The American Society of Hematology: a success at age 50.

abstract：:Recombinant erythropoietin (EPO) and iron substitution are a standard of care for treatment of anemias associated with chronic inflammation, including anemia of chronic kidney disease. A black box warning for EPO therapy and concerns about negative side effects related to high-dose iron supplementation as well as the ...

journal_title：Blood

authors： Petzer V,Tymoszuk P,Asshoff M,Carvalho J,Papworth J,Deantonio C,Bayliss L,Wake MS,Seifert M,Brigo N,Valente de Souza L,Hilbe R,Grubwieser P,Demetz E,Dichtl S,Volani C,Berger S,Böhm F,Hoffmann A,Pfeifhofer-Obermair C

更新日期：2020-08-27 00:00:00

abstract：UNLABELLED:Better methods to characterize normal human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facilitate improving recovery rates in transplanted patients.We now show that 5-fold more human myeloid cells are produced in sublethally irradiated NOD/SCID-IL-2Receptor-γchain-n...

journal_title：Blood

authors： Miller PH,Cheung AM,Beer PA,Knapp DJ,Dhillon K,Rabu G,Rostamirad S,Humphries RK,Eaves CJ

更新日期：2013-01-31 00:00:00

abstract：:Interleukin-1beta (IL-1beta) elevates H- and L-ferritin subunit synthesis in both human hepatoma cells (HepG2) and primary human umbilical vein endothelial cells. Ferritin induction is greater than the increase in total HepG2 protein synthesis in response to IL-1. IL-6 causes a moderate increase in L-subunit synthesis...

journal_title：Blood

authors： Rogers JT

更新日期：1996-03-15 00:00:00

abstract：:The survival of patients with aggressive non-Hodgkin lymphoma (NHL) is increasing, but the incidence of secondary cancer and late toxicity is poorly defined for those treated with cyclophosphamide-hydroxydaunomycin/doxorubicin-Oncovin-prednisone (CHOP)-like chemotherapy. From February 1984 to January 1998, 2837 patien...

journal_title：Blood

authors： André M,Mounier N,Leleu X,Sonet A,Brice P,Henry-Amar M,Tilly H,Coiffier B,Bosly A,Morel P,Haioun C,Gaulard P,Reyes F,Gisselbrecht C,Groupe D'Etude Des Lymphomes De L'Adulte.

更新日期：2004-02-15 00:00:00

abstract：:Under normal conditions, platelets do not adhere to endothelium. However, when platelets or endothelial cells are stimulated by thrombin or cytokines, respectively, platelets bind avidly to endothelium. Because there is accumulating evidence that endothelial cells may become apoptotic under certain proinflammatory or ...

journal_title：Blood

authors： Bombeli T,Schwartz BR,Harlan JM

更新日期：1999-06-01 00:00:00

abstract：:In this issue of Blood, in a first-rate example of collaboration between academia (University of California) and industry (Sangamo), Hoban et al show in situ gene correction of sickle cell anemia (SCA), a prototypical hemoglobinopathy. ...

journal_title：Blood

authors： Tolar J

更新日期：2015-04-23 00:00:00

abstract：:A model of Protein C (PC) activation in vivo was used to investigate the complexing of activated PC (APC) with its plasma inhibitors, PC inhibitor (PCI) and alpha 1-antitrypsin (alpha 1AT). Chimpanzees were infused with a bolus of activated factor X (F.Xa) together with vesicles of phosphatidylcholine and phosphatidyl...

journal_title：Blood

authors： Hoogendoorn H,Nesheim ME,Giles AR

更新日期：1990-06-01 00:00:00

abstract：:We demonstrate a methodology for tracing the clonal history of hematopoietic stem and progenitor cells (HSPCs) behavior in live tissues in 4 dimensions (4D). This integrates genetic combinatorial marking using lentiviral vectors encoding various fluorescent proteins (FPs) with advanced imaging methods. Five FPs: Cerul...

journal_title：Blood

authors： Malide D,Métais JY,Dunbar CE

更新日期：2012-12-20 00:00:00

abstract：:Neutrophils recruited from the blood are key players in the innate immune response. Selectins play critical roles in neutrophil recruitment by mediating their tethering and rolling in inflamed venules. While the roles of P- and E-selectin in this process are well established, the mechanisms of L-selectin-mediated neut...

journal_title：Blood

authors： Shigeta A,Matsumoto M,Tedder TF,Lowe JB,Miyasaka M,Hirata T

更新日期：2008-12-15 00:00:00

abstract：:To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138(+) plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters desc...

journal_title：Blood

authors： Broyl A,Hose D,Lokhorst H,de Knegt Y,Peeters J,Jauch A,Bertsch U,Buijs A,Stevens-Kroef M,Beverloo HB,Vellenga E,Zweegman S,Kersten MJ,van der Holt B,el Jarari L,Mulligan G,Goldschmidt H,van Duin M,Sonneveld P

更新日期：2010-10-07 00:00:00

abstract：:In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the first few hours after stroke, and the utility of current platelet aggregation inhibitors, including GPIIb/IIIa receptor antagonists, and anticoagulants is counterbalanced by the risk of intracerebral bleeding complications...

journal_title：Blood

authors： Stoll G,Kleinschnitz C,Nieswandt B

更新日期：2008-11-01 00:00:00

abstract：:Incubation of human platelets, human neutrophils, or highly metastatic mouse lymphoma cells with sulfate-labeled extracellular matrix (ECM) results in heparanase-mediated release of labeled heparan sulfate cleavage fragments (0.5 less than Kav less than 0.85 on Sepharose 6B). This degradation was inhibited by native h...

journal_title：Blood

authors： Bar-Ner M,Eldor A,Wasserman L,Matzner Y,Cohen IR,Fuks Z,Vlodavsky I

更新日期：1987-08-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification. In an unselected series of 1897 AML cases, 54 patients with an 11q23/MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence...

journal_title：Blood

authors： Schoch C,Schnittger S,Klaus M,Kern W,Hiddemann W,Haferlach T

更新日期：2003-10-01 00:00:00

abstract：:Affinity purified anticardiolipin antibodies (ACLA) raised in rabbits showed cross-reactivities with various negatively charged phospholipids as shown by both the solid phase enzyme-linked immunosorbent assay (ELISA) and inhibition studies. In ELISA, ACLA showed strong cross-reactivity to both sphingomyelin (SM) and p...

journal_title：Blood

authors： Lin YL,Wang CT

更新日期：1992-12-15 00:00:00

abstract：:Human platelets contain tortuous channels in their cytoplasm, the surface-connected or open canalicular system (OCS), that communicate directly with the surrounding medium through openings on the surface membrane. Some workers have suggested that the OCS serves as the egress route for products secreted during the rele...

journal_title：Blood

authors： White JG

更新日期：1987-03-01 00:00:00

abstract：:Vinblastine was administered to anemic baboons to test whether stimulation of Hb F takes place following distortion of erythropoiesis by an M-stage-specific compound. The treatments elicited erythroid cell cytoreduction followed by regeneration. During the phase of reticulocyte reduction, gamma/gamma + beta biosynthet...

journal_title：Blood

authors： Veith R,Papayannopoulou T,Kurachi S,Stamatoyannopoulos G

更新日期：1985-08-01 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00

abstract：:The incidence of chronic lymphocytic leukemia (CLL) in Taiwan is markedly lower than that in Western countries, but we have seen a drastically increasing trend. We explored this distinct incidence trend of CLL for Taiwanese. The epidemiologic data of CLL for Taiwanese and Caucasian Americans during 1986 to 2005 were o...

journal_title：Blood

authors： Wu SJ,Huang SY,Lin CT,Lin YJ,Chang CJ,Tien HF

更新日期：2010-11-25 00:00:00

abstract：:The pathophysiology of iron-induced compromised fertility in women with thalassemia major (TM) was evaluated in 26 adult TM females. Low gonadotropin secretion resulted in reduced ovarian antral follicle count and ovarian volume, but levels of anti-müllerian hormone (AMH), a sensitive marker for ovarian reserve indepe...

journal_title：Blood

authors： Singer ST,Vichinsky EP,Gildengorin G,van Disseldorp J,Rosen M,Cedars MI

更新日期：2011-09-08 00:00:00

abstract：:Platelet factor 4 (PF4) is an abundant platelet alpha-granule C-X-C chemokine that has weak chemotactic potency but strongly inhibits hematopoiesis through an unknown mechanism. We find that PF4 binds to human CD34+ hematopoietic progenitor cells (HPCs) with a median effective concentration of 1 microg/mL but not afte...

journal_title：Blood

authors： Dudek AZ,Nesmelova I,Mayo K,Verfaillie CM,Pitchford S,Slungaard A

更新日期：2003-06-15 00:00:00

abstract：:We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immortalized fetal hepatocytes yields CD34(+) cells that can be expanded in serum-free liquid culture into large numbers of megaloblastic nucleated erythroblasts resembling yolk sac-derived cells. We show here that these pri...

journal_title：Blood

authors： Qiu C,Olivier EN,Velho M,Bouhassira EE

更新日期：2008-02-15 00:00:00

abstract：:Lymphomas in 10 cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied with regard to proliferative activity and apoptosis-related gene expression. All were diffuse large-cell lymphomas, showed mono or oligoclonality and a 9/10 diploid cellular DNA content. Expression of a simian homolog...

journal_title：Blood

authors： Castaños-Vélez E,Heiden T,Ekman M,Lawrence J,Biberfeld G,Biberfeld P

更新日期：1999-02-15 00:00:00

abstract：:Lymphocytes bound at endothelial cell junctions extravasate within minutes. Lymphocyte-endothelial cell binding is mediated by receptors such as vascular cell adhesion molecule 1 (VCAM-1). VCAM-1 activates endothelial cell nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in minutes, and this activity is req...

journal_title：Blood

authors： Deem TL,Cook-Mills JM

更新日期：2004-10-15 00:00:00

abstract：:Minimal residual disease (MRD) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1 ALL) who received allogeneic (n = 9) or autologous (n = 6) bone marrow transplantation (BMT) was evaluated by the polymerase chain reaction (PCR) for the bcr-abl transcript. Twelve patients received BMT a...

journal_title：Blood

authors： Miyamura K,Tanimoto M,Morishima Y,Horibe K,Yamamoto K,Akatsuka M,Kodera Y,Kojima S,Matsuyama K,Hirabayashi N

更新日期：1992-03-01 00:00:00

abstract：:Gene expression patterns of CD34(+)CD38(-) cells derived from human embryonic stem cells (ESCs) were compared with those of cells isolated from adult human bone marrow (BM) using microarrays; 1692 and 1494 genes were expressed at levels at least 3-fold above background in cells from BM and ESCs, respectively. Of these...

journal_title：Blood

authors： Lu SJ,Li F,Vida L,Honig GR

更新日期：2004-06-01 00:00:00

abstract：:We have used a single intensive chemotherapy regimen in the treatment of young patients with diffuse, aggressive, malignant lymphomas. There were two major histologic types of lymphoma in our series: lymphoblastic lymphomas, which presented most often with mediastinal tumor (64%), and undifferentiated lymphomas (mostl...

journal_title：Blood

authors： Magrath IT,Janus C,Edwards BK,Spiegel R,Jaffe ES,Berard CW,Miliauskas J,Morris K,Barnwell R

更新日期：1984-05-01 00:00:00

abstract：:Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patie...

journal_title：Blood

authors： Nakao S,Takamatsu H,Chuhjo T,Ueda M,Shiobara S,Matsuda T,Kaneshige T,Mizoguchi H

更新日期：1994-12-15 00:00:00

abstract：:This study reports a lentiviral gene transfer protocol for efficient transduction of adult human peripheral blood (PB)-derived CD34+ NOD/SCID-repopulating cells (SRCs) using vesicular stomatitis virus-G protein (VSV-G)-pseudotyped lentiviruses encoding for enhanced green fluorescence protein (eGFP). Lentiviral stocks ...

journal_title：Blood

authors： Scherr M,Battmer K,Blömer U,Schiedlmeier B,Ganser A,Grez M,Eder M

更新日期：2002-01-15 00:00:00

abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

journal_title：Blood

authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

更新日期：2007-07-15 00:00:00

abstract：:We designed a trial in which postremission therapy of young patients with de novo acute myeloid leukemia (AML) was decided combining cytogenetics/genetics and postconsolidation levels of minimal residual disease (MRD). After induction and consolidation, favorable-risk patients (FR) were to receive autologous stem cell...

journal_title：Blood

authors： Venditti A,Piciocchi A,Candoni A,Melillo L,Calafiore V,Cairoli R,de Fabritiis P,Storti G,Salutari P,Lanza F,Martinelli G,Luppi M,Mazza P,Martelli MP,Cuneo A,Albano F,Fabbiano F,Tafuri A,Chierichini A,Tieghi A,Frac

更新日期：2019-09-19 00:00:00