Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen.

abstract：:This prospective multicenter study examined whether simultaneous administration of granulocyte colony-stimulating factor (G-CSF; Filgrastim) and induction chemotherapy for adult acute lymphoblastic leukemia (ALL) could prevent treatment-related neutropenia, infections, and resulting treatment delays. Seventy-six patie...

journal_title：Blood

authors： Ottmann OG,Hoelzer D,Gracien E,Ganser A,Kelly K,Reutzel R,Lipp T,Busch FW,Schwonzen M,Heil G

更新日期：1995-07-15 00:00:00

abstract：:Besides regulating leukocyte trafficking in normal and injured tissues, several chemokines may positively or negatively regulate angiogenesis. Here we report that CCL16 activates an angiogenic program in vascular endothelial cells by activating CCR1. CCL16 induces dose-dependent random and directional migration of end...

journal_title：Blood

authors： Strasly M,Doronzo G,Cappello P,Valdembri D,Arese M,Mitola S,Moore P,Alessandri G,Giovarelli M,Bussolino F

更新日期：2004-01-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a potent adjuvant in cancer vaccination; however, the specific role of endogenous GM-CSF remains unknown. We performed cell-based vaccination in 2 tumor models. First, we vaccinated C57BL/6 mice lacking either GM-CSF, IL-5, or beta-common chain (betac), a re...

journal_title：Blood

authors： Zarei S,Schwenter F,Luy P,Aurrand-Lions M,Morel P,Kopf M,Dranoff G,Mach N

更新日期：2009-06-25 00:00:00

abstract：:Endotoxin is a component of gram-negative bacteria that causes hematologic and immunologic changes through its induction of cytokines. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of IL-1 that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity....

journal_title：Blood

authors： Granowitz EV,Porat R,Mier JW,Orencole SF,Callahan MV,Cannon JG,Lynch EA,Ye K,Poutsiaka DD,Vannier E

更新日期：1993-11-15 00:00:00

abstract：UNLABELLED:Polymorphonuclear neutrophil granulocytes (neutrophils) are tightly controlled by an incompletely understood homeostatic feedback loop adjusting the marrow's supply to peripheral needs. Although it has long been known that marrow cellularity is inversely correlated with G-CSF levels, the mechanism linking pe...

journal_title：Blood

authors： Bugl S,Wirths S,Radsak MP,Schild H,Stein P,André MC,Müller MR,Malenke E,Wiesner T,Märklin M,Frick JS,Handgretinger R,Rammensee HG,Kanz L,Kopp HG

更新日期：2013-01-31 00:00:00

abstract：:The deregulated Bcr/Abl tyrosine kinase is responsible for the development of Philadelphia (Ph)-positive leukemia in humans. To investigate the significance of the C-terminal Abl actin-binding domain within Bcr/Abl p190 in the development of leukemia/lymphoma in vivo, mutant p190 DNA constructs were used to generate t...

journal_title：Blood

authors： Heisterkamp N,Voncken JW,Senadheera D,Gonzalez-Gomez I,Reichert A,Haataja L,Reinikainen A,Pattengale PK,Groffen J

更新日期：2000-09-15 00:00:00

abstract：:CD44 is a widely expressed, multifunctional, cell-surface glycoprotein that has been implicated in the regulation of normal hematopoiesis. In addition, expression of particular isoforms of CD44 has been associated with malignant transformation and/or the acquisition of metastatic potential. In this study, we used two ...

journal_title：Blood

authors： Ghaffari S,Dougherty GJ,Lansdorp PM,Eaves AC,Eaves CJ

更新日期：1995-10-15 00:00:00

abstract：:Oxidative stress has been implicated in the triggering of apoptosis in neutrophils. Because red blood cells (RBCs) are well known to scavenge oxidants including H2O2, we tested the hypothesis that RBCs inhibit apoptosis of neutrophils by reducing intracellular oxidative stress. Apoptosis of neutrophils was evaluated b...

journal_title：Blood

authors： Aoshiba K,Nakajima Y,Yasui S,Tamaoki J,Nagai A

更新日期：1999-06-01 00:00:00

abstract：:Although it is recognized that red cells lose membrane during storage, estimation of the osmotic fragility of erythrocytes has not previously proven to be a useful measurement of the storage lesion. Erythrocytes from blood stored in CPD-A2 were found to have a markedly increased osmotic fragility. A major portion of t...

journal_title：Blood

authors： Beutler E,Kuhl W,West C

更新日期：1982-06-01 00:00:00

abstract：:Plasmodium falciparum-infected erythrocytes (IRBC) roll on the adhesion molecule P-selectin in vitro under flow conditions that approximate the shear stress in capillary and postcapillary venules in which cytoadherence occurs in vivo. The pathological significance of this adhesive interaction is currently unknown. In ...

journal_title：Blood

authors： Ho M,Schollaardt T,Niu X,Looareesuwan S,Patel KD,Kubes P

更新日期：1998-06-15 00:00:00

abstract：:Analysis of molecular mechanisms associated with stem cell commitment and differentiation requires an in vitro assay that identifies the most primitive hematopoietic stem cells in human bone marrow. Such primitive stem cells usually do not form colonies in short-term semisolid assays and are best identified by their a...

journal_title：Blood

authors： Issaad C,Croisille L,Katz A,Vainchenker W,Coulombel L

更新日期：1993-06-01 00:00:00

abstract：:Gossypin, a flavone originally isolated from Hibiscus vitifolius, has been shown to suppress angiogenesis, inflammation, and carcinogenesis. The mechanisms of these activities, however, are unknown. Because nuclear factor-kappaB (NF-kappaB) is associated with inflammation, carcinogenesis, hyperproliferation, invasion,...

journal_title：Blood

authors： Kunnumakkara AB,Nair AS,Ahn KS,Pandey MK,Yi Z,Liu M,Aggarwal BB

更新日期：2007-06-15 00:00:00

abstract：:Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for patients with a BPD is often unavailable. Many specialized tests are usually required to reach a put...

journal_title：Blood

authors： Simeoni I,Stephens JC,Hu F,Deevi SV,Megy K,Bariana TK,Lentaigne C,Schulman S,Sivapalaratnam S,Vries MJ,Westbury SK,Greene D,Papadia S,Alessi MC,Attwood AP,Ballmaier M,Baynam G,Bermejo E,Bertoli M,Bray PF,Bury L,

更新日期：2016-06-09 00:00:00

abstract：:It has recently been shown that the ultralarge platelet-recruiting von Willebrand factor (VWF) strings formed immediately at exocytosis from endothelial cells may be anchored to the cell surface by interaction with the integral membrane protein P-selectin. This finding of a new binding partner for VWF immediately prom...

journal_title：Blood

authors： Michaux G,Pullen TJ,Haberichter SL,Cutler DF

更新日期：2006-05-15 00:00:00

abstract：:Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of how CR affects the response to cancer therapy is still rudimentary. Here, using the Eµ-Myc transgenic mouse model of B-cell lymphoma, we report that by reducing ...

journal_title：Blood

authors： Meynet O,Zunino B,Happo L,Pradelli LA,Chiche J,Jacquin MA,Mondragón L,Tanti JF,Taillan B,Garnier G,Reverso-Meinietti J,Mounier N,Michiels JF,Michalak EM,Carles M,Scott CL,Ricci JE

更新日期：2013-10-03 00:00:00

abstract：:Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow ab...

journal_title：Blood

authors： Kessinger A,Bierman PJ,Vose JM,Armitage JO

更新日期：1991-06-01 00:00:00

abstract：:Acute chest syndrome (ACS) is a leading cause of death in sickle cell disease (SCD). Our previous work showed that hypoxia enhances the ability of sickle erythrocytes to adhere to human microvessel endothelium via interaction between very late activation antigen-4 (VLA4) expressed on sickle erythrocytes and the endoth...

journal_title：Blood

authors： Stuart MJ,Setty BN

更新日期：1999-09-01 00:00:00

abstract：:Among 1153 new adult cases of peripheral/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal natural killer (NK)/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and i...

journal_title：Blood

authors： Au WY,Weisenburger DD,Intragumtornchai T,Nakamura S,Kim WS,Sng I,Vose J,Armitage JO,Liang R,International Peripheral T-Cell Lymphoma Project.

更新日期：2009-04-23 00:00:00

abstract：:Growing evidence indicates antibody-dependent cellular cytotoxicity (ADCC) contributes to the clinical response to monoclonal antibody (mAb) therapy of lymphoma. Recent in vitro analysis suggests C3b can inhibit mAb-induced natural killer (NK)-cell activation and ADCC. Further studies were conducted to assess the effe...

journal_title：Blood

authors： Wang SY,Veeramani S,Racila E,Cagley J,Fritzinger DC,Vogel CW,St John W,Weiner GJ

更新日期：2009-12-17 00:00:00

abstract：:Diaspirin cross-linked hemoglobin (DCLHb) is an intramolecularly cross-linked hemoglobin-based oxygen carrier being developed as a therapy for acute blood loss. We report here the absence of immunogenicity of DCLHb in patients enrolled in phase II and III clinical trials of DCLHb. Two very sensitive immunoassays, an e...

journal_title：Blood

authors： Patel MJ,Webb EJ,Shelbourn TE,Mattia-Goldberg C,George AJ,Zhang F,Moore EG,Nelson DJ

更新日期：1998-01-15 00:00:00

abstract：:Eighteen patients with relapse of chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation (BMT) were treated with recombinant human alpha 2a interferon (IFN). Relapse was defined as greater than 90% metaphases containing the Philadelphia chromosome (Ph) and hematologic abnormalities consistent ...

journal_title：Blood

authors： Higano CS,Raskind WH,Singer JW

更新日期：1992-09-15 00:00:00

abstract：:Fibronectin is an adhesive protein that can promote phagocytosis and endothelial cell adhesion. Plasma fibronectin declines following burn in animals and patients, potentially due to its complexing with circulating collagenous debris as well as its rapid binding to sites of tissue injury. Such depletion of fibronectin...

journal_title：Blood

authors： La Celle P,Blumenstock FA,Saba TM

更新日期：1991-05-01 00:00:00

abstract：:We have previously shown that intravenously injected peripheral blood (PB) or bone marrow (BM) cells from newly diagnosed chronic myeloid leukemia (CML) patients can engraft the BM of sublethally irradiated severe combined immunodeficient (SCID) mice. We now report engraftment results for chronic phase CML cells in no...

journal_title：Blood

authors： Wang JC,Lapidot T,Cashman JD,Doedens M,Addy L,Sutherland DR,Nayar R,Laraya P,Minden M,Keating A,Eaves AC,Eaves CJ,Dick JE

更新日期：1998-04-01 00:00:00

abstract：:Retention of lipoproteins within the vasculature is a central event in the pathogenesis of atherosclerosis. However, the signals that mediate this process are only partially understood. Prompted by putative links between inflammation and atherosclerosis, we previously reported that alpha-defensins released by neutroph...

journal_title：Blood

authors： Bdeir K,Cane W,Canziani G,Chaiken I,Weisel J,Koschinsky ML,Lawn RM,Bannerman PG,Sachais BS,Kuo A,Hancock MA,Tomaszewski J,Raghunath PN,Ganz T,Higazi AA,Cines DB

更新日期：1999-09-15 00:00:00

abstract：:Chemokine stromal derived factor 1 (SDF-1) is involved in trafficking of hematopoietic stem cells (HSCs) from the bone marrow (BM) to peripheral blood (PB) and has been found to enhance postischemia angiogenesis. This study was aimed at investigating whether SDF-1 plays a role in differentiation of BM-derived c-kit(+)...

journal_title：Blood

authors： De Falco E,Porcelli D,Torella AR,Straino S,Iachininoto MG,Orlandi A,Truffa S,Biglioli P,Napolitano M,Capogrossi MC,Pesce M

更新日期：2004-12-01 00:00:00

abstract：:Reversible interactions of glycoconjugates on leukocytes with P- and E-selectin on endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the first step in their recruitment to sites of injury. Although selectin ligands on hematopoietic precursors have been identified, here we review ...

journal_title：Blood

authors： Zarbock A,Ley K,McEver RP,Hidalgo A

更新日期：2011-12-22 00:00:00

abstract：:To program pluripotent cells into blood, a knowledge of the locations of precursors during their journey through the embryo and the signals they experience would be informative. The anterior (a) and posterior (p) ventral blood islands (VBIs) in Xenopus are derived from opposite sides of the pregastrula embryo. The aVB...

journal_title：Blood

authors： Walmsley M,Cleaver D,Patient R

更新日期：2008-02-01 00:00:00

abstract：:A distinct pathologic entity (ALK+ lymphoma) that is characterized by expression of the anaplastic lymphoma kinase (ALK) protein has recently emerged within the heterogeneous group of CD30(+) anaplastic large-cell lymphomas. Information on clinical findings and treatment outcome of ALK+ lymphoma is still limited, and ...

journal_title：Blood

authors： Falini B,Pileri S,Zinzani PL,Carbone A,Zagonel V,Wolf-Peeters C,Verhoef G,Menestrina F,Todeschini G,Paulli M,Lazzarino M,Giardini R,Aiello A,Foss HD,Araujo I,Fizzotti M,Pelicci PG,Flenghi L,Martelli MF,Santucci A

更新日期：1999-04-15 00:00:00

abstract：:Transplantation of ex vivo expanded human umbilical cord blood cells (hCB) only partially enhances the hematopoietic recovery after myelosuppressive therapy. Incubation of hCB with optimal combinations of cytokines and niche cells, such as endothelial cells (ECs), could augment the efficiency of hCB expansion. We have...

journal_title：Blood

authors： Butler JM,Gars EJ,James DJ,Nolan DJ,Scandura JM,Rafii S

更新日期：2012-08-09 00:00:00

abstract：:Interleukin-8 (IL-8) is a neutrophil chemotactic and activating cytokine that is produced in response to several stimuli. Because monocytic cells are important producers of IL-8, we investigated whether interferon-gamma (IFN-gamma), a potent inducer of activation and differentiation of mononuclear phagocytes, affected...

journal_title：Blood

authors： Bosco MC,Gusella GL,Espinoza-Delgado I,Longo DL,Varesio L

更新日期：1994-01-15 00:00:00