Beta-glucan enhances complement-mediated hematopoietic recovery after bone marrow injury.

abstract：:Pharmacologic and immunologic methods of ex-vivo bone marrow (BM) purging for acute nonlymphocytic leukemia (ANLL) were combined to augment the effect of either method alone. Etoposide (VP16; 20 to 30 micrograms/mL) with or without cytosine arabinoside (Ara C; 10 mg/mL) was used in tandem with the anti-CD33 monoclonal...

journal_title：Blood

authors： Stiff PJ,Schulz WC,Bishop M,Marks L

更新日期：1991-01-15 00:00:00

abstract：:Obesity and inflammatory bowel disease (IBD) are systemic inflammatory disorders that predispose to arterial and venous thrombosis through similar prothrombotic mechanisms. Obesity and IBD are chronic risk factors that lead to a persistently elevated risk of thrombosis, although the thrombotic risk with IBD appears to...

journal_title：Blood

authors： Lentz SR

更新日期：2016-11-17 00:00:00

abstract：:Cutaneous T-cell lymphomas are disfiguring malignant lymphoproliferative disorders for which standard therapy has been principally palliative. 2-Chlorodeoxyadenosine (2-CdA), a new purine analogue resistant to degradation by adenosine deaminase that has substantial activity against lymphoid neoplasms, was administered...

journal_title：Blood

authors： Saven A,Carrera CJ,Carson DA,Beutler E,Piro LD

更新日期：1992-08-01 00:00:00

abstract：:To elucidate the role of thrombocytosis, alone or in combination with standard (age, previous cardiovascular events) and novel (leukocytosis, JAK2(V617F) mutational status) risk factors, in the cardiovascular events of essential thrombocythemia (ET), we analyzed a cohort of 1063 patients. We found that a platelet coun...

journal_title：Blood

authors： Carobbio A,Finazzi G,Antonioli E,Guglielmelli P,Vannucchi AM,Delaini F,Guerini V,Ruggeri M,Rodeghiero F,Rambaldi A,Barbui T

更新日期：2008-10-15 00:00:00

abstract：:CD56(high) acute myeloid leukemias (AMLs) have a poor prognosis, but it has been unclear how CD56 expression is controlled and how it relates to clinical aggressiveness. We show that CD56 expression on AML cells correlates with an abnormal expression pattern of runt-related transcription factor 1 (RUNX1) isoforms. Whe...

journal_title：Blood

authors： Gattenloehner S,Chuvpilo S,Langebrake C,Reinhardt D,Müller-Hermelink HK,Serfling E,Vincent A,Marx A

更新日期：2007-09-15 00:00:00

abstract：:Adult T-cell leukemia (ATL) is neoplasm of the mature helper T lymphocytes and human T-cell lymphotropic virus type-I (HTLV-I) has been shown to be causative virus of ATL. Because HTLV-I integrates its provirus randomly into host chromosomal DNA, monoclonal integration of HTLV-I provirus indicates the clonal prolifera...

journal_title：Blood

authors： Takemoto S,Matsuoka M,Yamaguchi K,Takatsuki K

更新日期：1994-11-01 00:00:00

abstract：:Heme is an essential cofactor for numerous cellular functions, but release of free heme during hemolysis results in oxidative tissue damage, vascular dysfunction, and inflammation. Macrophages play a key protective role in heme clearance; however, the mechanisms that regulate metabolic adaptations that are required fo...

journal_title：Blood

authors： Bories GFP,Yeudall S,Serbulea V,Fox TE,Isakson BE,Leitinger N

更新日期：2020-09-24 00:00:00

abstract：:Protein Z is a vitamin K-dependent glycoprotein that plays a role in the regulation of coagulation. A nucleotide substitution of G by C in exon II of the protein Z gene, resulting in the replacement of Glu-30 with Gln (E30Q), and a G to A transition at the 79th nucleotide in intron F (IntF79G/A) were heterozygously id...

journal_title：Blood

authors： Souri M,Koseki-Kuno S,Iwata H,Kemkes-Matthes B,Ichinose A

更新日期：2005-04-15 00:00:00

abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

journal_title：Blood

authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

更新日期：2013-03-21 00:00:00

abstract：:The ataxia telangiectasia mutated (ATM)-interacting protein ATMIN mediates noncanonical ATM signaling in response to oxidative and replicative stress conditions. Like ATM, ATMIN can function as a tumor suppressor in the hematopoietic system: deletion of Atmin under the control of CD19-Cre results in B-cell lymphomas i...

journal_title：Blood

authors： Anjos-Afonso F,Loizou JI,Bradburn A,Kanu N,Purewal S,Da Costa C,Bonnet D,Behrens A

更新日期：2016-10-20 00:00:00

abstract：:Expression of the myeloperoxidase (MPO) gene is tightly regulated in a tissue- and development-specific manner. Accumulation of MPO messenger RNA (mRNA) occurs only at the late myeloblastic and promyelocytic stages of myeloid differentiation and is negligible at other stages of myeloid development and in other tissues...

journal_title：Blood

authors： Lübbert M,Miller CW,Koeffler HP

更新日期：1991-07-15 00:00:00

abstract：:B19 parvovirus is the etiologic agent of fifth disease and transient aplastic crisis. In natural infections, B19 antigen and DNA have been detected in sera early in the course of aplastic crisis and only rarely in fifth disease. We have found B19 DNA in circulating cells of infected patients by DNA dot blot with a vir...

journal_title：Blood

authors： Kurtzman GJ,Gascon P,Caras M,Cohen B,Young NS

更新日期：1988-05-01 00:00:00

abstract：:Lymphomas in 10 cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied with regard to proliferative activity and apoptosis-related gene expression. All were diffuse large-cell lymphomas, showed mono or oligoclonality and a 9/10 diploid cellular DNA content. Expression of a simian homolog...

journal_title：Blood

authors： Castaños-Vélez E,Heiden T,Ekman M,Lawrence J,Biberfeld G,Biberfeld P

更新日期：1999-02-15 00:00:00

abstract：:Constitutively active JAK2V617F and thrombopoietin receptor (TpoR) W515L/K mutants are major determinants of human myeloproliferative neoplasms (MPNs). We show that a TpoRW515 mutation (W515A), which we detected in 2 myelofibrosis patients, and the Delta5TpoR active mutant, where the juxtamembrane R/KW(515)QFP motif i...

journal_title：Blood

authors： Pecquet C,Staerk J,Chaligné R,Goss V,Lee KA,Zhang X,Rush J,Van Hees J,Poirel HA,Scheiff JM,Vainchenker W,Giraudier S,Polakiewicz RD,Constantinescu SN

更新日期：2010-02-04 00:00:00

abstract：:Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla protein (MGP) is important in inhibiting calcification. Because MGP activation is vitamin K dependent, we performed a cross-sectional study investigating the relationship between the use of vitamin K antagonists and ext...

journal_title：Blood

authors： Rennenberg RJ,van Varik BJ,Schurgers LJ,Hamulyak K,Ten Cate H,Leiner T,Vermeer C,de Leeuw PW,Kroon AA

更新日期：2010-06-17 00:00:00

abstract：:CD4(+) T helper 1 (Th1) cells and Th2 cells are distinguished based on the pattern of cytokines they are able to produce. Selectin ligands and chemokine receptors are differentially expressed in Th1 and Th2 cells, providing a basis for tissue-specific recruitment of helper T-cell subsets. However, the modes and mechan...

journal_title：Blood

authors： Colantonio L,Iellem A,Clissi B,Pardi R,Rogge L,Sinigaglia F,D'Ambrosio D

更新日期：1999-11-01 00:00:00

abstract：:Depletion of guanine nucleotide pools after inhibition of inosine monophosphate dehydrogenase (IMPDH) potently inhibits DNA synthesis by arresting cells in G1 and has been shown to induce the differentiation of cultured myeloid and erythroid cell lines, as well as chronic granulocytic leukemic cells after blast transf...

journal_title：Blood

authors： Laliberté J,Yee A,Xiong Y,Mitchell BS

更新日期：1998-04-15 00:00:00

abstract：:Using data from ARISTOTLE, we describe the periprocedural management of anticoagulation and rates of subsequent clinical outcomes among patients chronically anticoagulated with warfarin or apixaban. We recorded whether (and for how long) anticoagulant therapy was interrupted preprocedure, whether bridging therapy was ...

journal_title：Blood

authors： Garcia D,Alexander JH,Wallentin L,Wojdyla DM,Thomas L,Hanna M,Al-Khatib SM,Dorian P,Ansell J,Commerford P,Flaker G,Lanas F,Vinereanu D,Xavier D,Hylek EM,Held C,Verheugt FW,Granger CB,Lopes RD

更新日期：2014-12-11 00:00:00

abstract：:Viral infections are common and are potentially life-threatening in patients with moderate to severe primary immunodeficiency disorders. Because T-cell immunity contributes to the control of many viral pathogens, adoptive immunotherapy with virus-specific T cells (VSTs) has been a logical and effective way of combatin...

journal_title：Blood

authors： Keller MD,Bollard CM

更新日期：2020-02-27 00:00:00

abstract：:Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only co...

journal_title：Blood

authors： Zhang DL,Ghosh MC,Ollivierre H,Li Y,Rouault TA

更新日期：2018-11-08 00:00:00

abstract：:Lymphomatoid granulomatosis (LyG) is an angiodestructive lymphoproliferative disorder (LPD) often involving the lungs. Its etiology is uncertain, but a number of previous studies had suggested it is a T-cell LPD associated with Epstein-Barr virus (EBV). Because of the similarity between LYG and nasal angiocentric lymp...

journal_title：Blood

authors： Wilson WH,Kingma DW,Raffeld M,Wittes RE,Jaffe ES

更新日期：1996-06-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) may affect T-cell homeostasis by multiple mechanisms, inducing polarization of cytokine secretion, inhibition of T-cell proliferation, and enhancement of T-cell apoptosis. We analyzed the production of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1)...

journal_title：Blood

authors： Rutella S,Pierelli L,Bonanno G,Sica S,Ameglio F,Capoluongo E,Mariotti A,Scambia G,d'Onofrio G,Leone G

更新日期：2002-10-01 00:00:00

abstract：:An imbalance between cellular apoptosis and survival may be critical for the pathogenesis of lymphoma. Therefore, the gene expression pattern in lymph node preparations from patients with mantle cell lymphoma (MCL) was compared to the pattern in nonmalignant hyperplastic lymph nodes (HLs). Oligonucleotide microarray a...

journal_title：Blood

authors： Hofmann WK,de Vos S,Tsukasaki K,Wachsman W,Pinkus GS,Said JW,Koeffler HP

更新日期：2001-08-01 00:00:00

abstract：:The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the Nat...

journal_title：Blood

authors： Collins PW,Palmer BP,Chalmers EA,Hart DP,Liesner R,Rangarajan S,Talks K,Williams M,Hay CR,UK Haemophilia Centre Doctors’ Organization.

更新日期：2014-11-27 00:00:00

abstract：:Vaccination of patients with cancer using dendritic cells (DCs) was shown to be effective for B-cell lymphoma and malignant melanoma. Here we provide evidence that patients with advanced breast and ovarian cancer can be efficiently vaccinated with autologous DCs pulsed with HER-2/neu- or MUC1-derived peptides. Ten pat...

journal_title：Blood

authors： Brossart P,Wirths S,Stuhler G,Reichardt VL,Kanz L,Brugger W

更新日期：2000-11-01 00:00:00

abstract：:To understand the regulatory mechanism of erythropoietin (EPO) receptor (EPOR) gene expression, the effect of EPO on the steady-state level of EPOR mRNA was examined using the human EPO-dependent cell line UT-7 as a model system. We found that the treatment of UT-7 cells with EPO resulted in a transient decrease of th...

journal_title：Blood

authors： Komatsu N,Kirito K,Kashii Y,Furukawa Y,Kikuchi J,Suwabe N,Yamamoto M,Miura Y

更新日期：1997-02-15 00:00:00

abstract：:CD8+ Foxp3+ T cells (Tregs) are a potent regulatory population whose functional and ontological similarities to CD4+ Fox3+ T cells have not been well delineated. Using an experimental model of graft-versus-host disease (GVHD), we observed that CD8+ Tregs were significantly less potent than CD4+ Tregs for the suppressi...

journal_title：Blood

authors： Agle K,Vincent BG,Piper C,Belle L,Zhou V,Shlomchik W,Serody JS,Drobyski WR

更新日期：2018-07-26 00:00:00

abstract：:Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages. The expression of short isoforms lacking DNA-binding motifs alters the differentiation capacities of hematopoietic progenitors, arresting lineage commitment. We sought to determine whether molecular abnormaliti...

journal_title：Blood

authors： Iacobucci I,Lonetti A,Messa F,Cilloni D,Arruga F,Ottaviani E,Paolini S,Papayannidis C,Piccaluga PP,Giannoulia P,Soverini S,Amabile M,Poerio A,Saglio G,Pane F,Berton G,Baruzzi A,Vitale A,Chiaretti S,Perini G,Foà R

更新日期：2008-11-01 00:00:00

abstract：:Peripheral T-cell lymphomas (PTCLs) are rare lymphomas with mostly poor outcome with current treatment. The addition of etoposide to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and upfront consolidation with autologous stem cell transplantation (auto-SCT) have shown promising results but have nev...

journal_title：Blood

authors： Ellin F,Landström J,Jerkeman M,Relander T

更新日期：2014-09-04 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disease caused by mutations in the WAS gene, leading to thrombocytopenia, eczema, recurrent infections, autoimmune disease, and malignancy. Hematopoietic cell transplantation (HCT) is the primary curative approach, with the goal of correcting the underlying immunodeficienc...

journal_title：Blood

authors： Burroughs LM,Petrovic A,Brazauskas R,Liu X,Griffith LM,Ochs HD,Bleesing JJ,Edwards S,Dvorak CC,Chaudhury S,Prockop SE,Quinones R,Goldman FD,Quigg TC,Chandrakasan S,Smith AR,Parikh S,Dávila Saldaña BJ,Thakar MS,Phela

更新日期：2020-06-04 00:00:00