are characteristic of the genetically heterogeneous inherited bone marrow failure syndrome, Fanconi anemia (FA). The protein encoded by the recently cloned FA complementation group A gene, FAA, has been expected to localize in the nucleus as bas...

journal_title：Blood

authors： Kruyt FA,Waisfisz Q,Dijkmans LM,Hermsen MA,Youssoufian H,Arwert F,Joenje H

更新日期：1997-11-01 00:00:00

abstract：:Selectins are carbohydrate-binding adhesion molecules that play important roles in control of leukocyte traffic. Glycosyltransferases involved in selectin ligand biosynthesis include the alpha1,3-fucosyltransferases FucT-VII and FucT-IV, one or more sialyltransferases, and at least one O-linked branching enzyme. Previ...

journal_title：Blood

authors： Snapp KR,Heitzig CE,Ellies LG,Marth JD,Kansas GS

更新日期：2001-06-15 00:00:00

abstract：:Mutations in the TET2 gene are frequent in myeloid disease, although their biologic and prognostic significance remains unclear. We analyzed 355 patients with myelodysplastic syndromes using "next-generation" sequencing for TET2 aberrations, 91 of whom were also subjected to single-nucleotide polymorphism 6.0 array ka...

journal_title：Blood

authors： Smith AE,Mohamedali AM,Kulasekararaj A,Lim Z,Gäken J,Lea NC,Przychodzen B,Mian SA,Nasser EE,Shooter C,Westwood NB,Strupp C,Gattermann N,Maciejewski JP,Germing U,Mufti GJ

更新日期：2010-11-11 00:00:00

abstract：:Recent studies have shown a discrepancy between the level of tissue factor (TF) expression and the level of TF procoagulant activity on the apical and basolateral surface domains of polarized epithelial cells. The present investigation was performed to elucidate possible reasons for the discordant expression of TF and...

journal_title：Blood

authors： Hansen CB,van Deurs B,Petersen LC,Rao LV

更新日期：1999-09-01 00:00:00

abstract：:Pyrimidine 5' nucleotidase (P5'N-1) deficiency is an autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associa...

journal_title：Blood

authors： Marinaki AM,Escuredo E,Duley JA,Simmonds HA,Amici A,Naponelli V,Magni G,Seip M,Ben-Bassat I,Harley EH,Thein SL,Rees DC

更新日期：2001-06-01 00:00:00

abstract：:Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells tha...

journal_title：Blood

authors： Krejcik J,Casneuf T,Nijhof IS,Verbist B,Bald J,Plesner T,Syed K,Liu K,van de Donk NW,Weiss BM,Ahmadi T,Lokhorst HM,Mutis T,Sasser AK

更新日期：2016-07-21 00:00:00

abstract：:The role of platelets in hemostasis and thrombosis is clearly established; however, the mechanisms by which platelets mediate inflammatory and immune pathways are less well understood. Platelets interact and modulate the function of blood and vascular cells by releasing bioactive molecules. Although the platelet is an...

journal_title：Blood

authors： Risitano A,Beaulieu LM,Vitseva O,Freedman JE

更新日期：2012-06-28 00:00:00

abstract：:Alloreactive T cells present in a bone marrow transplant are responsible for graft-versus-host disease (GVHD), but their depletion is associated with impaired engraftment, immunosuppression, and loss of the graft-versus-leukemia effect. We developed a therapeutic strategy against GVHD based on the selective destructio...

journal_title：Blood

authors： Cohen JL,Boyer O,Salomon B,Onclercq R,Charlotte F,Bruel S,Boisserie G,Klatzmann D

更新日期：1997-06-15 00:00:00

abstract：:Transforming mutations in NRAS and KRAS are thought to play a causative role in the development of numerous cancers, including myeloid malignancies. Although mutations at amino acids 12, 13, or 61 account for the majority of oncogenic Ras variants, we hypothesized that less frequent mutations at alternate residues may...

journal_title：Blood

authors： Tyner JW,Erickson H,Deininger MW,Willis SG,Eide CA,Levine RL,Heinrich MC,Gattermann N,Gilliland DG,Druker BJ,Loriaux MM

更新日期：2009-02-19 00:00:00

abstract：:Escherichia coli were labeled with 59Fe and then either treated with myeloperoxidase, H2O2, and chloride or opsonized and mixed with human neutrophils. The myeloperoxidase system at pH 7.4 caused release of most of the bacterial 59Fe. A similar result has been obtained by Rosen and Klebanoff (J Biol Chem 257:13731, 19...

journal_title：Blood

authors： Molloy AL,Winterbourn CC

更新日期：1990-02-15 00:00:00

abstract：:Using quantitative fluorescence in situ hybridization and flow cytometry, the telomere length of telomere repeat sequences after stem cell transplantation (SCT) were measured. The study included the telomeres of peripheral blood monocytes that should reflect the length of telomeres in stem cells and the telomeres of T...

journal_title：Blood

authors： Rufer N,Brümmendorf TH,Chapuis B,Helg C,Lansdorp PM,Roosnek E

更新日期：2001-01-15 00:00:00

abstract：:A randomized study was performed in 54 thrombocytopenic patients with acute leukemia. Alloimmunization of recipients of random multiple-donor platelet concentrates (MD group) was compared to that of patients receiving random single-donor platelets (SD group). In the SD patients, formation of alloantibodies (mostly ant...

journal_title：Blood

authors： Gmür J,von Felten A,Osterwalder B,Honegger H,Hörmann A,Sauter C,Deubelbeiss K,Berchtold W,Metaxas M,Scali G,Frick PG

更新日期：1983-08-01 00:00:00

abstract：:Little is known about the molecular characteristics of alloantigens recognized by alloreactive T cells mediating hematologic stem cell graft rejection. In particular, it has never been shown that such alloantigens can be encoded by HLA-DP beta alleles. Indeed, matching for HLA-DP antigens is generally not considered t...

journal_title：Blood

authors： Fleischhauer K,Zino E,Mazzi B,Sironi E,Servida P,Zappone E,Benazzi E,Bordignon C

更新日期：2001-08-15 00:00:00

abstract：:As tyrosine kinase inhibitors (TKIs) fail to induce long-term response in blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL), novel therapies targeting leukemia-dysregulated pathways are necessary. Exportin-1 (XPO1), also known as chromoso...

journal_title：Blood

authors： Walker CJ,Oaks JJ,Santhanam R,Neviani P,Harb JG,Ferenchak G,Ellis JJ,Landesman Y,Eisfeld AK,Gabrail NY,Smith CL,Caligiuri MA,Hokland P,Roy DC,Reid A,Milojkovic D,Goldman JM,Apperley J,Garzon R,Marcucci G,Shacham S

更新日期：2013-10-24 00:00:00

abstract：:Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic HSC resistance to modification with lentiviral vectors (LVs), thus requiring high doses or repe...

journal_title：Blood

authors： Ozog S,Timberlake ND,Hermann K,Garijo O,Haworth KG,Shi G,Glinkerman CM,Schefter LE,D'Souza S,Simpson E,Sghia-Hughes G,Carillo RR,Boger DL,Kiem HP,Slukvin I,Ryu BY,Sorrentino BP,Adair JE,Snyder SA,Compton AA,Torbet

更新日期：2019-10-17 00:00:00

abstract：:Overexpression of BAALC is an adverse prognostic factor in adults with cytogenetically normal acute myeloid leukemia and T-cell acute lymphoblastic leukemia (ALL). Here, we analyzed the prognostic significance of BAALC in B-precursor ALL. BAALC MRNA expression was determined in 368 primary adult B-precursor ALL patien...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Stroux A,Burmeister T,Neumann M,Heesch S,Haferlach T,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2010-05-06 00:00:00

abstract：:Arsenic trioxide (As2O3) induces clinical remission in acute promyelocytic leukemia (APL) with minimal toxicity and apoptosis in APL-derived NB4 cells at low (1 to 2 micromol/L) concentration. We examined the basis for NB4 cell sensitivity to As2O3 to identify experimental conditions that would render other malignant ...

journal_title：Blood

authors： Dai J,Weinberg RS,Waxman S,Jing Y

更新日期：1999-01-01 00:00:00