The effect of Hydrocortisone on the kinetics of normal human lymphocytes.

Abstract:

:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recirculating portion of the labeled cells rapidly equilibrated with the total intravascular lymphocyte pool and the vastly larger total-body recirculating lymphocyte pool, so that by 1 hr following infusion 21.8% plus or minus 3.2% of the labeled lymphocytes were left in the circulation. Four hundred milligrams of intravenous hydrocortisone administered 24 hr after infusion of labeled cells caused a profound but transient lymphocytopenia which was maximal at 4 hr with return of lymphocyte counts to normal by 24 hr after injection. Concomitant with the lymphocytopenia there was a dramatic increase in lymphocyte specific activity (cpm per 10-6 lymphocytes), while the total lymphocyte-associated radioactivity remaining in the circulation was unchanged, indicating that corticosteroid administration depleted the unlabeled recirculating cells. As the lymphocyte counts returned to normal following hydrocortisone, the specific activity also returned to normal. These studies indicated that hydrocortisone administration caused a transient lymphocytopenia by a preferential depletion of the recirculating portion of the intravascular lymphocyte pool

journal_name

Blood

journal_title

Blood

authors

Fauci AS,Dale DC

subject

Has Abstract

pub_date

1975-08-01 00:00:00

pages

235-43

issue

2

eissn

0006-4971

issn

1528-0020

journal_volume

46

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Results of a phase 2 trial of an oral CXCR4 antagonist, mavorixafor, for treatment of WHIM syndrome.

    abstract::Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020007197

    authors: Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

    更新日期:2020-12-24 00:00:00

  • Cytogenetic features of Hodgkin's disease suggest possible origin from a lymphocyte.

    abstract::Surface marker and gene rearrangement data have supported various hypotheses about the origin of the malignant cell in Hodgkin's disease. Cytogenetic data about this disorder, however, are very scanty. To determine if any chromosomal abnormalities that could add further information to this controversial point are pres...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Cabanillas F,Pathak S,Trujillo J,Grant G,Cork A,Hagemeister FB,Velasquez WS,McLaughlin P,Redman J,Katz R

    更新日期:1988-06-01 00:00:00

  • Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2.

    abstract::The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2006-01-023713

    authors: Sangerman J,Lee MS,Yao X,Oteng E,Hsiao CH,Li W,Zein S,Ofori-Acquah SF,Pace BS

    更新日期:2006-11-15 00:00:00

  • Fibrin formation, fibrinopeptide A release, and platelet thrombus dimensions on subendothelium exposed to flowing native blood: greater in factor XII and XI than in factor VIII and IX deficiency.

    abstract::Fibrin deposition and platelet thrombus dimensions on subendothelium were studied in four groups of patients with coagulation factor deficiencies. Five patients with factor VIII deficiency (APTT 120 +/- 8 sec) and three patients with factor IX deficiency (APTT 125 +/- 11 sec) were severe bleeders, whereas four patient...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Weiss HJ,Turitto VT,Vicic WJ,Baumgartner HR

    更新日期:1984-05-01 00:00:00

  • Stem cell factor contributes to intestinal mucosal mast cell hyperplasia in rats infected with Nippostrongylus brasiliensis or Trichinella spiralis, but anti-stem cell factor treatment decreases parasite egg production during N brasiliensis infection.

    abstract::We assessed the effects of the c-kit ligand, stem cell factor (SCF), in the jejunal mucosal mast cell hyperplasia that occurs during infection with the intestinal nematodes, Nippostrongylus brasiliensis or Trichinella spiralis in rats. Compared with vehicle-treated rats, rats treated with SCF (25 micrograms/kg/d, intr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Newlands GF,Miller HR,MacKellar A,Galli SJ

    更新日期:1995-09-01 00:00:00

  • Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.

    abstract::Folylpoly-gamma-gluatamate synthetase (FPGS) catalyzes the polyglutamylation and thus intracellular retention of folates and antifolates (eg, methotrexate; MTX) through the addition of multiple glutamate equivalents to their gamma-carboxyl residue. Since polyglutamylation of antifolates is crucial for their pharmacolo...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-08-173799

    authors: Stark M,Wichman C,Avivi I,Assaraf YG

    更新日期:2009-04-30 00:00:00

  • Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients.

    abstract::The survival of patients with aggressive non-Hodgkin lymphoma (NHL) is increasing, but the incidence of secondary cancer and late toxicity is poorly defined for those treated with cyclophosphamide-hydroxydaunomycin/doxorubicin-Oncovin-prednisone (CHOP)-like chemotherapy. From February 1984 to January 1998, 2837 patien...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-04-1124

    authors: André M,Mounier N,Leleu X,Sonet A,Brice P,Henry-Amar M,Tilly H,Coiffier B,Bosly A,Morel P,Haioun C,Gaulard P,Reyes F,Gisselbrecht C,Groupe D'Etude Des Lymphomes De L'Adulte.

    更新日期:2004-02-15 00:00:00

  • Inhibition of the intrinsic factor X activating complex by protein S: evidence for a specific binding of protein S to factor VIII.

    abstract::Protein S is a vitamin K-dependent nonenzymatic anticoagulant protein that acts as a cofactor to activated protein C. Recently it was shown that protein S inhibits the prothrombinase reaction independent of activated protein C. In this study, we show that protein S can also inhibit the intrinsic factor X activation vi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Koppelman SJ,Hackeng TM,Sixma JJ,Bouma BN

    更新日期:1995-08-01 00:00:00

  • Risk score to predict event-free survival after hematopoietic cell transplant for sickle cell disease.

    abstract::We developed a risk score to predict event-free survival (EFS) after allogeneic hematopoietic cell transplantation for sickle cell disease. The study population (n = 1425) was randomly split into training (n = 1070) and validation (n = 355) cohorts. Risk factors were identified and validated via Cox regression models....

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020005687

    authors: Brazauskas R,Scigliuolo GM,Wang HL,Cappelli B,Ruggeri A,Fitzhugh CD,Hankins JS,Kanter J,Meerpohl JJ,Panepinto JA,Rondelli D,Shenoy S,Walters MC,Wagner JE,Tisdale JF,Gluckman E,Eapen M

    更新日期:2020-07-30 00:00:00

  • Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors.

    abstract::During pregnancy the plasma concentration of two different inhibitors of plasminogen activators (PAIs) increases. The only one found in the plasma of nonpregnant women (PAI1) is immunologically related to a PAI of endothelial cells; its plasma activity, as deduced from the inhibition of single-chain tissue-type plasmi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Kruithof EK,Tran-Thang C,Gudinchet A,Hauert J,Nicoloso G,Genton C,Welti H,Bachmann F

    更新日期:1987-02-01 00:00:00

  • Synergy between tumor immunotherapy and antiangiogenic therapy.

    abstract::This study tested the hypothesis that combination of antiangiogenic therapy and tumor immunotherapy of cancer is synergistic. To inhibit angiogenesis, mice were immunized with dendritic cells (DCs) transfected with mRNA that encode products that are preferentially expressed during neoangiogenesis: vascular endothelial...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-12-3738

    authors: Nair S,Boczkowski D,Moeller B,Dewhirst M,Vieweg J,Gilboa E

    更新日期:2003-08-01 00:00:00

  • von Willebrand factor proteolytic processing and multimerization precede the formation of Weibel-Palade bodies.

    abstract::We investigated the intracellular site of pro-von Willebrand factor (pro-vWF) cleavage and multimerization, as well as the fate of the propolypeptide (von Willebrand antigen II) after cleavage. Analysis of subcellular fractions of endothelial cells metabolically labeled with sulfate showed that both cleavage and coval...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Vischer UM,Wagner DD

    更新日期:1994-06-15 00:00:00

  • Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics.

    abstract::Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not found in the...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-07-2514

    authors: Fang B,Zheng C,Liao L,Han Q,Sun Z,Jiang X,Zhao RC

    更新日期:2005-04-01 00:00:00

  • Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation.

    abstract::Dentin matrix protein 1 (DMP1) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family, a group of proteins initially described as mineralized extracellular matrices components. More recently, SIBLINGs have been implicated in several key steps of cancer progression, including angiogenes...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-08-298810

    authors: Pirotte S,Lamour V,Lambert V,Alvarez Gonzalez ML,Ormenese S,Noël A,Mottet D,Castronovo V,Bellahcène A

    更新日期:2011-02-24 00:00:00

  • Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.

    abstract::Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. Interleukin-10 (IL-10) is the crucial driving factor for Tr1 cell differentiation, but the molecular mechanisms underlying this induction remain unknown. We identi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-07-234872

    authors: Gregori S,Tomasoni D,Pacciani V,Scirpoli M,Battaglia M,Magnani CF,Hauben E,Roncarolo MG

    更新日期:2010-08-12 00:00:00

  • Use of 8-methoxypsoralen and ultraviolet-A pretreated platelet concentrates to prevent alloimmunization against class I major histocompatibility antigens.

    abstract::The use of 8-methoxypsoralen (8-MOP) and UV-A irradiation to inactivate contaminating donor leukocytes in platelet concentrates and to prevent primary alloimmunization against donor class I major histocompatibility (MHC) antigens in mice was investigated. CBA/CaH-T6J mice with the H2k haplotype and BALB/cByJ mice with...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Grana NH,Kao KJ

    更新日期:1991-06-01 00:00:00

  • Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species.

    abstract::Mechanisms involving the in vitro effect of rituximab in cells from 55 patients with B-cell lymphoproliferative disorders were investigated. No cytotoxic effect was observed when cells were incubated with rituximab alone, but in the presence of human AB serum rituximab induced complement-dependent cell death (R-CDC). ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v98.9.2771

    authors: Bellosillo B,Villamor N,López-Guillermo A,Marcé S,Esteve J,Campo E,Colomer D,Montserrat E

    更新日期:2001-11-01 00:00:00

  • The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate.

    abstract::Imatinib mesylate, a competitive inhibitor of Abl tyrosine kinase, is highly effective for the early stages of chronic myelogenous leukemia (CML), but remissions induced in advanced-phase CML and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia tend to be relatively short-lived. Therefore, the searc...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-01-0305

    authors: Kuroda J,Kimura S,Segawa H,Kobayashi Y,Yoshikawa T,Urasaki Y,Ueda T,Enjo F,Tokuda H,Ottmann OG,Maekawa T

    更新日期:2003-09-15 00:00:00

  • EBV-tissue positive primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity.

    abstract::Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characteri...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020008520

    authors: Gandhi MK,Hoang T,Law SC,Brosda S,O'Rourke K,Tobin JWD,Vari F,Murigneux V,Fink JL,Gunawardana J,Gould CM,Oey H,Bednarska K,Delecluse S,Trappe RU,de Long LM,Sabdia MB,Bhagat G,Hapgood G,Blyth E,Clancy LE,Wight J

    更新日期:2020-11-17 00:00:00

  • Immunologic reconstitution after haploidentical bone marrow transplantation for immune deficiency disorders: treatment of bone marrow cells with monoclonal antibody CT-2 and complement.

    abstract::Patients with congenital T lymphocyte deficiency disorders received transplants with parental bone marrow depleted of mature T cells by the use of an anti-T cell monoclonal antibody (CT-2) and complement. Our results with 16 consecutive patients (20 transplants) showed rapid engraftment of donor cells; cytoreduction (...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Moen RC,Horowitz SD,Sondel PM,Borcherding WR,Trigg ME,Billing R,Hong R

    更新日期:1987-09-01 00:00:00

  • Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression.

    abstract::Many lineage-specific developmental regulator genes are transcriptionally primed in embryonic stem (ES) cells; RNA Pol(II) is bound at their promoters but is prevented from productive elongation by the activity of polycomb repressive complexes (PRC) 1 and 2. This epigenetically poised state is thought to enable ES cel...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-03-273128

    authors: Mazzarella L,Jørgensen HF,Soza-Ried J,Terry AV,Pearson S,Lacaud G,Kouskoff V,Merkenschlager M,Fisher AG

    更新日期:2011-01-06 00:00:00

  • Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease.

    abstract::Erdheim-Chester disease (ECD) pathophysiology remains largely unknown. Its treatment is not codified and usually disappointing. Interferon (IFN)-α therapy lacks efficacy for some life-threatening manifestations and has a poor tolerance profile. Because interleukin (IL)-1Ra synthesis is naturally induced after stimulat...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-04-279240

    authors: Aouba A,Georgin-Lavialle S,Pagnoux C,Martin Silva N,Renand A,Galateau-Salle F,Le Toquin S,Bensadoun H,Larousserie F,Silvera S,Provost N,Candon S,Seror R,de Menthon M,Hermine O,Guillevin L,Bienvenu B

    更新日期:2010-11-18 00:00:00

  • Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism?

    abstract::Despite many studies on the pathophysiology of antiphospholipid antibodies (aPL), the mechanism by which aPL causes thrombosis has not been established. We have tried to elucidate the paradox between the prolongation of the clotting time of phospholipid-dependent coagulation tests in vitro and the occurrence of thromb...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Oosting JD,Derksen RH,Bobbink IW,Hackeng TM,Bouma BN,de Groot PG

    更新日期:1993-05-15 00:00:00

  • Interleukin-4 induces secretion of CSF for granulocytes and CSF for macrophages by peripheral blood monocytes.

    abstract::T cells are known to interact cooperatively with monocytes to produce Colony-Stimulating Factors (CSF), although T cell-mediated signals leading to CSF secretion by monocytes are not completely understood. We have made use of Northern blot hybridization and specific bioassays to study the effects of the T cell product...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Wieser M,Bonifer R,Oster W,Lindemann A,Mertelsmann R,Herrmann F

    更新日期:1989-04-01 00:00:00

  • Hemoglobin stimulates mononuclear leukocytes to release interleukin-8 and tumor necrosis factor alpha.

    abstract::Incubation of human mononuclear leukocytes (MNL) with human stroma-free hemolysate (SFH), purified adult hemoglobin Ao (HbAo), and oxidized HbAo (METHb) caused MNL to release compounds into the supernate that mediated neutrophil (polymorphonuclear leukocytes, PMN) chemotaxis and PMN adherence to human umbilical vein e...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: McFaul SJ,Bowman PD,Villa VM,Gutierrez-Ibanez MJ,Johnson M,Smith D

    更新日期:1994-11-01 00:00:00

  • Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation.

    abstract::Donor-derived T cells have been proposed to play a role in pathogenesis of chronic graft-versus-host disease (cGVHD). The impact of ex vivo T-cell depletion (TCD) on cGVHD was analyzed in a randomized multicenter trial involving unrelated donor marrow transplants. A total of 404 patients diagnosed with hematologic mal...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1182/blood-2005-04-1614

    authors: Pavletic SZ,Carter SL,Kernan NA,Henslee-Downey J,Mendizabal AM,Papadopoulos E,Gingrich R,Casper J,Yanovich S,Weisdorf D,National Heart, Lung, and Blood Institute Unrelated Donor Marrow Transplantation Trial.

    更新日期:2005-11-01 00:00:00

  • Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse.

    abstract::We have developed an in vitro clonal assay of murine hematopoietic precursor cells that form spleen colonies (CFU-S day 12) or produce in vitro clonable progenitors in the marrow (MRA cells) of lethally irradiated mice. The assay is essentially a long-term bone marrow culture in microtiter wells containing marrow-deri...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Ploemacher RE,van der Sluijs JP,van Beurden CA,Baert MR,Chan PL

    更新日期:1991-11-15 00:00:00

  • Hematopoietic bone marrow recovery after radiation therapy: MRI evaluation.

    abstract::Magnetic resonance imaging (MRI) is able to detect the increase of adipocytes in the hematopoietic bone marrow that occurs as a consequence of radiotherapy and is indicative of the loss of myeloid tissue. By monitoring this process, it is also possible to determine the recovery of the bone marrow. The amount of viable...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Casamassima F,Ruggiero C,Caramella D,Tinacci E,Villari N,Ruggiero M

    更新日期:1989-05-01 00:00:00

  • Point mutations in the uroporphyrinogen III synthase gene in congenital erythropoietic porphyria (Günther's disease).

    abstract::Congenital erythropoietic porphyria (Günther's disease) is a rare disorder of heme biosynthesis inherited in an autosomal recessive fashion. The molecular abnormality responsible for the characteristic defect in uroporphyrinogen III synthase activity was investigated in two patients. For the first patient, complementa...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Deybach JC,de Verneuil H,Boulechfar S,Grandchamp B,Nordmann Y

    更新日期:1990-05-01 00:00:00

  • Characterization and use of an antibody detecting the CBFbeta-SMMHC fusion protein in inv(16)/t(16;16)-associated acute myeloid leukemias.

    abstract::The inv(16)(p13q22) and t(16;16)(p13;q22) cytogenetic abnormalities occur commonly in acute myeloid leukemia (AML), typically associated with French-American-British (FAB) AML-M4Eo subtype. Reverse transcriptase-polymerase chain reaction (RT-PCR) techniques have been recently developed to detect the presence of severa...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Viswanatha DS,Chen I,Liu PP,Slovak ML,Rankin C,Head DR,Willman CL

    更新日期:1998-03-15 00:00:00