Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells.

abstract：:Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, is an antioxidant with chemopreventive and chemotherapeutic actions. Based on its ability to modulate growth factor-mediated cell proliferation, we evaluated its efficacy in multiple myeloma (MM). EGCG induced both dose- and time-dependent growt...

journal_title：Blood

authors： Shammas MA,Neri P,Koley H,Batchu RB,Bertheau RC,Munshi V,Prabhala R,Fulciniti M,Tai YT,Treon SP,Goyal RK,Anderson KC,Munshi NC

更新日期：2006-10-15 00:00:00

abstract：:Cytoplasmic free calcium concentration (Ca2+)i was measured in neutrophils from patients with the classical X-linked form of chronic granulomatous disease (CGD) by trapping the fluorescent calcium indicator Quin 2 in intact cells. CGD neutrophils do not produce superoxide and are only slightly depolarized upon stimula...

journal_title：Blood

authors： Lew PD,Wollheim C,Seger RA,Pozzan T

更新日期：1984-01-01 00:00:00

abstract：:Although imatinib, a BCR-ABL tyrosine kinase inhibitor, is used to treat acute Philadelphia chromosome-positive (Ph(+)) leukemia, it does not prevent central nervous system (CNS) relapses resulting from poor drug penetration through the blood-brain barrier. Imatinib and dasa-tinib (a dual-specific SRC/BCR-ABL kinase i...

journal_title：Blood

authors： Porkka K,Koskenvesa P,Lundán T,Rimpiläinen J,Mustjoki S,Smykla R,Wild R,Luo R,Arnan M,Brethon B,Eccersley L,Hjorth-Hansen H,Höglund M,Klamova H,Knutsen H,Parikh S,Raffoux E,Gruber F,Brito-Babapulle F,Dombret H,Dua

更新日期：2008-08-15 00:00:00

abstract：:Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to...

journal_title：Blood

authors： Reyes M,Li S,Foraker J,Kimura E,Chamberlain JS

更新日期：2005-11-15 00:00:00

abstract：:MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown function, associated with numbers of human inflammatory disorders. Both molecules have been described as L1 complex, cystic fibrosis antigen, or p8 and p14. We report here the cloning of mouse MRP8 and MRP14 and their pattern of expression during hem...

journal_title：Blood

authors： Lagasse E,Weissman IL

更新日期：1992-04-15 00:00:00

abstract：:Congenital blood disorders are common and yet clinically challenging globin disorders. Gene therapy continues to serve as a potential therapeutic method to treat these disorders. While tremendous advances have been made in vivo, gene delivery protocols and vector prototypes still require optimization. Alternative cis-...

journal_title：Blood

authors： Staplin WR,Knezetic JA

更新日期：2003-03-01 00:00:00

abstract：:In thrombophilic families, protein S deficiency is clearly associated with venous thrombosis. We aimed to determine whether the same holds true in a population-based case-control study (n = 5317). Subjects were regarded protein S deficient when protein S levels were < 2.5th percentile of the controls. Free and total p...

journal_title：Blood

authors： Pintao MC,Ribeiro DD,Bezemer ID,Garcia AA,de Visser MC,Doggen CJ,Lijfering WM,Reitsma PH,Rosendaal FR

更新日期：2013-10-31 00:00:00

abstract：:In previous studies we have found that monocytes produce soluble factors that stimulate human umbilical vein endothelial cells to produce granulocyte-macrophage colony-stimulating activity (CSA), burst-promoting activity (BPA), and megakaryocyte colony-stimulating activity (Meg-CSA) as well as factors that stimulate T...

journal_title：Blood

authors： Broudy VC,Zuckerman KS,Jetmalani S,Fitchen JH,Bagby GC Jr

更新日期：1986-08-01 00:00:00

abstract：:Natural suppressor (NS) activity, the capacity of unprimed cells to suppress immunologic responses, is present in mouse, rabbit, and human bone marrow (BM). In this study we characterize NS activity in bone marrow cells of the rhesus monkey. Greatest NS activity was found in low-density cells (1.0600 to 1.0655 g/mL) o...

journal_title：Blood

authors： Sugiura K,Ikehara S,Gengozian N,Inaba M,Sardiña EE,Ogata H,Seong SM,Good RA

更新日期：1990-03-01 00:00:00

abstract：:The human CD34 surface antigen is selectively expressed on stem/progenitor cells within the hematopoietic system. Because CD34 expression is tightly linked to the immature status of hematopoietic cells, with expression being rapidly lost as hematopoietic cells mature and differentiate, an examination of its regulation...

journal_title：Blood

authors： He XY,Cockerill PN,Cen D,Davis BR

更新日期：1994-04-01 00:00:00

abstract：:Fc receptors play an important role in leukocyte activation and the modulation of ligand binding ("activation") is a critical point of regulation. Previous studies demonstrated that the Fc receptor for IgA (FcalphaRI/CD89) is regulated by cytokine stimulation, switching it to a high-binding state. To investigate the m...

journal_title：Blood

authors： Bracke M,Lammers JW,Coffer PJ,Koenderman L

更新日期：2001-06-01 00:00:00

abstract：:CTLA-4 is an inhibitory molecule that down-regulates T-cell activation. Although polymorphisms at CTLA-4 have been correlated with autoimmune diseases their association with clinical outcome after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has yet to be explored. A total of 5 CTLA-4 single-nucleoti...

journal_title：Blood

authors： Pérez-García A,De la Cámara R,Román-Gómez J,Jiménez-Velasco A,Encuentra M,Nieto JB,de la Rubia J,Urbano-Ispizúa A,Brunet S,Iriondo A,González M,Serrano D,Espigado I,Solano C,Ribera JM,Pujal JM,Hoyos M,Gallardo D,GVHD\

更新日期：2007-07-01 00:00:00

abstract：:Marrow graft failure observed in association with histocompatibility differences between donor and recipient is often attributed to rejection mediated by host-derived cytolytic T lymphocytes. The data presented in this report indicate that persistent host antibodies specific for donor antigen may also mediate graft fa...

journal_title：Blood

authors： Barge AJ,Johnson G,Witherspoon R,Torok-Storb B

更新日期：1989-10-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cells are characterized by unlimited self-renewal and an impaired capacity to undergo terminal differentiation. The MUC1 oncoprotein is aberrantly expressed in AML cells; however, there has been no evidence for involvement of MUC1 in myeloid leukemogenesis. Cell-penetrating peptide inhibit...

journal_title：Blood

authors： Yin L,Wu Z,Avigan D,Rosenblatt J,Stone R,Kharbanda S,Kufe D

更新日期：2011-05-05 00:00:00

abstract：:Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of...

journal_title：Blood

authors： Gaines AR

更新日期：2000-04-15 00:00:00

abstract：:In a single institution, we have used recombinant interferon- (IFN-) to treat 116 newly diagnosed Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) patients and analyzed the predictive factors for response and survival. The patients whose median age was 50.3 years (range, 9 to 70) were administered IFN- (5 mi...

journal_title：Blood

authors： Mahon FX,Fabères C,Pueyo S,Cony-Makhoul P,Salmi R,Boiron JM,Marit G,Bilhou-Nabera C,Carrère A,Montastruc M,Pigneux A,Bernard P,Reiffers J

更新日期：1998-12-01 00:00:00

abstract：:Contraction of blood clots is necessary for hemostasis and wound healing and to restore flow past obstructive thrombi, but little is known about the structure of contracted clots or the role of erythrocytes in contraction. We found that contracted blood clots develop a remarkable structure, with a meshwork of fibrin a...

journal_title：Blood

authors： Cines DB,Lebedeva T,Nagaswami C,Hayes V,Massefski W,Litvinov RI,Rauova L,Lowery TJ,Weisel JW

更新日期：2014-03-06 00:00:00

abstract：:Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not found in the...

journal_title：Blood

authors： Fang B,Zheng C,Liao L,Han Q,Sun Z,Jiang X,Zhao RC

更新日期：2005-04-01 00:00:00

abstract：:Vascular bypass procedures in the central nervous system (CNS) remain technically challenging, hindered by complications and often failing to prevent adverse outcome such as stroke. Thus, there is an unmet clinical need for a safe and effective CNS revascularization. Vascular endothelial growth factors (VEGFs) are pro...

journal_title：Blood

authors： Gaál EI,Tammela T,Anisimov A,Marbacher S,Honkanen P,Zarkada G,Leppänen VM,Tatlisumak T,Hernesniemi J,Niemelä M,Alitalo K

更新日期：2013-08-01 00:00:00

abstract：:Oncogenic RAS alleles encode proteins that accumulate in the guanosine triphosphate (GTP)-bound state. Because post-translational processing of Ras by farnesyltransferase is essential for biologic function, inhibitors of this enzyme have been developed as rational cancer therapeutics. We have investigated farnesyltran...

journal_title：Blood

authors： Mahgoub N,Taylor BR,Gratiot M,Kohl NE,Gibbs JB,Jacks T,Shannon KM

更新日期：1999-10-01 00:00:00

abstract：:A patient with recurrent pulmonary abscess, weight loss, and alcoholism was found to have extremely high serum vitamin B12 and unsaturated vitamin B12-binding capacity (UBBC) levels. While transcobalamin (TC) II was also increased, most of his UBBC was due to an abnormal binding protein which carried greater than 80% ...

journal_title：Blood

authors： Carmel R,Tatsis B,Baril L

更新日期：1977-06-01 00:00:00

abstract：:Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs of asthmatics after allergen exposure suggests platelets participate in various aspects of asthma; although their importance is unknown in the context of airway remodeling, their involvement in atherosclerosis is established. St...

journal_title：Blood

authors： Pitchford SC,Riffo-Vasquez Y,Sousa A,Momi S,Gresele P,Spina D,Page CP

更新日期：2004-01-15 00:00:00

abstract：:Anticoagulation with vitamin K antagonists (VKAs) is problematic because of difficulties in safely managing dosing. Polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase genes (VKORC1) have been shown to affect VKA dosing in adults. The association of these polymorphisms on VKA dosing in childr...

journal_title：Blood

authors： Nowak-Göttl U,Dietrich K,Schaffranek D,Eldin NS,Yasui Y,Geisen C,Mitchell LG

更新日期：2010-12-23 00:00:00

abstract：:Monoclonal antibodies were raised after injecting mice with isolated human dense granules. Several of these monoclonals were found to recognize a 40-Kd dense granule membrane protein. Western blot and immunofluorescent analysis confirmed the dense-granule specificity. After thrombin activation, the protein was found i...

journal_title：Blood

authors： Gerrard JM,Lint D,Sims PJ,Wiedmer T,Fugate RD,McMillan E,Robertson C,Israels SJ

更新日期：1991-01-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. Recently, oncogenic mutations in NRAS/KRAS, upstream regulators of the RAF/MEK/ERK pathway, have been reported in pulm...

journal_title：Blood

authors： Kamata T,Giblett S,Pritchard C

更新日期：2017-07-27 00:00:00

abstract：:Following antigen acquisition and maturation, dendritic cells (DCs) disengage from the extracellular matrix, cross basement membranes, and travel to draining lymph nodes to activate T cells. CCR7 expression is necessary but not sufficient for the directional migration of DCs. Prostaglandin E2 (PGE2), present in inflam...

journal_title：Blood

authors： Yen JH,Khayrullina T,Ganea D

更新日期：2008-01-01 00:00:00

abstract：:Lumiliximab is a chimeric macaque-human monoclonal antibody to CD23, a protein expressed on virtually all chronic lymphocytic leukemia (CLL) cells. We examined the ability of lumiliximab to mediate apoptosis, antibody-dependent cellular cytotoxicity, and complement-dependent cytotoxicity against primary CLL cells and ...

journal_title：Blood

authors： Pathan NI,Chu P,Hariharan K,Cheney C,Molina A,Byrd J

更新日期：2008-02-01 00:00:00

abstract：:Quantitative studies of bone marrow neutrophil pool sizes and production rates and of blood neutrophil kinetics were performed in 16 patients with chronic neutropenia without splenomegaly. Marrow netrophil cellularity was determined from a ferrokinetic estimate of marrow normoblasts and from neutrophil-erythroid ratio...

journal_title：Blood

authors： Price TH,Lee MY,Dale DC,Finch CA

更新日期：1979-09-01 00:00:00

abstract：:Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development ...

journal_title：Blood

authors： Druker BJ

更新日期：2008-12-15 00:00:00

abstract：:The peripheral blood lymphocytes from 42 patients with multiple myeloma (MM) and 13 patients with monoclonal gammopathy of undetermined significance (MGUS) were studied by three-color immunofluorescence (IF) using antibodies directed to a broad range of B-cell markers (CD19, CD20, CD21, CD24), CALLA (CD10), PCA-1 (a p...

journal_title：Blood

authors： Jensen GS,Mant MJ,Belch AJ,Berenson JR,Ruether BA,Pilarski LM

更新日期：1991-08-01 00:00:00