Corticosteroids reversibly inhibit chemotactic peptide-receptor binding and granulocyte response, yet allow desensitization and receptor down-regulation.

abstract：:Under normal conditions, platelets do not adhere to endothelium. However, when platelets or endothelial cells are stimulated by thrombin or cytokines, respectively, platelets bind avidly to endothelium. Because there is accumulating evidence that endothelial cells may become apoptotic under certain proinflammatory or ...

journal_title：Blood

authors： Bombeli T,Schwartz BR,Harlan JM

更新日期：1999-06-01 00:00:00

abstract：:To investigate underlying mechanisms of thrombocytopenia in myelodysplastic syndrome (MDS), radiolabeled platelet studies were performed in 30 MDS patients with platelet counts less than 100 x 10(9)/L. Furthermore, plasma thrombopoietin and glycocalicin index (a parameter of platelet or megakaryocyte destruction) were...

journal_title：Blood

authors： Houwerzijl EJ,Blom NR,van der Want JJ,Louwes H,Esselink MT,Smit JW,Vellenga E,de Wolf JT

更新日期：2005-05-01 00:00:00

abstract：:Erythroid Kruppel-like factor (EKLF) is a transcription factor of the C2H2 zinc-finger class that is essential for definitive erythropoiesis. We generated immortal erythroid cell lines from EKLF(-/-) fetal liver progenitor cells that harbor a single copy of the entire human beta-globin locus and then reintroduced EKLF...

journal_title：Blood

authors： Coghill E,Eccleston S,Fox V,Cerruti L,Brown C,Cunningham J,Jane S,Perkins A

更新日期：2001-03-15 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 are proteins with proteinase-inhibiting and cytokine properties. TIMP-1 is active primarily in B cells and B-cell lymphomas, whereas TIMP-2 expression is restricted to T cells. The expression of TIMP-1 and TIMP-2 in lymph nodes from patients with Hodgkin disea...

journal_title：Blood

authors： Oelmann E,Herbst H,Zühlsdorf M,Albrecht O,Nolte A,Schmitmann C,Manzke O,Diehl V,Stein H,Berdel WE

更新日期：2002-01-01 00:00:00

abstract：:The present studies were undertaken to determine whether factor VIII/von Willebrand factor (vWF) present in the vessel wall (in addition to that in plasma) may mediate the attachment of platelets to subendothelium. Subendothelium from everted rabbit aorta was exposed to human citrated blood flowing through an annular ...

journal_title：Blood

authors： Turitto VT,Weiss HJ,Zimmerman TS,Sussman II

更新日期：1985-04-01 00:00:00

abstract：:Lymphomas in 10 cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied with regard to proliferative activity and apoptosis-related gene expression. All were diffuse large-cell lymphomas, showed mono or oligoclonality and a 9/10 diploid cellular DNA content. Expression of a simian homolog...

journal_title：Blood

authors： Castaños-Vélez E,Heiden T,Ekman M,Lawrence J,Biberfeld G,Biberfeld P

更新日期：1999-02-15 00:00:00

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00

abstract：:Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds...

journal_title：Blood

authors： Toubiana J,Okada S,Hiller J,Oleastro M,Lagos Gomez M,Aldave Becerra JC,Ouachée-Chardin M,Fouyssac F,Girisha KM,Etzioni A,Van Montfrans J,Camcioglu Y,Kerns LA,Belohradsky B,Blanche S,Bousfiha A,Rodriguez-Gallego C,Meyts

更新日期：2016-06-23 00:00:00

abstract：:A high proportion of carriers of classic hemophilia can be identified in the laboratory because, in comparison to normal women, the concentration of antigens related to antihemophilic factor (AHF, factor VIII) that are detected in their plasma by heterologous antiserum (factor VIIIR:Ag) is relatively higher than the t...

journal_title：Blood

authors： Fishman DJ,Jones PK,Menitove JE,Ratnoff OD,Everson B

更新日期：1982-06-01 00:00:00

abstract：:The present studies were initiated to define the coding region of a 34 kilodalton (kd) protein (p34) frequently observed with antibodies from HTLV-III/LAV-infected people by immunoblotting and radioimmunoprecipitation (RIP) techniques. We have directly mapped this viral protein to the pol gene of HTLV-III/LAV by radio...

journal_title：Blood

authors： Allan JS,Coligan JE,Lee TH,Barin F,Kanki PJ,M'Boup S,McLane MF,Groopman JE,Essex M

更新日期：1987-01-01 00:00:00

abstract：:A single-stage disposable channel and seal that provides for leukocyte and granulocyte collection by continuous-flow cell separation (CFCS) has been designed by the IBM Corporation. This paper describes (1) the separation characteristics of whole blood as it responds to varying gravitational (G) forces and flow rates ...

journal_title：Blood

authors： Hester JP,Kellogg RM,Mulzet AP,Kruger VR,McCredie KB,Freireich EJ

更新日期：1979-07-01 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is expressed in almost all types of malignancies, making this protein a useful tool for the development of broadly applicable vaccination therapies. We used a recently identified HLA-A2 binding peptide and dendritic cells (DCs) from healthy donors to ind...

journal_title：Blood

authors： Schmidt SM,Schag K,Müller MR,Weck MM,Appel S,Kanz L,Grünebach F,Brossart P

更新日期：2003-07-15 00:00:00

abstract：:Interferons (IFNs) initiate their effects by interacting with specific high-affinity cell surface receptors, but little is known about the physiology of IFN receptor interaction in vivo. Treatment of patients suffering from hairy cell leukemia (HCL) with human recombinant alpha IFN results in significant tumor regress...

journal_title：Blood

authors： Billard C,Sigaux F,Castaigne S,Valensi F,Flandrin G,Degos L,Falcoff E,Aguet M

更新日期：1986-03-01 00:00:00

abstract：:The present studies investigated the effects of the recently cloned flt3 ligand (FL) on the in vitro growth and differentiation of primitive and committed subsets of human CD34+ bone marrow (BM) progenitor cells. FL alone was a weak growth stimulator of CD34+ BM cells, but synergistically and directly enhanced colony ...

journal_title：Blood

authors： Rusten LS,Lyman SD,Veiby OP,Jacobsen SE

更新日期：1996-02-15 00:00:00

abstract：:The metalloprotease ADAMTS13 is assumed to regulate the functional levels of von Willebrand factor (VWF) appropriate for normal hemostasis in vivo by reducing VWF multimer size, which directly represents the thrombogenic activity of this factor. Using an in vitro perfusion chamber system, we studied the mechanisms of ...

journal_title：Blood

authors： Shida Y,Nishio K,Sugimoto M,Mizuno T,Hamada M,Kato S,Matsumoto M,Okuchi K,Fujimura Y,Yoshioka A

更新日期：2008-02-01 00:00:00

abstract：:We investigated whether atorvastatin (AT) was capable of protecting animals from acute graft-versus-host disease (aGVHD) across major histocompatibility complex (MHC) mismatch barriers. AT treatment of the donor induced a Th-2 cytokine profile in the adoptively transferred T cells and reduced their in vivo expansion, ...

journal_title：Blood

authors： Zeiser R,Youssef S,Baker J,Kambham N,Steinman L,Negrin RS

更新日期：2007-12-15 00:00:00

abstract：:Factor VII levels have been studied in hemophilia A and B plasmas and normal controls in a controlled, prospective study. Three assay methods were used: a standard clotting assay (FVIIc-A); a modified clotting assay (FVIIc-B) (Seligsohn et al, Blood 52:978-988, 1978); and a coupled amidolytic assay. By the FVIIc-B ass...

journal_title：Blood

authors： Miller BC,Hultin MB,Jesty J

更新日期：1985-04-01 00:00:00

abstract：:Human hematopoietic stem cells are pluripotent, ie, capable of producing both lymphoid and myeloid progeny, and are therefore used for transplantation and gene therapy. An in vitro culture system was developed to study the multi-lineage developmental potential of a candidate human hematopoietic stem cell population, C...

journal_title：Blood

authors： Hao QL,Smogorzewska EM,Barsky LW,Crooks GM

更新日期：1998-06-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is suspected to be a strong mortality determinant of hemolytic disorders. However, direct contribution of acute intravascular hemolysis to fatal PAH has not been investigated. The roles of nitric oxide (NO) insufficiency and platelet activation in hemolysis-associated fatal PAH ha...

journal_title：Blood

authors： Hu W,Jin R,Zhang J,You T,Peng Z,Ge X,Bronson RT,Halperin JA,Loscalzo J,Qin X

更新日期：2010-09-02 00:00:00

abstract：:HLA-G is a major histocompatibility complex class Ib molecule whose constitutive tissue distribution is restricted mainly to trophoblast cells at the maternal-fetal interface during pregnancy. In this study, we demonstrated the ability of the soluble HLA-G1 (sHLA-G1) isoform to inhibit fibroblast growth factor-2 (FGF2...

journal_title：Blood

authors： Fons P,Chabot S,Cartwright JE,Lenfant F,L'Faqihi F,Giustiniani J,Herault JP,Gueguen G,Bono F,Savi P,Aguerre-Girr M,Fournel S,Malecaze F,Bensussan A,Plouët J,Le Bouteiller P

更新日期：2006-10-15 00:00:00

abstract：:The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-in...

journal_title：Blood

authors： Weller S,Braun MC,Tan BK,Rosenwald A,Cordier C,Conley ME,Plebani A,Kumararatne DS,Bonnet D,Tournilhac O,Tchernia G,Steiniger B,Staudt LM,Casanova JL,Reynaud CA,Weill JC

更新日期：2004-12-01 00:00:00

abstract：:Mutations leading to the alteration of cell-cycle checkpoint functions are a common feature of most cancers. Because of the highly regulated nature of the cell cycle, it seems likely that variation in gene dosage of key components due to functional regulatory polymorphisms could play an important role in cancer develo...

journal_title：Blood

authors： Healy J,Bélanger H,Beaulieu P,Larivière M,Labuda D,Sinnett D

更新日期：2007-01-15 00:00:00

abstract：:Recent analyses of circulating blood B cells in myeloma have generated controversy concerning the exact levels of these cells and whether they may represent circulating clonal tumor B cells. Previous reports suggested that CD19+ B cells are markedly increased in myeloma patients and that this population shares clonoty...

journal_title：Blood

authors： Kay NE,Leong T,Kyle RA,Greipp P,Billadeau D,Van Ness B,Bone N,Oken MM

更新日期：1997-07-01 00:00:00

abstract：:A randomized study was performed in 54 thrombocytopenic patients with acute leukemia. Alloimmunization of recipients of random multiple-donor platelet concentrates (MD group) was compared to that of patients receiving random single-donor platelets (SD group). In the SD patients, formation of alloantibodies (mostly ant...

journal_title：Blood

authors： Gmür J,von Felten A,Osterwalder B,Honegger H,Hörmann A,Sauter C,Deubelbeiss K,Berchtold W,Metaxas M,Scali G,Frick PG

更新日期：1983-08-01 00:00:00

abstract：:Hemoglobin and ferritin iron content have been followed during differentiation in tissue cultures of murine erythroleukemia cells (MELC) using the techniques of Mössbauer spectroscopy and electron microscopy. In undifferentiated cells grown without DMSO, only iron stored in ferritin was detected. The amount of iron in...

journal_title：Blood

authors： Ofer S,Fibach E,Kessel M,Bauminger ER,Cohen SG,Eikelboom J,Rachmilewitz EA

更新日期：1981-08-01 00:00:00

abstract：:Forkhead box P3 (FOXP3) is constitutively expressed by CD4(+)CD25(hi) regulatory T cells (nTregs). Mutations of FOXP3 cause a severe autoimmune syndrome known as immune dysregulation polyendocrinopathy enteropathy X-linked, in which nTregs are absent or dysfunctional. Whether FOXP3 is essential for both differentiatio...

journal_title：Blood

authors： Di Nunzio S,Cecconi M,Passerini L,McMurchy AN,Baron U,Turbachova I,Vignola S,Valencic E,Tommasini A,Junker A,Cazzola G,Olek S,Levings MK,Perroni L,Roncarolo MG,Bacchetta R

更新日期：2009-11-05 00:00:00

abstract：:Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of platelet shedding. Despite this, loss of Bcl-x(L) does not prevent the growth and maturation of megakaryocytes, suggesting redundancy with other prosurvival proteins....

journal_title：Blood

authors： Debrincat MA,Josefsson EC,James C,Henley KJ,Ellis S,Lebois M,Betterman KL,Lane RM,Rogers KL,White MJ,Roberts AW,Harvey NL,Metcalf D,Kile BT

更新日期：2012-06-14 00:00:00

abstract：:Chemokines as well as the signaling through the adhesion molecules intercellular adhesion molecule (ICAM)-3 and CD43 are able to induce in T lymphocytes their switching from a spherical to a polarized motile morphology, with the formation of a uropod at the rear of the cell. We investigated here the role of CD43 in th...

journal_title：Blood

authors： Serrador JM,Nieto M,Alonso-Lebrero JL,del Pozo MA,Calvo J,Furthmayr H,Schwartz-Albiez R,Lozano F,González-Amaro R,Sánchez-Mateos P,Sánchez-Madrid F

更新日期：1998-06-15 00:00:00

abstract：:Adult T-cell leukemia (ATL) and human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are known to be caused by HTLV-I infection. However, current methods used to determine HTLV-I infection do not differentiate between HTLV-I asymptomatic carriers (ACs) and ATL an...

journal_title：Blood

authors： Enose-Akahata Y,Abrams A,Johnson KR,Maloney EM,Jacobson S

更新日期：2012-03-22 00:00:00

abstract：:Iron is a transition metal whose physicochemical properties make it the focus of vital biologic processes in virtually all living organisms. Among numerous roles, iron is essential for oxygen transport, cellular respiration, and DNA synthesis. Paradoxically, the same characteristics that biochemistry exploits make iro...

journal_title：Blood

authors： Sheftel AD,Zhang AS,Brown C,Shirihai OS,Ponka P

更新日期：2007-07-01 00:00:00