Abstract:
:The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given variable platelet release of VEGF. We therefore compared plasma levels of VEGF in 29 patients with POEMS syndrome with those of other disorders (n = 76). We demonstrated that plasma VEGF levels are useful in differentiating POEMS from other plasma cell dyscrasias, neuropathic processes, and multisystem illnesses. Plasma VEGF is also useful in monitoring disease activity after treatment and correlates with clinical improvements better than hematologic response.
journal_name
Bloodjournal_title
Bloodauthors
D'Souza A,Hayman SR,Buadi F,Mauermann M,Lacy MQ,Gertz MA,Kyle RA,Kumar S,Greipp PR,Lust JA,Russell SJ,Zeldenrust S,Dingli D,Witzig TE,Rajkumar SV,Dispenzieri Adoi
10.1182/blood-2011-06-362392subject
Has Abstractpub_date
2011-10-27 00:00:00pages
4663-5issue
17eissn
0006-4971issn
1528-0020pii
blood-2011-06-362392journal_volume
118pub_type
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