In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo.

abstract：:Peripheral blood cell (PBC) rescue has become the mainstay for autologous transplantation in patients with lymphoma, multiple myeloma, and solid tumors. Different methods of hematopoietic progenitor cell (HPC) mobilization are in use without an established standard. Forty-seven patients with relapsed or refractory lym...

journal_title：Blood

authors： Narayanasami U,Kanteti R,Morelli J,Klekar A,Al-Olama A,Keating C,O'Connor C,Berkman E,Erban JK,Sprague KA,Miller KB,Schenkein DP

更新日期：2001-10-01 00:00:00

abstract：:Ubiquitin is suggested to play a key role in essential intracellular functions, such as heat shock response, protein breakdown, and regulation of immune responses. Ubiquitin has also been detected in the extracellular space, but the function and biologic significance is unclear. We describe a new function of extracell...

journal_title：Blood

authors： Majetschak M,Krehmeier U,Bardenheuer M,Denz C,Quintel M,Voggenreiter G,Obertacke U

更新日期：2003-03-01 00:00:00

abstract：:Infections during granulocytopenia are major complications of autologous bone marrow transplantation (ABMT). Since recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) has proved to accelerate bone marrow recovery after cytostatic chemotherapy, we studied its effects on hematopoietic regenera...

journal_title：Blood

authors： Link H,Boogaerts MA,Carella AM,Ferrant A,Gadner H,Gorin NC,Harabacz I,Harousseau JL,Hervé P,Holldack J

更新日期：1992-11-01 00:00:00

abstract：:Recently, messenger RNAs in eukaryotes have shown to associate with antisense (AS) transcript partners that are often referred to as long noncoding RNAs (lncRNAs) whose function is largely unknown. Here, we have identified a natural AS transcript for tyrosine kinase containing immunoglobulin and epidermal growth facto...

journal_title：Blood

authors： Li K,Blum Y,Verma A,Liu Z,Pramanik K,Leigh NR,Chun CZ,Samant GV,Zhao B,Garnaas MK,Horswill MA,Stanhope SA,North PE,Miao RQ,Wilkinson GA,Affolter M,Ramchandran R

更新日期：2010-01-07 00:00:00

abstract：:The generation of Ab-secreting plasma cells depends critically on CD4 T-follicular helper (TFH) cells during the germinal center reaction. Germinal center TFH cells share functional properties with circulating CXCR5(+) CD4 T cells, referred to herein as peripheral TFH (pTFH) cells. Because deficient Ab production and ...

journal_title：Blood

authors： Pallikkuth S,Parmigiani A,Silva SY,George VK,Fischl M,Pahwa R,Pahwa S

更新日期：2012-08-02 00:00:00

abstract：:The POEMS syndrome (polyradiculoneuropathy, organomegaly, multiple endocrinopathies, monoclonal protein, skin changes) is a rare disease associated with a plasma cell dyscrasia. Patients with disseminated POEMS can be treated with high-dose therapy and autologous stem cell transplantation (ASCT). While clinical improv...

journal_title：Blood

authors： D'Souza A,Lacy M,Gertz M,Kumar S,Buadi F,Hayman S,Dingli D,Zeldenrust S,Kyle R,Ansell S,Inwards D,Johnston P,Micallef I,Porrata L,Litzow M,Gastineau D,Hogan W,Dispenzieri A

更新日期：2012-07-05 00:00:00

abstract：:Increasing evidence indicates that the gut microbiota is closely associated with acute graft-versus-host disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota transplantation (FMT) could represent an alternative treatment option for aGVHD. However, FMT for SCT patients carries a potential risk of infect...

journal_title：Blood

authors： Kakihana K,Fujioka Y,Suda W,Najima Y,Kuwata G,Sasajima S,Mimura I,Morita H,Sugiyama D,Nishikawa H,Hattori M,Hino Y,Ikegawa S,Yamamoto K,Toya T,Doki N,Koizumi K,Honda K,Ohashi K

更新日期：2016-10-20 00:00:00

abstract：:We prepared a heterohybrid cell line that secretes a human IgM monoclonal autoantibody that recognizes an antigen found on thrombin-activated or stored platelets. The surface expression of the epitope recognized by this autoantibody, 5E5, increases with time as platelets age in vitro, suggesting that it may represent ...

journal_title：Blood

authors： Nugent DJ,Kunicki TJ,Berglund C,Bernstein ID

更新日期：1987-07-01 00:00:00

abstract：:Human myeloma cells freshly isolated from 40 patients with IgG multiple myeloma (MM, 10 in stage I and 30 in stage III), were cultured for 48 hours with recombinant B cell stimulatory factor 2 (rBSF-2)/interleukin-6 (IL-6), which is considered a major growth factor for myeloma cells. Uptake of 3H-thymidine by these pu...

journal_title：Blood

authors： Asaoku H,Kawano M,Iwato K,Tanabe O,Tanaka H,Hirano T,Kishimoto T,Kuramoto A

更新日期：1988-08-01 00:00:00

abstract：:The large multimeric glyocoprotein von Willebrand factor (VWF) is a crucial component of both primary and secondary hemostasis. It is stored in secretory granules of vascular endothelial cells, the Weibel-Palade bodies (WPBs), and is released following stimulation by agonists that raise intracellular Ca(2+) or cyclic ...

journal_title：Blood

authors： Brandherm I,Disse J,Zeuschner D,Gerke V

更新日期：2013-08-08 00:00:00

abstract：:Using either hexazotized pararosaniline or new fuchsin as coupling agents, we investigated the ultrastructural localization of alpha-naphthyl acetate esterase (ANAE) activity in guinea pig bone marrow and peritoneal exudates, and in human peripheral blood cells. DFP-inhibitable ANAE activity was present on the cell su...

journal_title：Blood

authors： Monahan RA,Dvorak HF,Dvorak AM

更新日期：1981-12-01 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) results in a progressive depletion of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the marked loss of CD4+ T lymphocytes are incompletely understood. However, several lines of evidence indicate that direct cytopathology mediated ...

journal_title：Blood

authors： Cantin R,Fortin JF,Lamontagne G,Tremblay M

更新日期：1997-08-01 00:00:00

abstract：:The influence of the shape of the red blood cell during stomatocyte-echinocyte transformation on its deformability was studied by microsieving through pores with diameters of 2.6, 4.5, and 6.9 micron. A stomatocytic transformation was produced by chlorpromazine (0.02, 0.1, and 0.5 mmol/L) and an echinocytic transforma...

journal_title：Blood

authors： Reinhart WH,Chien S

更新日期：1986-04-01 00:00:00

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00

abstract：:We used the polymerase chain reaction (PCR) to detect ALL1-AF4 rearrangements, the molecular hallmark of t(4;11) in a series of 46 pre-pre-B (CD19+, CD24+, CD10/CD20/cylgM/sIgM-) acute lymphoblastic leukemias (ALL). Eighteen patients (39%) exhibited fusion transcripts including 4 of 12 children and 14 of 34 adults. Th...

journal_title：Blood

authors： Janssen JW,Ludwig WD,Borkhardt A,Spadinger U,Rieder H,Fonatsch C,Hossfeld DK,Harbott J,Schulz AS,Repp R

更新日期：1994-12-01 00:00:00

abstract：:Using a polyclonal antiserum against canine CD34, we previously found that CD34 is expressed on canine bone marrow progenitor cells in a manner analogous to that found in humans. To further characterize CD34+ cells and to facilitate preclinical canine stem cell transplant studies, monoclonal antibodies (MoAbs) were ra...

journal_title：Blood

authors： McSweeney PA,Rouleau KA,Wallace PM,Bruno B,Andrews RG,Krizanac-Bengez L,Sandmaier BM,Storb R,Wayner E,Nash RA

更新日期：1998-03-15 00:00:00

abstract：:Trial ALL-BFM 90 was designed to improve outcome in patients with childhood acute lymphoblastic leukemia (ALL) by using a reduced treatment regimen. Patients were stratified into a standard-risk group (SRG), a medium-risk group (MRG), both defined by adequate early treatment response; and a high-risk group (HRG), defi...

journal_title：Blood

authors： Schrappe M,Reiter A,Ludwig WD,Harbott J,Zimmermann M,Hiddemann W,Niemeyer C,Henze G,Feldges A,Zintl F,Kornhuber B,Ritter J,Welte K,Gadner H,Riehm H

更新日期：2000-06-01 00:00:00

abstract：:Eighty-three patients with circulating anticoagulants were studied at The New York Hospital. The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients. The inhibitor was identified using the blood and tissue thromboplastin inhibition tests. Inhibition by the lupus...

journal_title：Blood

authors： Schleider MA,Nachman RL,Jaffe EA,Coleman M

更新日期：1976-10-01 00:00:00

abstract：:Interleukin (IL)-32 was originally identified in natural killer cells and IL-2-activated human T lymphocytes. As T cells are activated in allogeneic transplantation, we determined the role of IL-32 in human mixed lymphocyte cultures (MLCs) and GVHD. In allogeneic MLCs, IL-32 increased two-fold in responding T cells, a...

journal_title：Blood

authors： Marcondes AM,Li X,Tabellini L,Bartenstein M,Kabacka J,Sale GE,Hansen JA,Dinarello CA,Deeg HJ

更新日期：2011-11-03 00:00:00

abstract：:Mpl ligand (thrombopoietin [TPO]) is the physiological regulator of platelet production. In mice, mRNA encoding the Mpl ligand (Mpl-L) is predominantly found by Northern blot analysis in the liver and kidney. To investigate the mode of regulation of the Mpl-L gene, we have developed several experimental models of seve...

journal_title：Blood

authors： Cohen-Solal K,Villeval JL,Titeux M,Lok S,Vainchenker W,Wendling F

更新日期：1996-10-01 00:00:00

abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

journal_title：Blood

authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

更新日期：2007-07-15 00:00:00

abstract：:Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indee...

journal_title：Blood

authors： Burger H,van Tol H,Boersma AW,Brok M,Wiemer EA,Stoter G,Nooter K

更新日期：2004-11-01 00:00:00

abstract：:CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD...

journal_title：Blood

authors： Cosmi L,Liotta F,Lazzeri E,Francalanci M,Angeli R,Mazzinghi B,Santarlasci V,Manetti R,Vanini V,Romagnani P,Maggi E,Romagnani S,Annunziato F

更新日期：2003-12-01 00:00:00

abstract：:Patients with polycythemia vera (PV) have a JAK2 (a cytosolic tyrosine kinase) mutation and an increased risk of vascular thrombosis related to red blood cell (RBC) mass and platelet activation. We investigated functional RBC abnormalities that could be involved in thrombosis. RBC adhesion to human umbilical vein endo...

journal_title：Blood

authors： Wautier MP,El Nemer W,Gane P,Rain JD,Cartron JP,Colin Y,Le Van Kim C,Wautier JL

更新日期：2007-08-01 00:00:00

abstract：:Lymphoepithelioid lymphoma (Lennert's lymphoma) was first described as a special variant of Hodgkin's disease. This lesion is characterized by a high percentage of epithelioid and T cells and rarely contains the classical Hodgkin's/Reed-Sternberg cells. Cytogenetic abnormalities indicate that Lennert's lymphoma is of ...

journal_title：Blood

authors： Feller AC,Griesser GH,Mak TW,Lennert K

更新日期：1986-09-01 00:00:00

abstract：:Interleukin 21 (IL-21) is a member of the common gamma-chain family of cytokines, which influence a broad spectrum of immunologic responses. A number of studies have examined the function of IL-21, but its specific role in Th1/Th2-cell differentiation and related effector responses remains to be clarified. Thus, we ge...

journal_title：Blood

authors： Fröhlich A,Marsland BJ,Sonderegger I,Kurrer M,Hodge MR,Harris NL,Kopf M

更新日期：2007-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact...

journal_title：Blood

authors： Zhang X,Kimura Y,Fang C,Zhou L,Sfyroera G,Lambris JD,Wetsel RA,Miwa T,Song WC

更新日期：2007-07-01 00:00:00

abstract：:The morphologic, immunophenotypic, genotypic, genomic, and functional features of an undifferentiated acute leukemia with stem cell features are reported. At light and electron microscopy, the leukemic population was represented by primitive progenitor cells with no evidence of differentiation. The blasts were CD34(+)...

journal_title：Blood

authors： Testa U,Torelli GF,Riccioni R,Muta AO,Militi S,Annino L,Mariani G,Guarini A,Chiaretti S,Ritz J,Mandelli F,Peschle C,Foa R

更新日期：2002-06-15 00:00:00

abstract：:Erythroid progenitors (BFU-E) from adult human peripheral blood generate erythroid bursts in semisolid culture supplemented with at least two growth factors, ie, erythropoietin (Ep) and interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). We have analyzed the hematopoietin(s) requirement ...

journal_title：Blood

authors： Valtieri M,Gabbianelli M,Pelosi E,Bassano E,Petti S,Russo G,Testa U,Peschle C

更新日期：1989-07-01 00:00:00

abstract：:Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors ...

journal_title：Blood

authors： Trobridge GD,Beard BC,Gooch C,Wohlfahrt M,Olsen P,Fletcher J,Malik P,Kiem HP

更新日期：2008-06-15 00:00:00