当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells.

Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells.

Abstract：

:Survivin, a member of the inhibitor of apoptosis protein family, is expressed in almost all types of malignancies, making this protein a useful tool for the development of broadly applicable vaccination therapies. We used a recently identified HLA-A2 binding peptide and dendritic cells (DCs) from healthy donors to induce survivin-specific cytotoxic T lymphocytes (CTLs) in vitro. These T cells efficiently lysed target cells pulsed with the cognate peptide. Furthermore, survivin-specific CTLs recognized HLA-A2-matched tumor cell lines and primary malignant cells from patients with leukemia in an antigen-specific and HLA-restricted manner as demonstrated with the use of cold target inhibition assays and blocking antibodies. To validate the immunogenicity of survivin we performed the experiments in an autologous setting and used monocyte-derived DCs as targets. Interestingly, we found that DCs up-regulate survivin expression on stimulation with tumor necrosis factor alpha (TNF-alpha). However, these mature DCs were not recognized by survivin-specific CTLs, whereas they lysed autologous mature DCs pulsed with the antigenic peptide or transfected with whole tumor RNA purified from a survivin-expressing cell line. To further analyze the possible use of survivin-specific CTLs in cancer therapies, we induced survivin-specific CTLs using peripheral blood mononuclear cells (PBMNCs) and DCs from a patient with chronic lymphocytic leukemia (CLL). The in vitro-generated T cells efficiently recognized autologous malignant CLL cells, whereas they spared autologous-purified nonmalignant B cells or DCs. Our results demonstrate that survivin epitopes are presented on a broad variety of malignancies and can be applied in vaccination therapies.

journal_name

Blood

journal_title

Blood

authors

Schmidt SM,Schag K,Müller MR,Weck MM,Appel S,Kanz L,Grünebach F,Brossart P

doi

10.1182/blood-2002-08-2554

subject

Has Abstract

pub_date

2003-07-15 00:00:00

pages

571-6

issue

2

eissn

0006-4971

issn

1528-0020

pii

2002-08-2554

journal_volume

102

pub_type

杂志文章

相关文献

BLOOD文献大全
  • In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation.

    abstract：:Expression of B7 family costimulatory molecules on B cells defines their capacity to function as antigen presenting cells (APCs). B cells that do not express B7 costimulatory molecules induce T-cell tolerance. Therefore, the expression of B7 costimulatory molecules on malignant B cells might be critical for their reco...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Dorfman DM,Schultze JL,Shahsafaei A,Michalak S,Gribben JG,Freeman GJ,Pinkus GS,Nadler LM

    更新日期：1997-12-01 00:00:00

  • Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia.

    abstract：:Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patie...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Nakao S,Takamatsu H,Chuhjo T,Ueda M,Shiobara S,Matsuda T,Kaneshige T,Mizoguchi H

    更新日期：1994-12-15 00:00:00

  • The incidence of chronic lymphocytic leukemia in Taiwan, 1986-2005: a distinct increasing trend with birth-cohort effect.

    abstract：:The incidence of chronic lymphocytic leukemia (CLL) in Taiwan is markedly lower than that in Western countries, but we have seen a drastically increasing trend. We explored this distinct incidence trend of CLL for Taiwanese. The epidemiologic data of CLL for Taiwanese and Caucasian Americans during 1986 to 2005 were o...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-05-285221

    authors： Wu SJ,Huang SY,Lin CT,Lin YJ,Chang CJ,Tien HF

    更新日期：2010-11-25 00:00:00

  • The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF.

    abstract：:While studying patient plasma containing an unusual pattern of von Willebrand factor (VWF) multimers, we discovered a previously unreported phenomenon: heavy predominance of dimeric VWF. Genomic analysis revealed a new congenital mutation (Tyr87Ser) that altered the final stages of VWF biosynthesis. This mutation in t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-03-0789

    authors： Rosenberg JB,Haberichter SL,Jozwiak MA,Vokac EA,Kroner PA,Fahs SA,Kawai Y,Montgomery RR

    更新日期：2002-09-01 00:00:00

  • The chemotherapy of lymphoblastic lymphoma.

    abstract：:Thirty-two patients treated on consecutive Southwest Oncology Group (SWOG) protocols for malignant lymphoma were subsequently diagnosed as having lymphoblastic lymphoma. Combination chemistry, usually adriamycin-based, produced complete responses (CR) in 17 patients (53%). Median survival was 15 mo. Patients achieving...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Voakes JB,Jones SE,McKelvey EM

    更新日期：1981-01-01 00:00:00

  • Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia.

    abstract：:CD44 is a widely expressed, multifunctional, cell-surface glycoprotein that has been implicated in the regulation of normal hematopoiesis. In addition, expression of particular isoforms of CD44 has been associated with malignant transformation and/or the acquisition of metastatic potential. In this study, we used two ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ghaffari S,Dougherty GJ,Lansdorp PM,Eaves AC,Eaves CJ

    更新日期：1995-10-15 00:00:00

  • Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation.

    abstract：:Activation of plasminogen, the zymogen of the primary thrombolytic enzyme, plasmin, is markedly promoted when plasminogen is bound to cell surfaces, arming cells with the broad spectrum proteolytic activity of plasmin. In addition to its role in thrombolysis, cell surface plasmin facilitates a wide array of physiologi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-11-188938

    authors： Andronicos NM,Chen EI,Baik N,Bai H,Parmer CM,Kiosses WB,Kamps MP,Yates JR 3rd,Parmer RJ,Miles LA

    更新日期：2010-02-18 00:00:00

  • Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas.

    abstract：:Salivary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neoplasms that are often associated with Sjogren's syndrome. To better define the cell of origin and evaluate whether antigen receptor stimulation may be playing a role in tumor growth, the Ig heavy and light chain var...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bahler DW,Miklos JA,Swerdlow SH

    更新日期：1997-05-01 00:00:00

  • IgE alone stimulates mast cell adhesion to fibronectin via pathways similar to those used by IgE + antigen but distinct from those used by Steel factor.

    abstract：:We recently demonstrated that immunoglobulin E (IgE), in the absence of cross-linking agents, activates signaling pathways in healthy murine bone marrow-derived mast cells (BMMCs) and that this activation enhances BMMC survival, at least in part, via secretion of autocrine-acting cytokines. We report herein that IgE a...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-10-3176

    authors： Lam V,Kalesnikoff J,Lee CW,Hernandez-Hansen V,Wilson BS,Oliver JM,Krystal G

    更新日期：2003-08-15 00:00:00

  • In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo.

    abstract：:Recent findings implied that the progression of hematologic malignancies, like that of solid tumors, is dependent on neovascularization. Recent studies on patients with acute myeloid leukemia (AML) showed increased levels of leukocyte-associated vascular endothelial growth factor (VEGF) and neovascularization of the b...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.V100.13.4622

    authors： Schuch G,Machluf M,Bartsch G Jr,Nomi M,Richard H,Atala A,Soker S

    更新日期：2002-12-15 00:00:00

  • A single genetic origin for a common Caucasian risk factor for venous thrombosis.

    abstract：:A common genetic risk factor for venous thrombosis among Caucasoid subpopulations is a polymorphism, nt G1691A, in blood coagulation factor V that replaces Arg506 with Gln and imparts resistance of factor Va to the anticoagulant, activated protein C. Haplotype analyses using six dimorphic sites in the factor V gene fo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Zivelin A,Griffin JH,Xu X,Pabinger I,Samama M,Conard J,Brenner B,Eldor A,Seligsohn U

    更新日期：1997-01-15 00:00:00

  • DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells.

    abstract：:The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens that stimulate T- and B-lymphocyte responses after sex-mismatched allogeneic hematopoietic cell transplantation (HCT). A CD8(+) cytotoxic T lymphocyte (CTL) clone that recognizes a novel HLA-B*2705-restricted H-Y antigen encoded by the DDX3...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-06-096313

    authors： Rosinski KV,Fujii N,Mito JK,Koo KK,Xuereb SM,Sala-Torra O,Gibbs JS,Radich JP,Akatsuka Y,Van den Eynde BJ,Riddell SR,Warren EH

    更新日期：2008-05-01 00:00:00

  • The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2.

    abstract：:The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA) are chemoattractants with high selectivity for neutrophils. Although IL-8 has been shown to act as an extremely potent mediator, reports on NAP-2 and MGSA are still contradictory. Here we s...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ludwig A,Petersen F,Zahn S,Götze O,Schröder JM,Flad HD,Brandt E

    更新日期：1997-12-01 00:00:00

  • Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment.

    abstract：:The exact mechanisms underlying the role of oxidative stress in the pathogenesis and the prothrombotic or proinflammatory status of antiphospholipid syndrome (APS) remain unknown. Here, we investigate the role of oxidative stress and mitochondrial dysfunction in the proatherothrombotic status of APS patients induced b...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-12-400986

    authors： Perez-Sanchez C,Ruiz-Limon P,Aguirre MA,Bertolaccini ML,Khamashta MA,Rodriguez-Ariza A,Segui P,Collantes-Estevez E,Barbarroja N,Khraiwesh H,Gonzalez-Reyes JA,Villalba JM,Velasco F,Cuadrado MJ,Lopez-Pedrera C

    更新日期：2012-06-14 00:00:00

  • IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation.

    abstract：:Despite the success of human leukocyte antigen (HLA) typing in allogeneic stem cell transplantation (SCT) it is rare to find an unrelated donor that is perfectly matched, making identification of "permissive" mismatches of paramount importance. Here, we describe novel associations between donor T-cell cytokine product...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-01-0192

    authors： Jordan WJ,Brookes PA,Szydlo RM,Goldman JM,Lechler RI,Ritter MA

    更新日期：2004-01-15 00:00:00

  • Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination.

    abstract：:Leukostasis and tissue infiltration by leukemic cells are poorly understood life-threatening complications of acute leukemia. This study has tested the hypothesis that adhesion receptors and cytokines secreted by blast cells play central roles in these reactions. Immunophenotypic studies showed that acute myeloid leuk...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v97.7.2121

    authors： Stucki A,Rivier AS,Gikic M,Monai N,Schapira M,Spertini O

    更新日期：2001-04-01 00:00:00

  • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells.

    abstract：:Vaccination of patients with cancer using dendritic cells (DCs) was shown to be effective for B-cell lymphoma and malignant melanoma. Here we provide evidence that patients with advanced breast and ovarian cancer can be efficiently vaccinated with autologous DCs pulsed with HER-2/neu- or MUC1-derived peptides. Ten pat...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：

    authors： Brossart P,Wirths S,Stuhler G,Reichardt VL,Kanz L,Brugger W

    更新日期：2000-11-01 00:00:00

  • A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS.

    abstract：:This study investigated the immunogenicity of Wilms tumor gene product 1 (WT1)-peptide vaccination in WT1-expressing acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients without curative treatment option. Vaccination consisted of granulocyte-macrophage colony-stimulating factor subcutaneously days ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-02-202598

    authors： Keilholz U,Letsch A,Busse A,Asemissen AM,Bauer S,Blau IW,Hofmann WK,Uharek L,Thiel E,Scheibenbogen C

    更新日期：2009-06-25 00:00:00

  • Adrenergic modulation of human polymorphonuclear leukocyte activation. Potentiating effect of adenosine.

    abstract：:The activation of polymorphonuclear leukocytes (PMN) is an important step in the development of tissue damage associated with inflammatory and ischemic conditions. Catecholamines have been reported to inhibit PMN functions, but the high concentrations required cast doubt on their actual relevance as a defense mechanis...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bazzoni G,Dejana E,Del Maschio A

    更新日期：1991-05-01 00:00:00

  • Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma.

    abstract：:Anaplastic large cell lymphoma (ALCL) is an aggressive lymphoma that is frequently associated with the t(2;5)(p23;q35), resulting in expression of a fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which can be detected by either monoclonal or polyclonal antibodies to the ALK protein. The clinical f...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Gascoyne RD,Aoun P,Wu D,Chhanabhai M,Skinnider BF,Greiner TC,Morris SW,Connors JM,Vose JM,Viswanatha DS,Coldman A,Weisenburger DD

    更新日期：1999-06-01 00:00:00

  • A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.

    abstract：:We hypothesized that a granulocyte macrophage colony-stimulating factor (GMCSF) and interleukin 15 (IL-15) fusokine (GIFT15) would possess greater immune-stimulatory properties than their combined use. Unexpectedly, tumor cells engineered to secrete GIFT15 protein led to suppression of natural killer (NK) and NKT-cell...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-07-037473

    authors： Rafei M,Wu JH,Annabi B,Lejeune L,François M,Galipeau J

    更新日期：2007-03-01 00:00:00

  • Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation.

    abstract：:This study demonstrates that the human platelet F11 receptor (F11R) functions as an adhesion molecule, and this finding is confirmed by the structure of the protein as revealed by molecular cloning. The F11R is a 32-/35-kd protein duplex that serves as the binding site through which a stimulatory monoclonal antibody c...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Sobocka MB,Sobocki T,Banerjee P,Weiss C,Rushbrook JI,Norin AJ,Hartwig J,Salifu MO,Markell MS,Babinska A,Ehrlich YH,Kornecki E

    更新日期：2000-04-15 00:00:00

  • Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes.

    abstract：:After invading human red blood cells (RBCs) the malaria parasite Plasmodium falciparum remodels the host cell by trafficking proteins to the RBC compartment. The virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) is responsible for cytoadherence of infected cells to host endothelial receptors. Thi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-12-4666

    authors： Knuepfer E,Rug M,Klonis N,Tilley L,Cowman AF

    更新日期：2005-05-15 00:00:00

  • Interrelationships of polymorphonuclear neutrophil membrane-bound calcium, membrane potential, and chemiluminescence: studies in single living cells.

    abstract：:Stimulated neutrophils show ionic fluxes that may function as "transducers" between stimuli and effector functions. Using fluorescent probes, patterns of membrane-associated calcium (chlortetracycline, CTC) and membrane potential (3-3'-dipentyloxacarbocyanine, di-O-C5 (3)) in single living human neutrophils were obser...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Sullivan GW,Donowitz GR,Sullivan JA,Mandell GL

    更新日期：1984-12-01 00:00:00

  • Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins.

    abstract：:Investigators in the United Kingdom have shown that hereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history is an ineffective screen, and tissue staining used to type amyloid is unreliable. Misdiagnosis of AL can lead to inappropriate use of chemotherapy and failure to diag...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-10-4148

    authors： Comenzo RL,Zhou P,Fleisher M,Clark B,Teruya-Feldstein J

    更新日期：2006-05-01 00:00:00

  • Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo.

    abstract：:Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-12-063636

    authors： Zhang X,Kimura Y,Fang C,Zhou L,Sfyroera G,Lambris JD,Wetsel RA,Miwa T,Song WC

    更新日期：2007-07-01 00:00:00

  • The AKT kinase is activated in multiple myeloma tumor cells.

    abstract：:Immunohistochemistry (IHC) was performed on archived bone marrow (BM) with a phosphospecific anti-AKT antibody. IHC on 26 BM biopsies from patients with multiple myeloma (MM) demonstrated phospho-AKT staining of malignant plasma cells in a cell membrane-specific pattern, whereas nonmalignant hematopoietic cells did no...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v98.9.2853

    authors： Hsu J,Shi Y,Krajewski S,Renner S,Fisher M,Reed JC,Franke TF,Lichtenstein A

    更新日期：2001-11-01 00:00:00

  • Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells.

    abstract：:As B-cell chronic lymphocytic leukemia (B-CLL) progresses, malignant cells extravasate and infiltrate lymphoid tissues. Several molecules, including gelatinase B/MMP-9, contribute to these processes. Although mainly a secreted protease, some MMP-9 is present at the B-CLL cell surface and the function, mode of anchorin...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-08-109249

    authors： Redondo-Muñoz J,Ugarte-Berzal E,García-Marco JA,del Cerro MH,Van den Steen PE,Opdenakker G,Terol MJ,García-Pardo A

    更新日期：2008-07-01 00:00:00

  • How I treat lymphoma in pregnancy.

    abstract：:Lymphomas afflict all age groups of people, with certain types demonstrating a female predilection in adolescents and young adults. A proportion of lymphomas that are diagnosed in this population demographic occur in the setting of pregnancy. Most of these behave aggressively at presentation and require immediate or u...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019000961

    authors： Dunleavy K,McLintock C

    更新日期：2020-11-05 00:00:00

  • Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells.

    abstract：:Several features of chronic lymphocytic leukemia (CLL) suggest that immune-based strategies may have therapeutic potential. A promising approach is provided by the transduction of CLL cells with CD40 ligand (CD40L) by viral vectors to enhance their immunogenicity. We compared the antigen-presenting capacity of CD40L-t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-04-1742

    authors： Mayr C,Kofler DM,Büning H,Bund D,Hallek M,Wendtner CM

    更新日期：2005-11-01 00:00:00