Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation.

abstract：:Alteration of lineage-specific transcriptional programs for hematopoiesis causes differentiation block and promotes leukemia development. Here, we show that AML1/ETO, the most common translocation fusion product in acute myeloid leukemia (AML), counteracts the activity of retinoic acid (RA), a transcriptional regulato...

journal_title：Blood

authors： Fazi F,Zardo G,Gelmetti V,Travaglini L,Ciolfi A,Di Croce L,Rosa A,Bozzoni I,Grignani F,Lo-Coco F,Pelicci PG,Nervi C

更新日期：2007-05-15 00:00:00

abstract：:In this issue of Blood, Nagai et al provide evidence that adult T-cell leukemia is hierarchically organized and sustained by a small population of transformed T memory stem cells. ...

journal_title：Blood

authors： Gattinoni L

更新日期：2015-06-04 00:00:00

abstract：:Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). We investigated the feasibility of intensified preemptive immunotherapy in children receiving allo-SCT for AML. Eighty-four...

journal_title：Blood

authors： Rettinger E,Willasch AM,Kreyenberg H,Borkhardt A,Holter W,Kremens B,Strahm B,Woessmann W,Mauz-Koerholz C,Gruhn B,Burdach S,Albert MH,Schlegel PG,Klingebiel T,Bader P

更新日期：2011-11-17 00:00:00

abstract：:Macrophages are reservoirs of HIV-1 infection, proposed to transmit virus to CD4(+) T cells, the primary target of the virus. Here we report that human monocyte-derived macrophages (MDMs) rapidly spread HIV-1 to autologous CD4(+) T cells resulting in productive infection. Transmission takes place across transient adhe...

journal_title：Blood

authors： Groot F,Welsch S,Sattentau QJ

更新日期：2008-05-01 00:00:00

abstract：:Glutathione-S-transferase (GST)-Grb2 fusion proteins have been used to identify the potential role of Grb2-binding proteins in platelet activation by the platelet low-affinity IgG receptor, Fc gamma RIIA. Two tyrosine phosphoproteins of 38 and 63 kD bind to the SH2 domain of Grb2 following Fc gamma RIIA stimulation of...

journal_title：Blood

authors： Robinson A,Gibbins J,Rodríguez-Liñares B,Finan PM,Wilson L,Kellie S,Findell P,Watson SP

更新日期：1996-07-15 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is now a commonplace procedure. Clinicians who care for patients with hematologic malignancies and aplastic anemia are almost certain to follow up patients after SCT. This review is intended to help clinicians observe patients for probably the most important late complication...

journal_title：Blood

authors： Vogelsang GB

更新日期：2001-03-01 00:00:00

abstract：:In this issue of Blood, Savona and an international consortium of clinical investigators propose uniform response criteria for treatment trials enrolling adult patients with myelodysplastic/myeloproliferative neoplasms (MDS/MPNs). Such a proposal is needed because new drugs are finally being tested in these rare “over...

journal_title：Blood

authors： Steensma DP

更新日期：2015-03-19 00:00:00

abstract：:Murine autoreactive anti-Smith (Sm) B cells are negatively regulated by anergy and developmental arrest, but are also positively selected into the marginal zone (MZ) and B-1 B-cell populations. Despite positive selection, anti-Sm production occurs only in autoimmune-prone mice. To investigate autoreactive B-cell activ...

journal_title：Blood

authors： Qian Y,Conway KL,Lu X,Seitz HM,Matsushima GK,Clarke SH

更新日期：2006-08-01 00:00:00

abstract：:Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common gamma chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendritic cells (DCs), ...

journal_title：Blood

authors： Brandt K,Bulfone-Paus S,Foster DC,Rückert R

更新日期：2003-12-01 00:00:00

abstract：:A deficiency of adenosine deaminase, an enzyme important in purine nucleoside catabolism, is associated with a severe combined immunodeficiency disease in children. Inhibition of this enzyme in vitro and in vivo results in an impairment in lymphoblast proliferation. We have investigated the pharmacologic inhibition of...

journal_title：Blood

authors： Grever MR,Siaw MF,Jacob WF,Neidhart JA,Miser JS,Coleman MS,Hutton JJ,Balcerzak SP

更新日期：1981-03-01 00:00:00

abstract：:In this issue of Blood, Buchlis and colleagues describe the long-term persistence (up to 10 years) of factor IX (FIX) expression in adeno-associated virus serotype 2 (AAV-2)–injected muscles of a patient with hemophilia B. ...

journal_title：Blood

authors： Benveniste O

更新日期：2012-03-29 00:00:00

abstract：:The aim of this study was to investigate whether interleukin (IL)-6 induces the production of IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from cancer patients participating in phase I and II trials of recombinant IL-6 administered as a 120-hour continuous intravenous (IV) infu...

journal_title：Blood

authors： Tilg H,Trehu E,Atkins MB,Dinarello CA,Mier JW

更新日期：1994-01-01 00:00:00

abstract：:Radioimmunotherapy (RIT) has emerged as an effective treatment for lymphoma, however the underlying mechanisms are poorly understood. We therefore investigated the relative contributions of antibody and targeted radiation to the clearance of tumor in vivo, using 2 different syngeneic murine B-cell lymphoma models. Alt...

journal_title：Blood

authors： Du Y,Honeychurch J,Cragg MS,Bayne M,Glennie MJ,Johnson PW,Illidge TM

更新日期：2004-02-15 00:00:00

abstract：:In a chromosome study in childhood T-cell leukemia/lymphoma, we found t(7;11)(q35;p13) in 2 patients, t(7;14) (q35;q11) in one patient, and t(7;14)(p15;q32) in 1 patient. Southern blotting and in situ chromosomal hybridization studies in one patient with the t(7;11) demonstrated that both alleles of the T-cell antigen...

journal_title：Blood

authors： Kaneko Y,Maseki N,Homma C,Sakurai M,Mizutani S,Takeda T,Shikano T,Fujimoto T,Yaoi K,Shimokawa T

更新日期：1988-08-01 00:00:00

abstract：:To study outcomes of adults with idiopathic thrombocytopenic purpura (ITP), we performed a follow-up study in a cohort of 152 consecutive patients who were treated according to a well-defined algorithm. Long-term outcomes were determined relative to the response 2 years after diagnosis, because most (93%) patients who...

journal_title：Blood

authors： Portielje JE,Westendorp RG,Kluin-Nelemans HC,Brand A

更新日期：2001-05-01 00:00:00

abstract：:This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by ...

journal_title：Blood

authors： Cervantes-Barragan L,Züst R,Weber F,Spiegel M,Lang KS,Akira S,Thiel V,Ludewig B

更新日期：2007-02-01 00:00:00

abstract：:Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a(-/-)) mice showed a normal hematologic phenotype under homeostatic conditions. However, f...

journal_title：Blood

authors： Chen Y,Ma X,Zhang M,Wang X,Wang C,Wang H,Guo P,Yuan W,Rudolph KL,Zhan Q,Ju Z

更新日期：2014-02-06 00:00:00

abstract：:Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of...

journal_title：Blood

authors： Corral J,Iniesta JA,González-Conejero R,Villalón M,Vicente V

更新日期：2001-05-15 00:00:00

abstract：:Dendritic cells are the most potent antigen-presenting cells of the immune system. Although dendritic cells are likely to secrete selective cytokines that facilitate antigen presentation, the difficulty in isolating pure dendritic cells in sufficient numbers has made assessment of this function imprecise. In this stud...

journal_title：Blood

authors： Zhou LJ,Tedder TF

更新日期：1995-11-01 00:00:00

abstract：:The effect of heterologous anti-human platelet antibody on human platelet function was examined in the presence and absence of whole plasma as an in vitro model for antibody-induced immune damage to cells. Heterologous IgG anti-human platelet antibody mediated platelet aggregation and released serotonin from both plat...

journal_title：Blood

authors： Colman RW,Schreiber AD

更新日期：1976-07-01 00:00:00

abstract：:To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silencing. Ribosomal pro...

journal_title：Blood

authors： Zhu YX,Yin H,Bruins LA,Shi CX,Jedlowski P,Aziz M,Sereduk C,Kortuem KM,Schmidt JE,Champion M,Braggio E,Keith Stewart A

更新日期：2015-01-15 00:00:00

abstract：:MRP14 (S100A9) is the major calcium-binding protein of neutrophils and monocytes. Targeted gene disruption reveals an essential role of this S100 protein for transendothelial migration of phagocytes. The underlying molecular mechanism comprises major alterations of cytoskeletal metabolism. MRP14, in complex with its b...

journal_title：Blood

authors： Vogl T,Ludwig S,Goebeler M,Strey A,Thorey IS,Reichelt R,Foell D,Gerke V,Manitz MP,Nacken W,Werner S,Sorg C,Roth J

更新日期：2004-12-15 00:00:00

abstract：:Peroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant protein in the erythrocyte, and its absence in knock-out mice gives rise to hemolytic anemia. We have found that in human erythrocytes, Prx2 was extremely sensitive to oxidation by H(2)O(2), as dimerization was observed after exposure of ...

journal_title：Blood

authors： Low FM,Hampton MB,Peskin AV,Winterbourn CC

更新日期：2007-03-15 00:00:00

abstract：:Bleeding problems are associated with defects in platelet alpha-granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized ...

journal_title：Blood

authors： Lo B,Li L,Gissen P,Christensen H,McKiernan PJ,Ye C,Abdelhaleem M,Hayes JA,Williams MD,Chitayat D,Kahr WH

更新日期：2005-12-15 00:00:00

abstract：:We report 2 new mutations identified in 3 patients and characterized by the markedly decreased affinity of von Willebrand factor (vWF) for factor VIII (FVIII). Patients 2 and 3, who have a typical type 2N phenotype, were found to be compound heterozygous for Arg91Gln and Cys25Tyr or Cys95Phe, respectively. Patient 1, ...

journal_title：Blood

authors： Jorieux S,Fressinaud E,Goudemand J,Gaucher C,Meyer D,Mazurier C

更新日期：2000-05-15 00:00:00

abstract：:The treatment of multiple myeloma is considered a continuously evolving paradigm as a result of the growing availability of new and highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. Clinical trials advocate long-term rather than sh...

journal_title：Blood

authors： Delforge M,Ludwig H

更新日期：2017-04-27 00:00:00

abstract：:The number of neutrophils in the blood is tightly regulated to ensure adequate protection against microbial pathogens while minimizing damage to host tissue. Neutrophil homeostasis in the blood is achieved through a balance of neutrophil production, release from the bone marrow, and clearance from the circulation. Acc...

journal_title：Blood

authors： Eash KJ,Means JM,White DW,Link DC

更新日期：2009-05-07 00:00:00

abstract：:To characterize genetic contributions toward aberrant splicing of the hyaluronan synthase 1 (HAS1) gene in multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), we sequenced 3616 bp in HAS1 exons and introns involved in aberrant splicing, from 17 patients. We identified a total of 197 HAS1 genetic variations (...

journal_title：Blood

authors： Adamia S,Reichert AA,Kuppusamy H,Kriangkum J,Ghosh A,Hodges JJ,Pilarski PM,Treon SP,Mant MJ,Reiman T,Belch AR,Pilarski LM

更新日期：2008-12-15 00:00:00

abstract：:Anemia and vitamin D deficiency are conditions that both result in significant morbidity and increase with age. The potential relationship between them remains poorly understood, particularly in the elderly. We used the Third National Health and Nutrition Examination Survey to examine the association of vitamin D defi...

journal_title：Blood

authors： Perlstein TS,Pande R,Berliner N,Vanasse GJ

更新日期：2011-03-10 00:00:00

abstract：:The paradoxical correlation between thrombosis and the lupus anticoagulant (LAC) effect is an enigmatic feature of the antiphospholipid (aPL) syndrome. The Dutch authors previously reported that thrombosis-related anti-beta2-glycoprotein I (beta2GPI) antibodies recognize domain I and cause LAC. The American authors re...

journal_title：Blood

authors： de Laat B,Wu XX,van Lummel M,Derksen RH,de Groot PG,Rand JH

更新日期：2007-02-15 00:00:00