Management of alloimmune thrombocytopenia: antenatal diagnosis and in utero transfusion of maternal platelets.

abstract：:Diaspirin cross-linked hemoglobin (DCLHb) is an intramolecularly cross-linked hemoglobin-based oxygen carrier being developed as a therapy for acute blood loss. We report here the absence of immunogenicity of DCLHb in patients enrolled in phase II and III clinical trials of DCLHb. Two very sensitive immunoassays, an e...

journal_title：Blood

authors： Patel MJ,Webb EJ,Shelbourn TE,Mattia-Goldberg C,George AJ,Zhang F,Moore EG,Nelson DJ

更新日期：1998-01-15 00:00:00

abstract：:The PAX-5 gene codes for the transcription factor BSAP, which is expressed throughout B-cell development. Although loss-of-function mutation in the mouse showed an essential role for Pax-5 in early B lymphopoiesis, gain-of-function mutations have implicated the human PAX-5 gene in the control of late B-cell differenti...

journal_title：Blood

authors： Morrison AM,Jäger U,Chott A,Schebesta M,Haas OA,Busslinger M

更新日期：1998-11-15 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transc...

journal_title：Blood

authors： Daenthanasanmak A,Iamsawat S,Chakraborty P,Nguyen HD,Bastian D,Liu C,Mehrotra S,Yu XZ

更新日期：2019-01-17 00:00:00

abstract：:Little is known about the molecular mechanisms controlling primitive hematopoietic stem cells, especially during embryogenesis. Homeobox genes encode a family of transcription factors that have gained increasing attention as master regulators of developmental processes and recently have been implicated in the differen...

journal_title：Blood

authors： Helgason CD,Sauvageau G,Lawrence HJ,Largman C,Humphries RK

更新日期：1996-04-01 00:00:00

abstract：:Sickle cell disease (SCD) is characterized by a single point mutation in the seventh codon of the β-globin gene. Site-specific correction of the sickle mutation in hematopoietic stem cells would allow for permanent production of normal red blood cells. Using zinc-finger nucleases (ZFNs) designed to flank the sickle mu...

journal_title：Blood

authors： Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A

更新日期：2015-04-23 00:00:00

abstract：:Whereas the chimeric type I anti-CD20 Ab rituximab has improved outcomes for patients with B-cell malignancies significantly, many patients with non-Hodgkin lymphoma (NHL) remain incurable. Obinutuzumab (GA101) is a glycoengineered, humanized anti-CD20 type II Ab that has demonstrated superior activity against type I ...

journal_title：Blood

authors： Salles G,Morschhauser F,Lamy T,Milpied N,Thieblemont C,Tilly H,Bieska G,Asikanius E,Carlile D,Birkett J,Pisa P,Cartron G

更新日期：2012-05-31 00:00:00

abstract：:Phospholipase C (PLC)-mediated hydrolysis of membrane phospholipids results in the production of diacylglycerol, inositol phosphates, and choline metabolites. Inositol triphosphate increases calcium levels, while diacylglycerol activates protein kinase C. The present studies demonstrate that exogenous PLC generates in...

journal_title：Blood

authors： Stone RM,Weber BL,Spriggs DR,Kufe DW

更新日期：1988-08-01 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by the discovery of g...

journal_title：Blood

authors： Elliott NE,Cleveland SM,Grann V,Janik J,Waldmann TA,Davé UP

更新日期：2011-10-06 00:00:00

abstract：:The recent discovery of microRNAs (miRNAs) has revealed a new layer of gene expression regulation, affecting the immune system. Here, we identify their roles in regulating human plasmacytoid dendritic cell (PDC) activation. miRNA profiling showed the significantly differential expression of 19 miRNAs in PDCs after Tol...

journal_title：Blood

authors： Zhou H,Huang X,Cui H,Luo X,Tang Y,Chen S,Wu L,Shen N

更新日期：2010-12-23 00:00:00

abstract：:Personalized immunotherapy of lymphoma based on tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellular immune responses in 50%-75% of follicular lymphoma patients, indicating that this therapy can be clinically successful. We have developed a novel vaccine against lymphoma consist...

journal_title：Blood

authors： Carlring J,Szabo MJ,Dickinson R,De Leenheer E,Heath AW

更新日期：2012-03-01 00:00:00

abstract：:Hematopoietic stem cells differentiate in the thymus to T cells along precisely defined intermediates. This process is thymic epithelium dependent and involves cytokines and cell-cell interactions between thymic stroma and T-cell precursors. Here we report that highly purified human CD34++ fetal liver stem cells diffe...

journal_title：Blood

authors： Plum J,De Smedt M,Defresne MP,Leclercq G,Vandekerckhove B

更新日期：1994-09-01 00:00:00

abstract：:Recent studies have identified nonredundant roles for basophils in immune responses including allergy and protective immunity. It is well known that activated basophils release granule contents such as histamine and proteases as do mast cells. However, the functional significance of basophil-derived proteases remains ...

journal_title：Blood

authors： Iki M,Tanaka K,Deki H,Fujimaki M,Sato S,Yoshikawa S,Yamanishi Y,Karasuyama H

更新日期：2016-12-22 00:00:00

abstract：:Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in ...

journal_title：Blood

authors： Lindemann A,Ludwig WD,Oster W,Mertelsmann R,Herrmann F

更新日期：1989-03-01 00:00:00

abstract：:In this issue of Blood, Pagel et al carefully deliniate some fascinating phenotype/genotype correlations in a larger cohort than in their earlier reports of familial hemophagocytic lymphohistiocytosis (HLH). ...

journal_title：Blood

authors： McClain KL

更新日期：2012-06-21 00:00:00

abstract：:Current monoclonal antibody therapies for multiple myeloma have had limited success, perhaps due to narrow target specificity. We have previously described the ability of polyclonal rabbit antithymocyte globulin (rATG) to induce caspase- and cathepsin-mediated apoptosis in human B and plasma cells. We now extend this ...

journal_title：Blood

authors： Zand MS,Vo T,Pellegrin T,Felgar R,Liesveld JL,Ifthikharuddin JJ,Abboud CN,Sanz I,Huggins J

更新日期：2006-04-01 00:00:00

abstract：:ADAMTS13 proteolytically regulates the platelet-tethering function of von Willebrand factor (VWF). ADAMTS13 function is dependent upon multiple exosites that specifically bind the unraveled VWF A2 domain and enable proteolysis. We carried out a comprehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich)...

journal_title：Blood

authors： de Groot R,Lane DA,Crawley JT

更新日期：2015-03-19 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha), a cytokine possessing pleiotropic biological activities, is produced by leukemic lymphocytes in patients with chronic lymphocytic leukemia (CLL) and acts as an autocrine and paracrine growth factor in this disease. In this study, TNF-alpha levels were determined in 150 patients...

journal_title：Blood

authors： Ferrajoli A,Keating MJ,Manshouri T,Giles FJ,Dey A,Estrov Z,Koller CA,Kurzrock R,Thomas DA,Faderl S,Lerner S,O'Brien S,Albitar M

更新日期：2002-08-15 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is composed of large, frequently bizarre, cells of T- or null-cell phenotype that show a preferential sinusoidal growth pattern and consistent CD30 positivity. Whether these tumors represent a single entity or several, and what the exact cell origin, is controversial. Recently, gr...

journal_title：Blood

authors： Krenacs L,Wellmann A,Sorbara L,Himmelmann AW,Bagdi E,Jaffe ES,Raffeld M

更新日期：1997-02-01 00:00:00

abstract：:Two tumor necrosis factor receptors (TNFRs) with molecular weights of 55 kD (TNFR-p55) and 75 kD (TNFR-p75) have recently been identified and cloned. In previous studies, TNFR-p55 has been shown to exclusively mediate bidirectional effects of TNF-alpha on committed bone marrow granulocyte-macrophage progenitor cells, ...

journal_title：Blood

authors： Rusten LS,Jacobsen SE

更新日期：1995-02-15 00:00:00

abstract：:von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a...

journal_title：Blood

authors： Flood VH,Christopherson PA,Gill JC,Friedman KD,Haberichter SL,Bellissimo DB,Udani RA,Dasgupta M,Hoffmann RG,Ragni MV,Shapiro AD,Lusher JM,Lentz SR,Abshire TC,Leissinger C,Hoots WK,Manco-Johnson MJ,Gruppo RA,Boggio LN

更新日期：2016-05-19 00:00:00

abstract：:Recently G alpha 16, a new guanosine triphosphate (GTP) binding protein alpha subunit has been described to be specifically expressed in human hematopoietic cells. Expression of G alpha 16 was observed in human cell lines of myelomonocytic and T-lymphocytic origin, but not in human B-cell lines Raji and IM9. We studie...

journal_title：Blood

authors： Mapara MY,Bommert K,Bargou RC,Leng C,Beck C,Ludwig WD,Gierschik P,Dörken B

更新日期：1995-04-01 00:00:00

abstract：:The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8(+) T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-deriv...

journal_title：Blood

authors： Longman RS,Talal AH,Jacobson IM,Albert ML,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:Macrophages are motile leukocytes, targeted by HIV-1, thought to play a critical role in host dissemination of the virus. However, whether infection impacts their migration capacity remains unknown. We show that 2-dimensional migration and the 3-dimensional (3D) amoeboid migration mode of HIV-1-infected human monocyte...

journal_title：Blood

authors： Vérollet C,Souriant S,Bonnaud E,Jolicoeur P,Raynaud-Messina B,Kinnaer C,Fourquaux I,Imle A,Benichou S,Fackler OT,Poincloux R,Maridonneau-Parini I

更新日期：2015-03-05 00:00:00

abstract：:Erythropoiesis was investigated in 32 children wih short stature and in eight children with skeletal dysplasia by studying blood hemoglobin in relation to growth and to serum concentrations of insulin-like growth factor I (IGF-I), IGF binding protein-3 (IGFBP-3), and erythropoietin (EPO) before, during, and after 12 m...

journal_title：Blood

authors： Vihervuori E,Virtanen M,Koistinen H,Koistinen R,Seppälä M,Siimes MA

更新日期：1996-03-01 00:00:00

abstract：:Thrombospondin is a principal glycoprotein secreted by thrombin-stimulated platelets and has known affinities for fibrinogen and fibrin. We studied the distribution of thrombospondin in clots formed in situ on Formvar-coated coverslips at 37 degrees C for intervals up to 17 hours. The distributions of three other majo...

journal_title：Blood

authors： Murphy-Ullrich JE,Mosher DF

更新日期：1985-11-01 00:00:00

abstract：:We have used monoclonal antibodies (M Abs) and proteolytic fragmentation to localize structurally the functional sites of human von Willebrand factor (vWF) responsible for interaction with membrane glycoproteins GPIb, GPIIb/IIIa, and with collagen. SpII (215 kd) and SpIII (320 kd), the S aureus V-8 protease homodimeri...

journal_title：Blood

authors： Girma JP,Kalafatis M,Piétu G,Lavergne JM,Chopek MW,Edgington TS,Meyer D

更新日期：1986-05-01 00:00:00

abstract：:Activated protein C (APC) is inhibited by two major plasma inhibitors (PCIs). To find evidence for in vivo complexation of APC, immunoblotting studies were performed on plasmas of 85 patients with suspected disseminated intravascular coagulation (DIC). Samples from 62 of these patients contained 5% to 35% of protein C...

journal_title：Blood

authors： Heeb MJ,Mosher D,Griffin JH

更新日期：1989-02-01 00:00:00

abstract：:Thrombohemorrhagic complications are a major cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV). The pathogenesis of these complications is not completely clarified. Several studies have described abnormalities of red blood cells and platelets in these patients....

journal_title：Blood

authors： Falanga A,Marchetti M,Evangelista V,Vignoli A,Licini M,Balicco M,Manarini S,Finazzi G,Cerletti C,Barbui T

更新日期：2000-12-15 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00

abstract：:Inhibition of the B-cell receptor (BCR) signaling pathway is a promising treatment strategy in multiple B-cell malignancies. However, the role of BCR blockade in diffuse large B-cell lymphoma (DLBCL) remains undefined. We recently characterized primary DLBCL subsets with distinct genetic bases for perturbed BCR/phosph...

journal_title：Blood

authors： Bojarczuk K,Wienand K,Ryan JA,Chen L,Villalobos-Ortiz M,Mandato E,Stachura J,Letai A,Lawton LN,Chapuy B,Shipp MA

更新日期：2019-01-03 00:00:00