当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.

Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.

Abstract：

:Trial ALL-BFM 90 was designed to improve outcome in patients with childhood acute lymphoblastic leukemia (ALL) by using a reduced treatment regimen. Patients were stratified into a standard-risk group (SRG), a medium-risk group (MRG), both defined by adequate early treatment response; and a high-risk group (HRG), defined by inadequate response to the cytoreductive prednisone prephase, induction failure, or Philadelphia-chromosome-positive ALL. Four treatment modifications were evaluated: dose intensification in induction by a more rapid drug sequence; administration of L-asparaginase during consolidation therapy in the MRG (randomized); enforced consolidation by rotational elements in the HRG; and reduction in the dose of anthracyclines and use of only 12-Gy preventive cranial radiotherapy in the MRG and HRG, with the aim of avoiding toxicity. Among all 2178 patients (

journal_name

Blood

journal_title

Blood

authors

Schrappe M,Reiter A,Ludwig WD,Harbott J,Zimmermann M,Hiddemann W,Niemeyer C,Henze G,Feldges A,Zintl F,Kornhuber B,Ritter J,Welte K,Gadner H,Riehm H

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

3310-22

issue

11

eissn

0006-4971

issn

1528-0020

journal_volume

95

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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