Establishment and characterization of a new human leukemia cell line derived from M4E0.

abstract：:B-cell precursors are present in the thymus, and the thymic microenvironment is the source of lymphopoietic factors that include interleukin-7 (IL-7). Despite the fact that intrathymic B-cell progenitors are bone marrow-derived cells, the data in this report demonstrate that these progenitors accumulate at an early pr...

journal_title：Blood

authors： Hashimoto Y,Montecino-Rodriguez E,Leathers H,Stephan RP,Dorshkind K

更新日期：2002-11-15 00:00:00

abstract：:Vascular tube morphogenesis requires the establishment of endothelial cell (EC) apical-basal polarity in three-dimensional (3D) extracellular matrices. To date, there is little understanding of how EC polarity is controlled during these highly dynamic and rapid morphogenic events. We show that the microtubule tip comp...

journal_title：Blood

authors： Kim DJ,Martinez-Lemus LA,Davis GE

更新日期：2013-04-25 00:00:00

abstract：:Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended clinical trials so far have been hampered by the fact that conventional approaches to produce these antibodies suffer from low yields, ill-defined byproducts, or laborious purification proc...

journal_title：Blood

authors： Löffler A,Kufer P,Lutterbüse R,Zettl F,Daniel PT,Schwenkenbecher JM,Riethmüller G,Dörken B,Bargou RC

更新日期：2000-03-15 00:00:00

abstract：:Mutations in the kinase domain (KD) of BCR-ABL are the most prevalent mechanism of acquired imatinib resistance in patients with chronic myeloid leukemia (CML). Here we examine predisposing factors underlying acquisition of KD mutations, evidence for acquisition of mutations before and during therapy, and whether the ...

journal_title：Blood

authors： O'Hare T,Eide CA,Deininger MW

更新日期：2007-10-01 00:00:00

abstract：:Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse functions, and the composition of iNKT cell subsets can alter disease outcomes. In ...

journal_title：Blood

authors： Erkers T,Xie BJ,Kenyon LJ,Smith B,Rieck M,Jensen KP,Ji X,Basina M,Strober S,Negrin RS,Maecker HT,Meyer EH

更新日期：2020-03-12 00:00:00

abstract：:The human CD34 surface antigen is selectively expressed on stem/progenitor cells within the hematopoietic system. Because CD34 expression is tightly linked to the immature status of hematopoietic cells, with expression being rapidly lost as hematopoietic cells mature and differentiate, an examination of its regulation...

journal_title：Blood

authors： He XY,Cockerill PN,Cen D,Davis BR

更新日期：1994-04-01 00:00:00

abstract：:A hamster antimouse CD3 monoclonal antibody (MoAb) opened the way to experimental studies on the suppression of allograft rejection and cytokine-related morbidity after treatment with antibodies modulating the CD3/T-cell receptor complex (CD3/TCR). Because earlier attempts to suppress graft-versus-host disease (GVHD) ...

journal_title：Blood

authors： Mysliwietz J,Thierfelder S

更新日期：1992-11-15 00:00:00

abstract：:We have investigated the hormonal responsiveness of K562 cells using a serum-substituted in vitro clonogenic assay. Dexamethasone inhibited colony formation by the K562 cells, and the inhibitory effect could be reversed by progesterone (10(-6) M). Fluoxymesterone caused a prominent enhancement of K562 colony growth, w...

journal_title：Blood

authors： Gauwerky C,Golde DW

更新日期：1980-11-01 00:00:00

abstract：:p38 MAP kinase in human platelets is activated by platelet agonists including thrombin, thromboxane A2 (TxA2), ADP, and others. However, both upstream mechanisms of p38 MAP kinase activation, and their downstream sequelae, are presently controversial and essentially unclear. Certain studies report sequential activatio...

journal_title：Blood

authors： Begonja AJ,Geiger J,Rukoyatkina N,Rauchfuss S,Gambaryan S,Walter U

更新日期：2007-01-15 00:00:00

abstract：:The number of cells transplanted and their capacity to induce graft-versus-host reactivity (GvHR) are two factors that are suspected to influence the engraftment of allogeneic bone marrow. We have investigated their impact on graft rejection rates in busulfan-treated LEW rats. In a series of experiments, we varied (1)...

journal_title：Blood

authors： Uharek L,Gassmann W,Glass B,Steinmann J,Loeffler H,Mueller-Ruchholtz W

更新日期：1992-03-15 00:00:00

abstract：:The distinct combination of homing receptors such as selectins, chemokine receptors, and integrins directs the migration of lymphocytes throughout the body. Upon activation lymphocytes irreversibly switch their set of homing receptors, now guiding them to entirely different destinations. Here we report that exposure o...

journal_title：Blood

authors： Berberich S,Förster R,Pabst O

更新日期：2007-06-01 00:00:00

abstract：:Ruxolitinib is JAK1/JAK2 inhibitor with established clinical benefit in myelofibrosis (MF). We analyzed long-term outcomes of 107 patients with intermediate-2 or high-risk MF receiving ruxolitinib at MD Anderson Cancer Center (MDACC) on phase 1/2 trial. After a median of 32 months of follow-up, 58 patients (54%) were ...

journal_title：Blood

authors： Verstovsek S,Kantarjian HM,Estrov Z,Cortes JE,Thomas DA,Kadia T,Pierce S,Jabbour E,Borthakur G,Rumi E,Pungolino E,Morra E,Caramazza D,Cazzola M,Passamonti F

更新日期：2012-08-09 00:00:00

abstract：:Reactivation of fetal hemoglobin remains a critical goal in the treatment of patients with sickle cell disease and β-thalassemia. Previously, we discovered that silencing of the fetal γ-globin gene requires the erythroid-specific eIF2α kinase heme-regulated inhibitor (HRI), suggesting that HRI might present a pharmaco...

journal_title：Blood

authors： Huang P,Peslak SA,Lan X,Khandros E,Yano JA,Sharma M,Keller CA,Giardine B,Qin K,Abdulmalik O,Hardison RC,Shi J,Blobel GA

更新日期：2020-06-11 00:00:00

abstract：:Thalassemia is a congenital hemolytic disorder caused by a partial or complete deficiency of alpha- or beta-globin chain synthesis. Homozygous carriers of beta-globin gene defects suffer from severe anemia and other serious complications from early childhood. The disease is treated by chronic blood transfusion. Howeve...

journal_title：Blood

authors： Eldor A,Rachmilewitz EA

更新日期：2002-01-01 00:00:00

abstract：:Diverse human cancers with poor prognosis, including many lymphoid and myeloid malignancies, exhibit high levels of Mcl-1. To explore the impact of Mcl-1 overexpression on the hematopoietic compartment, we have generated vavP-Mcl-1 transgenic mice. Their lymphoid and myeloid cells displayed increased resistance to a v...

journal_title：Blood

authors： Campbell KJ,Bath ML,Turner ML,Vandenberg CJ,Bouillet P,Metcalf D,Scott CL,Cory S

更新日期：2010-10-28 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is associated with complement system dysregulation, and more than 25% of pediatric aHUS cases are linked to mutations in complement factor H (CFH) or CFH autoantibodies. The observation of thrombocytopenia and platelet-rich thrombi in the glomerular microvasculature indicates ...

journal_title：Blood

authors： Licht C,Pluthero FG,Li L,Christensen H,Habbig S,Hoppe B,Geary DF,Zipfel PF,Kahr WH

更新日期：2009-11-12 00:00:00

abstract：:Human embryonic stem cells are a promising tool to study events associated with the earliest ontogenetic stages of hematopoiesis. We describe the generation of erythroid cells from hES (H1) by subsequent processing of cells present at early and late stages of embryoid body (EB) differentiation. Kinetics of hematopoiet...

journal_title：Blood

authors： Chang KH,Nelson AM,Cao H,Wang L,Nakamoto B,Ware CB,Papayannopoulou T

更新日期：2006-09-01 00:00:00

abstract：:Toll-like receptors orchestrate rapid local protective innate-immune responses to invading pathogens and optimize leukocyte priming of subsequent adaptive responses. Paradoxically, systemic excess of the TLR2 ligand, bacterial lipoprotein (BLP), suppresses peripheral inflammatory responses. Here, we demonstrate that t...

journal_title：Blood

authors： McKimmie CS,Moore M,Fraser AR,Jamieson T,Xu D,Burt C,Pitman NI,Nibbs RJ,McInnes IB,Liew FY,Graham GJ

更新日期：2009-04-30 00:00:00

abstract：:The anemia of chronic disease (ACD) results from 3 major processes: slightly shortened red cell survival, impaired reticuloendothelial system iron mobilization, and impaired erythropoiesis. Hepcidin is an acute-phase protein with specific iron regulatory properties, which, along with the anemia seen with increased hep...

journal_title：Blood

authors： Dallalio G,Law E,Means RT Jr

更新日期：2006-04-01 00:00:00

abstract：:Treatment outcome of acute myeloid leukemia (AML) in elderly patients remains unsatisfactory. It has been shown that the infusion of granulocyte colony-stimulating factor-mobilized donor peripheral blood stem cells (G-PBSCs) can enhance graft-versus-leukemia effects and speed hematopoietic recovery. Fifty-eight AML pa...

journal_title：Blood

authors： Guo M,Hu KX,Yu CL,Sun QY,Qiao JH,Wang DH,Liu GX,Sun WJ,Wei L,Sun XD,Huang YJ,Qiao JX,Dong Z,Ai HS

更新日期：2011-01-20 00:00:00

abstract：:We have investigated the structure of the Ig heavy (IGH) chain locus in 309 cases of acute leukemia. Seventy-one cases of B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were analyzed: in six cases deletion of joining (JH) segments in the presence of cytogenetically normal chromosome 14 was observed. Similar...

journal_title：Blood

authors： Dyer MJ,Heward JM,Zani VJ,Buccheri V,Catovsky D

更新日期：1993-08-01 00:00:00

abstract：:It has been suggested that neutrophil tissue repopulation following bone marrow transplantation (BMT) serves as an earlier and more relevant marker of susceptibility to infection than circulating neutrophil counts. In a previous study using an oral rinse protocol, we found that oral neutrophil recovery always preceded...

journal_title：Blood

authors： Cheretakis C,Leung R,Sun CX,Dror Y,Glogauer M

更新日期：2006-10-15 00:00:00

abstract：:The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement, and criteria for renal response have never been validated. Newly diagnosed patients from the Pavia (n = 461, testing cohort) and Heidelberg (n = 271, val...

journal_title：Blood

authors： Palladini G,Hegenbart U,Milani P,Kimmich C,Foli A,Ho AD,Vidus Rosin M,Albertini R,Moratti R,Merlini G,Schönland S

更新日期：2014-10-09 00:00:00

abstract：:We investigated treatment with gemtuzumab ozogamicin (GO) in 51 patients aged 65 years or older with newly diagnosed acute myeloid leukemia (AML), refectory anemia (RA) with excess of blasts in transformation, or RA with excess blasts. GO was given in doses of 9 mg/m(2) of body-surface area on days 1 and 8 or, therape...

journal_title：Blood

authors： Estey EH,Thall PF,Giles FJ,Wang XM,Cortes JE,Beran M,Pierce SA,Thomas DA,Kantarjian HM

更新日期：2002-06-15 00:00:00

abstract：:The development of peroxidase (PO) reaction in the nuclear envelope (NE) and endoplasmic reticulum (ER) of monocytes differentiating in vitro and its relationship with arachidonic acid metabolism were studied. The PO, as visualized by the diaminobenzidine (DAB) technique, appeared in the NE and ER of the majority of m...

journal_title：Blood

authors： Deimann W,Seitz M,Gemsa D,Fahimi HD

更新日期：1984-08-01 00:00:00

abstract：:Interleukin-8 (IL-8) belongs to a family of chemoattractant cytokines involved in chemotaxis and activation of neutrophils. As in vivo administration of IL-8 induces granulocytosis and the release of immature white blood cells into the circulation, we assessed a possible mobilizing effect of IL-8 on myeloid progenitor...

journal_title：Blood

authors： Laterveer L,Lindley IJ,Hamilton MS,Willemze R,Fibbe WE

更新日期：1995-04-15 00:00:00

abstract：:Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells....

journal_title：Blood

authors： Keren Z,Naor S,Nussbaum S,Golan K,Itkin T,Sasaki Y,Schmidt-Supprian M,Lapidot T,Melamed D

更新日期：2011-03-17 00:00:00

abstract：:Primary effusion lymphoma (PEL) constitutes a subset of non-Hodgkin lymphoma whose incidence is highly increased in the context of HIV infection. Kaposi sarcoma-associated herpesvirus is the causative agent of PEL. The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a critical role in cell proliferation a...

journal_title：Blood

authors： Bhatt AP,Bhende PM,Sin SH,Roy D,Dittmer DP,Damania B

更新日期：2010-06-03 00:00:00

abstract：:Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (e.g., p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therap...

journal_title：Blood

authors： Ranganathan P,Yu X,Na C,Santhanam R,Shacham S,Kauffman M,Walker A,Klisovic R,Blum W,Caligiuri M,Croce CM,Marcucci G,Garzon R

更新日期：2012-08-30 00:00:00

abstract：:In this issue of Blood, Roach and colleagues show that individuals with prior superficial venous thrombosis are at increased risk of developing venous thromboembolism when exposed to acquired clinical risk factors. ...

journal_title：Blood

authors： Bates SM

更新日期：2013-12-19 00:00:00