Neddylation plays an important role in the regulation of murine and human dendritic cell function.

abstract：:Although well characterized in the mouse, the role of Notch signaling in the human T-cell receptor alphabeta (TCR-alphabeta) versus TCR-gammadelta lineage decision is still unclear. Although it is clear in the mouse that TCR-gammadelta development is less Notch dependent compared with TCR-alphabeta differentiation, re...

journal_title：Blood

authors： Van de Walle I,De Smet G,De Smedt M,Vandekerckhove B,Leclercq G,Plum J,Taghon T

更新日期：2009-03-26 00:00:00

abstract：:Natural killer T (NKT) cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self-antigens. The nature of NKT-cell autoreactive activation remains poorly understood. We show here that the mitogen-activated protein kinase (MAPK) pathway is operative during human NKT...

journal_title：Blood

authors： Wang X,Chen X,Rodenkirch L,Simonson W,Wernimont S,Ndonye RM,Veerapen N,Gibson D,Howell AR,Besra GS,Painter GF,Huttenlocher A,Gumperz JE

更新日期：2008-11-15 00:00:00

abstract：:Heterogeneity in the human and rat plasma fibrinogen (FBG) gamma chains is due to differential splicing of the primary gamma chain mRNA transcript. The subunit composition of FBG containing the predominant form of the gamma chain is homodimeric (human: A alpha 2, B beta 2, gamma 50-gamma 50; rat: A alpha 2, B beta 2, ...

journal_title：Blood

authors： Lawrence SO,Wright TW,Francis CW,Fay PJ,Haidaris PJ

更新日期：1993-10-15 00:00:00

abstract：:We retrospectively analyzed outcomes among 567 patients with hematologic malignancies who had hematopoietic cell transplantation from human leukocyte antigen-identical sibling donors between 2001 and 2007 for a correlation between statin use and risk of graft-versus-host disease (GVHD). Compared with allografts where ...

journal_title：Blood

authors： Rotta M,Storer BE,Storb RF,Martin PJ,Heimfeld S,Peffer A,Maloney DG,Deeg HJ,Sandmaier BM,Appelbaum FR,Mielcarek M

更新日期：2010-02-11 00:00:00

abstract：:The capacity to convert exogenous leukotriene A4 to lipoxins (LXs) was investigated in platelet suspensions from patients with myeloproliferative disorders (MPD) (n = 22) and healthy control subjects (n = 14). Platelets isolated from the controls produced mainly LXA4, but also 6(S)-LXA4 and the all-trans isomers of li...

journal_title：Blood

authors： Stenke L,Edenius C,Samuelsson J,Lindgren JA

更新日期：1991-12-01 00:00:00

abstract：:Exposure to HIV-1 does not necessarily result in infection and progression toward disease, thus suggesting that the control of viral infection may be achieved. Antibodies to CCR5 have been detected in HIV-exposed but uninfected subjects (ESNs); thus, these antibodies could be involved in HIV protection. To assess whet...

journal_title：Blood

authors： Pastori C,Weiser B,Barassi C,Uberti-Foppa C,Ghezzi S,Longhi R,Calori G,Burger H,Kemal K,Poli G,Lazzarin A,Lopalco L

更新日期：2006-06-15 00:00:00

abstract：:Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. In this report, we investigate the potential role of PLSCR1 in...

journal_title：Blood

authors： Zhao KW,Li X,Zhao Q,Huang Y,Li D,Peng ZG,Shen WZ,Zhao J,Zhou Q,Chen Z,Sims PJ,Wiedmer T,Chen GQ

更新日期：2004-12-01 00:00:00

abstract：:The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylated in B-cell lymphoma cell lines and in primary cases of B-cell lymphomas, namely, follicular lymph...

journal_title：Blood

authors： Guan H,Xie L,Leithäuser F,Flossbach L,Möller P,Wirth T,Ushmorov A

更新日期：2010-09-02 00:00:00

abstract：:To assess a possible role in tumor progression, the occurrence and type of K- and N-RAS mutations were determined in purified tumor cells, including samples from patients with premalignant monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), and extramedullary plasma cell (PC) tumors (ExPC...

journal_title：Blood

authors： Rasmussen T,Kuehl M,Lodahl M,Johnsen HE,Dahl IM

更新日期：2005-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent progenitor cells that have emerged as a promising tool for clinical application. Further clinical interest has been raised by the observation that MSCs are immunoprivileged and, more important, display immunosuppressive capacities. These properties may be of therapeutic va...

journal_title：Blood

authors： Nauta AJ,Westerhuis G,Kruisselbrink AB,Lurvink EG,Willemze R,Fibbe WE

更新日期：2006-09-15 00:00:00

abstract：:Reconstitution of cytomegalovirus (CMV)-specific CD8(+) T cells is essential to the control of CMV infection in CMV-positive recipients (R(+)) after allogeneic hematopoietic stem cell transplantation (HCT). Six-color flow cytometry was used to assess the functional profile of CMV-specific CD8(+) T cells in 62 of 178 R...

journal_title：Blood

authors： Zhou W,Longmate J,Lacey SF,Palmer JM,Gallez-Hawkins G,Thao L,Spielberger R,Nakamura R,Forman SJ,Zaia JA,Diamond DJ

更新日期：2009-06-18 00:00:00

abstract：:Intravenously applied normal human immunoglobulin G (IgG) has anti-inflammatory effects in the treatment of autoimmune diseases. Systemic inflammation can originate from an overreacting amplification loop of the complement system. In blood, C3b2-containing complexes maintain complement amplification much better than t...

journal_title：Blood

authors： Lutz HU,Stammler P,Bianchi V,Trüeb RM,Hunziker T,Burger R,Jelezarova E,Späth PJ

更新日期：2004-01-15 00:00:00

abstract：:The U-A10 cell line, a doxorubicin-selected variant of human U-937 myeloid leukemia cells, exhibits a redistribution of anthracyclines into a expanded vesicular compartment. The acidic nature of this compartment was confirmed by vital staining with a pH sensitive dye, LysoSensor yellow/blue DND-160. Identification of ...

journal_title：Blood

authors： Hurwitz SJ,Terashima M,Mizunuma N,Slapak CA

更新日期：1997-05-15 00:00:00

abstract：:Although a number of studies have indicated correlations between histologic subtypes of tumors and certain nonrandom chromosome changes, cytogenetic studies of lymphoma are in an early stage compared to those of leukemia. No comprehensive analysis of available data has so far been attempted in the literature either. H...

journal_title：Blood

authors： Koduru PR,Filippa DA,Richardson ME,Jhanwar SC,Chaganti SR,Koziner B,Clarkson BD,Lieberman PH,Chaganti RS

更新日期：1987-01-01 00:00:00

abstract：:Immune thrombocytopenias are usually associated with normal or increased numbers of megakaryocytes in the marrow. Therefore, the mechanism(s) responsible for the destruction of circulating platelets may not affect megakaryocytes in the same way. One of the possibilities which could account for the differential effect ...

journal_title：Blood

authors： Stahl CP,Zucker-Franklin D,McDonald TP

更新日期：1986-02-01 00:00:00

abstract：:In this issue of Blood, Tebas et al report antiviral effects in a clinical trial of multiple infusions of lentiviral vector–modified autologous CD4T lymphocytes in 17 HIV-infected patients aviremic on antiretroviral therapy (ART). ...

journal_title：Blood

authors： Jacobson JM

更新日期：2013-02-28 00:00:00

abstract：:In this issue of Blood, Baychelier et al identify a ligand for a major natural killer (NK) cell receptor that mediates natural cytotoxicity toward tumor cells, thus ending a search that lasted well over a decade. ...

journal_title：Blood

authors： Rajagopalan S,Long EO

更新日期：2013-10-24 00:00:00

abstract：:Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell-like T cells with the ability to self-renew and differentiate into potent effector cells. Here, we investigated the in vivo existence of stem cell-like antigen-specific T cells in allogeneic stem cell transplantation (allo-S...

journal_title：Blood

authors： van der Waart AB,van de Weem NM,Maas F,Kramer CS,Kester MG,Falkenburg JH,Schaap N,Jansen JH,van der Voort R,Gattinoni L,Hobo W,Dolstra H

更新日期：2014-11-27 00:00:00

abstract：:Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors ...

journal_title：Blood

authors： Trobridge GD,Beard BC,Gooch C,Wohlfahrt M,Olsen P,Fletcher J,Malik P,Kiem HP

更新日期：2008-06-15 00:00:00

abstract：:Sixteen patients with adult T-cell leukemia/lymphoma (ATL) who were all over 50 years of age underwent allogeneic stem cell transplantation with reduced-conditioning intensity (RIST) from HLA-matched sibling donors after a conditioning regimen consisting of fludarabine (180 mg/m2), busulfan (8 mg/kg), and rabbit antit...

journal_title：Blood

authors： Okamura J,Utsunomiya A,Tanosaki R,Uike N,Sonoda S,Kannagi M,Tomonaga M,Harada M,Kimura N,Masuda M,Kawano F,Yufu Y,Hattori H,Kikuchi H,Saburi Y

更新日期：2005-05-15 00:00:00

abstract：:Ristocetin and vancomycin are structurally similar glycopeptide antibiotics. Both vancomycin and ristocetin in high concentrations (3.0 mg/ml) cause the precipitation of fibrinogen, plasminogen, and IgG from platelet-poor plasma (PPP). In contrast to ristocetin, vanomycin (0.5-1.5 mg/ml) does not agglutinate platelets...

journal_title：Blood

authors： Moake JL,Cimo PL,Peterson DM,Roper P,Natelson EA

更新日期：1977-09-01 00:00:00

abstract：:Natural killer (NK) cell activation is the result of a balance between positive and negative signals triggered by specific membrane receptors. We report here the activation of NK cells induced through the transmembrane glycoprotein CD43 (leukosialin, sialophorin). Engagement of CD43 by specific antibodies stimulated t...

journal_title：Blood

authors： Nieto M,Rodríguez-Fernández JL,Navarro F,Sancho D,Frade JM,Mellado M,Martínez-A C,Cabañas C,Sánchez-Madrid F

更新日期：1999-10-15 00:00:00

abstract：:To investigate the natural history of stage A chronic lymphocytic leukemia (CLL) we reviewed 84 such patients. Among 74 cases evaluable for disease progression, 22 (29.6%) progressed to more advanced clinical stages (9 to stage B, 13 to stage C); the actuarial estimation of such an event at 4 years was 30% (95% CI: 26...

journal_title：Blood

authors： Molica S

更新日期：1991-08-15 00:00:00

abstract：:Surrogate light chain expression during B lineage differentiation was examined by using indicator fluorochrome-filled liposomes in an enhanced immunofluorescence assay. Pro-B cells bearing surrogate light chain components were found in mice, but not in humans. A limited subpopulation of relatively large pre-B cells in...

journal_title：Blood

authors： Wang YH,Stephan RP,Scheffold A,Kunkel D,Karasuyama H,Radbruch A,Cooper MD

更新日期：2002-04-01 00:00:00

abstract：:The binding of neutrophil beta2 integrin to intercellular adhesion molecule-1 (ICAM-1) expressed on the inflamed endothelium is critical for neutrophil arrest at sites of tissue inflammation. To quantify the strength and kinetics of this interaction, we measured the adhesion between chemotactically stimulated neutroph...

journal_title：Blood

authors： Neelamegham S,Taylor AD,Burns AR,Smith CW,Simon SI

更新日期：1998-09-01 00:00:00

abstract：:Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. Interleukin-10 (IL-10) is the crucial driving factor for Tr1 cell differentiation, but the molecular mechanisms underlying this induction remain unknown. We identi...

journal_title：Blood

authors： Gregori S,Tomasoni D,Pacciani V,Scirpoli M,Battaglia M,Magnani CF,Hauben E,Roncarolo MG

更新日期：2010-08-12 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has a specific genetic rearrangement between the retinoic acid receptor (RAR)-alpha gene and the pml nuclear protein gene. All-trans retinoic acid (ATRA) induces granulocytic differentiation of APL-derived cells and is used to treat APL patients. However, ATRA interacts with normal c...

journal_title：Blood

authors： Makishima M,Umesono K,Shudo K,Naoe T,Kishi K,Honma Y

更新日期：1998-06-15 00:00:00

abstract：:We have used two in vitro models to identify genes whose expression may serve as markers of lineage commitment during the development of hematopoietic stem cells. One system involves the development in vitro of blastocyst-derived embryonic stem cells into embryoid bodies. The second involves culturing of day 3.5 blast...

journal_title：Blood

authors： McClanahan T,Dalrymple S,Barkett M,Lee F

更新日期：1993-06-01 00:00:00

abstract：:An inverse relationship between BCL-2 expression and cell cycle transition has been suggested by recent studies in murine models. To investigate the clinical relevance of these laboratory studies, a group of 116 paraffin-embedded non-Hodgkin's lymphoma (NHL) biopsy specimens (Working Formulation Groups D-H, and J) fro...

journal_title：Blood

authors： Winter JN,Andersen J,Reed JC,Krajewski S,Variakojis D,Bauer KD,Fisher RI,Gordon LI,Oken MM,Jiang S,Jeffries D,Domer P

更新日期：1998-02-15 00:00:00

abstract：:Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is putatively derived from a thymic B cell. Accounting for up to 10% of cases of DLBCL, this subtype predominantly affects women in the third and fourth decades of life. Its clinical and molecular characteristics are ...

journal_title：Blood

authors： Dunleavy K,Wilson WH

更新日期：2015-01-01 00:00:00