Inhibition of immature erythroid progenitor cell proliferation by macrophage inflammatory protein-1alpha by interacting mainly with a C-C chemokine receptor, CCR1.

abstract：:To determine whether the sensitivity of the human long-term culture-initiating cell (LTC-IC) assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for their abilities to influence the number of cells detectable as LTC-IC, to influence LTC-IC maintenance, and/or to influence LTC-IC d...

journal_title：Blood

authors： Hogge DE,Lansdorp PM,Reid D,Gerhard B,Eaves CJ

更新日期：1996-11-15 00:00:00

abstract：:Recent findings implied that the progression of hematologic malignancies, like that of solid tumors, is dependent on neovascularization. Recent studies on patients with acute myeloid leukemia (AML) showed increased levels of leukocyte-associated vascular endothelial growth factor (VEGF) and neovascularization of the b...

journal_title：Blood

authors： Schuch G,Machluf M,Bartsch G Jr,Nomi M,Richard H,Atala A,Soker S

更新日期：2002-12-15 00:00:00

abstract：:The fibrinogen structural variant, Marburg (A alpha 1-460B beta gamma)2, is comprised of normal B beta and gamma chains but contains severely truncated A alpha chains that are missing approximately one half of their factor XIIIa cross-linking domain. Immunochemical studies of fibrin(ogen) Marburg were conducted to cha...

journal_title：Blood

authors： Sobel JH,Trakht I,Wu HQ,Rudchenko S,Egbring R

更新日期：1995-08-01 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is approved for treatment of ischemic stroke patients, but it increases the risk of intracranial bleeding (ICB). Previously, we have shown in a mouse stroke model that stromelysin-1 (matrix metalloproteinase-3 [MMP-3]) induced in endothelial cells was critical for ICB induced b...

journal_title：Blood

authors： Suzuki Y,Nagai N,Yamakawa K,Kawakami J,Lijnen HR,Umemura K

更新日期：2009-10-08 00:00:00

abstract：:We have studied adenovirus-mediated cytotoxicity after infection of malignant cells obtained from patients with chronic lymphocytic leukemia (CLL). Our studies indicate that adenoviruses can infect primary CLL cells and that infection of CLL cells with a replication-competent strain of human adenovirus 5 (Ad5dl309) re...

journal_title：Blood

authors： Medina DJ,Sheay W,Goodell L,Kidd P,White E,Rabson AB,Strair RK

更新日期：1999-11-15 00:00:00

abstract：:CTLA-4 inhibits T-cell activation and protects against the development of autoimmunity. We and others previously showed that the coreceptor can induce T-cell motility and shorten dwell times with dendritic cells (DCs). However, it has been unclear whether this property of CTLA-4 affects both conventional T cells (Tcon...

journal_title：Blood

authors： Lu Y,Schneider H,Rudd CE

更新日期：2012-11-29 00:00:00

abstract：:Crosslineage T-cell receptor delta (TCR delta) rearrangements are widely used as tumor markers for the follow up of minimal residual disease in childhood B-precursor acute lymphoblastic leukemia (ALL) by polymerase chain reaction (PCR). The major drawback of this approach is the risk of false-negative results due to c...

journal_title：Blood

authors： Steenbergen EJ,Verhagen OJ,van Leeuwen EF,van den Berg H,von dem Borne AE,van der Schoot CE

更新日期：1995-07-15 00:00:00

abstract：:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be...

journal_title：Blood

authors： Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JV

更新日期：2001-12-15 00:00:00

abstract：:Umbilical cord blood (UCB) is an attractive cell source for hematopoietic cell transplantation (HCT). Here we examine whether the combination of homeobox B4 (HOXB4) and Delta-1 ligand (DL) synergize when used together. Monkey and human UCB CD34(+) cells were transduced with a HOXB4-expressing gammaretroviral vector an...

journal_title：Blood

authors： Watts KL,Delaney C,Humphries RK,Bernstein ID,Kiem HP

更新日期：2010-12-23 00:00:00

abstract：:Six hundred twelve eligible, previously untreated patients with active multiple myeloma and at least some data available for analysis were entered into a randomized trial (Southwest Oncology Group [SWOG] Phase III myeloma study 8229/30), in which the prognostic significance of pretreatment serum beta 2 microglobulin l...

journal_title：Blood

authors： Durie BG,Stock-Novack D,Salmon SE,Finley P,Beckord J,Crowley J,Coltman CA

更新日期：1990-02-15 00:00:00

abstract：:Monocytes/macrophages exert a series of important functions in vivo. To facilitate detailed investigation of their functional capacity and the mechanism leading to their differentiation, several cell lines have been established from primary material. We present here a new human monoblastic cell line, designated UG3. U...

journal_title：Blood

authors： Ikeda T,Sasaki K,Ikeda K,Yamaoka G,Kawanishi K,Kawachi Y,Uchida T,Takahara J,Irino S

更新日期：1998-06-15 00:00:00

abstract：:The glycoprotein CD47 (integrin-associated protein, IAP) is present on the surface of virtually all cells, including red blood cells (RBCs). CD47 acts like a marker of self by ligating the macrophage inhibitory receptor signal regulatory protein alpha (SIRPalpha). In this manner mild reactivity of wild-type RBCs with ...

journal_title：Blood

authors： Oldenborg PA,Gresham HD,Chen Y,Izui S,Lindberg FP

更新日期：2002-05-15 00:00:00

abstract：:Thymus atrophy is the most common immunopathology in humans, and its occurrence is hastened by several factors that coalesce in patients receiving chemotherapy and most of all in recipients of hematopoietic cell transplantation. We have shown previously that posthematopoietic cell transplantation thymic function was i...

journal_title：Blood

authors： Heinonen KM,Vanegas JR,Brochu S,Shan J,Vainio SJ,Perreault C

更新日期：2011-11-10 00:00:00

abstract：:The effect of both congenital and acquired factor VII deficiency on the cuticle bleeding time (CBT) was evaluated in dogs. The CBT has been previously documented to be a sensitive indicator of factor VIII:C deficiency in hemophilic dogs. Serial CBT determinations were made on normal dogs treated with high-dose warfari...

journal_title：Blood

authors： Giles AR,Tinlin S,Brosseau L,Hoogendoorn H

更新日期：1985-05-01 00:00:00

abstract：:Interleukin-3 (IL-3) is involved in proliferation and differentiation of hematopoietic progenitor cells. Its expression is subject to precise, tissue-specific regulation, and has been studied extensively in the gibbon T-cell line MLA 144 by a combination of functional assays and DNA binding experiments. To extend thes...

journal_title：Blood

authors： Cameron S,Taylor DS,TePas EC,Speck NA,Mathey-Prevot B

更新日期：1994-05-15 00:00:00

abstract：:A critical role for the endothelium of yolk sac and dorsal aorta has been shown in embryonic hematopoiesis. A stromal cell line derived from yolk sac, YSCL-72, has been chosen to search for a novel molecule associated with embryonic hematopoiesis. Analysis between YSCL-72 and an adult aorta-derived endothelial cell li...

journal_title：Blood

authors： Ohneda O,Ohneda K,Arai F,Lee J,Miyamoto T,Fukushima Y,Dowbenko D,Lasky LA,Suda T

更新日期：2001-10-01 00:00:00

abstract：:Glanzmann thrombasthenia is an autosomal recessive disorder of the platelet glycoproteins (GP) IIb and IIIa. These glycoproteins normally serve as receptors for other adhesive glycoproteins, including fibrinogen, von Willebrand factor, and fibronectin. Most patients affected by Glanzmann thrombasthenia have low levels...

journal_title：Blood

authors： Russell ME,Seligsohn U,Coller BS,Ginsberg MH,Skoglund P,Quertermous T

更新日期：1988-11-01 00:00:00

abstract：:Loss or mutation of the TP53 tumor suppressor gene is not commonly observed in acute myeloid leukemia (AML), suggesting that there is an alternate route for cell transformation. We investigated the hypothesis that previously observed Bcl-2 family member overexpression suppresses wild-type p53 activity in AML. We demon...

journal_title：Blood

authors： Irish JM,Anensen N,Hovland R,Skavland J,Børresen-Dale AL,Bruserud O,Nolan GP,Gjertsen BT

更新日期：2007-03-15 00:00:00

abstract：:Interleukin-13 (IL-13) induced a potent mitogenic response in IL-3-dependent TF-1 cells and DNA synthesis to a lesser extent in MO7E and FDC-P1 cells. IL-13 stimulation of these lines, like IL-4 and insulin-like growth factor-1 (IGF-1), resulted in tyrosine phosphorylation of a 170-kD substrate. The tyrosine-phosphory...

journal_title：Blood

authors： Wang LM,Michieli P,Lie WR,Liu F,Lee CC,Minty A,Sun XJ,Levine A,White MF,Pierce JH

更新日期：1995-12-01 00:00:00

abstract：:Alteration of lineage-specific transcriptional programs for hematopoiesis causes differentiation block and promotes leukemia development. Here, we show that AML1/ETO, the most common translocation fusion product in acute myeloid leukemia (AML), counteracts the activity of retinoic acid (RA), a transcriptional regulato...

journal_title：Blood

authors： Fazi F,Zardo G,Gelmetti V,Travaglini L,Ciolfi A,Di Croce L,Rosa A,Bozzoni I,Grignani F,Lo-Coco F,Pelicci PG,Nervi C

更新日期：2007-05-15 00:00:00

abstract：:A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (C...

journal_title：Blood

authors： Stocker JW,De Franceschi L,McNaughton-Smith GA,Corrocher R,Beuzard Y,Brugnara C

更新日期：2003-03-15 00:00:00

abstract：:Seventy-one patients with hematologic malignancies received bone marrow from a histocompatible sibling (n = 48) or a partially matched relative (n = 23) that had been depleted of CD5+ T cells with either an anti-CD5 mooclonal antibody (MoAb) plus complement (anti-Leu1 + C) or an anti-CD5 MoAb conjugated to ricin A cha...

journal_title：Blood

authors： Antin JH,Bierer BE,Smith BR,Ferrara J,Guinan EC,Sieff C,Golan DE,Macklis RM,Tarbell NJ,Lynch E

更新日期：1991-10-15 00:00:00

abstract：:An increasing number of reports document instances in which individual leukemic cells coexpress markers normally believed to be restricted to a single lineage. This has been interpreted by McCulloch and colleagues as aberrant programming or lineage infidelity and contrasts with earlier suggestions that lineage fidelit...

journal_title：Blood

authors： Greaves MF,Chan LC,Furley AJ,Watt SM,Molgaard HV

更新日期：1986-01-01 00:00:00

abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...

journal_title：Blood

authors： Nichols WL,Gastineau DA,Solberg LA Jr,Mann KG

更新日期：1985-06-01 00:00:00

abstract：:Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimmunoblastic T-cell lymp...

journal_title：Blood

authors： Liu C,Iqbal J,Teruya-Feldstein J,Shen Y,Dabrowska MJ,Dybkaer K,Lim MS,Piva R,Barreca A,Pellegrino E,Spaccarotella E,Lachel CM,Kucuk C,Jiang CS,Hu X,Bhagavathi S,Greiner TC,Weisenburger DD,Aoun P,Perkins SL,McKeith

更新日期：2013-09-19 00:00:00

abstract：:We have examined the effects of administration of stem cell-factor (SCF) on the number and distribution of pluripotent hematopoietic stem cells (PHSC) in normal mice. Using the competitive repopulation assay we found that in vivo administration of SCF increases the absolute number of PHSC per mouse threefold. The incr...

journal_title：Blood

authors： Bodine DM,Seidel NE,Zsebo KM,Orlic D

更新日期：1993-07-15 00:00:00

abstract：:Vinblastine was administered to anemic baboons to test whether stimulation of Hb F takes place following distortion of erythropoiesis by an M-stage-specific compound. The treatments elicited erythroid cell cytoreduction followed by regeneration. During the phase of reticulocyte reduction, gamma/gamma + beta biosynthet...

journal_title：Blood

authors： Veith R,Papayannopoulou T,Kurachi S,Stamatoyannopoulos G

更新日期：1985-08-01 00:00:00

abstract：:Human alpha2-antiplasmin (alpha2AP), also known as alpha2-plasmin inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. There are 2 N-terminal forms of alpha2AP that circulate in human plasma: a 464-residue protein with Met as the N-terminus, Met-alpha2AP, and a 452-residue version w...

journal_title：Blood

authors： Lee KN,Jackson KW,Christiansen VJ,Chung KH,McKee PA

更新日期：2004-05-15 00:00:00

abstract：:The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or wheth...

journal_title：Blood

authors： Taveirne S,Filtjens J,Van Ammel E,De Colvenaer V,Kerre T,Taghon T,Vandekerckhove B,Plum J,Held W,Leclercq G

更新日期：2011-07-14 00:00:00

abstract：:A 72-yr-old male with a lifelong history of easy bruisability and posttraumatic bleeding had a prolonged prothrombin time and activated partial thromboplastin time. His plasma Stypven, Taipan, and Echis carinatus venom clotting times were prolonged. The presence of a dysprothrombin was confirmed by the discrepancy bet...

journal_title：Blood

authors： Weinger RS,Rudy C,Moake JL,Olson JD,Cimo PL

更新日期：1980-05-01 00:00:00