A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.

abstract：:Human herpesvirus-8 (HHV-8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction caused by a cytokine storm often including interleukin-6. iMCD accou...

journal_title：Blood

authors： Fajgenbaum DC,Uldrick TS,Bagg A,Frank D,Wu D,Srkalovic G,Simpson D,Liu AY,Menke D,Chandrakasan S,Lechowicz MJ,Wong RS,Pierson S,Paessler M,Rossi JF,Ide M,Ruth J,Croglio M,Suarez A,Krymskaya V,Chadburn A,Colleoni

更新日期：2017-03-23 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:Interleukin-21 (IL-21) is a recently described immunoregulatory cytokine. It has been identified as a very potent immunotherapeutic agent in several cancer types in animal models, and clinical studies are ongoing. IL-21 belongs to the type I cytokine family of which other members, ie, IL-2, IL-15, and IL-4, have been ...

journal_title：Blood

authors： Castermans K,Tabruyn SP,Zeng R,van Beijnum JR,Eppolito C,Leonard WJ,Shrikant PA,Griffioen AW

更新日期：2008-12-15 00:00:00

abstract：:The membrane skeleton of normal erythrocytes is largely organized into a hexagonal lattice of junctional complexes (JC) crosslinked by spectrin tetramers, and occasional double tetramers and hexamers. To explore possible skeletal alterations in hereditary spherocytosis (HS), elliptocytosis (HE), and pyropoikilocytosis...

journal_title：Blood

authors： Liu SC,Derick LH,Agre P,Palek J

更新日期：1990-07-01 00:00:00

abstract：:Normal human B cell proliferation is controlled by various immunoregulatory signals including the T cell-derived lymphokine B cell growth factor (BCGF). The role of BCGF in the regulation of malignant B cell proliferation is unclear. Therefore, we studied the proliferative response of purified chronic lymphocytic leuk...

journal_title：Blood

authors： Perri RT

更新日期：1986-04-01 00:00:00

abstract：:In an attempt to decrease the relapse rate after bone marrow transplantation (BMT) for advanced acute leukemia, we initiated studies using 131I-labeled anti-CD45 antibody (BC8) to deliver radiation specifically to hematopoietic tissues, followed by a standard transplant preparative regimen. Biodistribution studies wer...

journal_title：Blood

authors： Matthews DC,Appelbaum FR,Eary JF,Fisher DR,Durack LD,Bush SA,Hui TE,Martin PJ,Mitchell D,Press OW

更新日期：1995-02-15 00:00:00

abstract：:The c-myc oncoprotein accelerates programmed cell death (apoptosis) after growth factor deprivation or pharmacological insult in many cell lines. We have shown that max, the obligate c-myc heterodimeric partner protein, also promotes apoptosis after serum withdrawal in NIH3T3 fibroblasts or cytokine deprivation in int...

journal_title：Blood

authors： Nesbit CE,Fan S,Zhang H,Prochownik EV

更新日期：1998-08-01 00:00:00

abstract：:Surprisingly little is known about the interaction of human blood mononuclear cells with viruses. Here, we show that monocytes are the predominant cell type infected when peripheral blood mononuclear cells are exposed to viruses ex vivo. Remarkably, infection with vesicular stomatitis virus, vaccinia virus, and a vari...

journal_title：Blood

authors： Hou W,Gibbs JS,Lu X,Brooke CB,Roy D,Modlin RL,Bennink JR,Yewdell JW

更新日期：2012-03-29 00:00:00

abstract：:The extravasation of leukocytes from the lumen of the vessel to a site of inflammation requires specific binding events. The interaction of leukocytes with endothelium, via specific receptors, may provide intracellular signals that activate extravasating cells. In the present study, we have investigated the production...

journal_title：Blood

authors： Lukacs NW,Strieter RM,Elner V,Evanoff HL,Burdick MD,Kunkel SL

更新日期：1995-10-01 00:00:00

abstract：:Many B-lineage-specific genes are down-regulated in Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL). We investigated the involvement of epigenetic modifications in gene silencing in cHL cell lines and in microdissected primary HRS cells. We assessed the expression and methylation status of C...

journal_title：Blood

authors： Ushmorov A,Leithäuser F,Sakk O,Weinhaüsel A,Popov SW,Möller P,Wirth T

更新日期：2006-03-15 00:00:00

abstract：:Human platelets are aggregated and induced to release their granule contents and form thromboxane by peptides as short as 6-amino acid residues (SFLLRN) corresponding to the newly released N-terminus of the thrombin receptor that is cleaved by thrombin. Using washed platelets, we found that these responses to SFLLRN (...

journal_title：Blood

authors： Kinlough-Rathbone RL,Rand ML,Packham MA

更新日期：1993-07-01 00:00:00

abstract：:The cell-surface expression and the functional status of the CD95/Fas antigen on primitive hematopoietic progenitors (PHPs) freshly isolated from human fetal liver (FL) were studied. PHPs were phenotypically defined as CD34++ CD38 -/+ cells. The most immature subfractions of PHPs, CD34++CD38- and CD34+2CD38+ FL cells,...

journal_title：Blood

authors： Bárcena A,Park SW,Banapour B,Muench MO,Mechetner E

更新日期：1996-09-15 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cells have radically improved the treatment of B cell-derived malignancies by targeting CD19. The success has not yet expanded to treat acute myeloid leukemia (AML). We developed a Sequentially Tumor-Selected Antibody and Antigen Retrieval (STAR) system to rapidly isolate multiple nan...

journal_title：Blood

authors： He X,Feng Z,Ma J,Ling S,Cao Y,Gurung B,Wu Y,Katona BW,O'Dwyer KP,Siegel DL,June CH,Hua X

更新日期：2020-03-05 00:00:00

abstract：:Human embryonic stem cells are a promising tool to study events associated with the earliest ontogenetic stages of hematopoiesis. We describe the generation of erythroid cells from hES (H1) by subsequent processing of cells present at early and late stages of embryoid body (EB) differentiation. Kinetics of hematopoiet...

journal_title：Blood

authors： Chang KH,Nelson AM,Cao H,Wang L,Nakamoto B,Ware CB,Papayannopoulou T

更新日期：2006-09-01 00:00:00

abstract：:Chronic myelocytic leukemia (CML) is a common neoplasm of hematopoietic pluripotent stem cells. Although the evolution from chronic phase to blast crisis (BC) in CML patients is an inevitable clinical feature, little is understood about the mechanisms responsible for the transformation. We have previously performed al...

journal_title：Blood

authors： Mori N,Morosetti R,Spira S,Lee S,Ben-Yehuda D,Schiller G,Landolfi R,Mizoguchi H,Koeffler HP

更新日期：1998-11-01 00:00:00

abstract：:In multiple myeloma, cytogenetic changes are important predictors of patient outcome. In this setting, the most important changes are deletion 17p, del(17p), and translocation of chromosomes 4 and 14, t(4;14), conferring a poor outcome. However, a certain degree of heterogeneity is observed in the survival of these hi...

journal_title：Blood

authors： Hebraud B,Magrangeas F,Cleynen A,Lauwers-Cances V,Chretien ML,Hulin C,Leleu X,Yon E,Marit G,Karlin L,Roussel M,Stoppa AM,Belhadj K,Voillat L,Garderet L,Macro M,Caillot D,Mohty M,Facon T,Moreau P,Attal M,Munshi N

更新日期：2015-03-26 00:00:00

abstract：:Soluble HLA-G (sHLA-G) inhibits natural killer (NK) cell functions. Here, we investigated sHLA-G-mediated modulation of (1) chemokine receptor and NK receptor expression and function and (2) cytokine and chemokine secretion in CD56bright and CD56dim NK cells. sHLA-G-treated or untreated peripheral blood (PB) and tonsi...

journal_title：Blood

authors： Morandi F,Ferretti E,Castriconi R,Dondero A,Petretto A,Bottino C,Pistoia V

更新日期：2011-11-24 00:00:00

abstract：:Human immunodeficiency virus-1 (HIV-1)-Tat, the transactivating gene product of HIV-1, has been shown to interact with different cell types, inducing gene expression, altering their growth and migratory behavior. In this study we examined whether Tat might affect functions of acquired immunodeficiency syndrome (AIDS)-...

journal_title：Blood

authors： Chirivi RG,Taraboletti G,Bani MR,Barra L,Piccinini G,Giacca M,Bussolino F,Giavazzi R

更新日期：1999-09-01 00:00:00

abstract：:Four of 9 PAX transcription factor genes have been associated with chromosomal translocations in human tumors, although their oncogenic potential has not yet been demonstrated in transgenic mouse models. The B-lymphoidPAX5 gene participates in the generation of the t(9;14)(p13;q32) translocation in germinal center B c...

journal_title：Blood

authors： Souabni A,Jochum W,Busslinger M

更新日期：2007-01-01 00:00:00

abstract：:B-lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI, BCMA, and BAFF-R, which are expressed by mature B cells. How these receptors are differentially activated is not entirely understood, because the primary ligand BAFF binds to all three. We searched for alterna...

journal_title：Blood

authors： Bischof D,Elsawa SF,Mantchev G,Yoon J,Michels GE,Nilson A,Sutor SL,Platt JL,Ansell SM,von Bulow G,Bram RJ

更新日期：2006-04-15 00:00:00

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:We made a disease-specific comparison of unrelated cord blood (CB) recipients and human leukocyte antigen allele-matched unrelated bone marrow (BM) recipients among 484 patients with acute myeloid leukemia (AML; 173 CB and 311 BM) and 336 patients with acute lymphoblastic leukemia (ALL; 114 CB and 222 BM) who received...

journal_title：Blood

authors： Atsuta Y,Suzuki R,Nagamura-Inoue T,Taniguchi S,Takahashi S,Kai S,Sakamaki H,Kouzai Y,Kasai M,Fukuda T,Azuma H,Takanashi M,Okamoto S,Tsuchida M,Kawa K,Morishima Y,Kodera Y,Kato S,Japan Cord Blood Bank Network.

更新日期：2009-02-19 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is dependent on assessment in preclinical murine models of cGVHD. Rho-associated kinase 2 (ROCK2) recently was shown to be implicated in regulation of inter...

journal_title：Blood

authors： Flynn R,Paz K,Du J,Reichenbach DK,Taylor PA,Panoskaltsis-Mortari A,Vulic A,Luznik L,MacDonald KK,Hill GR,Nyuydzefe MS,Weiss JM,Chen W,Trzeciak A,Serody JS,Aguilar EG,Murphy WJ,Maillard I,Munn D,Koreth J,Cutler CS

更新日期：2016-04-28 00:00:00

abstract：:Endotoxin-free purified recombinant human erythroid-potentiating activity (EPA) was administered to normal and bled mice. In anemic ICR mice EPA treatment led to a significant increase in the number of reticulocytes in the peripheral blood and erythroid precursors in the spleen. Stimulation of CFU-E and BFU-E in the s...

journal_title：Blood

authors： Niskanen E,Gasson JC,Teates CD,Golde DW

更新日期：1988-08-01 00:00:00

abstract：:In a previous study, we reported that a single injection of cyclophosphamide (CTX) in tumor-bearing mice resulted in tumor eradication when the animals were subsequently injected with tumor-sensitized lymphocytes. Notably, CTX acted by inducing bystander effects on T cells, and the response to the combined CTX/adoptiv...

journal_title：Blood

authors： Schiavoni G,Mattei F,Di Pucchio T,Santini SM,Bracci L,Belardelli F,Proietti E

更新日期：2000-03-15 00:00:00

abstract：:Previous studies demonstrated that Kit activation confers radioprotection. However, the mechanism by which Kit signaling interferes with cellular response to ionizing radiation (IR) has not been firmly established. Based on the role of the sphingomyelin (SM) cycle apoptotic pathway in IR-induced apoptosis, we hypothes...

journal_title：Blood

authors： Maddens S,Charruyer A,Plo I,Dubreuil P,Berger S,Salles B,Laurent G,Jaffrézou JP

更新日期：2002-08-15 00:00:00

abstract：:Serine proteinase inhibitors (serpins) play a vital regulatory role in a wide range of biological processes, and serpins from viruses have been implicated in pathogen evasion of the host defence system. For the first time, we report a functional serpin gene from nematodes that may function in this manner. This gene, n...

journal_title：Blood

authors： Zang X,Yazdanbakhsh M,Jiang H,Kanost MR,Maizels RM

更新日期：1999-08-15 00:00:00

abstract：:Subsets of natural killer (NK) cells are characterized by the expression of inhibitory and/or stimulatory receptors specific for major histocompatibility complex (MHC) class I determinants. In mice, these include the Ly49 family of molecules. One mechanism by which tumor cells may evade NK cell killing is by expressin...

journal_title：Blood

authors： Koh CY,Blazar BR,George T,Welniak LA,Capitini CM,Raziuddin A,Murphy WJ,Bennett M

更新日期：2001-05-15 00:00:00

abstract：:We describe the membrane localization of a new platelet-specific alloantigen, designated Naka, that is involved in refractoriness to HLA-matched platelet transfusions. By indirect immunoprecipitation, anti-Naka antibody precipitated a single, radiolabeled platelet membrane protein with a molecular weight (mol wt) of 9...

journal_title：Blood

authors： Tomiyama Y,Take H,Ikeda H,Mitani T,Furubayashi T,Mizutani H,Yamamoto N,Tandon NN,Sekiguchi S,Jamieson GA

更新日期：1990-02-01 00:00:00

abstract：:Adherent cell layers and their associated extracellular matrices form when human marrow is incubated in cultures containing hydrocortisone and horse serum. These stromal layers contain cells positive for alkaline phosphatase; secrete collagens types I and III and fibronectin, bind the anti-actin monoclonal antibodies ...

journal_title：Blood

authors： Liesveld JL,Abboud CN,Duerst RE,Ryan DH,Brennan JK,Lichtman MA

更新日期：1989-05-15 00:00:00