Platelet modulation of polymorphonuclear leukocyte shear induced aggregation.

abstract：:This study includes 47 normal subjects and 25 hemophilia B patients without inhibitor(s), showing different factor IX coagulant activity and antigen levels. Genomic DNA, digested with various restriction endonucleases, was hybridized with two different factor IX probes, ie, the cDNA and the subgenomic probe for the in...

journal_title：Blood

authors： Hassan HJ,Orlando M,Leonardi A,Chelucci C,Guerriero R,Mannucci PM,Mariani G,Peschle C

更新日期：1985-02-01 00:00:00

abstract：:The balanced manifestation of effector functions and the generation of long-living memory cells is a hallmark of efficient CD8(+) T-cell response. Accumulating data pinpoint CD4(+) CD25(high) regulatory T (Treg) cells as a key factor for the inefficiency of CD8(+) T-cell responses in viral persistence. Little is known...

journal_title：Blood

authors： Nikolova M,Lelievre JD,Carriere M,Bensussan A,Lévy Y

更新日期：2009-05-07 00:00:00

abstract：:We have studied the impact of B-cell receptor (BCR) or CD40 ligation on the in vitro chemotactic response of tonsillar B cells to 4 chemokines: stromal cell-derived factor (SDF)-1alpha, macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and B-cell-attracting chemokine (BCA)-1. In the tonsil, SDF-1 and MIP-3alpha...

journal_title：Blood

authors： Casamayor-Pallejà M,Mondière P,Verschelde C,Bella C,Defrance T

更新日期：2002-03-15 00:00:00

abstract：:Neonatal alloimmune thrombocytopenia (NAIT) can cause severe bleeding in the central nervous system (CNS) and death or severe neurologic sequelae. The expression of the PLA1 antigen is detectable as early as 19 weeks of gestation. Alloimmunization can therefore lead to fetal thrombocytopenia very early in pregnancy. U...

journal_title：Blood

authors： Kaplan C,Daffos F,Forestier F,Cox WL,Lyon-Caen D,Dupuy-Montbrun MC,Salmon C

更新日期：1988-07-01 00:00:00

abstract：:Natural killer (NK) cells are large granular lymphocytes (LGLs) that contain distinct lysosomal granules. The present study was undertaken to determine if these lysosomes contain glycosaminoglycans (GAGs) similar to those previously described in myeloid cells. Mononuclear cells from human blood were stained with HNK-1...

journal_title：Blood

authors： Parmley RT,Rahemtulla F,Cooper MD,Rodén L

更新日期：1985-07-01 00:00:00

abstract：:In mouse mid-gestational embryos, definitive hematopoietic stem progenitor cells are derived directly from a very small proportion of the arterial endothelium. However, the physiological mechanisms restraining excessive endothelial-hematopoietic transition remain elusive. We show here that genetic deletion of Smad4 fr...

journal_title：Blood

authors： Lan Y,He W,Li Z,Wang Y,Wang J,Gao J,Wang W,Cheng T,Liu B,Yang X

更新日期：2014-04-03 00:00:00

abstract：:To develop safer and more effective vectors for gene therapy of X-linked severe combined immunodeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV virus. The CL20i4-hgamma(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by t...

journal_title：Blood

authors： Zhou S,Mody D,DeRavin SS,Hauer J,Lu T,Ma Z,Hacein-Bey Abina S,Gray JT,Greene MR,Cavazzana-Calvo M,Malech HL,Sorrentino BP

更新日期：2010-08-12 00:00:00

abstract：:The malaria parasite Plasmodium falciparum releases the ring-infected erythrocyte surface antigen (RESA) inside the red cell on entry. The protein migrates to the host cell membrane, where it binds to spectrin, but neither the nature of the interaction nor its functional consequences have previously been defined. Here...

journal_title：Blood

authors： Pei X,Guo X,Coppel R,Bhattacharjee S,Haldar K,Gratzer W,Mohandas N,An X

更新日期：2007-08-01 00:00:00

abstract：:Myeloperoxidase (MPO) is a heme containing enzyme involved in the oxygen-dependent microbicidal activity of human polymorphonuclear leukocytes (PMN). Complete hereditary and acquired MPO deficiencies are defined as lack of peroxidase activity in PMN. Using this criterion, we studied a patient with complete hereditary ...

journal_title：Blood

authors： Tobler A,Selsted ME,Miller CW,Johnson KR,Novotny MJ,Rovera G,Koeffler HP

更新日期：1989-05-15 00:00:00

abstract：:Expression patterns of interleukin-6 (IL-6), IL-6 receptor (IL-6R), and gp130 genes in 39 patients with acute myeloid leukemia (AML), in 23 patients with acute lymphoblastic leukemia (ALL), and in 7 patients with acute mixed lineage leukemia (AMLL) were studied by quantitative reverse transcriptase-polymerase chain re...

journal_title：Blood

authors： Inoue K,Sugiyama H,Ogawa H,Yamagami T,Azuma T,Oka Y,Miwa H,Kita K,Hiraoka A,Masaoka T

更新日期：1994-10-15 00:00:00

abstract：:The short-term beneficial effect of hydroxyurea (HU) in sickle cell disease (SCD) has been proven by randomized studies in children and adults. The Belgian registry of HU-treated SCD patients was created to evaluate its long-term efficacy and toxicity. The median follow-up of the 93 patients registered is 3.5 years; c...

journal_title：Blood

authors： Ferster A,Tahriri P,Vermylen C,Sturbois G,Corazza F,Fondu P,Devalck C,Dresse MF,Feremans W,Hunninck K,Toppet M,Philippet P,Van Geet C,Sariban E

更新日期：2001-06-01 00:00:00

abstract：:Platelet activation is normally induced by primary agonists such as adenosine diphosphate (ADP), thrombin, and collagen, whereas other agonists, such as epinephrine, can play important accessory roles. It is now reported that the macrophage-derived chemokine (MDC), thymus activation-regulated chemokine (TARC), and str...

journal_title：Blood

authors： Gear AR,Suttitanamongkol S,Viisoreanu D,Polanowska-Grabowska RK,Raha S,Camerini D

更新日期：2001-02-15 00:00:00

abstract：:Filamin A (FLNa), a dimeric actin cross-linking and scaffold protein with numerous intracellular binding partners, anchors the platelet adhesion glycoprotein (GP) Ib-IX-V receptor to actin cytoskeleton. We mapped the GPIbalpha binding site to a single domain of FLNa and resolved the structure of this domain and its in...

journal_title：Blood

authors： Nakamura F,Pudas R,Heikkinen O,Permi P,Kilpeläinen I,Munday AD,Hartwig JH,Stossel TP,Ylänne J

更新日期：2006-03-01 00:00:00

abstract：:Recent studies performed in mice knocked out for the tumor necrosis factor (TNF ), the lymphotoxin-alpha, or the type I TNF receptor (R), genes have shown that these animals display gross defects in germinal center (GC) formation, suggesting that members of the TNF and TNFR superfamilies are involved in the control of...

journal_title：Blood

authors： Corcione A,Ottonello L,Tortolina G,Tasso P,Ghiotto F,Airoldi I,Taborelli G,Malavasi F,Dallegri F,Pistoia V

更新日期：1997-12-01 00:00:00

abstract：:Stem cell factor (SCF) and interleukin-3 (IL-3) both act on several target hematopoietic populations, including mast cells. We have isolated a unique murine mast cell line, B6M, that is phenotypically similar to immature mast cells. For B6M cells, IL-3 is a survival factor and alone does not stimulate proliferation. S...

journal_title：Blood

authors： O'Farrell AM,Ichihara M,Mui AL,Miyajima A

更新日期：1996-05-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome-associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is...

journal_title：Blood

authors： Neri A,Barriga F,Inghirami G,Knowles DM,Neequaye J,Magrath IT,Dalla-Favera R

更新日期：1991-03-01 00:00:00

abstract：:Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of how CR affects the response to cancer therapy is still rudimentary. Here, using the Eµ-Myc transgenic mouse model of B-cell lymphoma, we report that by reducing ...

journal_title：Blood

authors： Meynet O,Zunino B,Happo L,Pradelli LA,Chiche J,Jacquin MA,Mondragón L,Tanti JF,Taillan B,Garnier G,Reverso-Meinietti J,Mounier N,Michiels JF,Michalak EM,Carles M,Scott CL,Ricci JE

更新日期：2013-10-03 00:00:00

abstract：:The use of 8-methoxypsoralen (8-MOP) and UV-A irradiation to inactivate contaminating donor leukocytes in platelet concentrates and to prevent primary alloimmunization against donor class I major histocompatibility (MHC) antigens in mice was investigated. CBA/CaH-T6J mice with the H2k haplotype and BALB/cByJ mice with...

journal_title：Blood

authors： Grana NH,Kao KJ

更新日期：1991-06-01 00:00:00

abstract：:Expression of the CD4 antigen was observed on human fetal liver, fetal bone marrow (BM), and umbilical cord blood progenitors expressing high levels of CD34. Using clonal and liquid-culture assays, CD4+ CD34++ Lin- (lineage = CD3, CD8, CD10, CD14, CD15, CD16, CD19, CD20, and glycophorin A) fetal liver progenitors were...

journal_title：Blood

authors： Muench MO,Roncarolo MG,Namikawa R

更新日期：1997-02-15 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disease caused by mutations in the WAS gene, leading to thrombocytopenia, eczema, recurrent infections, autoimmune disease, and malignancy. Hematopoietic cell transplantation (HCT) is the primary curative approach, with the goal of correcting the underlying immunodeficienc...

journal_title：Blood

authors： Burroughs LM,Petrovic A,Brazauskas R,Liu X,Griffith LM,Ochs HD,Bleesing JJ,Edwards S,Dvorak CC,Chaudhury S,Prockop SE,Quinones R,Goldman FD,Quigg TC,Chandrakasan S,Smith AR,Parikh S,Dávila Saldaña BJ,Thakar MS,Phela

更新日期：2020-06-04 00:00:00

abstract：:Antithymocyte globulin (ATG) has recently been popularized as an effective treatment in myelodysplastic syndrome (MDS). We treated 8 anemic MDS patients (refractory anemia [RA] and refractory anemia with excess blasts [RAEB-1]) with ATG (40 mg/kg/d for 4 days) and prednisone in a phase 2 trial. The study was stopped e...

journal_title：Blood

authors： Steensma DP,Dispenzieri A,Moore SB,Schroeder G,Tefferi A

更新日期：2003-03-15 00:00:00

abstract：:We made a disease-specific comparison of unrelated cord blood (CB) recipients and human leukocyte antigen allele-matched unrelated bone marrow (BM) recipients among 484 patients with acute myeloid leukemia (AML; 173 CB and 311 BM) and 336 patients with acute lymphoblastic leukemia (ALL; 114 CB and 222 BM) who received...

journal_title：Blood

authors： Atsuta Y,Suzuki R,Nagamura-Inoue T,Taniguchi S,Takahashi S,Kai S,Sakamaki H,Kouzai Y,Kasai M,Fukuda T,Azuma H,Takanashi M,Okamoto S,Tsuchida M,Kawa K,Morishima Y,Kodera Y,Kato S,Japan Cord Blood Bank Network.

更新日期：2009-02-19 00:00:00

abstract：:The developmental relationship between the blood and endothelial cell (EC) lineages remains unclear. In the extra-embryonic blood islands of birds and mammals, ECs and blood cells are closely intermixed, and blood island precursor cells in the primitive streak express many of the same molecular markers, leading to the...

journal_title：Blood

authors： Myers CT,Krieg PA

更新日期：2013-12-05 00:00:00

abstract：:A new human leukemia cell line, KT-1, was established from a patient in the blastic crisis phase of chronic myelogenous leukemia (CML). This cell line had a positive reaction for intracytoplasmic myeloperoxidase and two Philadelphia chromosomes (Ph1) [t(9;22)(q34;q11)] and lacked normal copies of chromosomes 9 and 22....

journal_title：Blood

authors： Yanagisawa K,Yamauchi H,Kaneko M,Kohno H,Hasegawa H,Fujita S

更新日期：1998-01-15 00:00:00

abstract：:BB-10010 is a variant of the human form of macrophage inflammatory protein-1alpha (MIP-1alpha), which has been shown in mice to block the entry of hematopoietic stem cells into S-phase and to increase their self-renewal capacity during recovery from cytotoxic damage. Its use may constitute a novel approach for protect...

journal_title：Blood

authors： Clemons MJ,Marshall E,Dürig J,Watanabe K,Howell A,Miles D,Earl H,Kiernan J,Griffiths A,Towlson K,DeTakats P,Testa NG,Dougal M,Hunter MG,Wood LM,Czaplewski LG,Millar A,Dexter TM,Lord BI

更新日期：1998-09-01 00:00:00

abstract：:We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 patients, a significa...

journal_title：Blood

authors： Gutman JA,Turtle CJ,Manley TJ,Heimfeld S,Bernstein ID,Riddell SR,Delaney C

更新日期：2010-01-28 00:00:00

abstract：:Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (...

journal_title：Blood

authors： Bortin MM,D'Amaro J,Bach FH,Rimm AA,van Rood JJ

更新日期：1987-07-01 00:00:00

abstract：:Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh frozen plasma and c...

journal_title：Blood

authors： George JN,Pickett EB,Heinz R

更新日期：1986-07-01 00:00:00

abstract：:The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8(+) T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-deriv...

journal_title：Blood

authors： Longman RS,Talal AH,Jacobson IM,Albert ML,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:Interleukin (IL)-23 is a proinflammatory cytokine belonging to the IL-12 superfamily. The antitumor activity of IL-23 is controversial, and it is unknown whether or not the cytokine can act directly on tumor cells. The aim of this study was to investigate the potential direct antitumor activity of IL-23 in pediatric B...

journal_title：Blood

authors： Cocco C,Canale S,Frasson C,Di Carlo E,Ognio E,Ribatti D,Prigione I,Basso G,Airoldi I

更新日期：2010-11-11 00:00:00