Abstract:
:Using quantitative fluorescence in situ hybridization and flow cytometry, the telomere length of telomere repeat sequences after stem cell transplantation (SCT) were measured. The study included the telomeres of peripheral blood monocytes that should reflect the length of telomeres in stem cells and the telomeres of T lymphocytes that could shorten as a result of peripheral expansion. The loss of telomeres in monocytes and in memory T cells, although accelerated initially, became comparable to the loss of telomeres in healthy controls from the second year after transplantation. In addition, the telomere length in the naive T cells that were produced by the thymus was comparable to the telomere length in the naive T cells of the donor. Compared to the total length of telomeres available, the loss of telomere repeats in leukocytes after SCT resembles the accelerated shortening seen in early childhood and remains, therefore, relatively insignificant.
journal_name
Bloodjournal_title
Bloodauthors
Rufer N,Brümmendorf TH,Chapuis B,Helg C,Lansdorp PM,Roosnek Edoi
10.1182/blood.v97.2.575subject
Has Abstractpub_date
2001-01-15 00:00:00pages
575-7issue
2eissn
0006-4971issn
1528-0020journal_volume
97pub_type
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