Self-renewal in late-stage erythropoiesis.

abstract：:The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes. Changes in molecular species composition of PC altered morphology as well as cellular defo...

journal_title：Blood

authors： Kuypers FA,Chiu D,Mohandas N,Roelofsen B,Op den Kamp JA,Lubin B

更新日期：1987-10-01 00:00:00

abstract：:Forty-nine patients with primary myelodysplastic syndromes (MDS) were subclassified according to French-American-British (FAB) Cooperative Group criteria. Eight patients had acquired idiopathic sideroblastic anemia (AISA), ten had chronic myelomonocytic leukemia (CMMoL), 14 had refractory anemia (RA), nine had refract...

journal_title：Blood

authors： Jacobs RH,Cornbleet MA,Vardiman JW,Larson RA,Le Beau MM,Rowley JD

更新日期：1986-06-01 00:00:00

abstract：:The enhancement of in vitro human hematopoiesis by the addition of a noncytotoxic monoclonal antibody, 9.1C3, is described. Enhancement of all aspects of in vitro hematopoiesis was observed on addition of 9.1C3 antibody to cultures of mononuclear cells from normal bone marrow, cord blood, and peripheral blood from bet...

journal_title：Blood

authors： Kannourakis G,Johnson GR,Begley CG,Werkmeister JA,Burns GF

更新日期：1988-10-01 00:00:00

abstract：:We have previously reported on a unique patient in whom homozygosity for a mutation at IRF8 (IRF8(K108E)) causes a severe immunodeficiency. Laboratory evaluation revealed a highly unusual myeloid compartment, remarkable for the complete absence of CD141 and CD161 monocytes, absence of CD11c1 conventional dendritic cel...

journal_title：Blood

authors： Salem S,Langlais D,Lefebvre F,Bourque G,Bigley V,Haniffa M,Casanova JL,Burk D,Berghuis A,Butler KM,Leahy TR,Hambleton S,Gros P

更新日期：2014-09-18 00:00:00

abstract：:Even if neoplastic cells express tumor associated antigens they still may fail to function as antigen presenting cells (APC) if they lack expression of one or more molecules critical for the induction of productive immunity. These cellular defects can be repaired by physiologic activation, transfection, or fusion of t...

journal_title：Blood

authors： Cardoso AA,Schultze JL,Boussiotis VA,Freeman GJ,Seamon MJ,Laszlo S,Billet A,Sallan SE,Gribben JG,Nadler LM

更新日期：1996-07-01 00:00:00

abstract：:To screen for point mutations causing protein S deficiency, we used a sequence of techniques specifically for the study of the protein S active gene, PS alpha. This strategy comprises amplification of exons and intron/exon junctions by means of the polymerase chain reaction (PCR) and electrophoresis of the amplified f...

journal_title：Blood

authors： Gandrille S,Borgel D,Eschwege-Gufflet V,Aillaud M,Dreyfus M,Matheron C,Gaussem P,Abgrall JF,Jude B,Sie P

更新日期：1995-01-01 00:00:00

abstract：:Cytofluorimetric detection of the multidrug resistance (MDR)-associated membrane protein (P-170) was performed at the time of diagnosis in 158 patients with acute myeloid leukemia using the C219 monoclonal antibody (MoAb). In 108 of these cases the JSB1 MoAb was also tested. An improved histogram subtraction analysis,...

journal_title：Blood

authors： Del Poeta G,Stasi R,Aronica G,Venditti A,Cox MC,Bruno A,Buccisano F,Masi M,Tribalto M,Amadori S,Papa G

更新日期：1996-03-01 00:00:00

abstract：:The structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (Delta K-scuPA) bound to soluble uPAR (suPAR)...

journal_title：Blood

authors： Bdeir K,Kuo A,Sachais BS,Rux AH,Bdeir Y,Mazar A,Higazi AA,Cines DB

更新日期：2003-11-15 00:00:00

abstract：:Severe congenital neutropenia (SCN) is a syndrome characterized by an isolated block in granulocytic differentiation and an increased risk of developing acute myeloid leukemia (AML). Recent studies have demonstrated that the majority of patients with SCN and cyclic neutropenia, a related disorder characterized by peri...

journal_title：Blood

authors： Grenda DS,Johnson SE,Mayer JR,McLemore ML,Benson KF,Horwitz M,Link DC

更新日期：2002-11-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency with microthrombocytopenia, eczema, recurrent infections, autoimmune disorders, and malignancies that are life-threatening in the majority of patients. In this long-term, retrospective, multicenter study, we analyzed events that occurred in 96 WAS pati...

journal_title：Blood

authors： Ozsahin H,Cavazzana-Calvo M,Notarangelo LD,Schulz A,Thrasher AJ,Mazzolari E,Slatter MA,Le Deist F,Blanche S,Veys P,Fasth A,Bredius R,Sedlacek P,Wulffraat N,Ortega J,Heilmann C,O'Meara A,Wachowiak J,Kalwak K,Matthes-

更新日期：2008-01-01 00:00:00

abstract：:Human herpesvirus 6 activity (HHV-6) was studied in 15 allogeneic and 11 autologous marrow transplantation patients. After transplantation, HHV-6 was isolated from the peripheral blood mononuclear cells of 12 of 26 patients (6 allogeneic and 6 autologous). All isolates were variant B. Eleven of 26 and 12 of 19 patient...

journal_title：Blood

authors： Kadakia MP,Rybka WB,Stewart JA,Patton JL,Stamey FR,Elsawy M,Pellett PE,Armstrong JA

更新日期：1996-06-15 00:00:00

abstract：:Time-lapse videotape recordings of polymorphonuclear leukocytes (PMNs) from clot preparations were used to quantify the locomotive behavior of individual PMNs from normal subjects. Tracings derived from the videotapes allow one to quantify multiple parameters of the locomotive behavior of PMNs--direction, distance, ra...

journal_title：Blood

authors： Howard TH

更新日期：1982-05-01 00:00:00

abstract：:This phase 2 study evaluated the efficacy and safety of the oral farnesyltransferase inhibitor tipifarnib in adults with refractory or relapsed acute myeloid leukemia (AML). Patients (n=252) received tipifarnib 600 mg twice a day for 21 days in 28-day cycles. Median age was 62 years; 99 (39%) patients were 65 years or...

journal_title：Blood

authors： Harousseau JL,Lancet JE,Reiffers J,Lowenberg B,Thomas X,Huguet F,Fenaux P,Zhang S,Rackoff W,De Porre P,Stone R,Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group.

更新日期：2007-06-15 00:00:00

abstract：:Multicentric Castleman disease (MCD) is a lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection among persons with human immunodeficiency virus (HIV) infection. Treatment often includes chemotherapy, and progression to non-Hodgkin lymphoma frequently occurs. MCD is characterized in part by...

journal_title：Blood

authors： Casper C,Nichols WG,Huang ML,Corey L,Wald A

更新日期：2004-03-01 00:00:00

abstract：:Human hematopoietic colony-forming cells (CFC) express the CD34 antigen (CD34+) as well as differentiation antigens such as CD33 and HLA-DR. CD34+ cells that do not express these latter differentiation antigens have been shown to contain few CFC in direct culture, but generate increasing numbers of CFC when cultured o...

journal_title：Blood

authors： Litzow MR,Brashem-Stein C,Andrews RG,Bernstein ID

更新日期：1991-06-01 00:00:00

abstract：:Professional antigen-presenting cells (APCs) are sentinel cells of the immune system that present antigen to T lymphocytes and mediate an appropriate immune response. It is therefore surprising that knowledge of the professional APCs in human lymph nodes is limited. Using 3-color immunohistochemistry, we have identifi...

journal_title：Blood

authors： Angel CE,Chen CJ,Horlacher OC,Winkler S,John T,Browning J,MacGregor D,Cebon J,Dunbar PR

更新日期：2009-02-05 00:00:00

abstract：:We have designed two subfamilies of lipophilic iron (III) chelators previously termed reversed siderophores (RSFs). The agents display physicochemical properties that favor extraction of iron beyond membrane barriers of Plasmodium falciparum-infected red blood cells. We studied the in vitro antimalarial potency of RSF...

journal_title：Blood

authors： Lytton SD,Mester B,Dayan I,Glickstein H,Libman J,Shanzer A,Cabantchik ZI

更新日期：1993-01-01 00:00:00

abstract：:Additional sex combs-like 1 (ASXL1), an epigenetic modulator, is frequently mutated in myeloid neoplasms. Recent analyses of mutant ASXL1 conditional knockin (ASXL1-MT-KI) mice suggested that ASXL1-MT alone is insufficient for myeloid transformation. In our previous study, we used retrovirus-mediated insertional mutag...

journal_title：Blood

authors： Takeda R,Asada S,Park SJ,Yokoyama A,Becker HJ,Kanai A,Visconte V,Hershberger C,Hayashi Y,Yonezawa T,Tamura M,Fukushima T,Tanaka Y,Fukuyama T,Matsumoto A,Yamasaki S,Nakai K,Yamazaki S,Inaba T,Shibata T,Inoue D,Ho

更新日期：2020-10-01 00:00:00

abstract：:The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders me...

journal_title：Blood

authors： Ephrem A,Chamat S,Miquel C,Fisson S,Mouthon L,Caligiuri G,Delignat S,Elluru S,Bayry J,Lacroix-Desmazes S,Cohen JL,Salomon BL,Kazatchkine MD,Kaveri SV,Misra N

更新日期：2008-01-15 00:00:00

abstract：:Eighty patients with chronic myeloid leukemia (CML) underwent T cell-depleted stem cell transplantation from an HLA-identical sibling, with add-back of donor T cells on days 30 to 45 and days 60 to 100 in patients in whom grade 2 or greater acute graft-versus-host disease (GVHD) developed. The outcomes for 54 patients...

journal_title：Blood

authors： Savani BN,Rezvani K,Mielke S,Montero A,Kurlander R,Carter CS,Leitman S,Read EJ,Childs R,Barrett AJ

更新日期：2006-02-15 00:00:00

abstract：:Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

journal_title：Blood

authors： Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

更新日期：2020-12-24 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is characterized by delayed senescence and slow accumulation of monoclonal, small lymphocytes. Basic fibroblast growth factor (bFGF) is a pleiotropic cytokine that plays a role in hematopoiesis and apoptosis. Elevated bFGF levels have been detected in urine from patients with a varie...

journal_title：Blood

authors： Menzel T,Rahman Z,Calleja E,White K,Wilson EL,Wieder R,Gabrilove J

更新日期：1996-02-01 00:00:00

abstract：:Human umbilical vein endothelial cells in culture (HUVEC) express receptors for urokinase-type plasminogen activators (u-PA). The immunochemical nature of this receptor and its relationship to u-PA receptors expressed by other cell types is unknown. Cross-linking active site-blocked u-PA to HUVEC lead to an increase i...

journal_title：Blood

authors： Barnathan ES,Kuo A,Karikó K,Rosenfeld L,Murray SC,Behrendt N,Rønne E,Weiner D,Henkin J,Cines DB

更新日期：1990-11-01 00:00:00

abstract：:In contrast to other diverse therapies for the X-linked bleeding disorder hemophilia that are currently in clinical development, gene therapy holds the promise of a lasting cure with a single drug administration. Near-to-complete correction of hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficienc...

journal_title：Blood

authors： Perrin GQ,Herzog RW,Markusic DM

更新日期：2019-01-31 00:00:00

abstract：:Von Willebrand factor (VWF) is a key hemostatic protein synthesized in both endothelial cells and megakaryocytes. Megakaryocyte-derived VWF is stored in α-granules of platelets and is enriched in hyperactive "ultra-large" VWF multimers. To elucidate the specific contribution of platelet VWF in hemostasis and thrombosi...

journal_title：Blood

authors： Verhenne S,Denorme F,Libbrecht S,Vandenbulcke A,Pareyn I,Deckmyn H,Lambrecht A,Nieswandt B,Kleinschnitz C,Vanhoorelbeke K,De Meyer SF

更新日期：2015-10-01 00:00:00

abstract：:The experience at a single institution in harvesting marrow for allogeneic transplantation on 1,270 occasions from 1,160 normal donors is presented in detail, together with an analysis of all the donor complications. Four donors were less than 2 years old, and the youngest was 6 1/2 months. No special difficulties wer...

journal_title：Blood

authors： Buckner CD,Clift RA,Sanders JE,Stewart P,Bensinger WI,Doney KC,Sullivan KM,Witherspoon RP,Deeg HJ,Appelbaum FR

更新日期：1984-09-01 00:00:00

abstract：:The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8(+) T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-deriv...

journal_title：Blood

authors： Longman RS,Talal AH,Jacobson IM,Albert ML,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet generation were recor...

journal_title：Blood

authors： Di Buduo CA,Wray LS,Tozzi L,Malara A,Chen Y,Ghezzi CE,Smoot D,Sfara C,Antonelli A,Spedden E,Bruni G,Staii C,De Marco L,Magnani M,Kaplan DL,Balduini A

更新日期：2015-04-02 00:00:00

abstract：:The relationship between platelet density and platelet age appears to vary between species with relatively few labeling studies in humans reported. In this study, irreversible monoamine oxidase (MAO) inhibitors were used to biochemically label the circulating platelet population in 15 humans. Platelet samples were the...

journal_title：Blood

authors： Chamberlain KG,Tong M,Chiu E,Penington DG

更新日期：1989-04-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome-associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is...

journal_title：Blood

authors： Neri A,Barriga F,Inghirami G,Knowles DM,Neequaye J,Magrath IT,Dalla-Favera R

更新日期：1991-03-01 00:00:00