CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.

abstract：:Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of gran...

journal_title：Blood

authors： Wong WY,Powars DR,Operskalski EA,Hassett J,Parker JW,Sarnaik S,Pegelow CH,Hilgartner MW,Johnson CS,Zhou Y

更新日期：1995-04-15 00:00:00

abstract：:Intensive leukapheresis has been used as the initial treatment of chronic granulocytic leukemia (CGL) in six patients. The number of leukaphereses ranged from 3 in 7 days to 13 in 39 days (mean, 8 in 22 days). The procedures were well tolerated, and in all patients there was improvement in hematologic values, in most ...

journal_title：Blood

authors： Lowenthal RM,Buskard NA,Goldman JM,Spiers AS,Bergier N,Graubner M,Galton DA

更新日期：1975-12-01 00:00:00

abstract：:The interleukin-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3) pathway contributes to the pathogenesis of multiple myeloma (MM) and protects MM cells from apoptosis. However, MM cells survive the IL-6R blockade if they are cocultured with bone marrow stromal cells (BMSCs), suggesting tha...

journal_title：Blood

authors： Chatterjee M,Stühmer T,Herrmann P,Bommert K,Dörken B,Bargou RC

更新日期：2004-12-01 00:00:00

abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...

journal_title：Blood

authors： Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,M

更新日期：2012-12-06 00:00:00

abstract：:In this issue of Blood, Neufeld and colleagues present promising results on the safety and efficacy of a novel iron chelator for the treatment of transfusional iron overload. ...

journal_title：Blood

authors： Taher AT,Musallam KM

更新日期：2012-04-05 00:00:00

abstract：:Extensive in vitro self-renewal of proerythroblasts from the earliest period of definitive erythropoiesis, as reported by England and co-investigators in this issue of Blood, expands the potential role of self-renewal in mammalian hematopoiesis and suggests a possible source of blood cells for clinical treatments. ...

journal_title：Blood

authors： Koury MJ

更新日期：2011-03-03 00:00:00

abstract：:Quantitative studies of bone marrow neutrophil pool sizes and production rates and of blood neutrophil kinetics were performed in 16 patients with chronic neutropenia without splenomegaly. Marrow netrophil cellularity was determined from a ferrokinetic estimate of marrow normoblasts and from neutrophil-erythroid ratio...

journal_title：Blood

authors： Price TH,Lee MY,Dale DC,Finch CA

更新日期：1979-09-01 00:00:00

abstract：:While investigating 2592 patients enrolled in multicenter myeloma trials, we found light chain-only (LCO) patients had worse median survival times (1.9 years) than patients with IgA and IgG paraproteins (2.3 and 2.5 years, respectively) (P < .001). However, IgA and IgG patients with levels of LC excretion similar to t...

journal_title：Blood

authors： Drayson M,Begum G,Basu S,Makkuni S,Dunn J,Barth N,Child JA

更新日期：2006-09-15 00:00:00

abstract：:Between February 1996 and December 2004, the German Leukemia Study Initiative registered 1766 consecutive patients for the acute myeloid leukemia (AML) 96 study, all of whom were diagnosed by central cytomorphology according to the French-American-British (FAB) and the new World Health Organization (WHO) classificatio...

journal_title：Blood

authors： Wandt H,Schäkel U,Kroschinsky F,Prange-Krex G,Mohr B,Thiede C,Pascheberg U,Soucek S,Schaich M,Ehninger G

更新日期：2008-02-15 00:00:00

abstract：:Little is known about the molecular mechanisms controlling primitive hematopoietic stem cells, especially during embryogenesis. Homeobox genes encode a family of transcription factors that have gained increasing attention as master regulators of developmental processes and recently have been implicated in the differen...

journal_title：Blood

authors： Helgason CD,Sauvageau G,Lawrence HJ,Largman C,Humphries RK

更新日期：1996-04-01 00:00:00

abstract：:A new human leukemia cell line, designated as ME-1, was established from the peripheral blood leukemia cells of a patient with acute myelomonocytic leukemia with eosinophilia (M4E0). This cell line has the characteristic chromosome abnormality of M4E0, inv(16) (p13q22). When cultured in RPMI 1640 medium containing 10%...

journal_title：Blood

authors： Yanagisawa K,Horiuchi T,Fujita S

更新日期：1991-07-15 00:00:00

abstract：:Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently, an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in murine studies with constitutive depletion of DCs, as well as in patients with congenital...

journal_title：Blood

authors： Humblet-Baron S,Barber JS,Roca CP,Lenaerts A,Koni PA,Liston A

更新日期：2019-01-24 00:00:00

abstract：:Circulating lymphocytes leave the blood by binding to specialized high endothelial cells lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating through the vessel wall into the surrounding tissue. The capacity of lymphocytes to recognize and bind to high endothelial venules (HEVs)...

journal_title：Blood

authors： Jalkanen ST,Butcher EC

更新日期：1985-09-01 00:00:00

abstract：:Naive and memory CD8(+) T cells can undergo programmed activation and expansion in response to a short T-cell receptor stimulus, but the extent to which in vitro programming can qualitatively substitute for an in vivo antigen stimulation remains unknown. We show that self-/tumor-reactive effector memory CD8(+) T cells...

journal_title：Blood

authors： Klebanoff CA,Yu Z,Hwang LN,Palmer DC,Gattinoni L,Restifo NP

更新日期：2009-08-27 00:00:00

abstract：:We report 2 novel, cryptic chromosomal abnormalities in precursor B-cell acute lymphoblastic leukemia (BCP-ALL): a translocation, either t(X;14)(p22;q32) or t(Y;14)(p11;q32), in 33 patients and an interstitial deletion, either del(X)(p22.33p22.33) or del(Y)(p11.32p11.32), in 64 patients, involving the pseudoautosomal ...

journal_title：Blood

authors： Russell LJ,Capasso M,Vater I,Akasaka T,Bernard OA,Calasanz MJ,Chandrasekaran T,Chapiro E,Gesk S,Griffiths M,Guttery DS,Haferlach C,Harder L,Heidenreich O,Irving J,Kearney L,Nguyen-Khac F,Machado L,Minto L,Majid A,

更新日期：2009-09-24 00:00:00

abstract：:Therapeutic preparations of polyspecific IgG obtained from plasma pools of a large number of normal donors (IVIg) express anti-idiotypic activity against a wide spectrum of natural and disease-associated autoantibodies. The present study investigated the origin of anti-idiotypic activity against autoantibodies to fact...

journal_title：Blood

authors： Dietrich G,Algiman M,Sultan Y,Nydegger UE,Kazatchkine MD

更新日期：1992-06-01 00:00:00

abstract：:IL-12 exerts several regulatory effects on natural killer (NK) cells by activating IL-12 signaling. IL-12 signaling is tightly auto-regulated to control its onset and termination, with prolonged IL-12 treatment resulting in IL-12 hyporesponsiveness. However, the mechanisms underlying IL-12 auto-regulation are still un...

journal_title：Blood

authors： Huang Y,Lei Y,Zhang H,Hou L,Zhang M,Dayton AI

更新日期：2011-12-22 00:00:00

abstract：:Seventy-one patients with acute myeloid leukemia (AML), most of them (63/71) considered ineligible for conventional allogeneic hematopoietic stem cell transplantation (HSCT), were enrolled into a phase 2 study on reduced-intensity myeloablative conditioning with fractionated 8-Gy total body irradiation (TBI) and fluda...

journal_title：Blood

authors： Stelljes M,Bornhauser M,Kroger M,Beyer J,Sauerland MC,Heinecke A,Berning B,Scheffold C,Silling G,Buchner T,Neubauer A,Fauser AA,Ehninger G,Berdel WE,Kienast J,Cooperative German Transplant Study Group.

更新日期：2005-11-01 00:00:00

abstract：:Gene expression patterns of CD34(+)CD38(-) cells derived from human embryonic stem cells (ESCs) were compared with those of cells isolated from adult human bone marrow (BM) using microarrays; 1692 and 1494 genes were expressed at levels at least 3-fold above background in cells from BM and ESCs, respectively. Of these...

journal_title：Blood

authors： Lu SJ,Li F,Vida L,Honig GR

更新日期：2004-06-01 00:00:00

abstract：:The tyrosine kinase receptor fetal liver kinase 1 (Flk-1) plays a crucial role in vasculogenesis and angiogenesis, but its target genes remain elusive. Comparing Flk-1(+/+) with Flk-1(-/-) embryonic stem (ES) cells, we identified transcripts regulated by the vascular endothelial growth factor A (VEGF-A)/Flk-1 pathway ...

journal_title：Blood

authors： Zippo A,De Robertis A,Bardelli M,Galvagni F,Oliviero S

更新日期：2004-06-15 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) with thrombosis is a serious complication of heparin use. HIT sera can generate platelet-derived microparticles, which are produced in a heparin-dependent manner and are hypothesized to be important initial pathological participants because they promote vascular occlusion. To dat...

journal_title：Blood

authors： Hughes M,Hayward CP,Warkentin TE,Horsewood P,Chorneyko KA,Kelton JG

更新日期：2000-07-01 00:00:00

abstract：:Receptor tyrosine kinases are known to be important in growth and differentiation. We have recently found that c-kit, the tyrosine kinase receptor for steel factor, also regulates cell-matrix adhesion. Because Steel factor helps regulate cell migration and localization, this may be an important biologic function. Inte...

journal_title：Blood

authors： Kinashi T,Escobedo JA,Williams LT,Takatsu K,Springer TA

更新日期：1995-09-15 00:00:00

abstract：:Heparin is a widely used anticoagulant. Because of its negative charge, it forms complexes with positively charged platelet factor 4 (PF4). This can induce anti-PF4/heparin IgG Abs. Resulting immune complexes activate platelets, leading to the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT)....

journal_title：Blood

authors： Krauel K,Hackbarth C,Fürll B,Greinacher A

更新日期：2012-02-02 00:00:00

abstract：:Patients who are chronically infected with hepatitis C virus (HCV) often develop mixed cryoglobulinemia (MC), a B-cell proliferative disorder with polyclonal activation and autoantibody production. We investigated if MC is associated with a deficit of CD4(+)CD25(+) immunoregulatory T (Treg) cells, which have been show...

journal_title：Blood

authors： Boyer O,Saadoun D,Abriol J,Dodille M,Piette JC,Cacoub P,Klatzmann D

更新日期：2004-05-01 00:00:00

abstract：:In most cases, the lack of Rh in Rh(null) red cells is associated with RHAG gene mutations. We explored the role of RhAG in the surface expression of Rh. Nonerythroid HEK293 cells, which lack Rh and RhAG, or erythroid K562 cells, which endogenously express RhAG but not Rh, were transfected with RhD and/or RhAG cDNAs u...

journal_title：Blood

authors： Mouro-Chanteloup I,D'Ambrosio AM,Gane P,Le Van Kim C,Raynal V,Dhermy D,Cartron JP,Colin Y

更新日期：2002-08-01 00:00:00

abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

journal_title：Blood

authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

更新日期：2013-10-31 00:00:00

abstract：:Numerous studies have reported the presence of oxidatively modified high-density lipoprotein (OxHDL) within the intima of atheromatous plaques as well as in plasma; however, its role in the pathogenesis of thrombotic disease is not established. We now report that OxHDL, but not native HDL, is a potent inhibitor of pla...

journal_title：Blood

authors： Valiyaveettil M,Kar N,Ashraf MZ,Byzova TV,Febbraio M,Podrez EA

更新日期：2008-02-15 00:00:00

abstract：:The PIT1/SLC20A1 protein, a well-described sodium/phosphate cotransporter and retrovirus receptor, has been identified recently as a modular of proliferation and apoptosis in vitro. The targeted deletion of the PIT1 gene in mice revealed a lethal phenotype due to severe anemia attributed to defects in liver developmen...

journal_title：Blood

authors： Forand A,Beck L,Leroy C,Rousseau A,Boitez V,Cohen I,Courtois G,Hermine O,Friedlander G

更新日期：2013-01-24 00:00:00

abstract：:Mammalian TOR (mTOR) regulates cell growth, proliferation, and migration. Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mouse by neo-insertion that partially disrupts mTOR transcription and creates a potential physiologic model of mTORC1/TORC2 inhibition. Homozygous knock-in mice exhi...

journal_title：Blood

authors： Zhang S,Readinger JA,DuBois W,Janka-Junttila M,Robinson R,Pruitt M,Bliskovsky V,Wu JZ,Sakakibara K,Patel J,Parent CA,Tessarollo L,Schwartzberg PL,Mock BA

更新日期：2011-01-27 00:00:00

abstract：:In Wiskott-Aldrich syndrome (WAS), immunodeficiency and autoimmunity often comanifest, yet how WAS mutations misregulate chromatin-signaling in Thelper (TH) cells favoring development of auto-inflammation over protective immunity is unclear. Previously, we identified an essential promoter-specific, coactivator role of...

journal_title：Blood

authors： Sarkar K,Sadhukhan S,Han SS,Vyas YM

更新日期：2015-10-01 00:00:00