当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Presence of functional dendritic cells in patients chronically infected with hepatitis C virus.

Presence of functional dendritic cells in patients chronically infected with hepatitis C virus.

Abstract：

:The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8(+) T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-derived DCs in chronically infected patients. As it is difficult to reconcile these data with the fact that patients with chronic HCV are immune competent, we re-evaluated this finding, carefully assessing phenotypic markers and functional activity of patient DCs as compared with noninfected controls. In contrast to these prior studies, DCs from 13 of 13 chronic HCV patients expressed typical maturation markers. These mature DCs were capable of priming allogeneic T lymphocytes, as well as stimulating influenza-specific memory T cells. This finding is consistent with clinical and immunologic data that the deficit in the patient's immune repertoire is HCV-specific and suggests that refined models are required for understanding the role of DCs in HCV pathogenesis.

journal_name

Blood

journal_title

Blood

authors

Longman RS,Talal AH,Jacobson IM,Albert ML,Rice CM

doi

10.1182/blood-2003-04-1339

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

1026-9

issue

3

eissn

0006-4971

issn

1528-0020

pii

2003-04-1339

journal_volume

103

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables.

    abstract：:To define the efficacy of venetoclax with extended follow-up and identify clinical or biological treatment effect modifiers, updated data for previously treated patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) enrolled in 4 early-phase trials were pooled. Rates of response, complete...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2018882555

    authors： Roberts AW,Ma S,Kipps TJ,Coutre SE,Davids MS,Eichhorst B,Hallek M,Byrd JC,Humphrey K,Zhou L,Chyla B,Nielsen J,Potluri J,Kim SY,Verdugo M,Stilgenbauer S,Wierda WG,Seymour JF

    更新日期：2019-07-11 00:00:00

  • Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.

    abstract：:Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from patients carrying mu...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-03-147090

    authors： Zhang X,Shang X,Guo F,Murphy K,Kirby M,Kelly P,Reeves L,Smith FO,Williams DA,Zheng Y,Pang Q

    更新日期：2008-09-01 00:00:00

  • Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies.

    abstract：:We investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients with chronic myelogenous leukemia (CML) in chronic, accelerated, or blastic phase and in 8 patients with myelofibrosis (MF) and 10 patients with multiple myeloma (MM). R115777 was administered at 600 mg orally twice dail...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2002-07-1973

    authors： Cortes J,Albitar M,Thomas D,Giles F,Kurzrock R,Thibault A,Rackoff W,Koller C,O'Brien S,Garcia-Manero G,Talpaz M,Kantarjian H

    更新日期：2003-03-01 00:00:00

  • High-dose chemotherapy and autologous stem cell transplantation for primary refractory or relapsed Hodgkin lymphoma: long-term outcome in the first 100 patients treated in Vancouver.

    abstract：:Beginning in 1985, patients in British Columbia with Hodgkin lymphoma (HL) that was not controlled by conventional chemotherapy routinely underwent high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT). Long-term complications of HD-ASCT have become apparent as more patients survive without recurre...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-12-4689

    authors： Lavoie JC,Connors JM,Phillips GL,Reece DE,Barnett MJ,Forrest DL,Gascoyne RD,Hogge DE,Nantel SH,Shepherd JD,Smith CA,Song KW,Sutherland HJ,Toze CL,Voss NJ,Nevill TJ

    更新日期：2005-08-15 00:00:00

  • Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy.

    abstract：:Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging diagnosis after hematopoietic stem cell transplantation. Although endothelial injury represents the final common pathway of disease, the exact pathophysiology of TA-TMA remains unclear. Potential causes include infections, chemotherapy, ra...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2011-02-321315

    authors： Laskin BL,Goebel J,Davies SM,Jodele S

    更新日期：2011-08-11 00:00:00

  • Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts.

    abstract：:Over the past few years, substantial advances have been made in understanding the pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and prognostic parameters and novel therapeutic targets with demonstrable clinical impact have been identified. Several of these new markers, molecular target...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2016-09-731893

    authors： Valent P,Akin C,Metcalfe DD

    更新日期：2017-03-16 00:00:00

  • Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation.

    abstract：:The effects of selectively depleting CD8+ cells from donor bone marrow were assessed in 36 patients receiving transplantation from an HLA-identical sibling as treatment for leukemia. Donor bone marrow underwent ex vivo treatment using anti-Leu-2 monoclonal antibody and complement. Patients received cyclosporine post-t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Champlin R,Ho W,Gajewski J,Feig S,Burnison M,Holley G,Greenberg P,Lee K,Schmid I,Giorgi J

    更新日期：1990-07-15 00:00:00

  • Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.

    abstract：:Secretion of platelet granules is necessary for normal hemostasis. Platelet secretion requires soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complex formation between different members of the syntaxin, SNAP-25, and vesicle-associated membrane protein (VAMP) gene families. Using m...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v100.3.1081

    authors： Polgár J,Chung SH,Reed GL

    更新日期：2002-08-01 00:00:00

  • Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation.

    abstract：:Activation of plasminogen, the zymogen of the primary thrombolytic enzyme, plasmin, is markedly promoted when plasminogen is bound to cell surfaces, arming cells with the broad spectrum proteolytic activity of plasmin. In addition to its role in thrombolysis, cell surface plasmin facilitates a wide array of physiologi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-11-188938

    authors： Andronicos NM,Chen EI,Baik N,Bai H,Parmer CM,Kiosses WB,Kamps MP,Yates JR 3rd,Parmer RJ,Miles LA

    更新日期：2010-02-18 00:00:00

  • Characterization of the mouse von Willebrand factor promoter.

    abstract：:Expression of the von Willebrand factor (vWF) gene is restricted to the endothelial and megakaryocyte lineages. Within the endothelium, expression of vWF varies between different vascular beds. We have previously shown that the human vWF promoter spanning a region between -2182 (relative to the start site of transcrip...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Guan J,Guillot PV,Aird WC

    更新日期：1999-11-15 00:00:00

  • Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.

    abstract：:A prominent feature of most if not all cancers is a striking genetic instability, leading to ongoing accrual of mutational changes, some of which underlie tumor progression, including acquisition of invasiveness, drug resistance, and metastasis. Thus, the molecular basis for the generation of this genetic diversity in...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-05-089193

    authors： Shammas MA,Shmookler Reis RJ,Koley H,Batchu RB,Li C,Munshi NC

    更新日期：2009-03-05 00:00:00

  • Refinement of the Lugano Classification lymphoma response criteria in the era of immunomodulatory therapy.

    abstract：:Uniformly adopted response criteria are essential for assessment of therapies incorporating conventional chemotherapy and chemoimmunotherapy regimens. Recently, immunomodulatory agents, such as immune checkpoint inhibitors, have demonstrated impressive activity in a broad range of lymphoma histologies. However, these ...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2016-05-718528

    authors： Cheson BD,Ansell S,Schwartz L,Gordon LI,Advani R,Jacene HA,Hoos A,Barrington SF,Armand P

    更新日期：2016-11-24 00:00:00

  • Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction.

    abstract：:The therapeutic potential of hematopoietic stem cell (HSC) gene therapy can be fully exploited only by reaching efficient gene transfer into HSCs without compromising their biologic properties. Although HSCs can be transduced by HIV-derived lentiviral vectors (LVs) in short ex vivo culture, they display low permissivi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-10-4047

    authors： Santoni de Sio FR,Cascio P,Zingale A,Gasparini M,Naldini L

    更新日期：2006-06-01 00:00:00

  • Gene therapy, an ongoing revolution.

    abstract：:In this issue of Blood, Buchlis and colleagues describe the long-term persistence (up to 10 years) of factor IX (FIX) expression in adeno-associated virus serotype 2 (AAV-2)–injected muscles of a patient with hemophilia B. ...

    journal_title：Blood

    pub_type： 评论,杂志文章

    doi：10.1182/blood-2012-02-409086

    authors： Benveniste O

    更新日期：2012-03-29 00:00:00

  • Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection.

    abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-09-306761

    authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

    更新日期：2011-05-19 00:00:00

  • Individual CD34+CD38lowCD19-CD10- progenitor cells from human cord blood generate B lymphocytes and granulocytes.

    abstract：:Identification of human hematopoietic stem cells and analysis of molecular mechanisms regulating their function require biological assays that permit differentiation in all hematopoietic lineages simultaneously. In this study, we established conditions that permit the joint expression of the B-lymphoid and myeloid pot...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Berardi AC,Meffre E,Pflumio F,Katz A,Vainchenker W,Schiff C,Coulombel L

    更新日期：1997-05-15 00:00:00

  • Ferritin iron absorption in man.

    abstract：:The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects wit...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Layrisse M,Martínez-Torres C,Renzy M,Leets I

    更新日期：1975-05-01 00:00:00

  • A new cytokine-dependent monoblastic cell line with t(9;11)(p22;q23) differentiates to macrophages with macrophage colony-stimulating factor (M-CSF) and to osteoclast-like cells with M-CSF and interleukin-4.

    abstract：:Monocytes/macrophages exert a series of important functions in vivo. To facilitate detailed investigation of their functional capacity and the mechanism leading to their differentiation, several cell lines have been established from primary material. We present here a new human monoblastic cell line, designated UG3. U...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ikeda T,Sasaki K,Ikeda K,Yamaoka G,Kawanishi K,Kawachi Y,Uchida T,Takahara J,Irino S

    更新日期：1998-06-15 00:00:00

  • Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T cells: implications for acquired immunodeficiency syndrome-associated vasculopathy.

    abstract：:Alterations in the vascular system and the onset of angioproliferative lesions such as Kaposi's sarcoma (KS) are common traits of human immunodeficiency virus-1 (HIV-1)-infected patients. To investigate possible factors involved in acquired immunodeficiency syndrome (AIDS)-associated vasculopathy and vascular malfunct...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ascherl G,Hohenadl C,Schatz O,Shumay E,Bogner J,Eckhart L,Tschachler E,Monini P,Ensoli B,Stürzl M

    更新日期：1999-06-15 00:00:00

  • Discovery and validation of graft-versus-host disease biomarkers.

    abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective tumor immunotherapy available. Although allo-HSCT provides beneficial graft-versus-tumor effects, acute GVHD (aGVHD) is the primary source of morbidity and mortality after HSCT. Diagnosis of aGVHD is typically based on clinical sympto...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2012-08-355990

    authors： Paczesny S

    更新日期：2013-01-24 00:00:00

  • Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD.

    abstract：:Graft-versus-host disease (GVHD) is a systemic inflammatory response due to the recognition of major histocompatibility complex disparity between donor and recipient after hematopoietic stem cell transplantation (HSCT). T-cell activation is critical to the induction of GVHD, and data from our group and others have sho...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-09-526020

    authors： Lin KL,Fulton LM,Berginski M,West ML,Taylor NA,Moran TP,Coghill JM,Blazar BR,Bear JE,Serody JS

    更新日期：2014-03-06 00:00:00

  • The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF.

    abstract：:While studying patient plasma containing an unusual pattern of von Willebrand factor (VWF) multimers, we discovered a previously unreported phenomenon: heavy predominance of dimeric VWF. Genomic analysis revealed a new congenital mutation (Tyr87Ser) that altered the final stages of VWF biosynthesis. This mutation in t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-03-0789

    authors： Rosenberg JB,Haberichter SL,Jozwiak MA,Vokac EA,Kroner PA,Fahs SA,Kawai Y,Montgomery RR

    更新日期：2002-09-01 00:00:00

  • The evolving contribution of hematopoietic progenitor cells to lymphomagenesis.

    abstract：:Recent genomic studies have outlined a landscape of recurrent alterations within some subtypes of lymphoid cancer. Yet, the timing and cellular contexts during which these alterations occur (ie, the molecular ontogeny) remain poorly understood. Lymphoid malignancies offer an exceptional opportunity to delineate the on...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2012-05-414995

    authors： Weigert O,Weinstock DM

    更新日期：2012-09-27 00:00:00

  • Munc18b/STXBP2 is required for platelet secretion.

    abstract：:Platelets are vital for hemostasis because they release their granule contents in response to vascular damage. Platelet exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), whose interactions are governed by regulators, eg, Sec/Munc18 proteins. These proteins chape...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-05-430629

    authors： Al Hawas R,Ren Q,Ye S,Karim ZA,Filipovich AH,Whiteheart SW

    更新日期：2012-09-20 00:00:00

  • Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia.

    abstract：:The glutathione S-transferase (GST) genes are involved in the metabolism of environmental carcinogens and of some classes of chemotherapy drugs. GSTM1 and GSTT1 genotypes are polymorphic in humans, and the phenotypic absence of enzyme activity is caused by a homozygous inherited deletion of the gene. Previous, smaller...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v100.1.67

    authors： Davies SM,Bhatia S,Ross JA,Kiffmeyer WR,Gaynon PS,Radloff GA,Robison LL,Perentesis JP

    更新日期：2002-07-01 00:00:00

  • Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3.

    abstract：:Bone morphogenetic proteins (BMPs), members of the transforming growth factor (TGF)-beta superfamily, are a group of related proteins that are capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. We show in this report a novel function of BMPs in hematopoietic cell...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Kawamura C,Kizaki M,Yamato K,Uchida H,Fukuchi Y,Hattori Y,Koseki T,Nishihara T,Ikeda Y

    更新日期：2000-09-15 00:00:00

  • Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia.

    abstract：:Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patie...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Nakao S,Takamatsu H,Chuhjo T,Ueda M,Shiobara S,Matsuda T,Kaneshige T,Mizoguchi H

    更新日期：1994-12-15 00:00:00

  • CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.

    abstract：:The Hermes receptor CD44 is a multifunctional adhesion molecule that plays an essential role in the homing and invasion of neoplastic stem cells in various myeloid malignancies. Although mast cells (MCs) reportedly express CD44, little is known about the regulation and function of this receptor in neoplastic cells in ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2018-02-833582

    authors： Mueller N,Wicklein D,Eisenwort G,Jawhar M,Berger D,Stefanzl G,Greiner G,Boehm A,Kornauth C,Muellauer L,Sehner S,Hoermann G,Sperr WR,Staber PB,Jaeger U,Zuber J,Arock M,Schumacher U,Reiter A,Valent P

    更新日期：2018-11-01 00:00:00

  • How I treat steroid-refractory acute graft-versus-host disease.

    abstract：:Steroid-resistant or steroid-refractory acute graft-versus-host disease (SR-aGVHD) poses one of the most vexing challenges faced by providers who care for patients after allogeneic hematopoietic cell transplantation. For the past 4 decades, research in the field has been driven by the premise that persistent graft-ver...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019000960

    authors： Martin PJ

    更新日期：2020-05-07 00:00:00

  • Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions in cutaneous lymphomas.

    abstract：:Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)-skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and m...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2004-01-0360

    authors： Dummer R,Hassel JC,Fellenberg F,Eichmüller S,Maier T,Slos P,Acres B,Bleuzen P,Bataille V,Squiban P,Burg G,Urosevic M

    更新日期：2004-09-15 00:00:00