Phospholipase C activates protein kinase C and induces monocytic differentiation of HL-60 cells.

abstract：:Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected f...

journal_title：Blood

authors： Pui CH,Mullighan CG,Evans WE,Relling MV

更新日期：2012-08-09 00:00:00

abstract：:The erythroblastic island (EI), formed by a central macrophage and developing erythroblasts (EBs), was first described decades ago and was recently shown to play an in vivo role in homeostatic and pathological erythropoiesis. The exact molecular mechanisms, however, mediating the interactions between macrophages and E...

journal_title：Blood

authors： Wei Q,Boulais PE,Zhang D,Pinho S,Tanaka M,Frenette PS

更新日期：2019-03-14 00:00:00

abstract：:Extracellular histones have been shown to play an important pathogenic role in many diseases, primarily through their cytotoxicity toward nucleated cells and their ability to promote platelet activation with resultant thrombosis and thrombocytopenia. In contrast, little is known about the effect of extracellular histo...

journal_title：Blood

authors： Kordbacheh F,O'Meara CH,Coupland LA,Lelliott PM,Parish CR

更新日期：2017-12-28 00:00:00

abstract：:The molecular mechanisms by which mesenchymal stem cells (MSCs) suppress T-cell proliferation are poorly understood, and whether a soluble factor plays a major role remains controversial. Here we demonstrate that the T-cell-receptor complex is not a target for the suppression, suggesting that downstream signals mediat...

journal_title：Blood

authors： Sato K,Ozaki K,Oh I,Meguro A,Hatanaka K,Nagai T,Muroi K,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recircula...

journal_title：Blood

authors： Fauci AS,Dale DC

更新日期：1975-08-01 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characteri...

journal_title：Blood

authors： Gandhi MK,Hoang T,Law SC,Brosda S,O'Rourke K,Tobin JWD,Vari F,Murigneux V,Fink JL,Gunawardana J,Gould CM,Oey H,Bednarska K,Delecluse S,Trappe RU,de Long LM,Sabdia MB,Bhagat G,Hapgood G,Blyth E,Clancy LE,Wight J

更新日期：2020-11-17 00:00:00

abstract：:Recently, a novel gene of the major histocompatibility complex (MHC) class I family, HFE (HLA-H), has been found to be mutated in a large proportion of hereditary hemochromatosis (HH) patients. Further support for a causative role of HFE in this disease comes from the observation that beta2-microglobulin knockout (bet...

journal_title：Blood

authors： Santos M,Clevers H,de Sousa M,Marx JJ

更新日期：1998-04-15 00:00:00

abstract：:The physical interactions between B cells and stromal cells from the lymphoid tissue microenvironment are critical to the survival of normal and malignant B cells. They are principally mediated by integrins expressed on B cells and counterreceptors on stromal cells. Specifically, alpha4beta1 integrin engagement rescue...

journal_title：Blood

authors： Astier AL,Xu R,Svoboda M,Hinds E,Munoz O,de Beaumont R,Crean CD,Gabig T,Freedman AS

更新日期：2003-02-01 00:00:00

abstract：:Plasma fibronectin (Fn) induces phagocytosis of C3b-opsonized sheep erythrocytes (EC3b) by human peripheral blood monocytes. However, Fn does not induce erythrophagocytosis of EC3b by human polymorphonuclear leukocytes (PMN), unless the PMN have been exposed to C5a or N-formyl-methionyl-leucyl-phenylalanine. Because o...

journal_title：Blood

authors： Pommier CG,O'Shea J,Chused T,Takahashi T,Ochoa M,Nutman TB,Bianco C,Brown EJ

更新日期：1984-10-01 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells with the capacity to prime naive T cells for efficient cellular responses against pathogens such as HIV-1. DCs are also susceptible to HIV-1 infection, which may impair their ability to induce immunity. Here, we examined the ability of HIV-1-infected, in vitro-derived...

journal_title：Blood

authors： Smed-Sörensen A,Loré K,Walther-Jallow L,Andersson J,Spetz AL

更新日期：2004-11-01 00:00:00

abstract：:Epithelial mesenchymal transitions are a remarkable example of cellular plasticity. These transitions are the hallmark of embryo development, are pivotal in cancer progression, and seem to occur infrequently in adult organisms. The reduced incidence of transitions in the adult could result from restrictive functions o...

journal_title：Blood

authors： Prindull G,Zipori D

更新日期：2004-04-15 00:00:00

abstract：:Clinical trials have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine-2,3-dioxygenase (IDO) with the IDO2-inhibitor dextro-1-methyl-tryptophan (D-1MT). Here we show that human dendritic cells (DCs) express both IDO-1 and IDO-2, but that only IDO1 mediates try...

journal_title：Blood

authors： Lob S,Konigsrainer A,Schafer R,Rammensee HG,Opelz G,Terness P

更新日期：2008-02-15 00:00:00

abstract：UNLABELLED:Better methods to characterize normal human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facilitate improving recovery rates in transplanted patients.We now show that 5-fold more human myeloid cells are produced in sublethally irradiated NOD/SCID-IL-2Receptor-γchain-n...

journal_title：Blood

authors： Miller PH,Cheung AM,Beer PA,Knapp DJ,Dhillon K,Rabu G,Rostamirad S,Humphries RK,Eaves CJ

更新日期：2013-01-31 00:00:00

abstract：:We have retrospectively assessed the neurological manifestations in 34 patients with hemophagocytic lymphohistiocytosis (HLH) in a single center. Clinical, radiological, and cerebrospinal fluid (CSF) cytology data were analyzed according to treatment modalities. Twenty-five patients (73%) had evidence of central nervo...

journal_title：Blood

authors： Haddad E,Sulis ML,Jabado N,Blanche S,Fischer A,Tardieu M

更新日期：1997-02-01 00:00:00

abstract：:Human embryonic stem cells are a promising tool to study events associated with the earliest ontogenetic stages of hematopoiesis. We describe the generation of erythroid cells from hES (H1) by subsequent processing of cells present at early and late stages of embryoid body (EB) differentiation. Kinetics of hematopoiet...

journal_title：Blood

authors： Chang KH,Nelson AM,Cao H,Wang L,Nakamoto B,Ware CB,Papayannopoulou T

更新日期：2006-09-01 00:00:00

abstract：:Understanding the molecular pathogenesis of lymphoma has led to paradigm-changing treatment opportunities. One example involves tailoring specific agents based on the cell of origin in aggressive lymphomas. Germinal center (GC)-derived diffuse large B-cell lymphoma (DLBCL) is known to be driven by an addiction to Bcl6...

journal_title：Blood

authors： Amengual JE,Clark-Garvey S,Kalac M,Scotto L,Marchi E,Neylon E,Johannet P,Wei Y,Zain J,O'Connor OA

更新日期：2013-09-19 00:00:00

abstract：:Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor...

journal_title：Blood

authors： Taylor PA,Ehrhardt MJ,Lees CJ,Panoskaltsis-Mortari A,Krieg AM,Sharpe AH,Murphy WJ,Serody JS,Hemmi H,Akira S,Levy RB,Blazar BR

更新日期：2008-10-15 00:00:00

abstract：:A noninferiority study was performed comparing low-dose and standard-dose prophylactic platelet transfusions. A double-blind randomized controlled trial (RCT) was performed in 6 sites in 3 countries. Thrombocytopenic adults requiring prophylactic platelet transfusion were randomly allocated to standard-dose (300-600 x...

journal_title：Blood

authors： Heddle NM,Cook RJ,Tinmouth A,Kouroukis CT,Hervig T,Klapper E,Brandwein JM,Szczepiorkowski ZM,AuBuchon JP,Barty RL,Lee KA,SToP Study Investigators of the BEST Collaborative.

更新日期：2009-02-12 00:00:00

abstract：:Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell neoplasm that most commonly arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. HSTCL is more common in adolescent and young adults and has a rapidly progressive clinical course and poor outcome due to its refractoriness to conventional chemo...

journal_title：Blood

authors： Pro B,Allen P,Behdad A

更新日期：2020-10-29 00:00:00

abstract：:Although the potential role of Pim2 as a cooperative oncogene has been well described in lymphoma, its role in leukemia has remained largely unexplored. Here we show that high expression of Pim2 is observed in patients with acute promyelocytic leukemia (APL). To further characterize the cooperative role of Pim2 with p...

journal_title：Blood

authors： Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H

更新日期：2010-06-03 00:00:00

abstract：:To further evaluate the role of sialic acid in the dysfibrinogenemia associated with liver disease, we studied the effect of removal of excess sialic acid residues from the fibrinogen of five patients with liver disease on the thrombin time and fibrin monomer aggregation. Patient fibrinogens containing 1.4-3.4 residue...

journal_title：Blood

authors： Martinez J,MacDonald KA,Palascak JE

更新日期：1983-06-01 00:00:00

abstract：:If bone marrow transplantation is to become widely applicable in the treatment of patients with leukemia and aplastic anemia, the necessity to have a perfectly histocompatible donor must be overcome. In an effort to define the roles of HL-A type and mixed lymphocyte culture (MLC) reactivity in the determination of suc...

journal_title：Blood

authors： Feig SA,Opelz G,Winter HS,Falk PM,Neerhout RC,Sparkes R,Gale RP

更新日期：1976-09-01 00:00:00

abstract：:We used our recently reported stable, transformed human renal carcinoma cell line as a model system to study the role of 3',5'-adenosine monophosphate (cAMP) in erythropoietin secretion. The erythropoietin produced by these cells is both biologically active and immunologically cross-reactive with purified native human...

journal_title：Blood

authors： Sherwood JB,Burns ER,Shouval D

更新日期：1987-04-01 00:00:00

abstract：:The t(11;14)(q13;q32) results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma, where it is also associated with a lymphoplasmacytic morphology. We performed an interphase fluorescent in situ hybridization (FISH) study to determine the clinical and biologic significance o...

journal_title：Blood

authors： Fonseca R,Blood EA,Oken MM,Kyle RA,Dewald GW,Bailey RJ,Van Wier SA,Henderson KJ,Hoyer JD,Harrington D,Kay NE,Van Ness B,Greipp PR

更新日期：2002-05-15 00:00:00

abstract：:A myeloma cell-reactive monoclonal antibody (MoAb), MM4, was generated from BALB/c mice immunized with alternate injections of cells from two human multiple myeloma (MM) cell lines. Screening by the enzyme-linked immunosorbent assay (ELISA) technique showed that MM4 reacted with human MM cell lines (7 of 7 positive), ...

journal_title：Blood

authors： Tong AW,Lee JC,Stone MJ

更新日期：1987-01-01 00:00:00

abstract：:The Sox4 transcription factor mediates early B-cell differentiation. Compared with normal pre-B cells, SOX4 promoter regions in Ph(+) ALL cells are significantly hypomethylated. Loss and gain-of-function experiments identified Sox4 as a critical activator of PI3K/AKT and MAPK signaling in ALL cells. ChIP experiments c...

journal_title：Blood

authors： Ramezani-Rad P,Geng H,Hurtz C,Chan LN,Chen Z,Jumaa H,Melnick A,Paietta E,Carroll WL,Willman CL,Lefebvre V,Müschen M

更新日期：2013-01-03 00:00:00

abstract：:Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its substrate of the int...

journal_title：Blood

authors： Nickel KF,Ronquist G,Langer F,Labberton L,Fuchs TA,Bokemeyer C,Sauter G,Graefen M,Mackman N,Stavrou EX,Ronquist G,Renné T

更新日期：2015-09-10 00:00:00

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00

abstract：:The effects of human recombinant erythropoietin (rEpo) in the presence of other stimulators on the growth of clonogenic leukemic blast cells from ten Japanese patients with acute myeloblastic leukemia were studied with an in vitro leukemic blast colony assay in methylcellulose culture. With the addition of rEpo alone,...

journal_title：Blood

authors： Asano Y,Okamura S,Shibuya T,Harada M,Niho Y

更新日期：1988-11-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin's lymphoma (NHL) that is highly heterogeneous from both clinical and histopathologic viewpoints. The immunoglobulin (Ig) heavy (H) chain variable region genes were examined in 71 patients with untreated primary DLBCL. Fifty-eight potentially functio...

journal_title：Blood

authors： Lossos IS,Okada CY,Tibshirani R,Warnke R,Vose JM,Greiner TC,Levy R

更新日期：2000-03-01 00:00:00