Abstract:
:Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated within the adherent cell component. Numerous studies of bone marrow chimeras in the human and the mouse point to a host origin of bone marrow stromal cells. Mesenchymal stem cells (MSCs), which coexist with stromal cells, have also been proven to be of host origin after allogeneic bone marrow transplantation in numerous studies. We report here that following syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPCs are of donor origin.
journal_name
Bloodjournal_title
Bloodauthors
Reyes M,Li S,Foraker J,Kimura E,Chamberlain JSdoi
10.1182/blood-2004-12-4603subject
Has Abstractpub_date
2005-11-15 00:00:00pages
3646-9issue
10eissn
0006-4971issn
1528-0020pii
2004-12-4603journal_volume
106pub_type
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