Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies.

abstract：:The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) introduced in association with the luciferase reporter gene into Jurkat T cells was strongly activated by a combination of human neutrophils and phorbol myristate acetate (PMA). Activation was not observed when normal neutrophils were replaced ...

journal_title：Blood

authors： Klebanoff SJ,Headley CM

更新日期：1999-01-01 00:00:00

abstract：:Infusions of large numbers (> 10(8)/kg) of donor leukocytes can induce remissions in patients with chronic myeloid leukemia (CML) who relapse after marrow transplantation. We wanted to determine if substantially lower numbers of donor leukocytes could induce remissions and, if so, whether this would reduce the 90% inc...

journal_title：Blood

authors： Mackinnon S,Papadopoulos EB,Carabasi MH,Reich L,Collins NH,Boulad F,Castro-Malaspina H,Childs BH,Gillio AP,Kernan NA

更新日期：1995-08-15 00:00:00

abstract：:The inv(16)(p13q22) and t(16;16)(p13;q22) cytogenetic abnormalities occur commonly in acute myeloid leukemia (AML), typically associated with French-American-British (FAB) AML-M4Eo subtype. Reverse transcriptase-polymerase chain reaction (RT-PCR) techniques have been recently developed to detect the presence of severa...

journal_title：Blood

authors： Viswanatha DS,Chen I,Liu PP,Slovak ML,Rankin C,Head DR,Willman CL

更新日期：1998-03-15 00:00:00

abstract：:One of the mechanisms by which normal hematopoietic progenitor cells remain localized within the bone marrow microenvironment is likely to involve adhesion of these cells to extracellular matrix (ECM) proteins. For example, there is evidence that uncommitted, HLA-DR-negative progenitor cells and committed erythroid pr...

journal_title：Blood

authors： Koenigsmann M,Griffin JD,DiCarlo J,Cannistra SA

更新日期：1992-02-01 00:00:00

abstract：:We studied the expression of the two tumor necrosis factor (TNF) receptors, p55 and p75, on B cells from patients with chronic lymphocytic leukemia (CLL), and the presence of soluble TNF receptors in serum. Expression of membrane-associated receptors was quantified by double labeling of peripheral blood mononuclear ce...

journal_title：Blood

authors： Waage A,Liabakk N,Lien E,Lamvik J,Espevik T

更新日期：1992-11-15 00:00:00

abstract：:Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cel...

journal_title：Blood

authors： Lin L,Goldberg YP,Ganz T

更新日期：2005-10-15 00:00:00

abstract：:Large granular lymphocytes (LGL) are defined as nonadherent mononuclear cells with cytoplasmic azurophilic granules, avid receptors for the Fc portion of IgG, and cytotoxic functions (NK or ADCC activities). In the present study, the granules of LGL isolated from human peripheral blood have been analyzed by enzyme cyt...

journal_title：Blood

authors： Grossi CE,Cadoni A,Zicca A,Leprini A,Ferrarini M

更新日期：1982-02-01 00:00:00

abstract：:Continuous treatment of malignancies with tyrosine kinase inhibitors (TKIs) may select for resistant clones (ie, imatinib mesylate). To study resistance to TKIs targeting FLT3, a receptor tyrosine kinase that is frequently mutated in acute myelogenous leukemia (AML), we developed resistant human cell lines through pro...

journal_title：Blood

authors： Piloto O,Wright M,Brown P,Kim KT,Levis M,Small D

更新日期：2007-02-15 00:00:00

abstract：:Signaling mediated by various Notch receptors and their ligands regulates diverse biological processes, including lymphoid cell fate decisions. Notch1 is required during T-cell development, while Notch2 and the Notch ligand Delta-like1 control marginal zone B (MZB) cell development. We previously determined that Maste...

journal_title：Blood

authors： Wu L,Maillard I,Nakamura M,Pear WS,Griffin JD

更新日期：2007-11-15 00:00:00

abstract：:Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (...

journal_title：Blood

authors： Bortin MM,D'Amaro J,Bach FH,Rimm AA,van Rood JJ

更新日期：1987-07-01 00:00:00

abstract：:Stem cells of highly regenerative organs including blood are susceptible to endogenous DNA damage caused by both intrinsic and extrinsic stress. Response mechanisms to such stress equipped in hematopoietic stem cells (HSCs) are crucial in sustaining hematopoietic homeostasis but remain largely unknown. In this study, ...

journal_title：Blood

authors： Yahata T,Takanashi T,Muguruma Y,Ibrahim AA,Matsuzawa H,Uno T,Sheng Y,Onizuka M,Ito M,Kato S,Ando K

更新日期：2011-09-15 00:00:00

abstract：:A hybridoma-derived monoclonal antibody, produced by immunization with the Burkitt's tumor-derived B-lymphoblastoid cell line, B35M, was previously shown to detect a 68,000 dalton surface membrane protein, BL2, on the surface of peripheral blood B cells, which is absent from thymocytes, T cells, and granulocytes. In t...

journal_title：Blood

authors： Knowles DM 2nd,Tolidjian B,Marboe CC,Halper JP,Azzo W,Wang CY

更新日期：1983-07-01 00:00:00

abstract：:Drug-induced immune thrombocytopenia (DITP) is an adverse drug effect mediated by drug-dependent antibodies. Intravenous immunoglobulin (IVIG) is frequently used to treat DITP and primary immune thrombocytopenia (ITP). Despite IVIG's proven beneficial effects in ITP, its efficacy in DITP is unclear. We have establishe...

journal_title：Blood

authors： Liang SX,Pinkevych M,Khachigian LM,Parish CR,Davenport MP,Chong BH

更新日期：2010-09-16 00:00:00

abstract：:Aurora-A kinase (Aur-A) is a member of the serine/threonine kinase family that regulates the cell division process, and has recently been implicated in tumorigenesis. In this study, we identified an antigenic 9-amino-acid epitope (Aur-A(207-215): YLILEYAPL) derived from Aur-A capable of generating leukemia-reactive cy...

journal_title：Blood

authors： Ochi T,Fujiwara H,Suemori K,Azuma T,Yakushijin Y,Hato T,Kuzushima K,Yasukawa M

更新日期：2009-01-01 00:00:00

abstract：:AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is selectively expressed on CD34(bright) hematopoietic stem and progenitor cells (progenitors) derived from human fetal liver and b...

journal_title：Blood

authors： Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

更新日期：1997-12-15 00:00:00

abstract：:Most juvenile chronic myelogenous leukemia (JCML) cells have limited long-term proliferative capacity, and only a minority of immature cells give rise to colonies in semisolid cultures. Clonogenic JCML progenitors cannot be maintained in culture because they differentiate, and within a few weeks the leukemic clone is ...

journal_title：Blood

authors： Lapidot T,Grunberger T,Vormoor J,Estrov Z,Kollet O,Bunin N,Zaizov R,Williams DE,Freedman MH

更新日期：1996-10-01 00:00:00

abstract：:Fas (CD95/Apo-1) mutations were previously reported as the genetic defect responsible for human lymphoproliferative syndrome associated with autoimmune manifestations (also known as autoimmune lymphoproliferative syndrome or Canale-Smith syndrome). We have identified 14 new heterozygous Fas mutations. Analysis of pati...

journal_title：Blood

authors： Rieux-Laucat F,Blachère S,Danielan S,De Villartay JP,Oleastro M,Solary E,Bader-Meunier B,Arkwright P,Pondaré C,Bernaudin F,Chapel H,Nielsen S,Berrah M,Fischer A,Le Deist F

更新日期：1999-10-15 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, or 5-HT), released from activated platelets, not only accelerates aggregation of platelets but also is known to promote mitosis, migration, and contraction of vascular smooth muscle cells (VSMCs). These effects are considered to contribute to thrombus formation and atherosclerosis. The ...

journal_title：Blood

authors： Kawano H,Tsuji H,Nishimura H,Kimura S,Yano S,Ukimura N,Kunieda Y,Yoshizumi M,Sugano T,Nakagawa K,Masuda H,Sawada S,Nakagawa M

更新日期：2001-03-15 00:00:00

abstract：:Pulmonary complication in severe Plasmodium falciparum malaria is manifested as a prolonged impairment of gas transfer or the more severe acute respiratory distress syndrome (ARDS). In either clinical presentation, vascular permeability is a major component of the pathologic process. In this report, we examined the ef...

journal_title：Blood

authors： Gillrie MR,Krishnegowda G,Lee K,Buret AG,Robbins SM,Looareesuwan S,Gowda DC,Ho M

更新日期：2007-11-01 00:00:00

abstract：:Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells (HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region. There is now compelling in vivo evidence that HSCs are generated from aortic endothelial cells and that this process is critically regulated b...

journal_title：Blood

authors： Lam EY,Hall CJ,Crosier PS,Crosier KE,Flores MV

更新日期：2010-08-12 00:00:00

abstract：:Among the most striking morphological features of acute nonlymphoblastic leukemias (ANLL) is the occurrence of eosinophilic cytoplasmic inclusions known as Auer rods on Auer bodies. We examined immature myeloid cells from the peripheral blood of 9 human fetuses of 16-19 wk gestation for the presence of such structures...

journal_title：Blood

authors： Newburger PE,Novak TJ,McCaffrey RP

更新日期：1983-03-01 00:00:00

abstract：:The biologic effects of endothelin-1 (ET-1) are not limited to its potent vasoconstricting activity. The endothelin receptors, ETA and ETB, have differential tissue and functional distributions. Here we showed that dendritic cells (DCs), the major antigen-presenting cells in the adaptive limb of the immune system, pro...

journal_title：Blood

authors： Guruli G,Pflug BR,Pecher S,Makarenkova V,Shurin MR,Nelson JB

更新日期：2004-10-01 00:00:00

abstract：:The prognostic significance of c-kit receptor expression on leukemic blast cells was determined in 122 children with acute myeloid leukemia (AML) entered onto Childrens Cancer Group protocol 213. Clinical and laboratory characteristics as well as outcome were analyzed according to the percentage of blast cells express...

journal_title：Blood

authors： Smith FO,Broudy VC,Zsebo KM,Lampkin BC,Buckley CV,Buckley JD,Opie T,Woods WG,Hammond GD,Bernstein ID

更新日期：1994-08-01 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) is an important growth and survival factor in multiple myeloma (MM). Here, we demonstrate that IGF-1 induces significant down-regulation of the proapoptotic BH3-only protein Bim in MM cells. Reduced Bim levels by RNA interference (RNAi) protected cells from drug-induced cell death....

journal_title：Blood

authors： De Bruyne E,Bos TJ,Schuit F,Van Valckenborgh E,Menu E,Thorrez L,Atadja P,Jernberg-Wiklund H,Vanderkerken K

更新日期：2010-03-25 00:00:00

abstract：:The pathogenesis of thrombotic thrombocytopenic purpura (TTP) is obscure. It is manifested classically by platelet thrombi and localized microvascular endothelial cell (EC) proliferation, in the absence of an inflammatory response. It is statistically associated with human retroviral disease, but pathological studies ...

journal_title：Blood

authors： Laurence J,Mitra D,Steiner M,Staiano-Coico L,Jaffe E

更新日期：1996-04-15 00:00:00

abstract：:Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8(+) and CD4(+) T cells, respectively. Here, we show that targeting Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) to one of them, the human multilectin DEC-205 receptor,...

journal_title：Blood

authors： Gurer C,Strowig T,Brilot F,Pack M,Trumpfheller C,Arrey F,Park CG,Steinman RM,Münz C

更新日期：2008-08-15 00:00:00

abstract：:Secretion of platelet granules is necessary for normal hemostasis. Platelet secretion requires soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complex formation between different members of the syntaxin, SNAP-25, and vesicle-associated membrane protein (VAMP) gene families. Using m...

journal_title：Blood

authors： Polgár J,Chung SH,Reed GL

更新日期：2002-08-01 00:00:00

abstract：:The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and multicentric Castleman's disease (MCD). Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in lymph nodes of about 40% of human immunodef...

journal_title：Blood

authors： Bélec L,Mohamed AS,Authier FJ,Hallouin MC,Soe AM,Cotigny S,Gaulard P,Gherardi RK

更新日期：1999-06-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome characterized by progressive bone marrow failure and cancer predisposition. Eight FA complementation groups have been identified. The FANCA, FANCC, FANCE, FANCF, and FANCG proteins form a nuclear complex required for the monoubiquination of the FANCD2 protein. To ...

journal_title：Blood

authors： Gordon SM,Buchwald M

更新日期：2003-07-01 00:00:00

abstract：:This report describes the clinical and immunoglobulin features of a patient with gamma heavy chain disease (HCD), who presented with a clinical picture suggestive of an underlying malignancy rather than the usual picture of lymphoma or granulomatous disease. A unique clinical feature was the nearly total replacement o...

journal_title：Blood

authors： Faguet GB,Barton BP,Smith LL,Garver FA

更新日期：1977-04-01 00:00:00