Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells.

abstract：:The platelet release reaction plays a critical role in thrombosis and contributes to the events that follow hemostasis. Previous studies have shown that platelet secretion is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins from granule and plasma membranes. The SNAREs form transmembrane complexes ...

journal_title：Blood

authors： Ye S,Karim ZA,Al Hawas R,Pessin JE,Filipovich AH,Whiteheart SW

更新日期：2012-09-20 00:00:00

abstract：:"Fetal" erythrocytes are present in older children and certain adults with hematologic disorders. To determine if regenerating bone marrow produces such cells, we examined the blood of seven allogeneic bone marrow transplant recipients. Six patients were engrafted with donor cells, while on e patients recovered autolo...

journal_title：Blood

authors： Alter BP,Rappeport JM,Huisman TH,Schroeder WA,Nathan DG

更新日期：1976-12-01 00:00:00

abstract：:The reported outcome of hematopoietic stem cell transplantation (HSCT) from HLA-mismatched family members has been inconsistent. The object of this study was to evaluate the true impact of HLA-mismatch by using recent data from a homogenous population, excluding HSCT procedures that used graft manipulations, and by co...

journal_title：Blood

authors： Kanda Y,Chiba S,Hirai H,Sakamaki H,Iseki T,Kodera Y,Karasuno T,Okamoto S,Hirabayashi N,Iwato K,Maruta A,Fujimori Y,Furukawa T,Mineishi S,Matsuo K,Hamajima N,Imamura M

更新日期：2003-08-15 00:00:00

abstract：:Endothelial cells in vivo form the interface between the vascular and interstitial compartments and are strategically located to mediate vascular permeability and hemostasis. One mechanism endothelial cells use to maintain a nonthrombogenic surface is to polarize basement membrane constituents to the basolateral cell ...

journal_title：Blood

authors： Kowalczyk AP,Tulloh RH,McKeown-Longo PJ

更新日期：1990-06-15 00:00:00

abstract：:Toll-like receptors (TLRs) are able to interact with pathogen-derived products and their signals induce the coordinated activation of innate and adaptive immune mechanisms. Dendritic cells (DCs) play a central role in these events. As the different TLRs are able to trigger MyD88/TRIF-dependent and -independent signali...

journal_title：Blood

authors： Warger T,Osterloh P,Rechtsteiner G,Fassbender M,Heib V,Schmid B,Schmitt E,Schild H,Radsak MP

更新日期：2006-07-15 00:00:00

abstract：:Various virus infections cause dysfunctional hemostasis and in some instances lead to the development of viral hemorrhagic fever syndrome. How do diverse viruses induce the expression of tissue factor on vascular cells? We hypothesize that a direct stimulation of pattern recognition receptors (PRR) by viral nucleic ac...

journal_title：Blood

authors： Shibamiya A,Hersemeyer K,Schmidt Wöll T,Sedding D,Daniel JM,Bauer S,Koyama T,Preissner KT,Kanse SM

更新日期：2009-01-15 00:00:00

abstract：:Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that UNC0638, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces γ-globin expression. EHMT1/2 catalyze mono- and dimethylation of lysine 9 on hi...

journal_title：Blood

authors： Renneville A,Van Galen P,Canver MC,McConkey M,Krill-Burger JM,Dorfman DM,Holson EB,Bernstein BE,Orkin SH,Bauer DE,Ebert BL

更新日期：2015-10-15 00:00:00

abstract：:Approximately 40% of children with acute myeloid leukemia (AML) who respond to initial therapy subsequently relapse. Multidimensional flow cytometry employing a standardized panel of monoclonal antibodies enables the detection of small numbers of occult leukemic cells that persist during therapy using technology adapt...

journal_title：Blood

authors： Sievers EL,Lange BJ,Alonzo TA,Gerbing RB,Bernstein ID,Smith FO,Arceci RJ,Woods WG,Loken MR

更新日期：2003-05-01 00:00:00

abstract：:Adenovirus infections occur in 5% to 21% of patients following stem cell transplantation (SCT), with an associated mortality of up to 50%. However, a lack of prospective studies has hampered further developments in the understanding and management of this infection in the posttransplantation setting. We prospectively ...

journal_title：Blood

authors： Chakrabarti S,Mautner V,Osman H,Collingham KE,Fegan CD,Klapper PE,Moss PA,Milligan DW

更新日期：2002-09-01 00:00:00

abstract：:This study investigated the immunogenicity of Wilms tumor gene product 1 (WT1)-peptide vaccination in WT1-expressing acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients without curative treatment option. Vaccination consisted of granulocyte-macrophage colony-stimulating factor subcutaneously days ...

journal_title：Blood

authors： Keilholz U,Letsch A,Busse A,Asemissen AM,Bauer S,Blau IW,Hofmann WK,Uharek L,Thiel E,Scheibenbogen C

更新日期：2009-06-25 00:00:00

abstract：:In this issue of Blood, Kochenderfer et al show that engineered CD19–chimeric antigen receptor (CAR) and donor-derived allogeneic T cells can safely treat CD19-positive B-cell malignancies, which have relapsed after allogeneic stem cell transplantation. ...

journal_title：Blood

authors： Rapoport AP

更新日期：2013-12-12 00:00:00

abstract：:Various abnormalities of lymphokine production have been described in patients with aplastic anemia. To determine if abnormal production of hematopoietic growth factors could contribute to the process of aplastic anemia we studied the in vitro production of human granulocyte-macrophage colony-stimulating factor (GM-CS...

journal_title：Blood

authors： Nimer SD,Golde DW,Kwan K,Lee K,Clark S,Champlin R

更新日期：1991-07-01 00:00:00

abstract：:Although the graft-versus-leukemia effect of allogeneic bone marrow transplantation (BMT) is of paramount importance in the maintenance of disease remission, the role played by the autologous T-cell response in antitumor immune surveillance is less defined. We evaluated the emergence of antileukemia cytotoxic T-lympho...

journal_title：Blood

authors： Montagna D,Maccario R,Locatelli F,Montini E,Pagani S,Bonetti F,Daudt L,Turin I,Lisini D,Garavaglia C,Dellabona P,Casorati G

更新日期：2006-12-01 00:00:00

abstract：:There has been increasing interest in the involvement of mammalian homeobox (HOX) genes in hematopoietic regulation. The HOX genes are clustered in 4 chromosomes in mice and humans. In general, 5' end HOX gene expression is predominant in hematopoietic stem cell populations, whereas 3' end HOX gene expression are prim...

journal_title：Blood

authors： Zimmermann F,Rich IN

更新日期：1997-04-15 00:00:00

abstract：:Protein Z is a vitamin K-dependent glycoprotein that plays a role in the regulation of coagulation. A nucleotide substitution of G by C in exon II of the protein Z gene, resulting in the replacement of Glu-30 with Gln (E30Q), and a G to A transition at the 79th nucleotide in intron F (IntF79G/A) were heterozygously id...

journal_title：Blood

authors： Souri M,Koseki-Kuno S,Iwata H,Kemkes-Matthes B,Ichinose A

更新日期：2005-04-15 00:00:00

abstract：:We investigated the effects of interleukin-4 (IL-4) on the survival of leukemic and normal B-cell progenitors cultured on bone marrow stroma. IL-4 (at 100 U/mL) was cytotoxic in 16 of 21 cases of B-lineage acute lymphoblastic leukemia, causing reductions in CD19+ cell numbers that ranged from 50% to greater than 99% (...

journal_title：Blood

authors： Manabe A,Coustan-Smith E,Kumagai M,Behm FG,Raimondi SC,Pui CH,Campana D

更新日期：1994-04-01 00:00:00

abstract：:Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and its human homologue GOS19.1/LD78 are members of the C-C chemokine/intercrine family of secreted proteins. They have proinflammatory properties and also inhibit cell cycle progression of hematopoietic stem cells. Characterization of MIP-1 alpha receptor(s) has b...

journal_title：Blood

authors： Avalos BR,Bartynski KJ,Elder PJ,Kotur MS,Burton WG,Wilkie NM

更新日期：1994-09-15 00:00:00

abstract：:Inhibition of complement-mediated granulocyte aggregation has recently been proposed as a mechanism of action of high-dose corticosteroids in shock states. Such inhibition may be effected through alteration of receptor function. Methylprednisolone inhibits binding of the synthetic chemotaxin f-methionine-leucine-pheny...

journal_title：Blood

authors： Skubitz KM,Hammerschmidt DE

更新日期：1986-10-01 00:00:00

abstract：:Anacardic acid (6-pentadecylsalicylic acid) is derived from traditional medicinal plants, such as cashew nuts, and has been linked to anticancer, anti-inflammatory, and radiosensitization activities through a mechanism that is not yet fully understood. Because of the role of nuclear factor-kappaB (NF-kappaB) activatio...

journal_title：Blood

authors： Sung B,Pandey MK,Ahn KS,Yi T,Chaturvedi MM,Liu M,Aggarwal BB

更新日期：2008-05-15 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) results in a progressive depletion of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the marked loss of CD4+ T lymphocytes are incompletely understood. However, several lines of evidence indicate that direct cytopathology mediated ...

journal_title：Blood

authors： Cantin R,Fortin JF,Lamontagne G,Tremblay M

更新日期：1997-08-01 00:00:00

abstract：:Recruitment of polymorphonuclear neutrophils (PMNs) to sites of acute inflammation critically depends on β2 integrins (CD11/CD18). Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an important adaptor protein regulating PMN trafficking downstream of β2 integrins. Here, we show that mAbp1 const...

journal_title：Blood

authors： Jakob SM,Pick R,Brechtefeld D,Nussbaum C,Kiefer F,Sperandio M,Walzog B

更新日期：2013-05-16 00:00:00

abstract：:A new human leukemia cell line, designated as ME-1, was established from the peripheral blood leukemia cells of a patient with acute myelomonocytic leukemia with eosinophilia (M4E0). This cell line has the characteristic chromosome abnormality of M4E0, inv(16) (p13q22). When cultured in RPMI 1640 medium containing 10%...

journal_title：Blood

authors： Yanagisawa K,Horiuchi T,Fujita S

更新日期：1991-07-15 00:00:00

abstract：:A major limitation to the widespread use of hematopoietic stem cells (HSC) is the relatively crude level of our knowledge of how to maintain these cells in vitro without loss of the long-term multilineage growth and differentiation properties required for their clinical utility. An experimental and theoretical framewo...

journal_title：Blood

authors： Zandstra PW,Lauffenburger DA,Eaves CJ

更新日期：2000-08-15 00:00:00

abstract：:One major obstacle to the effective treatment of cancer is to distinguish between tumor cells and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities are ideal therapeutic targets because they are unique to the disease. We describe the use of a novel approach based on the cataly...

journal_title：Blood

authors： Cobaleda C,Sánchez-García I

更新日期：2000-02-01 00:00:00

abstract：:We describe in vitro studies and a therapeutic trial of retinoic acid (RA) in a patient with acute promyelocytic leukemia (APL) refractory to chemotherapy. Bone marrow promyelocytes from the patient, prior to RA, matured morphologically in liquid culture with RA (97% maturing myeloid cells compared with 26% in control...

journal_title：Blood

authors： Flynn PJ,Miller WJ,Weisdorf DJ,Arthur DC,Brunning R,Branda RF

更新日期：1983-12-01 00:00:00

abstract：:The W locus of mice encodes the c-kit receptor tyrosine kinase. Heterozygous WJic/+ and Wn/+ mice and homozygous Wf/Wf mice were similar in appearance; all of them have large depigmented areas lacking any well-defined pattern. The WJic, Wn, and Wf mutant alleles were characterized and their molecular nature was correl...

journal_title：Blood

authors： Tsujimura T,Koshimizu U,Katoh H,Isozaki K,Kanakura Y,Tono T,Adachi S,Kasugai T,Tei H,Nishimune Y

更新日期：1993-05-15 00:00:00

abstract：:Cylindromatosis (CYLD) is a deubiquitinase that was initially identified as a tumor suppressor and has recently been implicated in diverse normal physiologic processes. In this study, we have investigated the involvement of CYLD in angiogenesis, the formation of new blood vessels from preexisting ones. We find that kn...

journal_title：Blood

authors： Gao J,Sun L,Huo L,Liu M,Li D,Zhou J

更新日期：2010-05-20 00:00:00

abstract：:As the principal component of the membrane skeleton, spectrin confers integrity and flexibility to red cell membranes. Although this network involves many interactions, the most common hemolytic anemia mutations that disrupt erythrocyte morphology affect the spectrin tetramerization domains. Although much is known cli...

journal_title：Blood

authors： Ipsaro JJ,Harper SL,Messick TE,Marmorstein R,Mondragón A,Speicher DW

更新日期：2010-06-10 00:00:00

abstract：:It is currently debated whether the mechanism of action of therapeutic doses of recombinant factor VIIa (rFVIIa, Novo-Seven) relies on the tissue factor (TF)-independent activity of the enzyme. The present study was conducted to investigate the in vivo hemostatic effects of rFVIIa and 3 analogs thereof with superior i...

journal_title：Blood

authors： Tranholm M,Kristensen K,Kristensen AT,Pyke C,Røjkjaer R,Persson E

更新日期：2003-11-15 00:00:00

abstract：:Interleukin-12 (IL-12) is a cytokine that plays a central role in the control of cell-mediated immunity. We have previously shown that transforming growth factor-beta1 (TGF-beta) inhibitory effects on human primary allogeneic cytotoxicity and proliferative responses interfere with IL-12 pathway. The present study was ...

journal_title：Blood

authors： Pardoux C,Ma X,Gobert S,Pellegrini S,Mayeux P,Gay F,Trinchieri G,Chouaib S

更新日期：1999-03-01 00:00:00