Autocrine interleukin-1 beta regulates both proliferation and apoptosis in EL4-6.1 thymoma cells.

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00

abstract：:Recent population-based studies demonstrate an increased fracture risk with monoclonal gammopathy of undetermined significance (MGUS). The etiology of this increased risk remains unclear, however, because areal bone mineral density (aBMD) measurements by dual-energy x-ray absorptiometry cannot assess bone microstructu...

journal_title：Blood

authors： Ng AC,Khosla S,Charatcharoenwitthaya N,Kumar SK,Achenbach SJ,Holets MF,McCready LK,Melton LJ 3rd,Kyle RA,Rajkumar SV,Drake MT

更新日期：2011-12-15 00:00:00

abstract：:Non-Hodgkin lymphoma (NHL) incidence is greatly increased after kidney transplantation. NHL risk was investigated in a nationwide cohort of 8164 kidney transplant recipients registered on the Australia and New Zealand Dialysis and Transplant Registry. NHL diagnoses were ascertained using linkage with national cancer r...

journal_title：Blood

authors： van Leeuwen MT,Grulich AE,Webster AC,McCredie MR,Stewart JH,McDonald SP,Amin J,Kaldor JM,Chapman JR,Vajdic CM

更新日期：2009-07-16 00:00:00

abstract：:Epithelial mesenchymal transitions are a remarkable example of cellular plasticity. These transitions are the hallmark of embryo development, are pivotal in cancer progression, and seem to occur infrequently in adult organisms. The reduced incidence of transitions in the adult could result from restrictive functions o...

journal_title：Blood

authors： Prindull G,Zipori D

更新日期：2004-04-15 00:00:00

abstract：:In this issue of Blood, Poli et al demonstrate that heparin analogs engineered to minimize their anticoagulant properties can potently downregulate hepcidin production in vitro and in vivo, and may potentially be used to treat the anemia of inflammation. ...

journal_title：Blood

authors： Babitt JL,Lin HY

更新日期：2014-03-06 00:00:00

abstract：:The reactivity of acute myeloid leukemia cells (AML) was determined in 29 patients using the fucose binding lectin Ulex europaeus agglutinin (UEA) as surface marker. We show a marked heterogeneity in the UEA-binding abilities of the cells in these patients as determined by fluorescence analysis of the blasts labeled w...

journal_title：Blood

authors： Delwel R,Touw I,Bot F,Löwenberg B

更新日期：1986-07-01 00:00:00

abstract：:Erythroid progenitors (BFU-E) from adult human peripheral blood generate erythroid bursts in semisolid culture supplemented with at least two growth factors, ie, erythropoietin (Ep) and interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). We have analyzed the hematopoietin(s) requirement ...

journal_title：Blood

authors： Valtieri M,Gabbianelli M,Pelosi E,Bassano E,Petti S,Russo G,Testa U,Peschle C

更新日期：1989-07-01 00:00:00

abstract：:Hemophilia A is an X-linked bleeding disorder caused by a deficiency or abnormality of factor VIII, affecting approximately 1 male in 10,000. A subgroup of the patients develops inhibitors against factor VIII during substitution therapy. Because a considerable percentage of all cases is thought to result from de novo ...

journal_title：Blood

authors： Higuchi M,Kochhan L,Schwaab R,Egli H,Brackmann HH,Horst J,Olek K

更新日期：1989-08-15 00:00:00

abstract：:The NADPH:O2 oxidoreductase catalyzing the respiratory burst in activated phagocytes from healthy individuals is not operative in phagocytes from patients with chronic granulomatous disease (CGD). In a microscopic slide test using the dye nitroblue tetrazolium (NBT), carriers of X-linked CGD can be recognized by a mos...

journal_title：Blood

authors： Verhoeven AJ,van Schaik ML,Roos D,Weening RS

更新日期：1988-02-01 00:00:00

abstract：:In sickle cell (SS) vaso-occlusion, the culminating event is blockage of blood vessels by sickled red blood cells (SS RBCs). As shown in animal models, SS RBC-induced vaso-occlusion is often partial, allowing for a residual flow, hence oxygen delivery to partially occluded vessels could reduce vaso-occlusion. The effi...

journal_title：Blood

authors： Kaul DK,Liu X,Nagel RL

更新日期：2001-11-15 00:00:00

abstract：:Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of how CR affects the response to cancer therapy is still rudimentary. Here, using the Eµ-Myc transgenic mouse model of B-cell lymphoma, we report that by reducing ...

journal_title：Blood

authors： Meynet O,Zunino B,Happo L,Pradelli LA,Chiche J,Jacquin MA,Mondragón L,Tanti JF,Taillan B,Garnier G,Reverso-Meinietti J,Mounier N,Michiels JF,Michalak EM,Carles M,Scott CL,Ricci JE

更新日期：2013-10-03 00:00:00

abstract：:Adhesive forces at endothelial cell-cell borders maintain vascular integrity. cAMP enhances barrier properties and controls cellular processes through protein kinase A bound to A-kinase anchoring proteins (AKAPs). It also activates exchange protein directly activated by cAMP (Epac1), an exchange factor for Ras-related...

journal_title：Blood

authors： Sehrawat S,Ernandez T,Cullere X,Takahashi M,Ono Y,Komarova Y,Mayadas TN

更新日期：2011-01-13 00:00:00

abstract：:Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in normal and sublethally irradiated mice, dogs, and primates. To assess its tolerance and efficacy in clinical use, we performed a randomized phase Ib study in patients with ovarian carcinoma. IL-6 was administered during an ...

journal_title：Blood

authors： D'Hondt V,Humblet Y,Guillaume T,Baatout S,Chatelain C,Berlière M,Longueville J,Feyens AM,de Greve J,Van Oosterom A

更新日期：1995-05-01 00:00:00

abstract：:A critical role for the endothelium of yolk sac and dorsal aorta has been shown in embryonic hematopoiesis. A stromal cell line derived from yolk sac, YSCL-72, has been chosen to search for a novel molecule associated with embryonic hematopoiesis. Analysis between YSCL-72 and an adult aorta-derived endothelial cell li...

journal_title：Blood

authors： Ohneda O,Ohneda K,Arai F,Lee J,Miyamoto T,Fukushima Y,Dowbenko D,Lasky LA,Suda T

更新日期：2001-10-01 00:00:00

abstract：:Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitous...

journal_title：Blood

authors： Gilchrist M,McCauley SD,Befus AD

更新日期：2004-07-15 00:00:00

abstract：:RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters. The major protein isoforms generated by P1 and P2 are RUNX1C and RUNX1B, respectively, which differ solely in their N-terminal amino acid sequences. ...

journal_title：Blood

authors： Draper JE,Sroczynska P,Leong HS,Fadlullah MZH,Miller C,Kouskoff V,Lacaud G

更新日期：2017-07-20 00:00:00

abstract：:We have analyzed the binding of Sp1, a ubiquitously expressed transactivator, to the promoter region of the gamma genes. Low-affinity Sp1 sites were found at -50 and -200. A high-affinity site was detected at -140, over the CACCC sequence. To analyze the function of these sites, Drosophila SL-2 cells, which lack Sp1, ...

journal_title：Blood

authors： Gumucio DL,Rood KL,Blanchard-McQuate KL,Gray TA,Saulino A,Collins FS

更新日期：1991-10-01 00:00:00

abstract：:Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (LCM) in the presence of phytohemagglutinin (PHA). Two types of colonies are recognized with high frequency: The first grows in the prese...

journal_title：Blood

authors： Minden MD,Till JE,McCulloch EA

更新日期：1978-09-01 00:00:00

abstract：:Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the huma...

journal_title：Blood

authors： Berger LC,Hawley RG

更新日期：1997-01-01 00:00:00

abstract：:In diffuse large B-cell lymphoma (DLBCL), previous studies have suggested that, while concordant bone marrow (BM) involvement confers a poor prognosis, discordant BM involvement does not. Whether this correlation is independent of the non-Hodgkin lymphoma International Prognostic Index (IPI) was previously unknown. We...

journal_title：Blood

authors： Chung R,Lai R,Wei P,Lee J,Hanson J,Belch AR,Turner AR,Reiman T

更新日期：2007-08-15 00:00:00

abstract：:Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of 1298 allogeneic hematopoietic cell transplantation (HCT) donors and recipients. Of 40 previously reported candidate SNPs, 6 were successfully genotyp...

journal_title：Blood

authors： Chien JW,Zhang XC,Fan W,Wang H,Zhao LP,Martin PJ,Storer BE,Boeckh M,Warren EH,Hansen JA

更新日期：2012-05-31 00:00:00

abstract：:Biopsies and cell lines of natural killer/T-cell lymphoma, nasal type (NKTCL) were subject to combined gene expression profiling and array-based comparative genomic hybridization analyses. Compared with peripheral T-cell lymphoma, not otherwise specified, NKTCL had greater transcript levels for NK-cell and cytotoxic m...

journal_title：Blood

authors： Huang Y,de Reyniès A,de Leval L,Ghazi B,Martin-Garcia N,Travert M,Bosq J,Brière J,Petit B,Thomas E,Coppo P,Marafioti T,Emile JF,Delfau-Larue MH,Schmitt C,Gaulard P

更新日期：2010-02-11 00:00:00

abstract：:The cellular and molecular events underlying the formation and differentiation of mesoderm to derivatives such as blood are critical to our understanding of the development and function of many tissues and organ systems. How different mesodermal populations are set aside to form specific lineages is not well understoo...

journal_title：Blood

authors： Willey S,Ayuso-Sacido A,Zhang H,Fraser ST,Sahr KE,Adlam MJ,Kyba M,Daley GQ,Keller G,Baron MH

更新日期：2006-04-15 00:00:00

abstract：:Many lineage-specific developmental regulator genes are transcriptionally primed in embryonic stem (ES) cells; RNA Pol(II) is bound at their promoters but is prevented from productive elongation by the activity of polycomb repressive complexes (PRC) 1 and 2. This epigenetically poised state is thought to enable ES cel...

journal_title：Blood

authors： Mazzarella L,Jørgensen HF,Soza-Ried J,Terry AV,Pearson S,Lacaud G,Kouskoff V,Merkenschlager M,Fisher AG

更新日期：2011-01-06 00:00:00

abstract：:Lipopolysaccharide (LPS) is a major gram-negative bacterial component that stimulates innate immune response and also induces B-lymphocyte activation. Recent studies have revealed that common molecular patterns of microorganisms such as LPS are recognized by toll-like receptors (TLRs). B cells have 2 known TLRs that m...

journal_title：Blood

authors： Yazawa N,Fujimoto M,Sato S,Miyake K,Asano N,Nagai Y,Takeuchi O,Takeda K,Okochi H,Akira S,Tedder TF,Tamaki K

更新日期：2003-08-15 00:00:00

abstract：:There have been no studies on patient outcome after allogeneic hematopoietic cell transplantation (HCT) in patients with X-linked inhibitor of apoptosis (XIAP) deficiency. To estimate the success of HCT, we conducted an international survey of transplantation outcomes. Data were reported for 19 patients. Seven patient...

journal_title：Blood

authors： Marsh RA,Rao K,Satwani P,Lehmberg K,Müller I,Li D,Kim MO,Fischer A,Latour S,Sedlacek P,Barlogis V,Hamamoto K,Kanegane H,Milanovich S,Margolis DA,Dimmock D,Casper J,Douglas DN,Amrolia PJ,Veys P,Kumar AR,Jordan MB

更新日期：2013-02-07 00:00:00

abstract：:Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML) remains a life-threatening malignancy in children, with current survival rates of ∼70%. State-of-the-art recommendations in adult AML have recently been published in this journal by Döhner et al. The primary goal of an internatio...

journal_title：Blood

authors： Creutzig U,van den Heuvel-Eibrink MM,Gibson B,Dworzak MN,Adachi S,de Bont E,Harbott J,Hasle H,Johnston D,Kinoshita A,Lehrnbecher T,Leverger G,Mejstrikova E,Meshinchi S,Pession A,Raimondi SC,Sung L,Stary J,Zwaan CM,K

更新日期：2012-10-18 00:00:00

abstract：:Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG...

journal_title：Blood

authors： Jandus P,Boligan KF,Smith DF,de Graauw E,Grimbacher B,Jandus C,Abdelhafez MM,Despont A,Bovin N,Simon D,Rieben R,Simon HU,Cummings RD,von Gunten S

更新日期：2019-11-28 00:00:00

abstract：:We have examined the effect of graft-versus-host disease (GVHD) on the reconstitution of donor hematopoiesis in a murine bone marrow transplant (BMT) model of GVHD to minor histocompatibility antigens. GVHD had no effect on peripheral blood counts, which normalized by 1 month after BMT, and did not affect numbers of h...

journal_title：Blood

authors： van Dijken PJ,Wimperis J,Crawford JM,Ferrara JL

更新日期：1991-11-15 00:00:00

abstract：:A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (C...

journal_title：Blood

authors： Stocker JW,De Franceschi L,McNaughton-Smith GA,Corrocher R,Beuzard Y,Brugnara C

更新日期：2003-03-15 00:00:00