Abstract:
:Sixteen patients with adult T-cell leukemia/lymphoma (ATL) who were all over 50 years of age underwent allogeneic stem cell transplantation with reduced-conditioning intensity (RIST) from HLA-matched sibling donors after a conditioning regimen consisting of fludarabine (180 mg/m2), busulfan (8 mg/kg), and rabbit antithymocyte globulin (5 mg/kg). The observed regimen-related toxicities and nonhematologic toxicities were all found to be acceptable. Disease relapse was the main cause of treatment failure. Three patients who had a relapse subsequently responded to a rapid discontinuation of the immunosuppressive agent and thereafter achieved another remission. After RIST, the human T-cell leukemia virus type 1 (HTLV-1) proviral load became undetectable in 8 patients. RIST is thus considered to be a feasible treatment for ATL. Our data also suggest the presence of a possible graft-versus-ATL effect; an anti-HTLV-1 activity was also found to be associated with this procedure.
journal_name
Bloodjournal_title
Bloodauthors
Okamura J,Utsunomiya A,Tanosaki R,Uike N,Sonoda S,Kannagi M,Tomonaga M,Harada M,Kimura N,Masuda M,Kawano F,Yufu Y,Hattori H,Kikuchi H,Saburi Ydoi
10.1182/blood-2004-11-4193subject
Has Abstractpub_date
2005-05-15 00:00:00pages
4143-5issue
10eissn
0006-4971issn
1528-0020pii
2004-11-4193journal_volume
105pub_type
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