Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.


:We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, whereas it had no effect on that of burst-forming units-erythroid or mixed erythroid-myeloid CFU. In addition, adiponectin inhibited proliferation of 4 of 9 myeloid cell lines but did not suppress proliferation of erythroid or lymphoid cell lines except for one cell line. These results suggest that adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells. At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. Aside from inhibiting growth of myelomonocytic progenitors, adiponectin suppressed mature macrophage functions. Treatment of cultured macrophages with adiponectin significantly inhibited their phagocytic activity and their lipopolysaccharide-induced production of tumor necrosis factor alpha. Suppression of phagocytosis by adiponectin is mediated by one of the complement C1q receptors, C1qRp, because this function was completely abrogated by the addition of an anti-C1qRp monoclonal antibody. These observations suggest that adiponectin is an important negative regulator in hematopoiesis and immune systems and raise the possibility that it may be involved in ending inflammatory responses through its inhibitory functions. (Blood. 2000;96:1723-1732)






Yokota T,Oritani K,Takahashi I,Ishikawa J,Matsuyama A,Ouchi N,Kihara S,Funahashi T,Tenner AJ,Tomiyama Y,Matsuzawa Y


Has Abstract


2000-09-01 00:00:00














  • Long-term immunity to measles, mumps, and rubella after allogeneic bone marrow transplantation.

    abstract::A total of 124 patients who had survived at least 2 years after allogeneic bone marrow transplantation (BMT) were studied. Serum was collected at least once yearly. IgG antibodies were determined by enzyme-linked immunosorbent assay for measles and mumps. Rubella antibodies were analyzed by radial hemolysis. Antibody ...


    pub_type: 杂志文章


    authors: Ljungman P,Lewensohn-Fuchs I,Hammarström V,Aschan J,Brandt L,Bolme P,Lönnqvist B,Johansson N,Ringdén O,Gahrton G

    更新日期:1994-07-15 00:00:00

  • T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation.

    abstract::T-cell depletion (TCD) of the donor marrow graft has been shown to reduce the severity of graft-versus-host disease (GVHD) in patients with chronic-phase (CP) chronic myelogenous leukemia (CML) undergoing HLA-identical sibling allogeneic marrow transplantation. However, there has been a corresponding reduction in the ...


    pub_type: 杂志文章


    authors: Drobyski WR,Hessner MJ,Klein JP,Kabler-Babbitt C,Vesole DH,Margolis DA,Keever-Taylor CA

    更新日期:1999-07-15 00:00:00

  • Distinct functional programming of human fetal and adult monocytes.

    abstract::Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-6, and IL-1 are produced in response to in utero i...


    pub_type: 杂志文章


    authors: Krow-Lucal ER,Kim CC,Burt TD,McCune JM

    更新日期:2014-03-20 00:00:00

  • SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.

    abstract::Tumors have several mechanisms to escape from the immune system. One of these involves expression of intracellular anticytotoxic proteins that modulate the execution of cell death. Previously, we have shown that the serine protease inhibitor (serpin) SPI-6, which inactivates the cytotoxic protease granzyme B (GrB), is...


    pub_type: 杂志文章


    authors: Bots M,Kolfschoten IG,Bres SA,Rademaker MT,de Roo GM,Krüse M,Franken KL,Hahne M,Froelich CJ,Melief CJ,Offringa R,Medema JP

    更新日期:2005-02-01 00:00:00

  • Monoclonal antibody F1 binds to the kringle domain of factor XII and induces enhanced susceptibility for cleavage by kallikrein.

    abstract::In a previous study we have shown that monoclonal antibody F1 (MoAb F1), directed against an epitope on the heavy chain of factor XII distinct from the binding site for anionic surfaces, is able to activate factor XII in plasma (Nuijens JH, et al: J Biol Chem 264; 12941, 1989). Here, we studied in detail the mechanism...


    pub_type: 杂志文章


    authors: Ravon DM,Citarella F,Lubbers YT,Pascucci B,Hack CE

    更新日期:1995-12-01 00:00:00

  • The treatment of Burkitt lymphoma in adults.

    abstract::Burkitt lymphoma (BL) is a highly aggressive, B-cell, non-Hodgkin lymphoma (NHL) categorized into endemic, sporadic and immunodeficiency-associated subtypes. BL has distinct pathologic and clinical features, characterized by rapidly progressive tumors with high rates of extranodal involvement. Next generation sequenci...


    pub_type: 杂志文章


    authors: Crombie JL,LaCasce AS

    更新日期:2020-11-10 00:00:00

  • Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease.

    abstract::In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial ...


    pub_type: 杂志文章


    authors: Ertault-Daneshpouy M,Leboeuf C,Lemann M,Bouhidel F,Ades L,Gluckman E,Socié G,Janin A

    更新日期:2004-06-15 00:00:00

  • A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.

    abstract::Angiotensin II (Ang-II) exerts inflammatory activity and is involved in different cardiovascular disorders. This study has evaluated the involvement of tumor necrosis factor alpha (TNFalpha) in the leukocyte accumulation elicited by Ang-II. Ang-II (1 nM intraperitoneally in rats) induced TNFalpha release at 1 hour fol...


    pub_type: 杂志文章


    authors: Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

    更新日期:2007-09-15 00:00:00

  • Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells.

    abstract::Understanding the repopulating characteristics of human hematopoietic stem/progenitor cells is crucial for predicting their performance after transplant into patients receiving high-dose radiochemotherapy. We have previously reported that CD34(+) cord blood (CB) cells can be expanded in vitro for several months in ser...


    pub_type: 杂志文章


    authors: Piacibello W,Sanavio F,Severino A,Danè A,Gammaitoni L,Fagioli F,Perissinotto E,Cavalloni G,Kollet O,Lapidot T,Aglietta M

    更新日期:1999-06-01 00:00:00

  • Defective homing and impaired induction of cytotoxic T cells by BCR/ABL-expressing dendritic cells.

    abstract::Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease arising from a hematopoietic stem cell expressing the BCR/ABL fusion protein. Leukemic and dendritic cells (DCs) develop from the same transformed hematopoietic progenitors. How BCR/ABL interferes with the immunoregulatory function of DCs in ...


    pub_type: 杂志文章


    authors: Mumprecht S,Claus C,Schürch C,Pavelic V,Matter MS,Ochsenbein AF

    更新日期:2009-05-07 00:00:00

  • A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

    abstract::The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...


    pub_type: 杂志文章


    authors: Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

    更新日期:2008-08-15 00:00:00

  • CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection.

    abstract::It has been suggested that human cytomegalovirus (HCMV) evades the immune system by infecting and paralyzing antigen-presenting cells. This view is based mainly on studies of dendritic cells (DCs) obtained after culture of monocytes (moDCs). It is contradicted by the asymptomatic course of HCMV infection in healthy pe...


    pub_type: 杂志文章


    authors: Kvale EØ,Dalgaard J,Lund-Johansen F,Rollag H,Farkas L,Midtvedt K,Jahnsen FL,Brinchmann JE,Olweus J

    更新日期:2006-03-01 00:00:00

  • Prognostic impact of circulating tumor DNA status post-allogeneic hematopoietic stem cell transplantation in AML and MDS.

    abstract::This study was performed to assess the utility of tumor-derived fragmentary DNA, or circulating tumor DNA (ctDNA), for identifying high-risk patients for relapse of acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after undergoing myeloablative allogeneic hematopoietic stem cell transplantation (alloSCT)....


    pub_type: 杂志文章


    authors: Nakamura S,Yokoyama K,Shimizu E,Yusa N,Kondoh K,Ogawa M,Takei T,Kobayashi A,Ito M,Isobe M,Konuma T,Kato S,Kasajima R,Wada Y,Nagamura-Inoue T,Yamaguchi R,Takahashi S,Imoto S,Miyano S,Tojo A

    更新日期:2019-06-20 00:00:00

  • CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.

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    pub_type: 杂志文章


    authors: Lagane B,Chow KY,Balabanian K,Levoye A,Harriague J,Planchenault T,Baleux F,Gunera-Saad N,Arenzana-Seisdedos F,Bachelerie F

    更新日期:2008-07-01 00:00:00

  • Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

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    pub_type: 杂志文章


    authors: Adams GN,LaRusch GA,Stavrou E,Zhou Y,Nieman MT,Jacobs GH,Cui Y,Lu Y,Jain MK,Mahdi F,Shariat-Madar Z,Okada Y,D'Alecy LG,Schmaier AH

    更新日期:2011-04-07 00:00:00

  • HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low-dose dexamethasone.

    abstract::Mechanisms underlying fetal hemoglobin (HbF) reactivation in stress erythropoiesis have not been fully elucidated. We suggested that a key role is played by kit ligand (KL). Because glucocorticoids (GCs) mediate stress erythropoiesis, we explored their capacity to potentiate the stimulatory effect of KL on HbF reactiv...


    pub_type: 杂志文章


    authors: Gabbianelli M,Testa U,Massa A,Morsilli O,Saulle E,Sposi NM,Petrucci E,Mariani G,Peschle C

    更新日期:2003-04-01 00:00:00

  • The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patients.

    abstract::We have previously determined that in African sickle cell anemia (SS) patients three different beta-like globin gene cluster haplotypes are associated with different percent G gamma (one of the two types of non-alpha chains comprising hemoglobin F [HbF]), mean percent HbF, and percent dense cells. We report now that i...


    pub_type: 杂志文章


    authors: Nagel RL,Erlingsson S,Fabry ME,Croizat H,Susuka SM,Lachman H,Sutton M,Driscoll C,Bouhassira E,Billett HH

    更新日期:1991-03-15 00:00:00

  • Coagulation factor XII in thrombosis and inflammation.

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    pub_type: 杂志文章,评审


    authors: Maas C,Renné T

    更新日期:2018-04-26 00:00:00

  • Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish.

    abstract::Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the role o...


    pub_type: 杂志文章


    authors: Shi X,He BL,Ma AC,Guo Y,Chi Y,Man CH,Zhang W,Zhang Y,Wen Z,Cheng T,Leung AY

    更新日期:2015-05-07 00:00:00

  • Interferon-beta interrupts interleukin-6-dependent signaling events in myeloma cells.

    abstract::Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the huma...


    pub_type: 杂志文章


    authors: Berger LC,Hawley RG

    更新日期:1997-01-01 00:00:00

  • Alternating v repeated postremission treatment in adult acute myelogenous leukemia: a randomized phase III study (AML6) of the EORTC Leukemia Cooperative Group.

    abstract::The value of a postremission treatment in acute myelogenous leukemia (AML), with alternating combinations of non-cross-resistant drugs, has been prospectively assessed. Of 515 evaluable patients, 347 (67.4%) entered into complete remission (CR), following induction treatment with daunorubicin (DNR), vincristine (VCR),...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zittoun R,Jehn U,Fière D,Haanen C,Löwenberg B,Willemze R,Abels J,Bury J,Peetermans M,Hayat M

    更新日期:1989-03-01 00:00:00

  • Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.

    abstract::Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Because miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs co...


    pub_type: 杂志文章


    authors: Havelange V,Ranganathan P,Geyer S,Nicolet D,Huang X,Yu X,Volinia S,Kornblau SM,Andreeff M,Croce CM,Marcucci G,Bloomfield CD,Garzon R

    更新日期:2014-04-10 00:00:00

  • Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.

    abstract::Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic stem and progenitor cells (LSPCs) persist long term, which may be partly attributable to cytokine-mediated resistance. We evaluated the express...


    pub_type: 杂志文章


    authors: Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK

    更新日期:2014-02-20 00:00:00

  • Extraembryonic expression of EPCR is essential for embryonic viability.

    abstract::The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary from E7.5 and weakly...


    pub_type: 杂志文章


    authors: Li W,Zheng X,Gu JM,Ferrell GL,Brady M,Esmon NL,Esmon CT

    更新日期:2005-10-15 00:00:00

  • Identification of human lymphoma cells by antisera to malignancy-associated nucleolar antigens.

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    pub_type: 杂志文章


    authors: Ford RJ,Cramer M,Davis FM

    更新日期:1984-03-01 00:00:00

  • Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage.

    abstract::MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown function, associated with numbers of human inflammatory disorders. Both molecules have been described as L1 complex, cystic fibrosis antigen, or p8 and p14. We report here the cloning of mouse MRP8 and MRP14 and their pattern of expression during hem...


    pub_type: 杂志文章


    authors: Lagasse E,Weissman IL

    更新日期:1992-04-15 00:00:00

  • Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse.

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    pub_type: 杂志文章


    authors: Ploemacher RE,van der Sluijs JP,van Beurden CA,Baert MR,Chan PL

    更新日期:1991-11-15 00:00:00

  • Monitoring unfractionated heparin in children: a parallel-cohort randomized controlled trial comparing 2 dose protocols.

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    pub_type: 杂志文章,随机对照试验


    authors: Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

    更新日期:2015-10-29 00:00:00

  • High-dose chemotherapy and autologous stem cell transplantation for primary refractory or relapsed Hodgkin lymphoma: long-term outcome in the first 100 patients treated in Vancouver.

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    pub_type: 杂志文章


    authors: Lavoie JC,Connors JM,Phillips GL,Reece DE,Barnett MJ,Forrest DL,Gascoyne RD,Hogge DE,Nantel SH,Shepherd JD,Smith CA,Song KW,Sutherland HJ,Toze CL,Voss NJ,Nevill TJ

    更新日期:2005-08-15 00:00:00

  • Hepatic injury after nonmyeloablative conditioning followed by allogeneic hematopoietic cell transplantation: a study of 193 patients.

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    pub_type: 杂志文章


    authors: Hogan WJ,Maris M,Storer B,Sandmaier BM,Maloney DG,Schoch HG,Woolfrey AE,Shulman HM,Storb R,McDonald GB

    更新日期:2004-01-01 00:00:00