Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients.

abstract：:Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population variability observed for this trait. B...

journal_title：Blood

authors： Viel KR,Machiah DK,Warren DM,Khachidze M,Buil A,Fernstrom K,Souto JC,Peralta JM,Smith T,Blangero J,Porter S,Warren ST,Fontcuberta J,Soria JM,Flanders WD,Almasy L,Howard TE

更新日期：2007-05-01 00:00:00

abstract：:Leukemic blasts from 774 children with newly diagnosed acute lymphocytic leukemia (ALL) have been phenotyped by microcytotoxicity testing with a panel of monoclonal antibodies and heteroantisera as part of a Pediatric Oncology Group classification study of acute leukemia. One hundred twenty-two cases, or 16% were desi...

journal_title：Blood

authors： Borowitz MJ,Dowell BL,Boyett JM,Falletta JM,Pullen DJ,Crist WM,Humphrey GB,Metzgar RS

更新日期：1985-04-01 00:00:00

abstract：:Interleukin-3 (IL-3) is exclusively expressed by activated T and natural killer cells, a function that is tightly controlled both in a lineage-specific and in a stimulation-dependent manner. We have investigated the protein binding characteristics and functional importance of the ACT-1-activating region of the IL-3 pr...

journal_title：Blood

authors： Davies K,TePas EC,Nathan DG,Mathey-Prevot B

更新日期：1993-02-15 00:00:00

abstract：:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be...

journal_title：Blood

authors： Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JV

更新日期：2001-12-15 00:00:00

abstract：:CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the nerve growth factor-receptor family, a group of homologous molecules involved in lymphocyte differentiation and selection. It is expressed on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. We investigated the expressio...

journal_title：Blood

authors： van Oers MH,Pals ST,Evers LM,van der Schoot CE,Koopman G,Bonfrer JM,Hintzen RQ,von dem Borne AE,van Lier RA

更新日期：1993-12-01 00:00:00

abstract：:Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in ∼12% of patients with acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2-hydroxyglutarate resulting in DNA and histone hypermethylation, which leads to blocked cellular differentiation. Enasidenib (AG-221/CC-90007) is a firs...

journal_title：Blood

authors： Stein EM,DiNardo CD,Pollyea DA,Fathi AT,Roboz GJ,Altman JK,Stone RM,DeAngelo DJ,Levine RL,Flinn IW,Kantarjian HM,Collins R,Patel MR,Frankel AE,Stein A,Sekeres MA,Swords RT,Medeiros BC,Willekens C,Vyas P,Tosolini A

更新日期：2017-08-10 00:00:00

abstract：:The effects of factor IX concentrate therapy on hemostasis in hemophilia patients were studied by means of the radiometric factor IXa assay, the coupled amidolytic assay for factor VIIa, and coagulant assays for factors II, IX, and X, and antithrombin III. Both activated and unactivated concentrates contained factors ...

journal_title：Blood

authors： Hultin MB

更新日期：1983-09-01 00:00:00

abstract：:Peripheral blood cells from nine patients with B-chronic lymphocytic leukemia (B-CLL) were treated in vitro with bryostatin 1 (a macrocyclic lactone derived from a marine invertebrate). Like the phorbol ester 12-0-tetradecanoyl-phorbol 13-acetate (TPA), bryostatin 1 activates protein kinase C (PKC), which plays a cent...

journal_title：Blood

authors： Drexler HG,Gignac SM,Jones RA,Scott CS,Pettit GR,Hoffbrand AV

更新日期：1989-10-01 00:00:00

abstract：:The association of fibrinogen with washed human platelets was examined by immunocytochemistry during aggregation induced by adenosine diphosphate (ADP) and during deaggregation. The platelets were suspended either in a medium containing 2 mmol/L Ca2+ or in a medium containing no added Ca2+ (20 mumol/L Ca2+). Platelets...

journal_title：Blood

authors： Suzuki H,Kinlough-Rathbone RL,Packham MA,Tanoue K,Yamazaki H,Mustard JF

更新日期：1988-04-01 00:00:00

abstract：:HIV-1-associated thrombocytopenia (HIV-1-ITP) is a common complication of HIV-1 infection, frequently caused by increased peripheral platelet destruction mediated by antiplatelet antibodies (Abs) and/or platelet-bound immune complexes. Little is known about the specificity of the antiplatelet Abs at a molecular level....

journal_title：Blood

authors： Koefoed K,Ditzel HJ

更新日期：2004-12-15 00:00:00

abstract：:An abnormality of platelet aggregation has been detected in six family members with mild bleeding tendencies. In citrated platelet-rich plasma, primary aggregation induced by ADP or epinephrine and agglutination in response to ristocetin were present but second wave aggregation and aggregation in response to collagen ...

journal_title：Blood

authors： Ingerman CM,Smith JB,Shapiro S,Sedar A,Silver MJ

更新日期：1978-08-01 00:00:00

abstract：:Until recently, the identification of cellular factors that govern the developmental program of human stem cells has been difficult due to the absence of repopulation assays that detect human stem cells. The transplantation of human bone marrow (BM) or cord blood (CB) into non-obese diabetic (NOD)/severe-combined immu...

journal_title：Blood

authors： Kapp U,Bhatia M,Bonnet D,Murdoch B,Dick JE

更新日期：1998-09-15 00:00:00

abstract：:The course and treatment of a life-threatening hemorrhagic episode in a patient with hemophilia A whose plasma contained a high concentration of an inhibitor of factor VIII activity is presented. The inhibitor of factor VIII was localized to the most anodal fractions of immunoglobulin G on electrophoresis, and was thu...

journal_title：Blood

authors： Sonoda T,Solomon A,Krauss S,Cruz P,Jones FS,Levin J

更新日期：1976-06-01 00:00:00

abstract：:The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral vector encoding GATA-2 and the green fluorescent protein (GFP) was used to maintain the high levels of...

journal_title：Blood

authors： Persons DA,Allay JA,Allay ER,Ashmun RA,Orlic D,Jane SM,Cunningham JM,Nienhuis AW

更新日期：1999-01-15 00:00:00

abstract：:Studies have demonstrated that common polymorphisms in Th1 and Th2 cytokine genes can alter gene expression, modulate the balance between Th1/Th2 responsiveness, and influence susceptibility for autoimmune disorders, infectious diseases, and cancer. We analyzed one or more single nucleotide polymorphisms (SNPs) in 20 ...

journal_title：Blood

authors： Lan Q,Zheng T,Rothman N,Zhang Y,Wang SS,Shen M,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Boyle P,Zhang B,Zou K,Zhu Y,Chanock S

更新日期：2006-05-15 00:00:00

abstract：:Mutations in PIEZO1 are the primary cause of hereditary xerocytosis, a clinically heterogeneous, dominantly inherited disorder of erythrocyte dehydration. We used next-generation sequencing-based techniques to identify PIEZO1 mutations in individuals from 9 kindreds referred with suspected hereditary xerocytosis (HX) ...

journal_title：Blood

authors： Glogowska E,Schneider ER,Maksimova Y,Schulz VP,Lezon-Geyda K,Wu J,Radhakrishnan K,Keel SB,Mahoney D,Freidmann AM,Altura RA,Gracheva EO,Bagriantsev SN,Kalfa TA,Gallagher PG

更新日期：2017-10-19 00:00:00

abstract：:ADAMTS13 metalloprotease cleaves von Willebrand factor (VWF), thereby inhibiting platelet aggregation and arterial thrombosis. An inability to cleave ultralarge VWF resulting from hereditary or acquired deficiency of plasma ADAMTS13 activity leads to a potentially fatal syndrome, thrombotic thrombocytopenic purpura (T...

journal_title：Blood

authors： Pickens B,Mao Y,Li D,Siegel DL,Poncz M,Cines DB,Zheng XL

更新日期：2015-05-21 00:00:00

abstract：:The bone marrow (BM) microenvironment consists of extracellular-matrix and the cellular compartment including immune cells. Multiple myeloma (MM) cell and BM accessory cell interaction promotes MM survival via both cell-cell contact and cytokines. Immunomodulatory agents (IMiDs) target not only MM cells, but also MM c...

journal_title：Blood

authors： Görgün G,Calabrese E,Soydan E,Hideshima T,Perrone G,Bandi M,Cirstea D,Santo L,Hu Y,Tai YT,Nahar S,Mimura N,Fabre C,Raje N,Munshi N,Richardson P,Anderson KC

更新日期：2010-10-28 00:00:00

abstract：:Several studies demonstrate that hemolysis and free heme in circulation cause endothelial barrier dysfunction and are associated with severe pathological conditions such as acute respiratory distress syndrome, acute chest syndrome, and sepsis. However, the precise molecular mechanisms involved in the pathology of heme...

journal_title：Blood

authors： James J,Srivastava A,Varghese MV,Eccles CA,Zemskova M,Rafikova O,Rafikov R

更新日期：2020-08-06 00:00:00

abstract：:This report discusses a case of T cell chronic lymphocytic leukemia (T-CLL) in an elderly white man whose lymphocytes expressed a post-thymic phenotype except for the coexpression of T4 and T8 on 80% to 95% of the cells. Because of the uncommon phenotype, in vitro functional assays were performed that showed decreased...

journal_title：Blood

authors： Simpkins H,Kiprov DD,Davis JL 3rd,Morand P,Puri S,Grahn EP

更新日期：1985-01-01 00:00:00

abstract：:In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL. ...

journal_title：Blood

authors： Moreno C

更新日期：2015-05-28 00:00:00

abstract：:The white-spotting (Ws) locus of rats represents a 12-base deletion of the c-kit receptor tyrosine kinase. Homozygous Ws/Ws rats are deficient in melanocytes, mast cells, and erythrocytes. Although mice possessing two mutant alleles at the c-kit (W) locus, such as mice of W/Wv genotype, show severe anemia even in adul...

journal_title：Blood

authors： Morimoto M,Kasugai T,Tei H,Jippo-Kanemoto T,Kanakura Y,Kitamura Y

更新日期：1993-12-01 00:00:00

abstract：:An increasing number of reports document instances in which individual leukemic cells coexpress markers normally believed to be restricted to a single lineage. This has been interpreted by McCulloch and colleagues as aberrant programming or lineage infidelity and contrasts with earlier suggestions that lineage fidelit...

journal_title：Blood

authors： Greaves MF,Chan LC,Furley AJ,Watt SM,Molgaard HV

更新日期：1986-01-01 00:00:00

abstract：:von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a...

journal_title：Blood

authors： Flood VH,Christopherson PA,Gill JC,Friedman KD,Haberichter SL,Bellissimo DB,Udani RA,Dasgupta M,Hoffmann RG,Ragni MV,Shapiro AD,Lusher JM,Lentz SR,Abshire TC,Leissinger C,Hoots WK,Manco-Johnson MJ,Gruppo RA,Boggio LN

更新日期：2016-05-19 00:00:00

abstract：:We report in this paper that a novel small molecule, JTZ-132, induced growth and differentiation of megakaryocytic progenitor cells and improved thrombocytopenia in myelosuppressed mice. JTZ-132 stimulated proliferation of UT-7/TPO cells, a cell line highly sensitive to thrombopoietin (TPO), and exhibited full efficac...

journal_title：Blood

authors： Inagaki K,Oda T,Naka Y,Shinkai H,Komatsu N,Iwamura H

更新日期：2004-07-01 00:00:00

abstract：:The rapid transformation of human blood platelets from inert discoid cells to spheroechinocytes that is induced by adenosine diphosphate (ADP) has been followed by right-angle light scattering intensity measurements using a laser light source and a sensitive photomultiplier. Two steps have been observed, and their rat...

journal_title：Blood

authors： Hantgan RR

更新日期：1984-10-01 00:00:00

abstract：:Murine myeloid cells can be transformed in vitro by infection with recombinant retroviruses carrying activated myb genes. While these myb-transformed hematopoietic cells (MTHCs) can proliferate continuously in culture, they exhibit several characteristics of progenitor cells of the granulocyte-macrophage (GM) lineage,...

journal_title：Blood

authors： Macmillan EM,Gonda TJ

更新日期：1994-01-01 00:00:00

abstract：:It was previously shown that patients with chronic myeloid leukemia (CML) have a rare but consistently detectable population of quiescent (G0) leukemic (Philadelphia chromosome-positive and BCR-ABL-positive [BCR-ABL+]) CD34+ cells. In the study described here, most such cells expressed a primitive phenotype (CD38-, CD...

journal_title：Blood

authors： Holyoake TL,Jiang X,Jorgensen HG,Graham S,Alcorn MJ,Laird C,Eaves AC,Eaves CJ

更新日期：2001-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification. In an unselected series of 1897 AML cases, 54 patients with an 11q23/MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence...

journal_title：Blood

authors： Schoch C,Schnittger S,Klaus M,Kern W,Hiddemann W,Haferlach T

更新日期：2003-10-01 00:00:00

abstract：:We have studied the impact of B-cell receptor (BCR) or CD40 ligation on the in vitro chemotactic response of tonsillar B cells to 4 chemokines: stromal cell-derived factor (SDF)-1alpha, macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and B-cell-attracting chemokine (BCA)-1. In the tonsil, SDF-1 and MIP-3alpha...

journal_title：Blood

authors： Casamayor-Pallejà M,Mondière P,Verschelde C,Bella C,Defrance T

更新日期：2002-03-15 00:00:00