Abstract:
:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be reversed in selected CML cell lines. Withdrawal of STI571 for varying lengths of time from cultures of 3 resistant lines (K562-r, KCL22-r, and Baf/BCR-ABL-r1) did not restore sensitivity to the inhibitor. In contrast, LAMA84-resistant cells experienced a sharp reduction in survival and proliferation during the first week of STI571 withdrawal but recovered thereafter. Moreover, when left off the inhibitor for 2 months or longer, this cell line reacquired sensitivity to STI571. It is hypothesized, therefore, that patients who have become resistant to the drug may respond again if STI571 therapy is temporarily interrupted.
journal_name
Bloodjournal_title
Bloodauthors
Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JVdoi
10.1182/blood.v98.13.3864subject
Has Abstractpub_date
2001-12-15 00:00:00pages
3864-7issue
13eissn
0006-4971issn
1528-0020journal_volume
98pub_type
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