Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes.

abstract：:Transplantation with 2-5 × 10(6) mobilized CD34(+)cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and a...

journal_title：Blood

authors： To LB,Levesque JP,Herbert KE

更新日期：2011-10-27 00:00:00

abstract：:Elevated plasma clot lysis time (CLT) increases risk of venous and arterial thrombosis. It is unclear which fibrinolytic factors contribute to thrombosis risk. In 743 healthy control subjects we investigated determinants of CLT. By comparison with 770 thrombosis patients, we assessed plasma levels of fibrinolytic prot...

journal_title：Blood

authors： Meltzer ME,Lisman T,de Groot PG,Meijers JC,le Cessie S,Doggen CJ,Rosendaal FR

更新日期：2010-07-08 00:00:00

abstract：:Gene therapy for hemophilia A requires efficient delivery of the factor VIII gene and sustained protein expression at circulating levels of at least 1% to 2% of normal. Adeno-associated viral type 2 (AAV2) vectors have a number of advantages over other viral vectors, including an excellent safety profile and persisten...

journal_title：Blood

authors： Scallan CD,Lillicrap D,Jiang H,Qian X,Patarroyo-White SL,Parker AE,Liu T,Vargas J,Nagy D,Powell SK,Wright JF,Turner PV,Tinlin SJ,Webster SE,McClelland A,Couto LB

更新日期：2003-09-15 00:00:00

abstract：:Murine autoreactive anti-Smith (Sm) B cells are negatively regulated by anergy and developmental arrest, but are also positively selected into the marginal zone (MZ) and B-1 B-cell populations. Despite positive selection, anti-Sm production occurs only in autoimmune-prone mice. To investigate autoreactive B-cell activ...

journal_title：Blood

authors： Qian Y,Conway KL,Lu X,Seitz HM,Matsushima GK,Clarke SH

更新日期：2006-08-01 00:00:00

abstract：:A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions an...

journal_title：Blood

authors： Boukerche H,Berthier-Vergnes O,Tabone E,Doré JF,Leung LL,McGregor JL

更新日期：1989-08-01 00:00:00

abstract：:Plasma cell myeloma is a more complex neoplasm than suggested by the relative uniformity of its dominant plasma cells, which represent the terminal stage of normal B-cell differentiation. Phenotypic, molecular, and cellular genetic data favor the presence of a myeloma stem cell early in hematopoietic development so th...

journal_title：Blood

authors： Barlogie B,Epstein J,Selvanayagam P,Alexanian R

更新日期：1989-03-01 00:00:00

abstract：:Patients with antineutrophil cytoplasmic antibodies (ANCAs) frequently develop severe vasculitis and glomerulonephritis. Although ANCAs, particularly antimyeloperoxidase (anti-MPO), have been shown to promote leukocyte adhesion in postcapillary venules, their ability to promote adhesion in the glomerular vasculature i...

journal_title：Blood

authors： Kuligowski MP,Kwan RY,Lo C,Wong C,James WG,Bourges D,Ooi JD,Abeynaike LD,Hall P,Kitching AR,Hickey MJ

更新日期：2009-06-18 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, or 5-HT), released from activated platelets, not only accelerates aggregation of platelets but also is known to promote mitosis, migration, and contraction of vascular smooth muscle cells (VSMCs). These effects are considered to contribute to thrombus formation and atherosclerosis. The ...

journal_title：Blood

authors： Kawano H,Tsuji H,Nishimura H,Kimura S,Yano S,Ukimura N,Kunieda Y,Yoshizumi M,Sugano T,Nakagawa K,Masuda H,Sawada S,Nakagawa M

更新日期：2001-03-15 00:00:00

abstract：:Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical presentation in a uniquely vulnerable host, its poor response to current therapies, and its fascinating biology. Increasingly, these biological insights are pointing the way toward novel therapeutic approaches. Using represent...

journal_title：Blood

authors： Brown P,Pieters R,Biondi A

更新日期：2019-01-17 00:00:00

abstract：:Although the mechanisms by which all-trans-retinoic acid (RA) regulates gene transcription are well understood, very little is known on the signaling events regulating RA-dependent initiation of mRNA translation. We examined whether the mammalian target of rapamycin (mTOR)/p70 S6 kinase pathway is activated by RA. RA ...

journal_title：Blood

authors： Lal L,Li Y,Smith J,Sassano A,Uddin S,Parmar S,Tallman MS,Minucci S,Hay N,Platanias LC

更新日期：2005-02-15 00:00:00

abstract：:RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters. The major protein isoforms generated by P1 and P2 are RUNX1C and RUNX1B, respectively, which differ solely in their N-terminal amino acid sequences. ...

journal_title：Blood

authors： Draper JE,Sroczynska P,Leong HS,Fadlullah MZH,Miller C,Kouskoff V,Lacaud G

更新日期：2017-07-20 00:00:00

abstract：:p15(INK4b) gene is an inhibitor of cyclin-dependent kinase (CDK) 4 and CDK6 whose expression is induced by transforming growth factor (TGF)beta. Recent reports suggest frequent methylation of the p15(INK4b) gene promoter in leukemias, and it has been proposed that this methylation could be necessary for leukemic cells...

journal_title：Blood

authors： Quesnel B,Guillerm G,Vereecque R,Wattel E,Preudhomme C,Bauters F,Vanrumbeke M,Fenaux P

更新日期：1998-04-15 00:00:00

abstract：:We demonstrate here that EL4-6.1 cells, a mouse thymoma that expresses high levels of membrane interleukin (IL)-1 receptors, produce IL-1 beta as an autocrine regulatory factor. Endogenous IL-1 beta sustains both proliferation and apoptosis: during the exponential phase, it mainly promotes proliferation, while during ...

journal_title：Blood

authors： Fratelli M,Gagliardini V,Galli G,Gnocchi P,Ghiara P,Ghezzi P

更新日期：1995-06-15 00:00:00

abstract：:During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet release occurs. This physiologic process involves proliferation, differentiation, ...

journal_title：Blood

authors： Dhanjal TS,Pendaries C,Ross EA,Larson MK,Protty MB,Buckley CD,Watson SP

更新日期：2007-05-15 00:00:00

abstract：:To study the role of different cytokine combinations on the proliferation and differentiation of highly purified primitive progenitor cells, a serum-free liquid culture system was used in combination with phenotypic and functional analysis of the cells produced in culture. CD34+ CD45RAlo CD71lo cells, purified from um...

journal_title：Blood

authors： Mayani H,Dragowska W,Lansdorp PM

更新日期：1993-06-15 00:00:00

abstract：:Considerable evidence indicates that activation of the contact system of intrinsic coagulation plays a role in the pathogenesis of septic shock. To monitor contact activation in patients with sepsis, we developed highly sensitive radioimmunoassays (RIAs) for factor XIIa-Cl(-)-inhibitor (Cl(-)-Inh) and kallikrein-Cl(-)...

journal_title：Blood

authors： Nuijens JH,Huijbregts CC,Eerenberg-Belmer AJ,Abbink JJ,Strack van Schijndel RJ,Felt-Bersma RJ,Thijs LG,Hack CE

更新日期：1988-12-01 00:00:00

abstract：:Cord blood (CB) is used increasingly as a source of hematopoietic stem cells because of a lower risk of acute and chronic graft-versus-host disease (GVHD). However, there is some concern regarding the ability to adequately reconstitute host immune response due to the immaturity and naivety of CB T cells. This study wa...

journal_title：Blood

authors： Talvensaari K,Clave E,Douay C,Rabian C,Garderet L,Busson M,Garnier F,Douek D,Gluckman E,Charron D,Toubert A

更新日期：2002-02-15 00:00:00

abstract：:Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications ...

journal_title：Blood

authors： Iannone R,Luznik L,Engstrom LW,Tennessee SL,Askin FB,Casella JF,Kickler TS,Goodman SN,Hawkins AL,Griffin CA,Noffsinger L,Fuchs EJ

更新日期：2001-06-15 00:00:00

abstract：:Late committed progenitor cells of erythropoiesis, CFU-E (colony-forming unit--erythroid), were isolated from mouse spleens to near homogeneity by a three-step enrichment procedure. The procedure included a four-day pretreatment of bled mice with the antibiotic thiamphenicol, a recovery period of 3 1/2 days, followed ...

journal_title：Blood

authors： Nijhof W,Wierenga PK,Staal GE,Jansen G

更新日期：1984-09-01 00:00:00

abstract：:Important predictors of adverse outcomes of thrombosis in children, including postthrombotic syndrome (PTS), have recently been identified. Given this knowledge and the encouraging preliminary pediatric experience with systemic thrombolysis, we sought to retrospectively analyze our institutional experience with a thro...

journal_title：Blood

authors： Goldenberg NA,Durham JD,Knapp-Clevenger R,Manco-Johnson MJ

更新日期：2007-07-01 00:00:00

abstract：:On the basis of the finding of alternatively spliced mRNAs, the alpha-subunit of the receptor for GM-CSF is thought to exist in both a membrane spanning (tmGMRalpha) and a soluble form (solGMRalpha). However, only limited data has been available to support that the solGMRalpha protein product exists in vivo. We hypoth...

journal_title：Blood

authors： Sayani F,Montero-Julian FA,Ranchin V,Prevost JM,Flavetta S,Zhu W,Woodman RC,Brailly H,Brown CB

更新日期：2000-01-15 00:00:00

abstract：:We examined the expression of messenger RNA (mRNA) of the human inducible nitric oxide synthase (hiNOS) gene in a panel of human T-cell lines. Reverse transcriptase-polymerase chain reaction showed that human T-cell leukemia virus type-I (HTLV-I)-infected T-cell lines (MT-1, SLB-1, and C5/MJ) expressed mRNA for the hi...

journal_title：Blood

authors： Mori N,Nunokawa Y,Yamada Y,Ikeda S,Tomonaga M,Yamamoto N

更新日期：1999-10-15 00:00:00

abstract：:Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes--i(21q), i(6p), i(...

journal_title：Blood

authors： Pui CH,Carroll AJ,Raimondi SC,Schell MJ,Head DR,Shuster JJ,Crist WM,Borowitz MJ,Link MP,Behm FG

更新日期：1992-05-01 00:00:00

abstract：:Identification of the regulatory inputs that direct megakaryocytopoiesis and platelet production is essential for the development of novel therapeutic strategies for the treatment of thrombosis and related hematologic disorders. We have previously shown that primary human megakaryocytes express the N-methyl-d-aspartat...

journal_title：Blood

authors： Hitchcock IS,Skerry TM,Howard MR,Genever PG

更新日期：2003-08-15 00:00:00

abstract：:In search of a possible involvement of the human herpesvirus type 6 (HHV-6) in human Hodgkin's and non-Hodgkin's lymphomas, we studied the levels of anti-HHV-6 antibodies in the sera of 94 cases by an immunofluorescence assay, as well as the presence of HHV-6 sequences in the affected tissues of 66 cases by polymerase...

journal_title：Blood

authors： Torelli G,Marasca R,Luppi M,Selleri L,Ferrari S,Narni F,Mariano MT,Federico M,Ceccherini-Nelli L,Bendinelli M

更新日期：1991-05-15 00:00:00

abstract：:It was found in a long-term bromodeoxyuridine (BrdU) infusion study that two or more different subpopulations of bone marrow stem cells exist in mice. One of these subpopulations appears to be noncycling and forms approximately 10% of eight-day CFU-S. Another one, a subpopulation of slowly cycling bone marrow cells, i...

journal_title：Blood

authors： Pietrzyk ME,Priestley GV,Wolf NS

更新日期：1985-12-01 00:00:00

abstract：:Fifty patients with Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML) in early chronic phase received imatinib mesylate, 400 mg orally daily. After a median follow-up of 9 months, 49 patients (98%) achieved a complete hematologic response and 45 patients (90%) achieved a major cytogenetic res...

journal_title：Blood

authors： Kantarjian HM,Cortes JE,O'Brien S,Giles F,Garcia-Manero G,Faderl S,Thomas D,Jeha S,Rios MB,Letvak L,Bochinski K,Arlinghaus R,Talpaz M

更新日期：2003-01-01 00:00:00

abstract：:We have recently shown that interleukin-9 (IL-9) strongly stimulates the proliferation of mouse thymic lymphomas in vitro. Here we report that this factor is also one of the most potent inhibitors of apoptosis induced by dexamethasone (DEX) in such cell lines, even if they do not depend on exogenous factors for growth...

journal_title：Blood

authors： Renauld JC,Vink A,Louahed J,Van Snick J

更新日期：1995-03-01 00:00:00

abstract：:The effects of interleukin (IL)-8 on spontaneous IgE and IgG4 production in atopic patients were studied. IL-8 inhibited IgE and IgG4 production by purified surface (s) IgE+ and sIgG4+ B cells, respectively, while it had no effect on IgG1, IgG2, IgG3, IgM, IgA1, and IgA2 production by corresponding sIg+ B cells. The I...

journal_title：Blood

authors： Kimata H,Lindley I,Furusho K

更新日期：1995-06-01 00:00:00

abstract：:Forced dimerization or oligomerization has emerged as a powerful mechanism for unleashing the oncogenic properties of chimeric transcription factors in acute leukemias. Fusion of transcriptional regulators with a variety of heterologous partner proteins as a consequence of chromosomal rearrangements induces inappropri...

journal_title：Blood

authors： So CW,Cleary ML

更新日期：2004-08-15 00:00:00