Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.

abstract：:Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative disorders characterized by an increased incidence of thrombo-hemorrhagic complications. The acquired somatic Janus kinase 2 (JAK2) V617F mutation is present in the majority of PV and ET patients. Because aberrant protein Tyr-phosp...

journal_title：Blood

authors： Randi ML,Brunati AM,Scapin M,Frasson M,Deana R,Magrin E,Fabris F,Donella-Deana A

更新日期：2010-01-21 00:00:00

abstract：:Current knowledge is inadequate to explain the different patterns of blast cell accumulation in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We compared the growth patterns of blast cell progenitors (CFU-L) in 23 patients with advanced MDS and 32 patients with de novo AML. Circulating blast progen...

journal_title：Blood

authors： Aul C,Gattermann N,Schneider W

更新日期：1992-08-01 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is less active in vivo and in vitro against clots that are enriched in platelets, even at therapeutic concentrations. The release of radioactivity from 125I-fibrin-labeled clots was decreased by 47% 6 hours after the addition of t-PA 400 U/mL when formed in platelet-rich versus...

journal_title：Blood

authors： Kunitada S,FitzGerald GA,Fitzgerald DJ

更新日期：1992-03-15 00:00:00

abstract：:To identify potential mutations in the gamma-glutamyl carboxylase gene, the sequence of all exons and intron/exon borders was determined in 4 patients from a consanguineous kindred with combined deficiency of all vitamin K-dependent procoagulants and anticoagulants and results were compared with normal genomic sequenc...

journal_title：Blood

authors： Brenner B,Sánchez-Vega B,Wu SM,Lanir N,Stafford DW,Solera J

更新日期：1998-12-15 00:00:00

abstract：:Drug-dependent antibodies (DDAbs) that cause acute thrombocytopenia upon drug exposure are nonreactive in the absence of the drug but bind tightly to a platelet membrane glycoprotein, usually α(IIb)/β3 integrin (GPIIb/IIIa) when the drug is present. How a drug promotes binding of antibody to its target is unknown and ...

journal_title：Blood

authors： Bougie DW,Peterson J,Rasmussen M,Aster RH

更新日期：2015-10-29 00:00:00

abstract：:DNA amplification combined with hybridization with 32P-labeled synthetic oligonucleotide probes has been used to identify base substitutions in the 5' promoter region of the A gamma globin gene in members of eleven families from China, Sardinia, Canada, and the United States who had a heterozygosity for the A gamma-be...

journal_title：Blood

authors： Yang KG,Stoming TA,Fei YJ,Liang S,Wong SC,Masala B,Huang RB,Wei ZP,Huisman TH

更新日期：1988-05-01 00:00:00

abstract：:Glutathione-S-transferase (GST)-Grb2 fusion proteins have been used to identify the potential role of Grb2-binding proteins in platelet activation by the platelet low-affinity IgG receptor, Fc gamma RIIA. Two tyrosine phosphoproteins of 38 and 63 kD bind to the SH2 domain of Grb2 following Fc gamma RIIA stimulation of...

journal_title：Blood

authors： Robinson A,Gibbins J,Rodríguez-Liñares B,Finan PM,Wilson L,Kellie S,Findell P,Watson SP

更新日期：1996-07-15 00:00:00

abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...

journal_title：Blood

authors： Nichols WL,Gastineau DA,Solberg LA Jr,Mann KG

更新日期：1985-06-01 00:00:00

abstract：:AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is selectively expressed on CD34(bright) hematopoietic stem and progenitor cells (progenitors) derived from human fetal liver and b...

journal_title：Blood

authors： Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

更新日期：1997-12-15 00:00:00

abstract：:Folate receptor (FR) type beta is a promising target for therapeutic intervention in acute myelogenous leukemia (AML) owing particularly to its specific up-regulation in AML cells by all-trans retinoic acid (ATRA). Here we identify functional elements in the FR-beta gene and examine the molecular mechanism of transcri...

journal_title：Blood

authors： Hao H,Qi H,Ratnam M

更新日期：2003-06-01 00:00:00

abstract：:Genetic variation in the PEAR1 locus is linked to platelet reactivity and cardiovascular disease. The major G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), is associated with higher PEAR1 expression in platelets and endothelial cells than the minor A allele. ...

journal_title：Blood

authors： Izzi B,Pistoni M,Cludts K,Akkor P,Lambrechts D,Verfaillie C,Verhamme P,Freson K,Hoylaerts MF

更新日期：2016-08-18 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is considered the gold standard in the frontline therapy of younger patients with multiple myeloma because it results in higher complete remission (CR) rates and longer event-free survival than conventional chemotherapy. The greatest benefit from ASCT is obtained in patients...

journal_title：Blood

authors： Bladé J,Rosiñol L,Cibeira MT,Rovira M,Carreras E

更新日期：2010-05-06 00:00:00

abstract：:Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarc...

journal_title：Blood

authors： Massa M,Rosti V,Ferrario M,Campanelli R,Ramajoli I,Rosso R,De Ferrari GM,Ferlini M,Goffredo L,Bertoletti A,Klersy C,Pecci A,Moratti R,Tavazzi L

更新日期：2005-01-01 00:00:00

abstract：:Human mast cells in adult tissues have been thought to have limited, if any, proliferative potential. The current study examined mast cells obtained from adult skin and cultured in serum-free medium with recombinant human stem cell factor. During the first 4 weeks of culture, the percentages of mast cells increased fr...

journal_title：Blood

authors： Kambe N,Kambe M,Kochan JP,Schwartz LB

更新日期：2001-04-01 00:00:00

abstract：:Activation of inflammatory and procoagulant mechanisms is thought to contribute significantly to the initiation of restenosis, a common complication after balloon angioplasty of obstructed arteries. During this process, expression of tissue factor (TF) represents one of the major physiologic triggers of coagulation th...

journal_title：Blood

authors： Kopp CW,Hölzenbein T,Steiner S,Marculescu R,Bergmeister H,Seidinger D,Mosberger I,Kaun C,Cejna M,Horvat R,Wojta J,Maurer G,Binder BR,Breuss JM,Ecker RC,de Martin R,Minar E

更新日期：2004-03-01 00:00:00

abstract：:Autologous bone marrow transplantation (ABMT) makes it possible to escalate the dose of cytotoxic treatment to a lethal range. Disease-free survival (DFS) following myeloablative therapy and ABMT has been shown to be superior to conventional treatment in high risk patients with acute myelogenous leukemia (AML). It was...

journal_title：Blood

authors： Körbling M,Hunstein W,Fliedner TM,Cayeux S,Dörken B,Fehrentz D,Haas R,Ho AD,Keilholz U,Knauf W

更新日期：1989-11-01 00:00:00

abstract：:To assess the frequency and significance of nonrandom abnormalities of chromosome 9p in childhood acute lymphoblastic leukemia (ALL), we analyzed our experience with 398 consecutive cases with completely banded karyotypes. Forty cases (10%) with abnormalities of 9p were identified: 26 with deletions, nine with unbalan...

journal_title：Blood

authors： Murphy SB,Raimondi SC,Rivera GK,Crone M,Dodge RK,Behm FG,Pui CH,Williams DL

更新日期：1989-07-01 00:00:00

abstract：:Previous results, presented in abstract form, indicate that replacement of thromboplastin with a mixture of phospholipid and truncated soluble tissue factor apoprotein results in a coagulation assay that can directly measure plasma factor VIIa levels without interference from zymogen factor VII (Atherosclerosis Thromb...

journal_title：Blood

authors： Wildgoose P,Nemerson Y,Hansen LL,Nielsen FE,Glazer S,Hedner U

更新日期：1992-07-01 00:00:00

abstract：:Initial molecular events leading to natural killer lymphocyte (NK) and dendritic cell (DC) interactions are largely unknown. Here, the role of CX3CL1 (fractalkine), a chemokine expressed on mature dendritic cells (mDCs) has been investigated. We show that CX3CL1 promotes NK activation by mDCs. After blocking of CX3CL1...

journal_title：Blood

authors： Pallandre JR,Krzewski K,Bedel R,Ryffel B,Caignard A,Rohrlich PS,Pivot X,Tiberghien P,Zitvogel L,Strominger JL,Borg C

更新日期：2008-12-01 00:00:00

abstract：:Using recombinantly expressed proteins and synthetic peptides, we examined the structural/functional features of the platelet chemokines, neutrophil-activating peptide-2 (NAP-2) and platelet factor 4 (PF4); that were important in their activation of neutrophils. Previous studies with the chemokine interleukin-8 (IL-8)...

journal_title：Blood

authors： Yan Z,Zhang J,Holt JC,Stewart GJ,Niewiarowski S,Poncz M

更新日期：1994-10-01 00:00:00

abstract：:T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene. In 2 patients with MALT lymphoma of th...

journal_title：Blood

authors： Streubel B,Lamprecht A,Dierlamm J,Cerroni L,Stolte M,Ott G,Raderer M,Chott A

更新日期：2003-03-15 00:00:00

abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...

journal_title：Blood

authors： Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

更新日期：2015-10-29 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characteri...

journal_title：Blood

authors： Gandhi MK,Hoang T,Law SC,Brosda S,O'Rourke K,Tobin JWD,Vari F,Murigneux V,Fink JL,Gunawardana J,Gould CM,Oey H,Bednarska K,Delecluse S,Trappe RU,de Long LM,Sabdia MB,Bhagat G,Hapgood G,Blyth E,Clancy LE,Wight J

更新日期：2020-11-17 00:00:00

abstract：:Primary cutaneous lymphomas (PCLs) are clonal T- or B-cell neoplasms, which originate in the skin. In recent years, mast cells were described as regulators of the tumor microenvironment in different human malignancies. Here, we investigated the role of mast cells in the tumor microenvironment of PCL. We found signific...

journal_title：Blood

authors： Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K

更新日期：2012-09-06 00:00:00

abstract：:Although combination regimens have improved outcomes over monotherapy in chronic lymphocytic leukemia (CLL), patients eventually relapse. Combined fludarabine, cyclophosphamide, and monoclonal anti-CD52 antibody alemtuzumab (FCC) provided synergistic cytotoxicity with effective clearing of minimal residual disease. Th...

journal_title：Blood

authors： Montillo M,Tedeschi A,Petrizzi VB,Ricci F,Crugnola M,Spriano M,Spedini P,Ilariucci F,Uziel L,Attolico I,Vismara E,De Blasio A,Zaccaria A,Morra E

更新日期：2011-10-13 00:00:00

abstract：:Myelotoxic injury in the bone marrow (BM) as a consequence of total body irradiation (TBI) or granulocyte colony-stimulating factor (G-CSF) mobilization results in the deposition of iC3b on BM stroma (stroma-iC3b). In the present study, we have examined how stroma-iC3b interacts with hematopoietic progenitor cells (HP...

journal_title：Blood

authors： Cramer DE,Allendorf DJ,Baran JT,Hansen R,Marroquin J,Li B,Ratajczak J,Ratajczak MZ,Yan J

更新日期：2006-01-15 00:00:00

abstract：:Mast cells are inflammatory and immunoregulatory cells resident in tissues. They develop from bone marrow-derived progenitor cells that enter the tissue through the blood circulation. The specific localization and migration of mast cells in tissues is dependent on their interaction with extracellular matrix (ECM) prot...

journal_title：Blood

authors： Lorentz A,Schuppan D,Gebert A,Manns MP,Bischoff SC

更新日期：2002-02-01 00:00:00

abstract：:More than 90% of both unfractionated and blast-enriched T cell-depleted mononuclear cells (MNC) from a patient with a morphologically and phenotypically unclassified acute leukemia expressed interleukin 2 receptors (IL2-R), whereas 50% unfractionated MNC displayed monocyte/myeloid- (My7, My9, and OKM1) and B cell-rest...

journal_title：Blood

authors： Bentaboulet M,Allouche M,Tsapis A,Jasmin C,Georgoulias V

更新日期：1987-10-01 00:00:00

abstract：:von Willebrand's antigen II (vW AgII), a plasma and platelet antigen immunologically and biochemically distinct from factor-VIII-related antigen (VIIIR:Ag), is decreased in von Willebrand's disease. vW AgII is released from platelets during aggregation and clotting. The release of platelet vW AgII was studied in washe...

journal_title：Blood

authors： Scott JP,Montgomery RR

更新日期：1981-12-01 00:00:00

abstract：:The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is considered to be frequently offset by graft-versus-host disease (GVHD). Thus, impr...

journal_title：Blood

authors： Kawase T,Matsuo K,Kashiwase K,Inoko H,Saji H,Ogawa S,Kato S,Sasazuki T,Kodera Y,Morishima Y,Japan Marrow Donor Program.

更新日期：2009-03-19 00:00:00