Abstract:
:Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. Thus, depletion of B cells in old mice was followed by expansion of multipotent primitive progenitors and common lymphoid progenitors, a revival of B-lymphopoiesis in the bone marrow, and generation of a rejuvenated peripheral compartment that enhanced the animal's immune responsiveness to antigenic stimulation. Collectively, our results suggest that immunosenescence in the B-lineage is not irreversible and that depletion of the long-lived B cells in old mice rejuvenates the B-lineage and enhances immune competence.
journal_name
Bloodjournal_title
Bloodauthors
Keren Z,Naor S,Nussbaum S,Golan K,Itkin T,Sasaki Y,Schmidt-Supprian M,Lapidot T,Melamed Ddoi
10.1182/blood-2010-09-307983subject
Has Abstractpub_date
2011-03-17 00:00:00pages
3104-12issue
11eissn
0006-4971issn
1528-0020pii
blood-2010-09-307983journal_volume
117pub_type
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