Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.

abstract：:A total of 124 patients who had survived at least 2 years after allogeneic bone marrow transplantation (BMT) were studied. Serum was collected at least once yearly. IgG antibodies were determined by enzyme-linked immunosorbent assay for measles and mumps. Rubella antibodies were analyzed by radial hemolysis. Antibody ...

journal_title：Blood

authors： Ljungman P,Lewensohn-Fuchs I,Hammarström V,Aschan J,Brandt L,Bolme P,Lönnqvist B,Johansson N,Ringdén O,Gahrton G

更新日期：1994-07-15 00:00:00

abstract：:T-cell depletion (TCD) of the donor marrow graft has been shown to reduce the severity of graft-versus-host disease (GVHD) in patients with chronic-phase (CP) chronic myelogenous leukemia (CML) undergoing HLA-identical sibling allogeneic marrow transplantation. However, there has been a corresponding reduction in the ...

journal_title：Blood

authors： Drobyski WR,Hessner MJ,Klein JP,Kabler-Babbitt C,Vesole DH,Margolis DA,Keever-Taylor CA

更新日期：1999-07-15 00:00:00

abstract：:Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-6, and IL-1 are produced in response to in utero i...

journal_title：Blood

authors： Krow-Lucal ER,Kim CC,Burt TD,McCune JM

更新日期：2014-03-20 00:00:00

abstract：:Tumors have several mechanisms to escape from the immune system. One of these involves expression of intracellular anticytotoxic proteins that modulate the execution of cell death. Previously, we have shown that the serine protease inhibitor (serpin) SPI-6, which inactivates the cytotoxic protease granzyme B (GrB), is...

journal_title：Blood

authors： Bots M,Kolfschoten IG,Bres SA,Rademaker MT,de Roo GM,Krüse M,Franken KL,Hahne M,Froelich CJ,Melief CJ,Offringa R,Medema JP

更新日期：2005-02-01 00:00:00

abstract：:In a previous study we have shown that monoclonal antibody F1 (MoAb F1), directed against an epitope on the heavy chain of factor XII distinct from the binding site for anionic surfaces, is able to activate factor XII in plasma (Nuijens JH, et al: J Biol Chem 264; 12941, 1989). Here, we studied in detail the mechanism...

journal_title：Blood

authors： Ravon DM,Citarella F,Lubbers YT,Pascucci B,Hack CE

更新日期：1995-12-01 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive, B-cell, non-Hodgkin lymphoma (NHL) categorized into endemic, sporadic and immunodeficiency-associated subtypes. BL has distinct pathologic and clinical features, characterized by rapidly progressive tumors with high rates of extranodal involvement. Next generation sequenci...

journal_title：Blood

authors： Crombie JL,LaCasce AS

更新日期：2020-11-10 00:00:00

abstract：:In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial ...

journal_title：Blood

authors： Ertault-Daneshpouy M,Leboeuf C,Lemann M,Bouhidel F,Ades L,Gluckman E,Socié G,Janin A

更新日期：2004-06-15 00:00:00

abstract：:Angiotensin II (Ang-II) exerts inflammatory activity and is involved in different cardiovascular disorders. This study has evaluated the involvement of tumor necrosis factor alpha (TNFalpha) in the leukocyte accumulation elicited by Ang-II. Ang-II (1 nM intraperitoneally in rats) induced TNFalpha release at 1 hour fol...

journal_title：Blood

authors： Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

更新日期：2007-09-15 00:00:00

abstract：:Understanding the repopulating characteristics of human hematopoietic stem/progenitor cells is crucial for predicting their performance after transplant into patients receiving high-dose radiochemotherapy. We have previously reported that CD34(+) cord blood (CB) cells can be expanded in vitro for several months in ser...

journal_title：Blood

authors： Piacibello W,Sanavio F,Severino A,Danè A,Gammaitoni L,Fagioli F,Perissinotto E,Cavalloni G,Kollet O,Lapidot T,Aglietta M

更新日期：1999-06-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease arising from a hematopoietic stem cell expressing the BCR/ABL fusion protein. Leukemic and dendritic cells (DCs) develop from the same transformed hematopoietic progenitors. How BCR/ABL interferes with the immunoregulatory function of DCs in ...

journal_title：Blood

authors： Mumprecht S,Claus C,Schürch C,Pavelic V,Matter MS,Ochsenbein AF

更新日期：2009-05-07 00:00:00

abstract：:The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...

journal_title：Blood

authors： Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:It has been suggested that human cytomegalovirus (HCMV) evades the immune system by infecting and paralyzing antigen-presenting cells. This view is based mainly on studies of dendritic cells (DCs) obtained after culture of monocytes (moDCs). It is contradicted by the asymptomatic course of HCMV infection in healthy pe...

journal_title：Blood

authors： Kvale EØ,Dalgaard J,Lund-Johansen F,Rollag H,Farkas L,Midtvedt K,Jahnsen FL,Brinchmann JE,Olweus J

更新日期：2006-03-01 00:00:00

abstract：:This study was performed to assess the utility of tumor-derived fragmentary DNA, or circulating tumor DNA (ctDNA), for identifying high-risk patients for relapse of acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after undergoing myeloablative allogeneic hematopoietic stem cell transplantation (alloSCT)....

journal_title：Blood

authors： Nakamura S,Yokoyama K,Shimizu E,Yusa N,Kondoh K,Ogawa M,Takei T,Kobayashi A,Ito M,Isobe M,Konuma T,Kato S,Kasajima R,Wada Y,Nagamura-Inoue T,Yamaguchi R,Takahashi S,Imoto S,Miyano S,Tojo A

更新日期：2019-06-20 00:00:00

abstract：:WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is an immune deficiency linked in many cases to heterozygous mutations causing truncations in the cytoplasmic tail of CXC chemokine receptor 4 (CXCR4). Leukocytes expressing truncated CXCR4 display enhanced responses to the receptor ligand CXC...

journal_title：Blood

authors： Lagane B,Chow KY,Balabanian K,Levoye A,Harriague J,Planchenault T,Baleux F,Gunera-Saad N,Arenzana-Seisdedos F,Bachelerie F

更新日期：2008-07-01 00:00:00

abstract：:Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invasive telemetric moni...

journal_title：Blood

authors： Adams GN,LaRusch GA,Stavrou E,Zhou Y,Nieman MT,Jacobs GH,Cui Y,Lu Y,Jain MK,Mahdi F,Shariat-Madar Z,Okada Y,D'Alecy LG,Schmaier AH

更新日期：2011-04-07 00:00:00

abstract：:Mechanisms underlying fetal hemoglobin (HbF) reactivation in stress erythropoiesis have not been fully elucidated. We suggested that a key role is played by kit ligand (KL). Because glucocorticoids (GCs) mediate stress erythropoiesis, we explored their capacity to potentiate the stimulatory effect of KL on HbF reactiv...

journal_title：Blood

authors： Gabbianelli M,Testa U,Massa A,Morsilli O,Saulle E,Sposi NM,Petrucci E,Mariani G,Peschle C

更新日期：2003-04-01 00:00:00

abstract：:We have previously determined that in African sickle cell anemia (SS) patients three different beta-like globin gene cluster haplotypes are associated with different percent G gamma (one of the two types of non-alpha chains comprising hemoglobin F [HbF]), mean percent HbF, and percent dense cells. We report now that i...

journal_title：Blood

authors： Nagel RL,Erlingsson S,Fabry ME,Croizat H,Susuka SM,Lachman H,Sutton M,Driscoll C,Bouhassira E,Billett HH

更新日期：1991-03-15 00:00:00

abstract：:Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. The factor XII-driven contact system starts coagulation and inflammatory mechanisms via the intrinsic pathway of coagulation and the bradykinin-producing kallikrein-kini...

journal_title：Blood

authors： Maas C,Renné T

更新日期：2018-04-26 00:00:00

abstract：:Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the role o...

journal_title：Blood

authors： Shi X,He BL,Ma AC,Guo Y,Chi Y,Man CH,Zhang W,Zhang Y,Wen Z,Cheng T,Leung AY

更新日期：2015-05-07 00:00:00

abstract：:Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the huma...

journal_title：Blood

authors： Berger LC,Hawley RG

更新日期：1997-01-01 00:00:00

abstract：:The value of a postremission treatment in acute myelogenous leukemia (AML), with alternating combinations of non-cross-resistant drugs, has been prospectively assessed. Of 515 evaluable patients, 347 (67.4%) entered into complete remission (CR), following induction treatment with daunorubicin (DNR), vincristine (VCR),...

journal_title：Blood

authors： Zittoun R,Jehn U,Fière D,Haanen C,Löwenberg B,Willemze R,Abels J,Bury J,Peetermans M,Hayat M

更新日期：1989-03-01 00:00:00

abstract：:Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Because miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs co...

journal_title：Blood

authors： Havelange V,Ranganathan P,Geyer S,Nicolet D,Huang X,Yu X,Volinia S,Kornblau SM,Andreeff M,Croce CM,Marcucci G,Bloomfield CD,Garzon R

更新日期：2014-04-10 00:00:00

abstract：:Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic stem and progenitor cells (LSPCs) persist long term, which may be partly attributable to cytokine-mediated resistance. We evaluated the express...

journal_title：Blood

authors： Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK

更新日期：2014-02-20 00:00:00

abstract：:The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary from E7.5 and weakly...

journal_title：Blood

authors： Li W,Zheng X,Gu JM,Ferrell GL,Brady M,Esmon NL,Esmon CT

更新日期：2005-10-15 00:00:00

abstract：:The non-Hodgkin's lymphomas (NHL) are a diverse group of human lymphoid neoplasms that have long presented pathologists with formidable diagnostic challenges. These tumors of the immune system are thought to represent neoplastic transformations of most of the recognized stages in T and B lymphocyte ontogeny. Lymphoma ...

journal_title：Blood

authors： Ford RJ,Cramer M,Davis FM

更新日期：1984-03-01 00:00:00

abstract：:MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown function, associated with numbers of human inflammatory disorders. Both molecules have been described as L1 complex, cystic fibrosis antigen, or p8 and p14. We report here the cloning of mouse MRP8 and MRP14 and their pattern of expression during hem...

journal_title：Blood

authors： Lagasse E,Weissman IL

更新日期：1992-04-15 00:00:00

abstract：:We have developed an in vitro clonal assay of murine hematopoietic precursor cells that form spleen colonies (CFU-S day 12) or produce in vitro clonable progenitors in the marrow (MRA cells) of lethally irradiated mice. The assay is essentially a long-term bone marrow culture in microtiter wells containing marrow-deri...

journal_title：Blood

authors： Ploemacher RE,van der Sluijs JP,van Beurden CA,Baert MR,Chan PL

更新日期：1991-11-15 00:00:00

abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...

journal_title：Blood

authors： Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

更新日期：2015-10-29 00:00:00

abstract：:Beginning in 1985, patients in British Columbia with Hodgkin lymphoma (HL) that was not controlled by conventional chemotherapy routinely underwent high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT). Long-term complications of HD-ASCT have become apparent as more patients survive without recurre...

journal_title：Blood

authors： Lavoie JC,Connors JM,Phillips GL,Reece DE,Barnett MJ,Forrest DL,Gascoyne RD,Hogge DE,Nantel SH,Shepherd JD,Smith CA,Song KW,Sutherland HJ,Toze CL,Voss NJ,Nevill TJ

更新日期：2005-08-15 00:00:00

abstract：:Liver injury is a frequent, serious complication of allogeneic hematopoietic cell transplantation (HCT) following myeloablative preparative regimens. We sought to determine the frequency and severity of hepatic injury after nonmyeloablative conditioning and its relationship to outcomes. One hundred ninety-three consec...

journal_title：Blood

authors： Hogan WJ,Maris M,Storer B,Sandmaier BM,Maloney DG,Schoch HG,Woolfrey AE,Shulman HM,Storb R,McDonald GB

更新日期：2004-01-01 00:00:00