Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood.

abstract：:Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for patients with a BPD is often unavailable. Many specialized tests are usually required to reach a put...

journal_title：Blood

authors： Simeoni I,Stephens JC,Hu F,Deevi SV,Megy K,Bariana TK,Lentaigne C,Schulman S,Sivapalaratnam S,Vries MJ,Westbury SK,Greene D,Papadia S,Alessi MC,Attwood AP,Ballmaier M,Baynam G,Bermejo E,Bertoli M,Bray PF,Bury L,

更新日期：2016-06-09 00:00:00

abstract：:Survivin and XIAP, members of the protein family known as the inhibitors of apoptosis, interfere with the activation of caspases, called the "cell death executioners." We examined Survivin (n = 116) and XIAP (n = 172) expression in primary acute myeloid leukemia (AML) blasts and assessed the impact of their expression...

journal_title：Blood

authors： Carter BZ,Kornblau SM,Tsao T,Wang RY,Schober WD,Milella M,Sung HG,Reed JC,Andreeff M

更新日期：2003-12-01 00:00:00

abstract：:The interaction of von Willebrand factor (vWF) with the alpha v beta 3 integrin of human umbilical vein endothelial cells is dependent on the RGD sequence present at residues 1744-1746 of the mature vWF subunit. We compared vWF and its two dimeric fragments, SpIII (residues 1-1365) and SpII (residues 1366-2050), as ad...

journal_title：Blood

authors： Denis C,Williams JA,Lu X,Meyer D,Baruch D

更新日期：1993-12-15 00:00:00

abstract：:The interaction of thrombin with plasminogen activator inhibitor 1 (PAI-1) is shown to result in the simultaneous formation of both cleaved PAI-1 and a sodium dodecyl sulfate-stable thrombin-PAI-1 complex. The kinetics of this reaction can be described by a "suicide substrate" mechanism that includes a branched reacti...

journal_title：Blood

authors： van Meijer M,Smilde A,Tans G,Nesheim ME,Pannekoek H,Horrevoets AJ

更新日期：1997-09-01 00:00:00

abstract：:The successful induction of a T-cell-mediated tumor-protective immunity against poorly immunogenic malignancies remains a major challenge for cancer immunotherapy. We achieved this by immunization with a tyrosine hydroxylase (mTH)-based DNA vaccine, enhanced with the posttranscriptional regulatory acting RNA element (...

journal_title：Blood

authors： Pertl U,Wodrich H,Ruehlmann JM,Gillies SD,Lode HN,Reisfeld RA

更新日期：2003-01-15 00:00:00

abstract：:Current treatment strategies for chronic lymphocytic leukemia (CLL) involve a combination of conventional chemotherapeutics, monoclonal antibodies, and targeted signaling inhibitors. However, CLL remains largely incurable, with drug resistance and treatment relapse a common occurrence, leading to the search for novel ...

journal_title：Blood

authors： Blunt MD,Carter MJ,Larrayoz M,Smith LD,Aguilar-Hernandez M,Cox KL,Tipton T,Reynolds M,Murphy S,Lemm E,Dias S,Duncombe A,Strefford JC,Johnson PW,Forconi F,Stevenson FK,Packham G,Cragg MS,Steele AJ

更新日期：2015-06-25 00:00:00

abstract：:Shear-induced platelet aggregation (SIPA) involves the sequential interaction of von Willebrand factor (VWF) with both glycoprotein Ib (GPIb) and alphaIIbbeta3 receptors. Type 2B recombinant VWF (2B-rVWF), characterized by an increased affinity for GPIb, induces strong SIPA at a high shear rate (4000 s-1). Despite the...

journal_title：Blood

authors： Mekrache M,Bachelot-Loza C,Ajzenberg N,Saci A,Legendre P,Baruch D

更新日期：2003-06-01 00:00:00

abstract：:We have shown previously that the cause of anemia in healthy elderly subjects can usually not be identified. In this study, hematopoiesis was examined in 18 healthy elderly subjects with unexplained anemia and in 15 young and 15 healthy elderly individuals without anemia. No reduction in circulating testosterone was n...

journal_title：Blood

authors： Lipschitz DA,Udupa KB,Milton KY,Thompson CO

更新日期：1984-03-01 00:00:00

abstract：:Molecular mechanisms by which the Src homology 2 domain-containing inositol 5-phosphatase (SHIP) negatively regulates phagocytosis in macrophages are unclear. We addressed the issue using bone marrow-derived macrophages from FcgammaR- or SHIP-deficient mice. Phagocytic activities of macrophages from FcgammaRII(b)(-/-)...

journal_title：Blood

authors： Nakamura K,Malykhin A,Coggeshall KM

更新日期：2002-11-01 00:00:00

abstract：:The promising activity of BET protein inhibitors (BETi's) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of BETi-persister/resistance (BETi-P/R) in human postmyeloproliferative neoplasm (post-MPN) secondary AML (sAML) cells demonstrated accessible and active chromatin i...

journal_title：Blood

authors： Saenz DT,Fiskus W,Mill CP,Perera D,Manshouri T,Lara BH,Karkhanis V,Sharma S,Horrigan SK,Bose P,Kadia TM,Masarova L,DiNardo CD,Borthakur G,Khoury JD,Takahashi K,Bhaskara S,Lin CY,Green MR,Coarfa C,Crews CM,Versto

更新日期：2020-04-09 00:00:00

abstract：:High doses of recombinant factor VIIa are useful in managing bleeding in hemophiliacs with inhibitors. Whether this therapeutic effect of factor VIIa is dependent on tissue factor (TF) is a matter of debate. We examined the ability of freshly isolated human monocytes (which lack TF) to support the activation of coagul...

journal_title：Blood

authors： Hoffman M,Monroe DM,Roberts HR

更新日期：1994-01-01 00:00:00

abstract：:The activation of murine dendritic cells by Toxoplasma gondii has recently been shown to depend on a parasite protein that signals through the chemokine receptor CCR5. Here we demonstrate that this molecule, cyclophilin-18 (C-18), is an inhibitor of HIV-1 cell fusion and infection with cell-free virus. T gondii C-18 e...

journal_title：Blood

authors： Golding H,Aliberti J,King LR,Manischewitz J,Andersen J,Valenzuela J,Landau NR,Sher A

更新日期：2003-11-01 00:00:00

abstract：:The American Society of Hematology (ASH) turns 50 years old in 2008, and we have much to celebrate. Over those years the Society established its principles: to promote both the art and science of hematology and to hold a high-quality Educational Meeting. ASH membership has grown from a few hundred curious attendees at...

journal_title：Blood

authors： Jaffé ER,Kaushansky K

更新日期：2008-01-01 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of Merkel cell carcinomas (MCC). Yet, clonal integration and truncating mutations of the large T antigen (LTAg) of MCPyV are restricted to MCC. We tested the presence and mutations of MCPyV in highly purified leukemic cells of 70 chronic lymphocytic leu...

journal_title：Blood

authors： Pantulu ND,Pallasch CP,Kurz AK,Kassem A,Frenzel L,Sodenkamp S,Kvasnicka HM,Wendtner CM,Zur Hausen A

更新日期：2010-12-09 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:A cone and plate viscometer and Coulter Counter were used to study platelet modulation of polymorphonuclear leukocyte (PMNL) aggregation caused by controlled shear stress. As an index of aggregation, the large-particle percentage (LPP) was calculated. This represents the ratio of aggregated cell count to total cell co...

journal_title：Blood

authors： Rhee BG,Hall ER,McIntire LV

更新日期：1986-01-01 00:00:00

abstract：:Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for the main...

journal_title：Blood

authors： Quesniaux VF,Clark SC,Turner K,Fagg B

更新日期：1992-09-01 00:00:00

abstract：:Natural killer (NK) cell activity is severely impaired in untreated patients with hairy cell leukemia (HCL). In an attempt to investigate whether this impairment is related to a defect at the target cell binding and/or at the post target cell binding level, we evaluated the peripheral blood mononuclear cells (PBMC) of...

journal_title：Blood

authors： Trentin L,Zambello R,Agostini C,Ambrosetti A,Chisesi T,Raimondi R,Bulian P,Pizzolo G,Semenzato G

更新日期：1990-04-01 00:00:00

abstract：:Among the most striking morphological features of acute nonlymphoblastic leukemias (ANLL) is the occurrence of eosinophilic cytoplasmic inclusions known as Auer rods on Auer bodies. We examined immature myeloid cells from the peripheral blood of 9 human fetuses of 16-19 wk gestation for the presence of such structures...

journal_title：Blood

authors： Newburger PE,Novak TJ,McCaffrey RP

更新日期：1983-03-01 00:00:00

abstract：:Following allogeneic hematopoietic stem cell transplantation (alloHSCT), children are at risk of life-threatening pneumococcal infections. Whereas vaccination with polysaccharide vaccines fails to elicit protective immunity in most alloHSC transplant recipients, pneumococcal conjugate vaccines may effectively prevent ...

journal_title：Blood

authors： Meisel R,Kuypers L,Dirksen U,Schubert R,Gruhn B,Strauss G,Beutel K,Groll AH,Duffner U,Blütters-Sawatzki R,Holter W,Feuchtinger T,Grüttner HP,Schroten H,Zielen S,Ohmann C,Laws HJ,Dilloo D,Impfung von Kindern nach allog

更新日期：2007-03-15 00:00:00

abstract：:Interleukin-25 (IL-25) is a recently described T helper 2 (T(H)2) cell-derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non-T-cell population. Here, we show that mast cells are also potent IL-25-producing cells. When bone marrow-derived mast cel...

journal_title：Blood

authors： Ikeda K,Nakajima H,Suzuki K,Kagami S,Hirose K,Suto A,Saito Y,Iwamoto I

更新日期：2003-05-01 00:00:00

abstract：:We established a model of canine marrow autografts after 9.2 Gy total body irradiation (TBI) to study the role of class II antigens in hematopoietic stem cell growth and differentiation. Twenty dogs were given 9.2 Gy TBI, marrow, and intravenous (IV) murine anti-class II monoclonal antibody (MoAb). Infusion of 0.6 mg/...

journal_title：Blood

authors： Greinix HT,Ladiges WC,Graham TC,Maslan S,Raff RF,Sandmaier BM,Appelbaum FR,Schuening FG,Deeg HJ,Storb R

更新日期：1991-10-15 00:00:00

abstract：:Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking. By combining chromatin immunoprecipitation se...

journal_title：Blood

authors： Kurotaki D,Osato N,Nishiyama A,Yamamoto M,Ban T,Sato H,Nakabayashi J,Umehara M,Miyake N,Matsumoto N,Nakazawa M,Ozato K,Tamura T

更新日期：2013-03-07 00:00:00

abstract：:TLRs expressed on dendritic cells (DCs) differentially activate DCs when activated alone or in combination, inducing distinct cytokines and costimulatory molecules that influence T-cell responses. Defining the requirements of DCs to program T cells during priming to become memory rather than effector cells could enhan...

journal_title：Blood

authors： Pufnock JS,Cigal M,Rolczynski LS,Andersen-Nissen E,Wolfl M,McElrath MJ,Greenberg PD

更新日期：2011-06-16 00:00:00

abstract：:Low concentrations of As(2)O(3) (

journal_title：Blood

authors： Jing Y,Dai J,Chalmers-Redman RM,Tatton WG,Waxman S

更新日期：1999-09-15 00:00:00

abstract：:We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, ...

journal_title：Blood

authors： Yokota T,Oritani K,Takahashi I,Ishikawa J,Matsuyama A,Ouchi N,Kihara S,Funahashi T,Tenner AJ,Tomiyama Y,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：:The beta-globin locus control region (LCR) is a large DNA element that is required for high-level expression of beta-like globin genes from the endogenous mouse locus or in transgenic mice carrying the human beta-globin locus. The LCR encompasses 6 DNaseI hypersensitive sites (HSs) that bind transcription factors. The...

journal_title：Blood

authors： Hu X,Bulger M,Bender MA,Fields J,Groudine M,Fiering S

更新日期：2006-01-15 00:00:00

abstract：:The bcl-2 gene is translocated into the Ig loci in about 80% of human follicular lymphomas and in 10% of B-type chronic lymphocytic leukemias (B-CLL), resulting in a high level of expression. We have compared the expression of bcl-2 transcripts and protein in B-CLL cells in their normal equivalent CD5+ B cells and in ...

journal_title：Blood

authors： Schena M,Larsson LG,Gottardi D,Gaidano G,Carlsson M,Nilsson K,Caligaris-Cappio F

更新日期：1992-06-01 00:00:00

abstract：:Hematopoietic growth factors (HGFs) interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) individually have been shown to increase the percentage of acute myeloid leukemia (AML) blasts in S phase and enhance the cytotoxic effects of Ara-C against these blasts in culture. We compared in vit...

journal_title：Blood

authors： Bhalla K,Holladay C,Arlin Z,Grant S,Ibrado AM,Jasiok M

更新日期：1991-11-15 00:00:00

abstract：:Familial pseudohyperkalemia is a "leaky red blood cell" condition in which the cells show a temperature-dependent loss of potassium (K) from red blood cells when stored at room temperature, manifesting as apparent hyperkalemia. The red blood cells show a reduced lifespan in vivo but there is no frank hemolysis. Studie...

journal_title：Blood

authors： Iolascon A,Stewart GW,Ajetunmobi JF,Perrotta S,Delaunay J,Carella M,Zelante L,Gasparini P

更新日期：1999-05-01 00:00:00