Murine myeloid cells transformed by myb require fibroblast-derived or autocrine growth factors in addition to granulocyte-macrophage colony-stimulating factor for proliferation.

abstract：:Human herpesvirus 6 (HHV-6) is detected in the plasma of approximately 40% of patients undergoing hematopoietic cell transplantation (HCT) and sporadically causes encephalitis in this population. The effect of HHV-6 reactivation on central nervous system function has not been fully characterized. This prospective stud...

journal_title：Blood

authors： Zerr DM,Fann JR,Breiger D,Boeckh M,Adler AL,Xie H,Delaney C,Huang ML,Corey L,Leisenring WM

更新日期：2011-05-12 00:00:00

abstract：:Previous studies demonstrated that Kit activation confers radioprotection. However, the mechanism by which Kit signaling interferes with cellular response to ionizing radiation (IR) has not been firmly established. Based on the role of the sphingomyelin (SM) cycle apoptotic pathway in IR-induced apoptosis, we hypothes...

journal_title：Blood

authors： Maddens S,Charruyer A,Plo I,Dubreuil P,Berger S,Salles B,Laurent G,Jaffrézou JP

更新日期：2002-08-15 00:00:00

abstract：:The three-dimensional tertiary structure of human von Willebrand Factor (vWF) on a hydrophobic surface under aqueous conditions and different shear stress regimes was studied by atomic force microscopy (AFM). vWF was imaged by AFM at molecular level resolution under negligible shear stress, under a local applied shear...

journal_title：Blood

authors： Siedlecki CA,Lestini BJ,Kottke-Marchant KK,Eppell SJ,Wilson DL,Marchant RE

更新日期：1996-10-15 00:00:00

abstract：:Although the proto-oncogene rhombotin-2 (RBTN-2) is widely expressed in most tissues, it is not expressed in T cells. We investigated the potential for overexpression of RBTN-2 to cause tumors in T cells and other tissues by constructing transgenic mice that expressed RBTN-2 under control of the metallothionein-1 prom...

journal_title：Blood

authors： Neale GA,Rehg JE,Goorha RM

更新日期：1995-10-15 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is a potential target for toxin-directed therapy, because it is overexpressed on many leukemias and solid tumors and apparently not on stem cells. To investigate the potential therapeutic use of GM-CSF toxins, we fused human GM-CSF to truncated fo...

journal_title：Blood

authors： Kreitman RJ,Pastan I

更新日期：1997-07-01 00:00:00

abstract：:Recent studies with long-term mouse marrow cultures have indicated the importance of the adherent layer as a primary reservoir of the most primitive stem cells, from which derivative stem cells and more differentiated progenitors are continuously generated. We have now examined the role of the adherent cell layer in l...

journal_title：Blood

authors： Coulombel L,Eaves AC,Eaves CJ

更新日期：1983-08-01 00:00:00

abstract：:Reduced lymphopoiesis during aging contributes to declines in immunity, but little consideration has been given to its effect on the development of hematologic disease. This report demonstrates that age-related defects in lymphopoiesis underlie the myeloid dominance of adult leukemia. Using a murine model of chronic m...

journal_title：Blood

authors： Signer RA,Montecino-Rodriguez E,Witte ON,McLaughlin J,Dorshkind K

更新日期：2007-09-15 00:00:00

abstract：:Src activation involves the coordinated regulation of positive and negative tyrosine phosphorylation sites. The mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not known. Here, we demonstrate that granulocyte colony-stimulating factor (G-CSF) activates Lyn, the predominan...

journal_title：Blood

authors： Futami M,Zhu QS,Whichard ZL,Xia L,Ke Y,Neel BG,Feng GS,Corey SJ

更新日期：2011-07-28 00:00:00

abstract：:There is growing evidence that lymphocyte trafficking contributes to the clinical course of chronic lymphocytic leukemia (CLL), but to date, only static in vitro cultures have been used to study these phenomena. To address this lack of data, we have developed a dynamic in vitro model in which CLL cells experience shea...

journal_title：Blood

authors： Walsby E,Buggins A,Devereux S,Jones C,Pratt G,Brennan P,Fegan C,Pepper C

更新日期：2014-06-05 00:00:00

abstract：:Evidence is presented showing that a protein tyrosine phosphatase different from CD45 is present on the membrane of human hematopoietic cells. The molecule recognized by the monoclonal antibody 143-41, which has been classified as CD148 in the VI International Workshop on Leukocyte Differentiation Antigens, was immuno...

journal_title：Blood

authors： de la Fuente-García MA,Nicolás JM,Freed JH,Palou E,Thomas AP,Vilella R,Vives J,Gayá A

更新日期：1998-04-15 00:00:00

abstract：:In healthy carriers of human cytomegalovirus (HCMV), the virus-specific memory CD8(+) T-cell population is often dominated by CD28(-) CD45RA(hi) cells that exhibit direct ex vivo cytotoxicity but whose capacity for proliferation and generation of further memory cells has been questioned. We show that when highly purif...

journal_title：Blood

authors： Waller EC,McKinney N,Hicks R,Carmichael AJ,Sissons JG,Wills MR

更新日期：2007-12-15 00:00:00

abstract：:Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimmunoblastic T-cell lymp...

journal_title：Blood

authors： Liu C,Iqbal J,Teruya-Feldstein J,Shen Y,Dabrowska MJ,Dybkaer K,Lim MS,Piva R,Barreca A,Pellegrino E,Spaccarotella E,Lachel CM,Kucuk C,Jiang CS,Hu X,Bhagavathi S,Greiner TC,Weisenburger DD,Aoun P,Perkins SL,McKeith

更新日期：2013-09-19 00:00:00

abstract：:Myeloma bone disease is due to interactions of myeloma cells with the bone marrow microenvironment, and is associated with pathologic fractures, neurologic symptoms and hypercalcemia. Adjacent to myeloma cells, the formation and activation of osteoclasts is increased, which results in enhanced bone resorption. The rec...

journal_title：Blood

authors： Sezer O,Heider U,Zavrski I,Kühne CA,Hofbauer LC

更新日期：2003-03-15 00:00:00

abstract：:Nonresponse to remission-induction chemotherapy, which remains a major problem in acute myeloblastic leukemia (AML), has been linked to cellular resistance to apoptosis. Because the apoptosis induced by chemotherapeutic drugs is mediated by loss of mitochondrial transmembrane potential (MTP), it was postulated that se...

journal_title：Blood

authors： Pallis M,Grundy M,Turzanski J,Kofler R,Russell N

更新日期：2001-07-15 00:00:00

abstract：:The regulatory mechanism of differentiation of granulocyte and macrophage precursor cells (G/M CFU-C) in bone marrow and spleen obtained from nude mice bearing colony-stimulating factor (CSF) producing tumor (G-mice), which developed marked granulocytosis, was studied. In these mice, granulopoiesis is enhanced in the ...

journal_title：Blood

authors： Motoyoshi K,Suda T,Takaku F,Miura Y

更新日期：1983-11-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) pediatric patients exhibit a deficiency in humoral immune memory. However, the mechanism by which Wiskott-Aldrich syndrome protein (WASP) regulates the differentiation and activation of memory B cells remains elusive. Here we examine the early activation events of memory B cells from the...

journal_title：Blood

authors： Bai X,Zhang Y,Huang L,Wang J,Li W,Niu L,Jiang H,Dai R,Zhou L,Zhang Z,Miller H,Song W,Zhao X,Liu C

更新日期：2016-09-29 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent progenitor cells that have emerged as a promising tool for clinical application. Further clinical interest has been raised by the observation that MSCs are immunoprivileged and, more important, display immunosuppressive capacities. These properties may be of therapeutic va...

journal_title：Blood

authors： Nauta AJ,Westerhuis G,Kruisselbrink AB,Lurvink EG,Willemze R,Fibbe WE

更新日期：2006-09-15 00:00:00

abstract：:One hundred forty-two patients between the ages of 1 and 17 years who survived disease-free more than 1 year after marrow transplantation for hematologic malignancy had growth and development evaluations from one to 14 years posttransplant (median 4 years). Prior to transplant all children received multiagent chemothe...

journal_title：Blood

authors： Sanders JE,Pritchard S,Mahoney P,Amos D,Buckner CD,Witherspoon RP,Deeg HJ,Doney KC,Sullivan KM,Appelbaum FR

更新日期：1986-11-01 00:00:00

abstract：:Analysis of molecular mechanisms associated with stem cell commitment and differentiation requires an in vitro assay that identifies the most primitive hematopoietic stem cells in human bone marrow. Such primitive stem cells usually do not form colonies in short-term semisolid assays and are best identified by their a...

journal_title：Blood

authors： Issaad C,Croisille L,Katz A,Vainchenker W,Coulombel L

更新日期：1993-06-01 00:00:00

abstract：:Vascular bypass procedures in the central nervous system (CNS) remain technically challenging, hindered by complications and often failing to prevent adverse outcome such as stroke. Thus, there is an unmet clinical need for a safe and effective CNS revascularization. Vascular endothelial growth factors (VEGFs) are pro...

journal_title：Blood

authors： Gaál EI,Tammela T,Anisimov A,Marbacher S,Honkanen P,Zarkada G,Leppänen VM,Tatlisumak T,Hernesniemi J,Niemelä M,Alitalo K

更新日期：2013-08-01 00:00:00

abstract：:Ravulizumab (ALXN1210), a new complement C5 inhibitor, provides immediate, complete, and sustained C5 inhibition. This phase 3, open-label study assessed the noninferiority of ravulizumab to eculizumab in complement inhibitor-naive adults with paroxysmal nocturnal hemoglobinuria (PNH). Patients with lactate dehydrogen...

journal_title：Blood

authors： Lee JW,Sicre de Fontbrune F,Wong Lee Lee L,Pessoa V,Gualandro S,Füreder W,Ptushkin V,Rottinghaus ST,Volles L,Shafner L,Aguzzi R,Pradhan R,Schrezenmeier H,Hill A

更新日期：2019-02-07 00:00:00

abstract：:The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...

journal_title：Blood

authors： Swimm A,Giver CR,DeFilipp Z,Rangaraju S,Sharma A,Ulezko Antonova A,Sonowal R,Capaldo C,Powell D,Qayed M,Kalman D,Waller EK

更新日期：2018-12-06 00:00:00

abstract：:Both extrinsic and intrinsic mechanisms tightly govern hematopoietic stem cell (HSC) decisions of self-renewal and differentiation. However, transcription factors that can selectively regulate HSC self-renewal division after stress remain to be identified. Slug is an evolutionarily conserved zinc-finger transcription ...

journal_title：Blood

authors： Sun Y,Shao L,Bai H,Wang ZZ,Wu WS

更新日期：2010-03-04 00:00:00

abstract：:Interphase cytogenetics by means of in situ hybridization with the chromosome 12-specific biotinylated alpha satellite DNA probe pSP 12-1 was used for the study of trisomy 12, the most common chromosomal abnormality in chronic lymphocytic leukemia. In situ hybridization was performed on methanol/acetic acid fixed cell...

journal_title：Blood

authors： Losada AP,Wessman M,Tiainen M,Hopman AH,Willard HF,Solé F,Caballín MR,Woessner S,Knuutila S

更新日期：1991-08-01 00:00:00

abstract：:In the maternal decidua, natural killer (NK) cells, characterized by lack of CD16, are found in direct contact with the fetal extravillous trophoblasts (EVTs). It is yet unknown which factors contribute to the specific homing of this unique NK subset to the decidua. In this study we analyze the chemokine receptor repe...

journal_title：Blood

authors： Hanna J,Wald O,Goldman-Wohl D,Prus D,Markel G,Gazit R,Katz G,Haimov-Kochman R,Fujii N,Yagel S,Peled A,Mandelboim O

更新日期：2003-09-01 00:00:00

abstract：:Stem cell factor (SCF) is expressed as an integral membrane growth factor that may be differentially processed to produce predominantly soluble (S) (SCF(248)) or membrane-associated (MA) (SCF(220)) protein. A critical role for membrane presentation of SCF in the hematopoietic microenvironment (HM) has been suggested f...

journal_title：Blood

authors： Kapur R,Cooper R,Xiao X,Weiss MJ,Donovan P,Williams DA

更新日期：1999-09-15 00:00:00

abstract：:Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial alphavbeta3 integrin. To determine the contribution of LW activation...

journal_title：Blood

authors： Zennadi R,Moeller BJ,Whalen EJ,Batchvarova M,Xu K,Shan S,Delahunty M,Dewhirst MW,Telen MJ

更新日期：2007-10-01 00:00:00

abstract：:Brentuximab vedotin induces an overall response rate of 75% in patients with relapsed/refractory Hodgkin lymphoma, but its impact on future allogeneic transplantation (allo-HCT) is not known. We retrospectively examined the records of 18 patients with relapsed/refractory Hodgkin lymphoma who were treated on brentuxima...

journal_title：Blood

authors： Chen R,Palmer JM,Thomas SH,Tsai NC,Farol L,Nademanee A,Forman SJ,Gopal AK

更新日期：2012-06-28 00:00:00

abstract：:Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-m...

journal_title：Blood

authors： Barbano G,Saleh MN,Mori PG,LoBuglio AF,Shaw DR

更新日期：1989-02-15 00:00:00

abstract：:We studied eight patients with intermittent bleeding episodes usually following trauma and associated with the ingestion of medicine known to interfere with platelet function. All patients had a normal or minimally prolonged baseline bleeding time. All had a normal platelet count, glass bead retention test, and platel...

journal_title：Blood

authors： Czapek EE,Deykin D,Salzman E,Lian EC,Hellerstein LJ,Rosoff CB

更新日期：1978-07-01 00:00:00