Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle.

abstract：:Fanconi anemia is a genetic disorder associated with diverse congenital abnormalities, progressive bone marrow failure, and increased risk of leukemia and other cancers. Affected persons often die before 30 years of age. Bone marrow transplantation is an effective treatment, but there are few data regarding factors as...

journal_title：Blood

authors： Gluckman E,Auerbach AD,Horowitz MM,Sobocinski KA,Ash RC,Bortin MM,Butturini A,Camitta BM,Champlin RE,Friedrich W,Good RA,Gordon-Smith EC,Harris RE,Klein JP,Ortega JJ,Pasquini R,Ramsay NK,Speck B,Vowels MR,Zhang MJ,

更新日期：1995-10-01 00:00:00

abstract：:Heme oxygenase-1 is an essential enzyme in heme catabolism, and its human gene promoter contains a putative heat shock element (HHO-HSE). This study was designed to analyze the regulation of human heme oxygenase-1 gene expression under thermal stress. The amounts of heme oxygenase-1 protein were not increased by heat ...

journal_title：Blood

authors： Okinaga S,Takahashi K,Takeda K,Yoshizawa M,Fujita H,Sasaki H,Shibahara S

更新日期：1996-06-15 00:00:00

abstract：:We have recently shown that proteasome inhibitor PS-341 induces apoptosis in drug-resistant multiple myeloma (MM) cells, inhibits binding of MM cells in the bone marrow microenvironment, and inhibits cytokines mediating MM cell growth, survival, drug resistance, and migration in vitro. PS-341 also inhibits human MM ce...

journal_title：Blood

authors： Hideshima T,Mitsiades C,Akiyama M,Hayashi T,Chauhan D,Richardson P,Schlossman R,Podar K,Munshi NC,Mitsiades N,Anderson KC

更新日期：2003-02-15 00:00:00

abstract：:To determine the risk factors and outcomes associated with rising cytomegalovirus (CMV) antigenemia levels during preemptive therapy among stem cell allograft recipients, 119 patients with CMV antigenemia were studied. Patients were prospectively monitored for CMV antigenemia weekly; those with positive findings on an...

journal_title：Blood

authors： Nichols WG,Corey L,Gooley T,Drew WL,Miner R,Huang M,Davis C,Boeckh M

更新日期：2001-02-15 00:00:00

abstract：:Several strategies can be used to manage fetal or neonatal alloimmune thrombocytopenia (FNAIT) in subsequent pregnancies. Serial fetal blood sampling (FBS) and intrauterine platelet transfusions (IUPT), as well as weekly maternal IV immunoglobulin infusion (IVIG), with or without additional corticosteroid therapy, are...

journal_title：Blood

authors： Winkelhorst D,Murphy MF,Greinacher A,Shehata N,Bakchoul T,Massey E,Baker J,Lieberman L,Tanael S,Hume H,Arnold DM,Baidya S,Bertrand G,Bussel J,Kjaer M,Kaplan C,Kjeldsen-Kragh J,Oepkes D,Ryan G

更新日期：2017-03-16 00:00:00

abstract：:Activated protein C (APC) resistance caused by the factor V Leiden mutation is associated with an increased risk of venous thrombosis. We investigated whether a reduced response to APC, not due to the factor V point mutation, is also a risk factor for venous thrombosis. For this analysis, we used the Leiden Thrombophi...

journal_title：Blood

authors： de Visser MC,Rosendaal FR,Bertina RM

更新日期：1999-02-15 00:00:00

abstract：:We prepared a heterohybrid cell line that secretes a human IgM monoclonal autoantibody that recognizes an antigen found on thrombin-activated or stored platelets. The surface expression of the epitope recognized by this autoantibody, 5E5, increases with time as platelets age in vitro, suggesting that it may represent ...

journal_title：Blood

authors： Nugent DJ,Kunicki TJ,Berglund C,Bernstein ID

更新日期：1987-07-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is essential for the host response to bacterial infection by controlling neutrophil production in the bone marrow. The G-CSF receptor (G-CSFR) activates the Jak/STAT pathway, although little is understood about how these signals regulate basal and stress-induced granulopoi...

journal_title：Blood

authors： Panopoulos AD,Zhang L,Snow JW,Jones DM,Smith AM,El Kasmi KC,Liu F,Goldsmith MA,Link DC,Murray PJ,Watowich SS

更新日期：2006-12-01 00:00:00

abstract：:In the present study, we investigated disease characteristics and clinical outcome in young patients (< 40 years) with World Health Organization (WHO)-defined essential thrombocythemia (ET) compared with early/prefibrotic primary myelofibrosis (PMF) with presenting thrombocythemia. We recruited 213 young patients (med...

journal_title：Blood

authors： Barbui T,Thiele J,Carobbio A,Passamonti F,Rumi E,Randi ML,Bertozzi I,Vannucchi AM,Gisslinger H,Gisslinger B,Finazzi G,Ruggeri M,Rodeghiero F,Rambaldi A,Gangat N,Tefferi A

更新日期：2012-07-19 00:00:00

abstract：:The EVI1 gene encodes a zinc-finger, DNA-binding protein originally described as the transforming gene associated with a common ecotropic viral insertion site in myeloid leukemias. Previous studies demonstrated EVI1 expression in human leukemias in cases with 3q26 translocations, but not in normal blood or bone marrow...

journal_title：Blood

authors： Russell M,List A,Greenberg P,Woodward S,Glinsmann B,Parganas E,Ihle J,Taetle R

更新日期：1994-08-15 00:00:00

abstract：:Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for the main...

journal_title：Blood

authors： Quesniaux VF,Clark SC,Turner K,Fagg B

更新日期：1992-09-01 00:00:00

abstract：:Hereditary hemochromatosis is caused by mutations in the hereditary hemochromatosis protein (HFE), transferrin-receptor 2 (TfR2), hemojuvelin, hepcidin, or ferroportin genes. Hepcidin is a key iron regulator, which is secreted by the liver, and decreases serum iron levels by causing the down-regulation of the iron tra...

journal_title：Blood

authors： Gao J,Chen J,De Domenico I,Koeller DM,Harding CO,Fleming RE,Koeberl DD,Enns CA

更新日期：2010-04-22 00:00:00

abstract：:The expression of Rhesus antigens on hematopoietic progenitor cells was studied using monoclonal antibodies. Because these antibodies are not capable of lysing mature red blood cells in a complement-dependent cytotoxicity assay, fluorescence-activated cell sorting was performed. Using the monoclonal anti-Rh 29 antibod...

journal_title：Blood

authors： Falkenburg JH,Fibbe WE,van der Vaart-Duinkerken N,Nichols ME,Rubinstein P,Jansen J

更新日期：1985-09-01 00:00:00

abstract：:Natural killer (NK) activity against K-562 tumor cells was evaluated in peripheral blood leukocytes (PBL) obtained from untreated patients affected by hairy cell leukemia (HCL). NK activity present in PBL from 10 HCL patients was at least six-fold lower (p less than 0.01) than that present in PBL from 15 healthy donor...

journal_title：Blood

authors： Ruco LP,Procopio A,Maccallini V,Calogero A,Uccini S,Annino L,Mandelli F,Baroni CD

更新日期：1983-06-01 00:00:00

abstract：:The reactivity of acute myeloid leukemia cells (AML) was determined in 29 patients using the fucose binding lectin Ulex europaeus agglutinin (UEA) as surface marker. We show a marked heterogeneity in the UEA-binding abilities of the cells in these patients as determined by fluorescence analysis of the blasts labeled w...

journal_title：Blood

authors： Delwel R,Touw I,Bot F,Löwenberg B

更新日期：1986-07-01 00:00:00

abstract：:Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas (cBCLs). We performed a survey of 84 canine NHL tumor...

journal_title：Blood

authors： Bushell KR,Kim Y,Chan FC,Ben-Neriah S,Jenks A,Alcaide M,Fornika D,Grande BM,Arthur S,Gascoyne RD,Steidl C,Morin RD

更新日期：2015-02-05 00:00:00

abstract：:Identification of a novel therapy for prevention of sudden death by ischemic cardiac infarction is an area of intensive investigation. We here report that the mortality due to an experimental acute myocardial infarction (AMI) was markedly increased in mice deficient in alpha2-antiplasmin (alpha2-AP(-/-) mice) but not ...

journal_title：Blood

authors： Matsuno H,Kozawa O,Yoshimi N,Akamatsu S,Hara A,Mori H,Okada K,Ueshima S,Matsuo O,Uematsu T

更新日期：2002-10-01 00:00:00

abstract：:This article reports a Glanzmann thrombasthenia (GT) patient, N.M., with a point mutation in the third cysteine-rich repeat of beta3-integrin or platelet glycoprotein (GP) IIIa, leading to the expression of a constitutively activated fibrinogen receptor. The diagnosis of GT was based on a severely reduced platelet-agg...

journal_title：Blood

authors： Ruiz C,Liu CY,Sun QH,Sigaud-Fiks M,Fressinaud E,Muller JY,Nurden P,Nurden AT,Newman PJ,Valentin N

更新日期：2001-10-15 00:00:00

abstract：:The human burst-forming unit-megakaryocyte (BFU-MK) is a primitive megakaryocytic progenitor cell. A marrow cell population enriched for BFU-MK (CD34+ DR-) was obtained by monoclonal antibody labeling and fluorescence-activated cell sorting. CD34+DR- cells were assayed in a serum-depleted, fibrin clot culture system. ...

journal_title：Blood

authors： Briddell RA,Hoffman R

更新日期：1990-08-01 00:00:00

abstract：:In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process? ...

journal_title：Blood

authors： Abshire T

更新日期：2011-02-24 00:00:00

abstract：:The induction of tumor cell differentiation represents an attractive strategy for the treatment of a wide range of malignancies. Differentiation of HL-60 promyelocytic leukemia cells towards neutrophils or monocytes has been shown to induce apoptotic cell death, which is inhibited by bcl-2 over-expression. However, th...

journal_title：Blood

authors： Benito A,Silva M,Grillot D,Nuñez G,Fernández-Luna JL

更新日期：1996-05-01 00:00:00

abstract：:The inclusion of exon 16 in the mature protein 4.1R messenger RNA (mRNA) is a critical event in red blood cell membrane biogenesis. It occurs during late erythroid development and results in inclusion of the 10-kd domain needed for stabilization of the spectrin/actin lattice. In this study, an experimental model was e...

journal_title：Blood

authors： Deguillien M,Huang SC,Morinière M,Dreumont N,Benz EJ Jr,Baklouti F

更新日期：2001-12-15 00:00:00

abstract：:An unusual mouse line (max 41) that carries an inserted transgene encoding the nuclear transcription factor, Max, exhibits a 50- to 60-fold elevation of blood neutrophils and a 10-fold elevation of blood monocytes. Analysis showed that these elevated levels of blood cells were sustained incrementally by a sevenfold in...

journal_title：Blood

authors： Metcalf D,Lindeman GJ,Nicola NA

更新日期：1995-05-01 00:00:00

abstract：:HTLV-II has been found in some cases of the rare T-cell form of hairy-cell leukemia (HCL) and in a leukopenic chronic T-cell leukemia mimicking HCL. We asked whether the virus is implicated in the more frequent B-cell form of HCL. DNA extracted from the mononuclear cells derived from spleen (eight cases) or peripheral...

journal_title：Blood

authors： Lion T,Razvi N,Golomb HM,Brownstein RH

更新日期：1988-10-01 00:00:00

abstract：:Platelet factor 4 (PF4) serves as a lineage-specific marker of megakaryocyte development. We previously identified two positively acting sequences in the human platelet factor 4 (hPF4) gene promoter that synergized to drive high-level luciferase reporter gene expression in vitro. Using portions of the hPF4 5'-flanking...

journal_title：Blood

authors： Cui Z,Reilly MP,Surrey S,Schwartz E,McKenzie SE

更新日期：1998-04-01 00:00:00

abstract：:Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells tha...

journal_title：Blood

authors： Krejcik J,Casneuf T,Nijhof IS,Verbist B,Bald J,Plesner T,Syed K,Liu K,van de Donk NW,Weiss BM,Ahmadi T,Lokhorst HM,Mutis T,Sasser AK

更新日期：2016-07-21 00:00:00

abstract：:We analyzed the effect of aspirin, salicylate, and other nonsteroidal antiinflammatory drugs (NSAIDs) on the viability of B-chronic lymphocytic leukemia (B-CLL) cells. Aspirin induced a decrease in cell viability in a dose- and time-dependent manner. The mean IC50 for cells from 5 patients was 5.9 +/- 1.13 mmol/L (ran...

journal_title：Blood

authors： Bellosillo B,Piqué M,Barragán M,Castaño E,Villamor N,Colomer D,Montserrat E,Pons G,Gil J

更新日期：1998-08-15 00:00:00

abstract：:The switch from fetal to adult hemoglobin is incomplete; the residual fetal hemoglobin in adults is restricted to a subset of erythrocytes called F cells. F-cell levels are influenced by a sequence variant (C-->T) at position -158 upstream of the gamma-globin gene, termed the XmnI-Ggamma polymorphism. How the Ggamma-1...

journal_title：Blood

authors： Garner C,Silver N,Best S,Menzel S,Martin C,Spector TD,Thein SL

更新日期：2004-10-01 00:00:00

abstract：:Recombinant rat stem cell factor (rrSCF) administered to rats as a single intravenous injection causes a dose-dependent neutrophilia and lymphocytosis as well as the appearance of immature myeloid cells and occasional blast cells in the circulation. Neutrophilia begins at 2 hours, peaks at 4 to 6 hours, and subsides b...

journal_title：Blood

authors： Ulich TR,del Castillo J,Yi ES,Yin S,McNiece I,Yung YP,Zsebo KM

更新日期：1991-08-01 00:00:00

abstract：:The best initial therapy for elderly patients with chronic lymphocytic leukemia (CLL) has not yet been defined. We investigated the activity of lenalidomide as initial therapy for elderly patients with CLL. Sixty patients with CLL 65 years of age and older received treatment with lenalidomide orally 5 mg daily for 56 ...

journal_title：Blood

authors： Badoux XC,Keating MJ,Wen S,Lee BN,Sivina M,Reuben J,Wierda WG,O'Brien SM,Faderl S,Kornblau SM,Burger JA,Ferrajoli A

更新日期：2011-09-29 00:00:00